JP2021532101A5 - - Google Patents
Info
- Publication number
- JP2021532101A5 JP2021532101A5 JP2021502987A JP2021502987A JP2021532101A5 JP 2021532101 A5 JP2021532101 A5 JP 2021532101A5 JP 2021502987 A JP2021502987 A JP 2021502987A JP 2021502987 A JP2021502987 A JP 2021502987A JP 2021532101 A5 JP2021532101 A5 JP 2021532101A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- alkyl
- group
- cycloalkyl
- halogen
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862701313P | 2018-07-20 | 2018-07-20 | |
| US62/701,313 | 2018-07-20 | ||
| PCT/US2019/042711 WO2020018975A1 (en) | 2018-07-20 | 2019-07-19 | Sulfonimidamide compounds as inhibitors of interleukin-1 activity |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021532101A JP2021532101A (ja) | 2021-11-25 |
| JPWO2020018975A5 JPWO2020018975A5 (https=) | 2022-07-25 |
| JP2021532101A5 true JP2021532101A5 (https=) | 2022-07-25 |
| JP7320595B2 JP7320595B2 (ja) | 2023-08-03 |
Family
ID=67659954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502987A Active JP7320595B2 (ja) | 2018-07-20 | 2019-07-19 | インターロイキン－１活性の阻害剤としてのスルホンイミドアミド化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US12234245B2 (https=) |
| EP (1) | EP3823974A1 (https=) |
| JP (1) | JP7320595B2 (https=) |
| KR (1) | KR20210034596A (https=) |
| CN (1) | CN112513048A (https=) |
| AR (1) | AR115822A1 (https=) |
| AU (1) | AU2019306658A1 (https=) |
| BR (1) | BR112021001044A2 (https=) |
| CA (1) | CA3105521A1 (https=) |
| CL (1) | CL2021000153A1 (https=) |
| CO (1) | CO2021001530A2 (https=) |
| CR (1) | CR20210022A (https=) |
| IL (1) | IL279256A (https=) |
| MA (1) | MA53172A (https=) |
| MX (1) | MX2021000780A (https=) |
| PE (1) | PE20211811A1 (https=) |
| PH (1) | PH12021500005A1 (https=) |
| SG (1) | SG11202013062VA (https=) |
| TW (1) | TWI825134B (https=) |
| UA (1) | UA128558C2 (https=) |
| WO (1) | WO2020018975A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3571187B1 (en) | 2017-01-23 | 2023-11-22 | Genentech, Inc. | Chemical compounds as inhibitors of interleukin-1 activity |
| ES2988798T3 (es) | 2017-07-24 | 2024-11-21 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP |
| EP3692020A1 (en) | 2017-10-03 | 2020-08-12 | Inflazome Limited | Novel compounds |
| CA3105521A1 (en) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Sulfonimidamide compounds as inhibitors of interleukin-1 activity |
| CR20210024A (es) | 2018-07-20 | 2021-02-22 | Hoffmann La Roche | Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1 |
| ES3042546T3 (en) * | 2018-11-13 | 2025-11-21 | Novartis Ag | Compounds and compositions for treating conditions associated with nlrp activity |
| US12134611B2 (en) | 2018-11-13 | 2024-11-05 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
| EP3880673B1 (en) | 2018-11-13 | 2024-01-03 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
| WO2020102576A1 (en) * | 2018-11-16 | 2020-05-22 | Novartis Inflammasome Research, Inc. | Compounds and compositions for treating conditions associated with nlrp activity |
| EP3914585A1 (en) * | 2019-01-23 | 2021-12-01 | Novartis AG | Sulfonimidamide compounds and compositions for treating conditions associated with nlrp activity |
| EP3986879B1 (en) | 2019-06-21 | 2024-10-02 | AC Immune SA | Fused 1,2-thiazoles and 1,2-thiazines which act as nlrp3 modulators |
| WO2021002887A1 (en) * | 2019-07-02 | 2021-01-07 | Novartis Inflammasome Research, Inc. | Gut-targeted nlrp3 antagonists and their use in therapy |
