JP2021532124A5 - - Google Patents
Info
- Publication number
- JP2021532124A5 JP2021532124A5 JP2021503752A JP2021503752A JP2021532124A5 JP 2021532124 A5 JP2021532124 A5 JP 2021532124A5 JP 2021503752 A JP2021503752 A JP 2021503752A JP 2021503752 A JP2021503752 A JP 2021503752A JP 2021532124 A5 JP2021532124 A5 JP 2021532124A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- triazine
- acetamide
- oxothieno
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18185580 | 2018-07-25 | ||
| EP18185580.0 | 2018-07-25 | ||
| EP19175246 | 2019-05-17 | ||
| EP19175246.8 | 2019-05-17 | ||
| PCT/IB2019/056278 WO2020021447A1 (en) | 2018-07-25 | 2019-07-23 | Nlrp3 inflammasome inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021532124A JP2021532124A (ja) | 2021-11-25 |
| JP2021532124A5 true JP2021532124A5 (enExample) | 2024-06-27 |
| JP7555327B2 JP7555327B2 (ja) | 2024-09-24 |
Family
ID=67989037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021503752A Active JP7555327B2 (ja) | 2018-07-25 | 2019-07-23 | Ｎｌｒｐ３インフラマソーム阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12168012B2 (enExample) |
| EP (1) | EP3827008B1 (enExample) |
| JP (1) | JP7555327B2 (enExample) |
| KR (1) | KR20210038877A (enExample) |
| CN (1) | CN112424207B (enExample) |
| AU (1) | AU2019309727B2 (enExample) |
| BR (1) | BR112021000964A2 (enExample) |
| CA (1) | CA3103943A1 (enExample) |
| CL (1) | CL2021000191A1 (enExample) |
| CO (1) | CO2021000537A2 (enExample) |
| CR (1) | CR20210045A (enExample) |
| CU (1) | CU20210009A7 (enExample) |
| DO (1) | DOP2021000019A (enExample) |
| EC (1) | ECSP21004787A (enExample) |
| IL (1) | IL280336A (enExample) |
| JO (1) | JOP20210017A1 (enExample) |
| MA (1) | MA53388A (enExample) |
| MX (1) | MX2021000925A (enExample) |
| PE (1) | PE20210406A1 (enExample) |
| PH (1) | PH12021550166A1 (enExample) |
| SG (1) | SG11202012321PA (enExample) |
| WO (1) | WO2020021447A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230330054A1 (en) * | 2020-03-31 | 2023-10-19 | Olatec Therapeutics Llc | Method for preventing or treating lung infection and lung inflammation |
| EP4135842B1 (en) | 2020-04-15 | 2024-10-23 | JANSSEN Pharmaceutica NV | Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway |
| CA3174837A1 (en) * | 2020-04-15 | 2021-10-21 | Daniel Oehlrich | Pyrazolo[1,5-d][1,2,4]triazine-5(4h)-acetamides as inhibitors of the nlrp3 inflammasome pathway |
| US20230203064A1 (en) | 2020-04-23 | 2023-06-29 | Janssen Pharmaceutica Nv | Tricyclic compounds as inhibitors of nlrp3 |
| WO2021219784A1 (en) | 2020-04-30 | 2021-11-04 | Janssen Pharmaceutica Nv | New triazinoindole compounds |
| KR20230016658A (ko) | 2020-05-28 | 2023-02-02 | 얀센 파마슈티카 엔.브이. | 화합물 |
| US12624010B2 (en) | 2020-06-19 | 2026-05-12 | Ac Immune Sa | Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway |
| AU2021324901A1 (en) * | 2020-08-14 | 2023-03-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP3974415A1 (en) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nlrp3 modulators |
| US20240043450A1 (en) | 2020-09-24 | 2024-02-08 | Janssen Pharmaceutica Nv | New compound |
| CN114478537B (zh) * | 2020-11-13 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 环酰胺并环化合物及其医药用途 |
| AU2021381396A1 (en) * | 2020-11-20 | 2023-06-22 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| KR20230152016A (ko) | 2021-03-04 | 2023-11-02 | 얀센 파마슈티카 엔브이 | Nlrp3을 조절하는 4-알콕시-6-옥소-피리다진 유도체 |
| CA3208414A1 (en) | 2021-03-04 | 2022-09-09 | Daniel Oehlrich | 4-amino-6-oxo-pyridazine derivatives modulating nlrp3 |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| WO2022221315A1 (en) * | 2021-04-13 | 2022-10-20 | Unity Biotechnology, Inc. | Methods of treating retinal vasculopathies |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| CA3212725A1 (en) * | 2021-04-29 | 2022-11-03 | Daniel Oehlrich | Phthalazinone derivatives as nlrp3 inflammasome inhibitors |
