JP2021532158A5 - - Google Patents
Info
- Publication number
- JP2021532158A5 JP2021532158A5 JP2021505202A JP2021505202A JP2021532158A5 JP 2021532158 A5 JP2021532158 A5 JP 2021532158A5 JP 2021505202 A JP2021505202 A JP 2021505202A JP 2021505202 A JP2021505202 A JP 2021505202A JP 2021532158 A5 JP2021532158 A5 JP 2021532158A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkoxy
- alkyl
- thioalkoxy
- sulfhydryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862712434P | 2018-07-31 | 2018-07-31 | |
| US62/712,434 | 2018-07-31 | ||
| PCT/US2019/044278 WO2020028461A1 (en) | 2018-07-31 | 2019-07-31 | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021532158A JP2021532158A (ja) | 2021-11-25 |
| JP2021532158A5 true JP2021532158A5 (enExample) | 2022-08-04 |
| JP7613743B2 JP7613743B2 (ja) | 2025-01-15 |
Family
ID=67734803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021505202A Active JP7613743B2 (ja) | 2018-07-31 | 2019-07-31 | 転移性癌および化学療法抵抗性癌の治療のためのテトラヒドロキノリノ誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12162855B2 (enExample) |
| EP (1) | EP3830079A1 (enExample) |
| JP (1) | JP7613743B2 (enExample) |
| CN (1) | CN112638881B (enExample) |
| AU (1) | AU2019315444B2 (enExample) |
| CA (1) | CA3107120A1 (enExample) |
| IL (1) | IL280395B2 (enExample) |
| WO (1) | WO2020028461A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112638881B (zh) | 2018-07-31 | 2025-01-07 | 普林斯顿大学托管委员会 | 用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物 |
| WO2021151062A1 (en) * | 2020-01-24 | 2021-07-29 | The Trustees Of Princeton Univeristy | Heterocyclic compounds and uses thereof |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
| IL324964A (en) | 2021-04-22 | 2026-01-01 | Kayothera Inc | Modified heterocycles as aldehyde dehydrogenase inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60126270A (ja) * | 1983-12-14 | 1985-07-05 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPS61145162A (ja) * | 1984-12-19 | 1986-07-02 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| DE3701277A1 (de) | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| JPH01319453A (ja) * | 1988-06-22 | 1989-12-25 | Wakamoto Pharmaceut Co Ltd | 新規ベンゾキノン誘導体 |
| ATE355273T1 (de) | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
| US20050209247A1 (en) * | 2003-11-07 | 2005-09-22 | Chiron Corporation | Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties |
| EP1718306A2 (en) * | 2004-02-20 | 2006-11-08 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
| JP2006349902A (ja) * | 2005-06-15 | 2006-12-28 | Fujifilm Holdings Corp | 黒白熱現像感光材料 |
| WO2007128884A1 (en) * | 2006-05-09 | 2007-11-15 | Oy Jurilab Ltd | Novel genes and markers in type 2 diabetes and obesity |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| WO2013027168A1 (en) | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| HUE051255T2 (hu) * | 2014-02-19 | 2021-03-01 | Aviv Therapeutics Inc | Mitokondriális aldehid dehidrogenáz 2 (ALDH2) kötõ policiklusos amidok és alkalmazásuk rák kezelésére |
| EP3143009B1 (en) | 2014-05-12 | 2019-09-18 | Fondazione Istituto Italiano di Tecnologia | Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| JP6759514B2 (ja) | 2014-08-01 | 2020-09-23 | ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ | ブロモドメインに対して活性な化合物 |
| CN112638881B (zh) | 2018-07-31 | 2025-01-07 | 普林斯顿大学托管委员会 | 用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物 |
| WO2021151062A1 (en) | 2020-01-24 | 2021-07-29 | The Trustees Of Princeton Univeristy | Heterocyclic compounds and uses thereof |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
| IL324964A (en) | 2021-04-22 | 2026-01-01 | Kayothera Inc | Modified heterocycles as aldehyde dehydrogenase inhibitors |
-
2019
- 2019-07-31 CN CN201980056669.3A patent/CN112638881B/zh active Active
- 2019-07-31 WO PCT/US2019/044278 patent/WO2020028461A1/en not_active Ceased
- 2019-07-31 IL IL280395A patent/IL280395B2/en unknown
- 2019-07-31 EP EP19758540.9A patent/EP3830079A1/en active Pending
- 2019-07-31 CA CA3107120A patent/CA3107120A1/en active Pending
- 2019-07-31 JP JP2021505202A patent/JP7613743B2/ja active Active
- 2019-07-31 AU AU2019315444A patent/AU2019315444B2/en active Active
-
2021
- 2021-01-29 US US17/162,827 patent/US12162855B2/en active Active
-
2024
- 2024-11-01 US US18/934,691 patent/US20250129046A1/en active Pending
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