| KR20220064364A (ko) | 2019-07-17 | 2022-05-18 | 조마젠 바이오사이언시즈 엘티디 | 다발성 경화증(ms)의 치료를 위한 nlpr3 조절제로서의 n-((1,2,3,5,6,7-헥사하이드로-s-인다센-4-일)카바모일)-4,5,6,7-테트라하이드로벤조푸란-2-설폰아미드 유도체 및 관련 화합물 |
| EP3999179A1 (en) | 2019-07-17 | 2022-05-25 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| JP7392169B2 (ja) * | 2019-11-12 | 2023-12-05 | 成都百裕制薬股▲ふん▼有限公司 | アミド誘導体及びその調製方法並びに医薬における応用 |
| PH12022551767A1 (en) * | 2020-01-22 | 2023-11-29 | Hoffmann La Roche | Sulfonimidamide compounds as nlrp3 modulators |
| PH12022552447A1 (en) * | 2020-03-16 | 2024-01-03 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| AU2021257619A1 (en) | 2020-04-15 | 2022-12-15 | Janssen Pharmaceutica Nv | Pyrazolo[1,5-d][1,2,4]triazine-5(4H)-acetamides as inhibitors of the NLRP3 inflammasome pathway |
| CN115485026A (zh) | 2020-04-15 | 2022-12-16 | 詹森药业有限公司 | Nlrp3炎体途径抑制剂吡唑并[1，2-d][1，2，4]三嗪-2-基-乙酰胺 |
| EP4139312A1 (en) | 2020-04-23 | 2023-03-01 | JANSSEN Pharmaceutica NV | Tricyclic compounds as inhibitors of nlrp3 |
| MX2022013637A (es) | 2020-04-30 | 2022-11-16 | Janssen Pharmaceutica Nv | Nuevos compuestos de triazinoindol. |
| US20230202989A1 (en) | 2020-05-28 | 2023-06-29 | Janssen Pharmaceutica Nv | Compounds |
| AU2021291065B2 (en) | 2020-06-19 | 2025-06-26 | Ac Immune Sa | Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway |
| CN116194445A (zh) | 2020-09-24 | 2023-05-30 | 詹森药业有限公司 | 新化合物 |
| EP3974415A1 (en) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nlrp3 modulators |
| CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| JP2024508017A (ja) | 2021-03-04 | 2024-02-21 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｌｒｐ３を調節する４－アルコキシ－６－オキソ－ピリダジン誘導体 |
| CN116964052A (zh) | 2021-03-04 | 2023-10-27 | 詹森药业有限公司 | 调节nlrp3的4-氨基-6-氧代-哒嗪衍生物 |
| AU2022263621A1 (en) | 2021-04-29 | 2023-12-14 | Janssen Pharmaceutica Nv | Phthalazinone derivatives as nlrp3 inflammasome inhibitors |
| CN116917282A (zh) * | 2021-05-10 | 2023-10-20 | 成都百裕制药股份有限公司 | 酰胺衍生物及其应用 |
| CN116635373A (zh) * | 2021-05-10 | 2023-08-22 | 成都百裕制药股份有限公司 | 酰胺衍生物及其应用 |
| KR20240029027A (ko) | 2021-07-01 | 2024-03-05 | 얀센 파마슈티카 엔브이 | 5-옥소-피리도[2,3-d]피리다진-6(5H)-일 아세트아미드 |
| MX2024000634A (es) * | 2021-07-19 | 2024-02-13 | Genentech Inc | Compuestos de sulfonimidamida y usos de los mismos. |
| CN115894478B (zh) * | 2021-09-30 | 2025-04-04 | 杭州民生药物研究院有限公司 | 一种新型吡啶并吡唑类杂环化合物及其应用 |
| CN118541366A (zh) | 2021-12-22 | 2024-08-23 | Ac免疫有限公司 | 二氢噁唑衍生物化合物 |
| CN116804018A (zh) * | 2022-03-25 | 2023-09-26 | 成都百裕制药股份有限公司 | 酰胺衍生物及其制备方法和在医药上的应用 |
| CN117247393A (zh) * | 2022-06-17 | 2023-12-19 | 成都百裕制药股份有限公司 | 酰胺衍生物及其制备方法和在医药上的应用 |
| WO2024010772A1 (en) * | 2022-07-06 | 2024-01-11 | Kodiak Sciences Inc. | Nlrp3 inhibitors |
| EP4554945A1 (en) | 2022-07-14 | 2025-05-21 | AC Immune SA | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| AU2023313032A1 (en) | 2022-07-28 | 2025-01-23 | Ac Immune Sa | Novel compounds |
| GEAP202516743A (en) | 2022-09-23 | 2025-08-11 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
| AU2024280075A1 (en) | 2023-06-02 | 2025-12-11 | Merck Sharp & Dohme Llc | 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3 |
| WO2025101716A1 (en) * | 2023-11-07 | 2025-05-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Processes for synthesis of trifunctionalized sulfur(vi) compounds |