| EP4347571B1 (en) | 2021-06-04 | 2026-04-22 | F. Hoffmann-La Roche AG | Triazine derivatives and their use in the treatment of cancer. |
| MX2026004033A (es) | 2021-06-23 | 2026-05-04 | Yoda Therapeutics Inc | Derivados del benzimidazol para el tratamiento y/o la prevencion de enfermedades y trastornos mediados por el nlrp3 |
| WO2023275230A1 (en) | 2021-07-01 | 2023-01-05 | Janssen Pharmaceutica Nv | 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides |
| WO2023288039A1 (en) * | 2021-07-16 | 2023-01-19 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| WO2023028536A1 (en) * | 2021-08-25 | 2023-03-02 | Ptc Therapeutics, Inc. | 1,2,4-triazine derivatives useful as inhibitors of nlrp3 |
| EP4401739A4 (en) * | 2021-09-17 | 2025-07-30 | Nico Therapeutics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| KR20230066899A (ko) | 2021-11-08 | 2023-05-16 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| JP2025502732A (ja) | 2021-12-22 | 2025-01-28 | エーシー・イミューン・エス・アー | ジヒドロオキサゾール誘導体化合物 |
| CN116375728B (zh) * | 2021-12-31 | 2025-06-10 | 成都赜灵生物医药科技有限公司 | 噻吩吡咯并三嗪酮类化合物及其用途 |
| WO2023158708A1 (en) * | 2022-02-16 | 2023-08-24 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| WO2023156643A1 (en) * | 2022-02-21 | 2023-08-24 | Sanofi | Thienopyrrolotriazine compounds, their preparation and their therapeutic use |
| JP2025524640A (ja) | 2022-07-14 | 2025-07-30 | エーシー・イミューン・エス・アー | Ｎｌｒｐ３インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体 |
| WO2024023266A1 (en) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | Novel compounds |
| WO2024033845A1 (en) * | 2022-08-10 | 2024-02-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR20240022938A (ko) | 2022-08-12 | 2024-02-20 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| CN119907797A (zh) | 2022-09-23 | 2025-04-29 | 默沙东有限责任公司 | 用作nod样受体蛋白3抑制剂的酞嗪衍生物 |
| CN120569372A (zh) | 2023-01-24 | 2025-08-29 | 第一三共株式会社 | 经取代的苯化合物 |
| PE20252770A1 (es) * | 2023-03-17 | 2025-12-22 | Ventus Therapeutics U S Inc | Derivados de amida para inhibir nlrp3 y usos de estos |
| AU2024280075A1 (en) | 2023-06-02 | 2025-12-11 | Merck Sharp & Dohme Llc | 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3 |
| WO2025046419A1 (ko) | 2023-08-25 | 2025-03-06 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| US20250223290A1 (en) | 2023-12-14 | 2025-07-10 | Merck Sharp & Dohme Llc | Azaindazole derivatives useful as inhibitors of nod-like receptor protein 3 |
| TW202535370A (zh) | 2023-12-14 | 2025-09-16 | 美商默沙東有限責任公司 | 作為nod樣受體蛋白3抑制劑之吲唑衍生物 |
| WO2025133307A1 (en) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| TW202545527A (zh) | 2024-01-16 | 2025-12-01 | 英商諾得瑟拉公司 | Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法 |
| CN122555707A (zh) | 2024-01-17 | 2026-08-11 | Ac免疫有限公司 | 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物 |
| CN122555708A (zh) | 2024-01-17 | 2026-08-11 | Ac免疫有限公司 | 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物 |
| WO2025163069A1 (en) | 2024-01-31 | 2025-08-07 | Ac Immune Sa | Novel compounds |
| WO2026024770A1 (en) * | 2024-07-23 | 2026-01-29 | New York Blood Center, Inc. | Compounds for treatment of hemolysis- and inflammasome-associated diseases |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
| WO2026132518A1 (en) | 2024-12-20 | 2026-06-25 | Ac Immune Sa | Heterocyclic compounds modulating the nlrp3 inflammasome pathway |
Family Cites Families (43)
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| WO2009008906A2 (en) * | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
| WO2010128152A1 (en) | 2009-05-07 | 2010-11-11 | Novartis Ag | Fused heterocyclic c-glycosides for the treatment of diabetes |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| KR20120087950A (ko) | 2009-10-20 | 2012-08-07 | 노파르티스 아게 | 글리코시드 유도체 및 그의 용도 |
| ES2622138T3 (es) | 2010-06-23 | 2017-07-05 | Hanmi Science Co., Ltd. | Nuevos derivados de pirimidina condensados para la inhibición de la actividad tirosina quinasa |
