IL279854A - Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells - Google Patents

Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells

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Publication number
IL279854A
IL279854A IL279854A IL27985420A IL279854A IL 279854 A IL279854 A IL 279854A IL 279854 A IL279854 A IL 279854A IL 27985420 A IL27985420 A IL 27985420A IL 279854 A IL279854 A IL 279854A
Authority
IL
Israel
Prior art keywords
immunoengineered
chimeric
stem cells
pluripotent stem
antigen receptor
Prior art date
Application number
IL279854A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL279854A publication Critical patent/IL279854A/en

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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • C12N15/09—Recombinant DNA-technology
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IL279854A 2018-07-17 2020-12-30 Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells IL279854A (en)

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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12264189B2 (en) 2018-10-31 2025-04-01 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
WO2020092736A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
KR102776627B1 (ko) 2019-05-06 2025-03-06 토마스 말콤 암 종양에 대한 맞춤화된 하이포면역 나노소포체 전달 시스템
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
WO2020231882A2 (en) 2019-05-10 2020-11-19 The Regents Of The University Of California Modified pluripotent cells
AU2021207810A1 (en) * 2020-01-13 2022-08-04 Sana Biotechnology, Inc. Modification of blood type antigens
MX2022011831A (es) * 2020-03-25 2023-01-04 Sana Biotechnology Inc Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
CN115916962A (zh) * 2020-04-27 2023-04-04 萨那生物技术股份有限公司 低免疫原性细胞的重复给药
EP4149525A4 (en) * 2020-05-15 2024-08-28 Rxcell Inc. HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES
IL300516A (en) * 2020-08-13 2023-04-01 Sana Biotechnology Inc Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
CA3200509A1 (en) * 2020-12-31 2022-07-07 Sonja SCHREPFER Methods and compositions for modulating car-t activity
US20250269022A1 (en) * 2021-05-06 2025-08-28 Mayo Foundation For Medical Education And Research Assessing and treating cancer
BR112023024231A2 (pt) 2021-05-19 2024-01-30 Sana Biotechnology Inc Células t primárias rhd negativas hipoimunogênicas
AU2022283291A1 (en) 2021-05-27 2023-11-02 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
KR20240046319A (ko) 2021-07-14 2024-04-08 사나 바이오테크놀로지, 인크. 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
MX2024000713A (es) * 2021-07-16 2024-03-25 Sana Biotechnology Inc Vectores policistrónicos para terapias a base de células.
WO2023008918A1 (ko) * 2021-07-28 2023-02-02 의료법인 성광의료재단 B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법
TW202321435A (zh) 2021-08-11 2023-06-01 美商薩那生物科技公司 用於改變低免疫原性細胞中之基因表現之可誘導系統
KR20240073006A (ko) 2021-08-11 2024-05-24 사나 바이오테크놀로지, 인크. 동종이계 세포 요법을 위한 유전자 변형된 1차 세포
WO2023019226A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
JP2024535677A (ja) 2021-08-11 2024-10-02 サナ バイオテクノロジー，インコーポレイテッド 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
WO2023069790A1 (en) 2021-10-22 2023-04-27 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
MX2024007528A (es) 2021-12-23 2024-08-30 Sana Biotechnology Inc Linfocitos t del receptor de antígeno quimérico (car) para el tratamiento de enfermedades autoinmunitarias y métodos asociados.
KR20240142624A (ko) * 2022-01-10 2024-09-30 사나 바이오테크놀로지, 인크. 만능줄기세포에서 분화된 면역저하 베타세포 및 관련 용도 및 방법
WO2023154578A1 (en) 2022-02-14 2023-08-17 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
KR20240155390A (ko) 2022-02-17 2024-10-28 사나 바이오테크놀로지, 인크. 조작된 cd47 단백질 및 이의 용도
CN119213117A (zh) * 2022-04-07 2024-12-27 菲特治疗公司 用于同种异体细胞疗法的参与免疫识别途径的隐形策略
EP4504914A4 (en) 2022-04-08 2026-04-29 Fate Therapeutics Inc Cells having solid tumor targeting backbone and use thereof
CA3247010A1 (en) 2022-04-08 2023-10-12 Ono Pharmaceutical Co., Ltd. CHIMERIC ANTIGEN RECEPTOR FOR TUMOR TARGETING
CA3254552A1 (en) * 2022-04-28 2023-11-02 Allogene Therapeutics Inc. METHODS FOR ANALYZING DONOR CELLS
JP2025518125A (ja) * 2022-05-25 2025-06-12 マルコルム，トーマス 生体模倣型ナノ小胞を作製するための低免疫原性細胞
WO2023230533A1 (en) * 2022-05-25 2023-11-30 Jasper Therapeutics, Inc. Modified stem cell compositions and methods for use
EP4547825A1 (en) 2022-07-01 2025-05-07 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
WO2024097315A2 (en) * 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Cell therapy products and methods for producing same
CN118207165B (zh) * 2022-12-07 2026-03-20 士泽生物医药（苏州）有限公司 一种表达stc1的通用型细胞及其制备方法
CN115612673A (zh) * 2022-12-14 2023-01-17 卡瑞济(北京)生命科技有限公司 一种改善car-t细胞群的持久性的方法
WO2024183750A1 (en) * 2023-03-07 2024-09-12 Qihan Hong Kong Limited A novel immune cell and use thereof for treating diseases
WO2025003393A1 (en) 2023-06-30 2025-01-02 Novo Nordisk A/S Enhancing neuronal differentiation of neural progenitor cells
WO2025029826A1 (en) * 2023-07-31 2025-02-06 Seraxis, Inc. Modified therapeutics cells and methods relating to the same
AU2024328949A1 (en) 2023-08-23 2026-03-12 Sana Biotechnology, Inc. Modified cd47 proteins and their uses
WO2025096757A1 (en) 2023-11-01 2025-05-08 Sana Biotechnology, Inc. Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas
CN117737130A (zh) * 2023-12-21 2024-03-22 南京康和细胞基因工程研究院有限公司 一种提高通用型car-t细胞产量和活性的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001297880B2 (en) * 2000-11-30 2007-05-31 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
AU2014248119B2 (en) * 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
EP3134515B1 (en) * 2014-04-24 2019-03-27 Board of Regents, The University of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
EP3294342A4 (en) * 2015-05-08 2018-11-07 President and Fellows of Harvard College Universal donor stem cells and related methods
GB201518136D0 (en) * 2015-10-14 2015-11-25 Glaxosmithkline Ip Dev Ltd Novel chimeric antigen receptors
JP6928604B2 (ja) * 2015-11-04 2021-09-01 フェイト セラピューティクス，インコーポレイテッド 万能性細胞のゲノム改変
CN110177869A (zh) * 2017-01-13 2019-08-27 加利福尼亚大学董事会 免疫改造的多能细胞
US20200109364A1 (en) * 2018-05-31 2020-04-09 Washington University Methods for genome-editing and activation of cells

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