| US20250223290A1 (en) | 2023-12-14 | 2025-07-10 | Merck Sharp & Dohme Llc | Azaindazole derivatives useful as inhibitors of nod-like receptor protein 3 |
| AR134646A1 (es) | 2023-12-14 | 2026-02-04 | Merck Sharp & Dohme Llc | Derivados de indazol útiles como inhibidores de la proteína 3 del receptor similar a nod |
| WO2025133307A1 (en) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2025153624A1 (en) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025153625A1 (en) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025163069A1 (en) | 2024-01-31 | 2025-08-07 | Ac Immune Sa | Novel compounds |
| WO2025222076A1 (en) | 2024-04-19 | 2025-10-23 | Kyorin Pharmaceutical Co., Ltd. | 1h-pyrrolo[2,3-b]pyridine derivatives as mrgprx2 antagonists for the treatment of inflammatory diseases |
| CN119100956B (zh) * | 2024-09-03 | 2025-12-02 | 大连理工大学 | 一种无催化剂的光驱动合成亚磺酰胺类化合物的方法 |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
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| AU2021291065B2 (en) | 2020-06-19 | 2025-06-26 | Ac Immune Sa | Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway |
| IL277528B (en) | 2020-09-22 | 2022-05-01 | Ag Plenus Ltd | Herbicidal compounds and methods of their use |
| CN116194445A (zh) | 2020-09-24 | 2023-05-30 | 詹森药业有限公司 | 新化合物 |
| JP2024508017A (ja) | 2021-03-04 | 2024-02-21 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｌｒｐ３を調節する４－アルコキシ－６－オキソ－ピリダジン誘導体 |
| AU2022263621A1 (en) | 2021-04-29 | 2023-12-14 | Janssen Pharmaceutica Nv | Phthalazinone derivatives as nlrp3 inflammasome inhibitors |
| CN116917282A (zh) | 2021-05-10 | 2023-10-20 | 成都百裕制药股份有限公司 | 酰胺衍生物及其应用 |
| KR20240029027A (ko) | 2021-07-01 | 2024-03-05 | 얀센 파마슈티카 엔브이 | 5-옥소-피리도[2,3-d]피리다진-6(5H)-일 아세트아미드 |
-
2019
- 2019-07-19 CA CA3105521A patent/CA3105521A1/en active Pending
- 2019-07-19 EP EP19753515.6A patent/EP3823974A1/en active Pending
- 2019-07-19 BR BR112021001044-0A patent/BR112021001044A2/pt unknown
- 2019-07-19 CN CN201980048375.6A patent/CN112513048A/zh active Pending
- 2019-07-19 JP JP2021502987A patent/JP7320595B2/ja active Active
- 2019-07-19 KR KR1020217002210A patent/KR20210034596A/ko not_active Withdrawn
- 2019-07-19 WO PCT/US2019/042711 patent/WO2020018975A1/en not_active Ceased
- 2019-07-19 MX MX2021000780A patent/MX2021000780A/es unknown
- 2019-07-19 PE PE2021000082A patent/PE20211811A1/es unknown
- 2019-07-19 CR CR20210022A patent/CR20210022A/es unknown
- 2019-07-19 SG SG11202013062VA patent/SG11202013062VA/en unknown
- 2019-07-19 MA MA053172A patent/MA53172A/fr unknown
- 2019-07-19 AU AU2019306658A patent/AU2019306658A1/en not_active Abandoned
- 2019-07-19 UA UAA202100695A patent/UA128558C2/uk unknown
- 2019-07-22 TW TW108125886A patent/TWI825134B/zh not_active IP Right Cessation
- 2019-07-22 AR ARP190102055A patent/AR115822A1/es not_active Application Discontinuation
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2020
- 2020-12-07 IL IL279256A patent/IL279256A/en unknown
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2021
- 2021-01-15 US US17/150,349 patent/US12234245B2/en active Active
- 2021-01-19 CL CL2021000153A patent/CL2021000153A1/es unknown
- 2021-01-19 PH PH12021500005A patent/PH12021500005A1/en unknown
- 2021-02-10 CO CONC2021/0001530A patent/CO2021001530A2/es unknown
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2024
- 2024-12-19 US US18/988,433 patent/US20250115618A1/en active Pending
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