JP2021527092A - １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 - Google Patents

１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 Download PDF

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JP2021527092A
JP2021527092A JP2020569024A JP2020569024A JP2021527092A JP 2021527092 A JP2021527092 A JP 2021527092A JP 2020569024 A JP2020569024 A JP 2020569024A JP 2020569024 A JP2020569024 A JP 2020569024A JP 2021527092 A JP2021527092 A JP 2021527092A
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JP2021527092A5 (enExample
Inventor
スティーブン ジェイ ケインズ，
ジェイムズ ジェイ． ドハーティ，
ハンダン グンドゥーズ−ブルース，
ジェフリー エム． ジョナス，
ロバート アルフォンソ ラサー，
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Sage Therapeutics LLC
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Sage Therapeutics LLC
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Publication of JP2021527092A5 publication Critical patent/JP2021527092A5/ja
Priority to JP2023205211A priority Critical patent/JP2024028849A/ja
Priority to JP2025064902A priority patent/JP2025108553A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020569024A 2018-06-12 2019-06-12 １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 Pending JP2021527092A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023205211A JP2024028849A (ja) 2018-06-12 2023-12-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2025064902A JP2025108553A (ja) 2018-06-12 2025-04-10 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862684155P 2018-06-12 2018-06-12
US62/684,155 2018-06-12
US201962789329P 2019-01-07 2019-01-07
US62/789,329 2019-01-07
US201962841645P 2019-05-01 2019-05-01
US62/841,645 2019-05-01
PCT/US2019/036848 WO2019241442A1 (en) 2018-06-12 2019-06-12 A 19-nor c3,3-disubstituted c21 -n-pyrazolyl steroid and methods of use thereof

Related Child Applications (1)

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JP2023205211A Division JP2024028849A (ja) 2018-06-12 2023-12-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Publications (2)

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JP2021527092A true JP2021527092A (ja) 2021-10-11
JP2021527092A5 JP2021527092A5 (enExample) 2022-06-16

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JP2020569024A Pending JP2021527092A (ja) 2018-06-12 2019-06-12 １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法
JP2023205211A Pending JP2024028849A (ja) 2018-06-12 2023-12-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2025064902A Pending JP2025108553A (ja) 2018-06-12 2025-04-10 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

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JP2023205211A Pending JP2024028849A (ja) 2018-06-12 2023-12-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2025064902A Pending JP2025108553A (ja) 2018-06-12 2025-04-10 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

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US (4) US20210338692A1 (enExample)
EP (1) EP3806863A1 (enExample)
JP (3) JP2021527092A (enExample)
KR (1) KR20210021005A (enExample)
CN (2) CN117959309A (enExample)
AU (2) AU2019287491B2 (enExample)
CA (1) CA3103421A1 (enExample)
IL (1) IL279315A (enExample)
MA (1) MA52894A (enExample)
MX (2) MX2020013557A (enExample)
SG (1) SG11202012344RA (enExample)
TW (1) TWI923545B (enExample)
WO (1) WO2019241442A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023504517A (ja) * 2019-12-05 2023-02-03 セージ セラピューティクス， インコーポレイテッド １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Families Citing this family (17)

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SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
RS62761B1 (sr) 2012-08-21 2022-01-31 Sage Therapeutics Inc Alopregnanolon za lečenje refraktornog epileptičkog statusa
SMT202100509T1 (it) 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2018013613A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
TW202604538A (zh) 2016-08-23 2026-02-01 美商賽吉醫療公司 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇
US20200291059A1 (en) 2017-12-08 2020-09-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
CN115551514A (zh) 2020-03-25 2022-12-30 萨奇治疗股份有限公司 用于治疗呼吸系统病症的药物的用途
CA3187178A1 (en) * 2020-07-20 2022-01-27 Sage Therapeutics, Inc. Formulations of 19-nor c3,3- disubstituted c21-n-pyrazolyl steroid and methods of use thereof
WO2022165017A1 (en) * 2021-01-28 2022-08-04 Sage Therapeutics, Inc. Use of neuroactive steroids for treatment of sexual dysfunction
JP2024510436A (ja) * 2021-03-17 2024-03-07 セージ セラピューティクス， インコーポレイテッド 大うつ病性障害の処置のための１９－ノルｃ３，３－２置換ｃ２１－ｎ－ピラゾリルステロイド
MX2023012728A (es) * 2021-04-29 2023-11-08 Sage Therapeutics Inc Esteroide neuroactivo para el tratamiento del trastorno depresivo mayor y la depresion posparto en una mujer lactante.
MX2023012727A (es) * 2021-04-29 2023-11-08 Sage Therapeutics Inc Esteroide c21 -n-pirazolilo disubstituido 19-nor c3,3 para uso en el tratamiento de principales trastorno depresivo y depresion posparto.
JP2025508406A (ja) * 2022-02-16 2025-03-26 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ関連障害を処置するための神経活性ステロイド
WO2025175214A1 (en) * 2024-02-16 2025-08-21 Engrail Therapeutics, Inc. Methods of treating generalized anxiety disorder

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SMT202100509T1 (it) * 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
JOP20200195A1 (ar) * 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
US20170233433A1 (en) * 2014-10-16 2017-08-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
PH12018501923B1 (en) * 2016-03-08 2024-06-28 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
TW202604538A (zh) * 2016-08-23 2026-02-01 美商賽吉醫療公司 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇
EP3678670A1 (en) * 2017-09-07 2020-07-15 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use

Non-Patent Citations (3)

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GUNDUZ-BRUCE, H. ET AL.: "SAGE-217 in Subjects with Major Depressive Disorder: Efficacy and Safety Results from Open-label Par", 30TH ECNP CONGRESS, JPN7023002150, 2017, ISSN: 0005273600 *
GUNDUZ-BRUCE, H. ET AL.: "SAGE-217 in Subjects with Major Depressive Disorder: Efficacy and Safety Results from Open-label Par", EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol. Vol.27, Supplement 4, JPN7023002151, 2017, pages 856 - 857, ISSN: 0005273599 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, JPN7023002149, 2017, pages 7810 - 7819, ISSN: 0005273601 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023504517A (ja) * 2019-12-05 2023-02-03 セージ セラピューティクス， インコーポレイテッド １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

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US20200113917A1 (en) 2020-04-16
AU2019287491B2 (en) 2025-05-15
CN112533611A (zh) 2021-03-19
US20210338692A1 (en) 2021-11-04
JP2025108553A (ja) 2025-07-23
MX2020013557A (es) 2021-05-27
TW202005653A (zh) 2020-02-01
SG11202012344RA (en) 2021-01-28
US20220323462A1 (en) 2022-10-13
EP3806863A1 (en) 2021-04-21
MA52894A (fr) 2021-04-21
AU2025217363A1 (en) 2025-09-04
CA3103421A1 (en) 2019-12-19
US20250339447A1 (en) 2025-11-06
MX2025000166A (es) 2025-03-07
TWI923545B (zh) 2026-05-01
CN117959309A (zh) 2024-05-03
KR20210021005A (ko) 2021-02-24
JP2024028849A (ja) 2024-03-05
AU2019287491A1 (en) 2021-01-07
WO2019241442A1 (en) 2019-12-19
IL279315A (en) 2021-01-31

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