| PH12013500246A1 (en) | 2010-08-10 | 2019-10-11 | Celgene Avilomics Res Inc | Besylate salt of a btk inhibitor |
| CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| US9073947B2 (en) | 2011-06-10 | 2015-07-07 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| BR112014012727B1 (pt) | 2011-11-29 | 2022-10-25 | Ono Pharmaceutical Co., Ltd | Cloridrato de 6-amino-9-[(3r)-1-(2-butinoil)-3-pirrolidinil]-7-(4-fenoxifenil)-7,9-di-hidro-8h-puri- 8-ona e composição farmacêutica |
| EP2858500A4 (en) | 2012-06-08 | 2016-04-06 | Biogen Ma Inc | BRUTON TYROSINE KINASE HEMMER |
| SMT201900344T1 (it) | 2012-09-10 | 2019-07-11 | Principia Biopharma Inc | Composti di pirazolopirimidina come inibitori di chinasi |
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| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
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| WO2015110923A2 (en) | 2014-01-21 | 2015-07-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia usng a btk inhibitor |
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| PL3099717T3 (pl) | 2014-01-31 | 2019-10-31 | Novartis Ag | Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie |
| EA201691765A1 (ru) | 2014-03-14 | 2016-12-30 | Новартис Аг | Молекулы антител против lag-3 и их применения |
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| MA42510A (fr) | 2015-06-10 | 2018-06-06 | Biogen Ma Inc | Formes et compositions d'inhibiteurs biaryles de la tyrosine kinase de bruton |
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| ES2875384T3 (es) | 2016-01-05 | 2021-11-10 | Jiangsu Hengrui Medicine Co | Forma cristalina del inhibidor de la quinasa BTK y método de preparación del mismo |
| EP3445761A1 (en) * | 2016-04-19 | 2019-02-27 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
| IL263815B (en) | 2016-06-29 | 2022-07-01 | Principia Biopharma Inc | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(Oxtan-3-yl)piperazin-1-yl)pent-2-ananitrile |
| KR101865120B1 (ko) | 2016-06-29 | 2018-06-08 | 숭실대학교 산학협력단 | 테스트 노드 기반의 무선 측위 방법 및 그 장치 |
| EP3272739A1 (en) | 2016-07-20 | 2018-01-24 | NodThera Limited | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
| GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| MX2020001776A (es) | 2017-08-15 | 2020-03-24 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3. |
| WO2019034693A1 (en) | 2017-08-15 | 2019-02-21 | Inflazome Limited | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
| CN111315733A (zh) | 2017-11-09 | 2020-06-19 | 英夫拉索姆有限公司 | 新颖磺酰胺甲酰胺化合物 |
-
2019
- 2019-07-23 US US17/259,252 patent/US12168012B2/en active Active
- 2019-07-23 MX MX2021000925A patent/MX2021000925A/es unknown
- 2019-07-23 AU AU2019309727A patent/AU2019309727B2/en not_active Ceased
- 2019-07-23 CU CU2021000009A patent/CU20210009A7/es unknown
- 2019-07-23 CA CA3103943A patent/CA3103943A1/en active Pending
- 2019-07-23 BR BR112021000964-7A patent/BR112021000964A2/pt not_active Application Discontinuation
- 2019-07-23 WO PCT/IB2019/056278 patent/WO2020021447A1/en not_active Ceased
- 2019-07-23 PE PE2021000092A patent/PE20210406A1/es unknown
- 2019-07-23 MA MA053388A patent/MA53388A/fr unknown
- 2019-07-23 CR CR20210045A patent/CR20210045A/es unknown
- 2019-07-23 KR KR1020217001895A patent/KR20210038877A/ko not_active Withdrawn
- 2019-07-23 JO JOP/2021/0017A patent/JOP20210017A1/ar unknown
- 2019-07-23 CN CN201980047047.4A patent/CN112424207B/zh active Active
- 2019-07-23 JP JP2021503752A patent/JP7555327B2/ja active Active
- 2019-07-23 EP EP19769892.1A patent/EP3827008B1/en active Active
- 2019-07-23 SG SG11202012321PA patent/SG11202012321PA/en unknown
-
2021
- 2021-01-21 PH PH12021550166A patent/PH12021550166A1/en unknown
- 2021-01-21 IL IL280336A patent/IL280336A/en unknown
- 2021-01-22 CO CONC2021/0000537A patent/CO2021000537A2/es unknown
- 2021-01-22 CL CL2021000191A patent/CL2021000191A1/es unknown
- 2021-01-22 EC ECSENADI20214787A patent/ECSP21004787A/es unknown
- 2021-01-22 DO DO2021000019A patent/DOP2021000019A/es unknown