JP2021529173A5 - - Google Patents
Info
- Publication number
- JP2021529173A5 JP2021529173A5 JP2020570909A JP2020570909A JP2021529173A5 JP 2021529173 A5 JP2021529173 A5 JP 2021529173A5 JP 2020570909 A JP2020570909 A JP 2020570909A JP 2020570909 A JP2020570909 A JP 2020570909A JP 2021529173 A5 JP2021529173 A5 JP 2021529173A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cancer
- nucleotide sequence
- rig
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862687606P | 2018-06-20 | 2018-06-20 | |
| US62/687,606 | 2018-06-20 | ||
| US201862743369P | 2018-10-09 | 2018-10-09 | |
| US62/743,369 | 2018-10-09 | ||
| US201962815870P | 2019-03-08 | 2019-03-08 | |
| US62/815,870 | 2019-03-08 | ||
| PCT/US2019/038323 WO2019246450A1 (en) | 2018-06-20 | 2019-06-20 | Rig-i agonists and treatments using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021529173A JP2021529173A (ja) | 2021-10-28 |
| JP2021529173A5 true JP2021529173A5 (enExample) | 2022-06-10 |
Family
ID=68982664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570909A Pending JP2021529173A (ja) | 2018-06-20 | 2019-06-20 | Ｒｉｇ−ｉアゴニストおよびそれを使用した処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US12472198B2 (enExample) |
| EP (1) | EP3810151B1 (enExample) |
| JP (1) | JP2021529173A (enExample) |
| CN (1) | CN112672748A (enExample) |
| CA (1) | CA3110102A1 (enExample) |
| WO (1) | WO2019246450A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180133327A1 (en) | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| PL3429618T3 (pl) | 2016-03-16 | 2024-07-01 | Amal Therapeutics Sa | Kombinacja modulatora immunologicznego punktu kontrolnego i kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do zastosowania w medycynie |
| HUE067838T2 (hu) | 2016-09-21 | 2024-11-28 | Amal Therapeutics Sa | Egy sejtpenetráló peptidet, egy multiepitópot és egy TLR peptidagonistát tartalmazó fúzió rák kezelésére |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| EP3863675A4 (en) * | 2018-10-09 | 2023-09-06 | Yale University | RIG-I AGONISTS AND METHODS OF USE THEREOF |
| EP4054560A4 (en) * | 2019-11-04 | 2023-11-29 | Yale University | RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF |
| JP2023545178A (ja) * | 2020-10-14 | 2023-10-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｔｉｎｇアゴニストと、細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む複合体との組合せ |
| US11786545B2 (en) * | 2020-12-09 | 2023-10-17 | Yale University | Compositions and methods for treating SARS-CoV-2 infection |
| AU2022302143A1 (en) | 2021-07-02 | 2024-01-18 | Yale University | Compositions and methods for treating cancers |
| EP4395832A1 (en) | 2021-08-31 | 2024-07-10 | Yale University | Compositions and methods for treating cancers |
| US20230303719A1 (en) | 2022-03-03 | 2023-09-28 | Yale University | Humanized 3e10 antibodies, variants, and antigen binding fragments thereof |
| CN114814231B (zh) * | 2022-03-08 | 2024-08-27 | 上海交通大学医学院附属瑞金医院 | 维甲酸诱导基因i在癌症治疗中的应用 |
| WO2025040743A1 (en) | 2023-08-22 | 2025-02-27 | Univerza V Ljubljani | Conjugated tlr7 and rig-i agonists |
| WO2026039779A1 (en) | 2024-08-15 | 2026-02-19 | Yale University | Humanized 3e10 antibodies and antigen binding fragments optimized for rad51 binding |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| ES2192672T3 (es) | 1996-11-18 | 2003-10-16 | Takeshi Imanishi | Nuevos analogos de nucleotidos. |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6143877A (en) | 1997-04-30 | 2000-11-07 | Epoch Pharmaceuticals, Inc. | Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids |
| JP4236812B2 (ja) | 1997-09-12 | 2009-03-11 | エクシコン エ／エス | オリゴヌクレオチド類似体 |
| US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| DE60029314T2 (de) | 1999-03-24 | 2007-07-12 | Exiqon A/S | Verbesserte Synthese für -2.2.1. I Bicyclo-Nukleoside |
