AU2019294699B2 - Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation - Google Patents

Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation Download PDF

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AU2019294699B2
AU2019294699B2 AU2019294699A AU2019294699A AU2019294699B2 AU 2019294699 B2 AU2019294699 B2 AU 2019294699B2 AU 2019294699 A AU2019294699 A AU 2019294699A AU 2019294699 A AU2019294699 A AU 2019294699A AU 2019294699 B2 AU2019294699 B2 AU 2019294699B2
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AU2019294699A1 (en
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Robert F. Dannals
Andrew G. HORTI
Ravi NAIK
Martin G. Pomper
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
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  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
AU2019294699A 2018-06-26 2019-06-26 Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation Active AU2019294699B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689958P 2018-06-26 2018-06-26
US62/689,958 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

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AU2019294699A1 AU2019294699A1 (en) 2021-01-21
AU2019294699B2 true AU2019294699B2 (en) 2025-05-01

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US (1) US20210290784A1 (https=)
EP (1) EP3813890A4 (https=)
JP (2) JP2021533087A (https=)
KR (1) KR20210013769A (https=)
CN (2) CN118743770A (https=)
AU (1) AU2019294699B2 (https=)
BR (1) BR112020026602A2 (https=)
CA (1) CA3104520A1 (https=)
EA (1) EA202092843A1 (https=)
IL (1) IL279768B2 (https=)
MX (1) MX2021000141A (https=)
WO (1) WO2020006075A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
WO2020132651A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Kif18a inhibitors
EP3898616B1 (en) 2018-12-20 2024-10-02 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
JP7676308B2 (ja) * 2018-12-20 2025-05-14 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド
US12540129B2 (en) 2019-08-02 2026-02-03 Amgen Inc. KIF18A inhibitors
WO2021026099A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
CA3221884A1 (en) * 2021-06-11 2022-12-15 Norman Lafrance Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
CN109069666B (zh) * 2016-04-29 2023-04-04 纪念斯隆凯特琳癌症中心 使靶向颗粒穿透、分布和响应于恶性脑肿瘤中的组合物和方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUER F ET AL: "Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor", Bioorganic Medicinal Chemistry, 2010, vol. 18, no. 15, pages 5489 - 5497. *
CARL R. ILLIG ET AL: "Discovery of novel FMS kinase inhibitors as anti-inflammatory agents", Bioorganic & Medicinal Chemistry Letters, 2008, vol. 18, pages 1642-1648 *
CARL R. ILLIG ET AL: "Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate (JNJ-28312141)", 《J. MED. CHEM.》, vol. 54 *
NAIK RAVI ET AL: "PET tracer for imaging the macrophage colony stimulating factor receptor", Journal of Nuclear Medicine, 2018, vol. 59 (supplement 1), page 547 *

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WO2020006075A1 (en) 2020-01-02
EP3813890A4 (en) 2022-03-23
MX2021000141A (es) 2021-03-25
KR20210013769A (ko) 2021-02-05
AU2019294699A1 (en) 2021-01-21
CN118743770A (zh) 2024-10-08
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
IL279768B2 (en) 2025-04-01
US20210290784A1 (en) 2021-09-23
JP2024133496A (ja) 2024-10-02
EA202092843A1 (ru) 2021-04-19
JP2021533087A (ja) 2021-12-02
CN112638431A (zh) 2021-04-09
CA3104520A1 (en) 2020-01-02
IL279768B1 (en) 2024-12-01
BR112020026602A2 (pt) 2021-03-23

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