JP2021530999A5 - - Google Patents

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Publication number
JP2021530999A5
JP2021530999A5 JP2021502620A JP2021502620A JP2021530999A5 JP 2021530999 A5 JP2021530999 A5 JP 2021530999A5 JP 2021502620 A JP2021502620 A JP 2021502620A JP 2021502620 A JP2021502620 A JP 2021502620A JP 2021530999 A5 JP2021530999 A5 JP 2021530999A5
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JP
Japan
Prior art keywords
optionally
cells
gene
isolated
car
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021502620A
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English (en)
Japanese (ja)
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JP2021530999A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/042123 external-priority patent/WO2020018620A1/en
Publication of JP2021530999A publication Critical patent/JP2021530999A/ja
Publication of JP2021530999A5 publication Critical patent/JP2021530999A5/ja
Pending legal-status Critical Current

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JP2021502620A 2018-07-17 2019-07-17 免疫改変多能性幹細胞由来のキメラ抗原受容体t細胞 Pending JP2021530999A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862698941P 2018-07-17 2018-07-17
US62/698,941 2018-07-17
PCT/US2019/042123 WO2020018620A1 (en) 2018-07-17 2019-07-17 Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells

Publications (2)

Publication Number Publication Date
JP2021530999A JP2021530999A (ja) 2021-11-18
JP2021530999A5 true JP2021530999A5 (https=) 2022-08-09

Family

ID=69164717

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021502620A Pending JP2021530999A (ja) 2018-07-17 2019-07-17 免疫改変多能性幹細胞由来のキメラ抗原受容体t細胞

Country Status (13)