| US7053207B2 (en) | 1999-05-04 | 2006-05-30 | Exiqon A/S | L-ribo-LNA analogues |
| US6287778B1 (en) | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
| US6660845B1 (en) | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
| US20090247613A1 (en) | 2002-02-20 | 2009-10-01 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| WO2004092383A2 (en) | 2003-04-15 | 2004-10-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| CA2538169A1 (en) | 2003-09-09 | 2005-03-17 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state analog inhibitors of ricin a-chain |
| US20080293053A1 (en) | 2006-12-28 | 2008-11-27 | The Regents Of The University Of Michigan | shRNA Materials and Methods of Using Same for Inhibition of DKK-1 |
| US20090123501A1 (en) | 2007-05-17 | 2009-05-14 | Baylor College Of Medicine | Inhibition of the sh2-domain containing protein tyr-phosphatase, shp-1, to enhance vaccines |
| EP2257313A2 (en) | 2008-02-21 | 2010-12-08 | University of Kentucky Research Foundation | Ultra-small rnas as toll-like receptor-3 antagonists |
| CA2721183C (en) | 2008-04-11 | 2019-07-16 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| US20110251258A1 (en) | 2008-07-24 | 2011-10-13 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses thereof |
| JP2012505657A (ja) | 2008-10-15 | 2012-03-08 | ソマジェニックス インク． | 遺伝子発現の阻害のためのショートヘアピンｒｎａ |
| WO2010111891A1 (zh) | 2009-04-03 | 2010-10-07 | 北京大学 | 修饰的寡聚核酸分子及其制备方法和应用 |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| JP2015502365A (ja) | 2011-12-12 | 2015-01-22 | オンコイミューニン，インコーポレイティド | オリゴヌクレオチドのイン−ビボ送達 |
| WO2014159990A1 (en) * | 2013-03-13 | 2014-10-02 | Yale University | Interferon production using short rna duplexes |
| PE20160080A1 (es) * | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| US10392444B2 (en) * | 2014-08-08 | 2019-08-27 | Oncoquest, Inc. | Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer |
| KR102129195B1 (ko) | 2016-02-15 | 2020-07-01 | 에프케이디 테라피즈 리미티드, | 향상된 인터페론 치료 |
| WO2017173427A1 (en) | 2016-04-01 | 2017-10-05 | Vycellix Inc | Novel rna construct and methods of use thereof for enhancing the therapeutic effects of cytotoxic cells and stem cells |
| CN109715205A (zh) * | 2016-08-19 | 2019-05-03 | 库瑞瓦格股份公司 | 用于癌症治疗的rna |
| US11382966B2 (en) * | 2017-03-24 | 2022-07-12 | Rigontec Gmbh | Method for designing RIG-I ligands |
| US10710272B2 (en) | 2017-12-14 | 2020-07-14 | United Technologies Corporation | Hybrid material airflow impression molds |
| CA3086040A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| US10736957B2 (en) | 2017-12-19 | 2020-08-11 | President And Fellows Of Harvard College | Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences |
| US12539308B2 (en) | 2018-01-08 | 2026-02-03 | The Trustees Of The University Of Pennsylvania | Immune-enhancing RNAs for combination with chimeric antigen receptor therapy |
| WO2019143297A1 (en) | 2018-01-17 | 2019-07-25 | Nanyang Technological University | Immunomodulatory small hairpin rna molecules |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
-
2019
- 2019-06-20 EP EP19822447.9A patent/EP3810151B1/en active Active
- 2019-06-20 US US17/251,921 patent/US12472198B2/en active Active
- 2019-06-20 CN CN201980055031.8A patent/CN112672748A/zh not_active Withdrawn
- 2019-06-20 JP JP2020570909A patent/JP2021529173A/ja active Pending
- 2019-06-20 CA CA3110102A patent/CA3110102A1/en active Pending
- 2019-06-20 WO PCT/US2019/038323 patent/WO2019246450A1/en not_active Ceased
- 2019-09-03 US US16/558,564 patent/US20200061097A1/en not_active Abandoned
-
2022
- 2022-07-13 US US17/864,199 patent/US20230201242A1/en not_active Abandoned
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