CL2021000153A1 - Compuestos de sulfonimidamida como inhibidores de la actividad de interleucina-1 - Google Patents
Compuestos de sulfonimidamida como inhibidores de la actividad de interleucina-1Info
- Publication number
- CL2021000153A1 CL2021000153A1 CL2021000153A CL2021000153A CL2021000153A1 CL 2021000153 A1 CL2021000153 A1 CL 2021000153A1 CL 2021000153 A CL2021000153 A CL 2021000153A CL 2021000153 A CL2021000153 A CL 2021000153A CL 2021000153 A1 CL2021000153 A1 CL 2021000153A1
- Authority
- CL
- Chile
- Prior art keywords
- interleukin
- inhibitors
- activity
- compounds
- sulfonimidamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente divulgación se refiere a novedosos compuestos de sulfonimidamida y compuestos relacionados y a su uso en el tratamiento de un trastorno que responde a la modulación de citocinas como IL-1β e IL-18, a la modulación de NLRP3 o a la inhibición de la activación de NLRP3 o componentes relacionados del proceso inflamatorio. (I)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862701313P | 2018-07-20 | 2018-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021000153A1 true CL2021000153A1 (es) | 2021-07-09 |
Family
ID=67659954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021000153A CL2021000153A1 (es) | 2018-07-20 | 2021-01-19 | Compuestos de sulfonimidamida como inhibidores de la actividad de interleucina-1 |
Country Status (20)
Country | Link |
---|---|
US (1) | US20210253596A1 (es) |
EP (1) | EP3823974A1 (es) |
JP (1) | JP7320595B2 (es) |
KR (1) | KR20210034596A (es) |
CN (1) | CN112513048A (es) |
AR (1) | AR115822A1 (es) |
AU (1) | AU2019306658A1 (es) |
BR (1) | BR112021001044A2 (es) |
CA (1) | CA3105521A1 (es) |
CL (1) | CL2021000153A1 (es) |
CO (1) | CO2021001530A2 (es) |
CR (1) | CR20210022A (es) |
IL (1) | IL279256A (es) |
MA (1) | MA53172A (es) |
MX (1) | MX2021000780A (es) |
PE (1) | PE20211811A1 (es) |
PH (1) | PH12021500005A1 (es) |
SG (1) | SG11202013062VA (es) |
TW (1) | TWI825134B (es) |
WO (1) | WO2020018975A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA55695A (fr) | 2017-01-23 | 2022-02-23 | Genentech Inc | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
WO2019068772A1 (en) | 2017-10-03 | 2019-04-11 | Inflazome Limited | NEW COMPOUNDS |
JP7411631B2 (ja) | 2018-07-20 | 2024-01-11 | エフ. ホフマン-ラ ロシュ アーゲー | インターロイキン-1活性の阻害剤としてのスルホニル尿素化合物 |
EP3880659B1 (en) * | 2018-11-16 | 2024-01-03 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
WO2020154499A1 (en) * | 2019-01-23 | 2020-07-30 | Novartis Inflammasome Research, Inc. | Sulfonimidamide compounds and compositions for treating conditions associated with nlrp activity |
US20220378801A1 (en) | 2019-06-21 | 2022-12-01 | Ac Immune Sa | Novel compounds |
WO2021002887A1 (en) * | 2019-07-02 | 2021-01-07 | Novartis Inflammasome Research, Inc. | Gut-targeted nlrp3 antagonists and their use in therapy |
EP4059930A4 (en) | 2019-11-12 | 2024-03-20 | Chengdu Baiyu Pharmaceutical Co Ltd | AMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR AND ITS APPLICATION IN MEDICINE |
KR20220131534A (ko) * | 2020-01-22 | 2022-09-28 | 에프. 호프만-라 로슈 아게 | Nlrp3 조절제로서의 술폰이미드아미드 화합물 |
IL296488A (en) | 2020-03-16 | 2022-11-01 | Zomagen Biosciences Ltd | nlrp3 modulators |
CN115485026A (zh) | 2020-04-15 | 2022-12-16 | 詹森药业有限公司 | Nlrp3炎体途径抑制剂吡唑并[1,2-d][1,2,4]三嗪-2-基-乙酰胺 |
BR112022020807A2 (pt) | 2020-04-15 | 2022-11-29 | Janssen Pharmaceutica Nv | Pirazolo[1,5-d][1,2,4]triazina-5(4h)-acetamidas como inibidores da trajetória de inflamassoma de nlrp3 |
EP4139312A1 (en) | 2020-04-23 | 2023-03-01 | JANSSEN Pharmaceutica NV | Tricyclic compounds as inhibitors of nlrp3 |
JP2023523756A (ja) | 2020-04-30 | 2023-06-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 新規なトリアジノインドール化合物 |
US20230202989A1 (en) | 2020-05-28 | 2023-06-29 | Janssen Pharmaceutica Nv | Compounds |
EP4168395A1 (en) | 2020-06-19 | 2023-04-26 | AC Immune SA | Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway |
JP2023542205A (ja) | 2020-09-24 | 2023-10-05 | ヤンセン ファーマシューティカ エヌ.ベー. | 新規化合物 |
EP3974415A1 (en) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nlrp3 modulators |
CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
CA3208988A1 (en) | 2021-03-04 | 2022-09-09 | Daniel Oehlrich | 4-alkoxy-6-oxo-pyridazine derivatives modulating nlrp3 |
EP4301754A1 (en) | 2021-03-04 | 2024-01-10 | Janssen Pharmaceutica NV | 4-amino-6-oxo-pyridazine derivatives modulating nlrp3 |
BR112023022471A2 (pt) | 2021-04-29 | 2024-01-16 | Janssen Pharmaceutica Nv | Derivados de ftalazinona como inibidores de inflamassoma nlrp3 |
WO2022237781A1 (zh) * | 2021-05-10 | 2022-11-17 | 成都百裕制药股份有限公司 | 酰胺衍生物及其应用 |
TW202246230A (zh) * | 2021-05-10 | 2022-12-01 | 大陸商成都百裕製藥股份有限公司 | 醯胺衍生物及其應用 |
EP4363418A1 (en) | 2021-07-01 | 2024-05-08 | JANSSEN Pharmaceutica NV | 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides |
IL308461A (en) * | 2021-07-19 | 2024-01-01 | Genentech Inc | Sulfonimidamide compounds and their uses |
WO2023118521A1 (en) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
WO2024010772A1 (en) * | 2022-07-06 | 2024-01-11 | Kodiak Sciences Inc. | Nlrp3 inhibitors |
WO2024013395A1 (en) | 2022-07-14 | 2024-01-18 | Ac Immune Sa | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
US20240101563A1 (en) | 2022-07-28 | 2024-03-28 | Ac Immune Sa | Novel compounds |
WO2024064245A1 (en) | 2022-09-23 | 2024-03-28 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2881228T3 (es) * | 2015-02-16 | 2021-11-29 | Univ Queensland | Sulfonilureas y compuestos relacionados y uso de los mismos |
MA55695A (fr) * | 2017-01-23 | 2022-02-23 | Genentech Inc | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
PT3658539T (pt) * | 2017-07-24 | 2024-04-26 | Novartis Ag | Compostos e composições para tratar condições associadas à atividade de nlrp |
WO2019068772A1 (en) * | 2017-10-03 | 2019-04-11 | Inflazome Limited | NEW COMPOUNDS |
-
2019
- 2019-07-19 JP JP2021502987A patent/JP7320595B2/ja active Active
- 2019-07-19 CR CR20210022A patent/CR20210022A/es unknown
- 2019-07-19 CA CA3105521A patent/CA3105521A1/en active Pending
- 2019-07-19 PE PE2021000082A patent/PE20211811A1/es unknown
- 2019-07-19 MA MA053172A patent/MA53172A/fr unknown
- 2019-07-19 WO PCT/US2019/042711 patent/WO2020018975A1/en unknown
- 2019-07-19 KR KR1020217002210A patent/KR20210034596A/ko unknown
- 2019-07-19 SG SG11202013062VA patent/SG11202013062VA/en unknown
- 2019-07-19 CN CN201980048375.6A patent/CN112513048A/zh active Pending
- 2019-07-19 BR BR112021001044-0A patent/BR112021001044A2/pt unknown
- 2019-07-19 MX MX2021000780A patent/MX2021000780A/es unknown
- 2019-07-19 EP EP19753515.6A patent/EP3823974A1/en active Pending
- 2019-07-19 AU AU2019306658A patent/AU2019306658A1/en active Pending
- 2019-07-22 TW TW108125886A patent/TWI825134B/zh active
- 2019-07-22 AR ARP190102055A patent/AR115822A1/es unknown
-
2020
- 2020-12-07 IL IL279256A patent/IL279256A/en unknown
-
2021
- 2021-01-15 US US17/150,349 patent/US20210253596A1/en active Pending
- 2021-01-19 CL CL2021000153A patent/CL2021000153A1/es unknown
- 2021-01-19 PH PH12021500005A patent/PH12021500005A1/en unknown
- 2021-02-10 CO CONC2021/0001530A patent/CO2021001530A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL279256A (en) | 2021-01-31 |
PE20211811A1 (es) | 2021-09-14 |
US20210253596A1 (en) | 2021-08-19 |
JP2021532101A (ja) | 2021-11-25 |
JP7320595B2 (ja) | 2023-08-03 |
EP3823974A1 (en) | 2021-05-26 |
CA3105521A1 (en) | 2020-01-23 |
CN112513048A (zh) | 2021-03-16 |
TW202016078A (zh) | 2020-05-01 |
WO2020018975A1 (en) | 2020-01-23 |
TWI825134B (zh) | 2023-12-11 |
CR20210022A (es) | 2021-02-18 |
SG11202013062VA (en) | 2021-02-25 |
CO2021001530A2 (es) | 2021-03-08 |
PH12021500005A1 (en) | 2021-09-13 |
AU2019306658A1 (en) | 2021-01-07 |
KR20210034596A (ko) | 2021-03-30 |
BR112021001044A2 (pt) | 2021-04-13 |
MA53172A (fr) | 2021-05-26 |
AR115822A1 (es) | 2021-03-03 |
MX2021000780A (es) | 2021-03-31 |
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