Country Link
US (1) US20210308183A1 (https=)
EP (1) EP3824075A4 (https=)
JP (1) JP2021530999A (https=)
KR (1) KR20210032449A (https=)
CN (1) CN112639081A (https=)
AU (1) AU2019305586B2 (https=)
BR (1) BR112021000639A2 (https=)
CA (1) CA3106022A1 (https=)
EA (1) EA202190295A1 (https=)
IL (1) IL279854A (https=)
MX (1) MX2021000607A (https=)
SG (1) SG11202100156UA (https=)
WO (1) WO2020018620A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3873540A4 (en) 2018-10-31 2022-07-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
WO2020092839A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3965829A4 (en) 2019-05-06 2023-05-24 Malcolm, Thomas ADAPTED HYPOIMMUNE NANOVESICULAR DELIVERY SYSTEM FOR CANCER TUMORS
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
US12221622B2 (en) 2019-05-10 2025-02-11 The Regents Of The University Of California Modified pluripotent cells
WO2021146222A1 (en) * 2020-01-13 2021-07-22 Sana Biotechnology, Inc. Modification of blood type antigens
KR20220158046A (ko) * 2020-03-25 2022-11-29 사나 바이오테크놀로지, 인크. 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포
AU2021262766A1 (en) * 2020-04-27 2022-11-24 Sana Biotechnology, Inc. Repeat dosing of hypoimmunogenic cells
EP4149525A4 (en) * 2020-05-15 2024-08-28 Rxcell Inc. HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES
WO2022036150A1 (en) 2020-08-13 2022-02-17 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
JP2024501971A (ja) * 2020-12-31 2024-01-17 サナ バイオテクノロジー,インコーポレイテッド Car-t活性を調節するための方法及び組成物
EP4334718A4 (en) * 2021-05-06 2025-04-23 Mayo Foundation for Medical Education and Research ASSESSMENT AND TREATMENT OF CANCER
BR112023024231A2 (pt) 2021-05-19 2024-01-30 Sana Biotechnology Inc Células t primárias rhd negativas hipoimunogênicas
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
KR20240046319A (ko) 2021-07-14 2024-04-08 사나 바이오테크놀로지, 인크. 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
MX2024000713A (es) * 2021-07-16 2024-03-25 Sana Biotechnology Inc Vectores policistrónicos para terapias a base de células.
WO2023008918A1 (ko) * 2021-07-28 2023-02-02 의료법인 성광의료재단 B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법
US20240358761A1 (en) 2021-08-11 2024-10-31 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
AU2022325232A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified primary cells for allogeneic cell therapy
EP4384598A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
JP2024535677A (ja) 2021-08-11 2024-10-02 サナ バイオテクノロジー,インコーポレイテッド 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
AU2022327174A1 (en) 2021-08-11 2024-02-15 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
US20250313861A1 (en) 2021-10-22 2025-10-09 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
CN119072319A (zh) 2021-12-23 2024-12-03 萨那生物技术股份有限公司 用于治疗自身免疫性疾病的嵌合抗原受体(car)t细胞及相关方法
KR20240142624A (ko) * 2022-01-10 2024-09-30 사나 바이오테크놀로지, 인크. 만능줄기세포에서 분화된 면역저하 베타세포 및 관련 용도 및 방법
US20250302953A1 (en) 2022-02-14 2025-10-02 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
EP4479416A1 (en) 2022-02-17 2024-12-25 Sana Biotechnology, Inc. Engineered cd47 proteins and uses thereof
KR20250008812A (ko) * 2022-04-07 2025-01-15 페이트 세러퓨틱스, 인코포레이티드 동종 세포 치료에 사용하기 위한 면역 인식 경로에 관여하는 스텔스 전략
US20250222029A1 (en) 2022-04-08 2025-07-10 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
US20250228943A1 (en) 2022-04-08 2025-07-17 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof
EP4515231A1 (en) * 2022-04-28 2025-03-05 Allogene Therapeutics, Inc. Methods for donor cell analysis
WO2023230533A1 (en) * 2022-05-25 2023-11-30 Jasper Therapeutics, Inc. Modified stem cell compositions and methods for use
JP2025518125A (ja) * 2022-05-25 2025-06-12 マルコルム,トーマス 生体模倣型ナノ小胞を作製するための低免疫原性細胞
US20260002124A1 (en) 2022-07-01 2026-01-01 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
WO2024097313A1 (en) * 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Methods for producing t cell therapy products
CN118207165B (zh) * 2022-12-07 2026-03-20 士泽生物医药(苏州)有限公司 一种表达stc1的通用型细胞及其制备方法
CN115612673A (zh) * 2022-12-14 2023-01-17 卡瑞济(北京)生命科技有限公司 一种改善car-t细胞群的持久性的方法
WO2024183750A1 (en) * 2023-03-07 2024-09-12 Qihan Hong Kong Limited A novel immune cell and use thereof for treating diseases
EP4735585A1 (en) 2023-06-30 2026-05-06 Novo Nordisk A/S Enhancing neuronal differentiation of neural progenitor cells
WO2025029826A1 (en) * 2023-07-31 2025-02-06 Seraxis, Inc. Modified therapeutics cells and methods relating to the same
WO2025043172A1 (en) 2023-08-23 2025-02-27 Sana Biotechnology, Inc. Modified cd47 proteins and their uses
WO2025096757A1 (en) 2023-11-01 2025-05-08 Sana Biotechnology, Inc. Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas
CN117737130A (zh) * 2023-12-21 2024-03-22 南京康和细胞基因工程研究院有限公司 一种提高通用型car-t细胞产量和活性的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001297880B2 (en) * 2000-11-30 2007-05-31 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
WO2014165707A2 (en) * 2013-04-03 2014-10-09 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
KR20200138445A (ko) * 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
CN107921148A (zh) * 2015-05-08 2018-04-17 哈佛学院校长同事会 通用供体干细胞和相关方法
GB201518136D0 (en) * 2015-10-14 2015-11-25 Glaxosmithkline Ip Dev Ltd Novel chimeric antigen receptors
KR20250141836A (ko) * 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
JP2020505025A (ja) * 2017-01-13 2020-02-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 免疫工学的な改変をした多能性細胞
JP2021525518A (ja) * 2018-05-31 2021-09-27 ワシントン・ユニバーシティWashington University 細胞をゲノム編集及び活性化するための方法

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