JP2021523106A5 - - Google Patents

Info

Publication number
JP2021523106A5
JP2021523106A5 JP2020560991A JP2020560991A JP2021523106A5 JP 2021523106 A5 JP2021523106 A5 JP 2021523106A5 JP 2020560991 A JP2020560991 A JP 2020560991A JP 2020560991 A JP2020560991 A JP 2020560991A JP 2021523106 A5 JP2021523106 A5 JP 2021523106A5
Authority
JP
Japan
Prior art keywords
msc
exosomes
stem cell
mesenchymal stem
effective amount
Prior art date
Application number
JP2020560991A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019217091A5 (https=
JP2021523106A (ja
JP7538044B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/029275 external-priority patent/WO2019217091A1/en
Publication of JP2021523106A publication Critical patent/JP2021523106A/ja
Publication of JP2021523106A5 publication Critical patent/JP2021523106A5/ja
Publication of JPWO2019217091A5 publication Critical patent/JPWO2019217091A5/ja
Priority to JP2024033810A priority Critical patent/JP2024138218A/ja
Application granted granted Critical
Publication of JP7538044B2 publication Critical patent/JP7538044B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020560991A 2018-04-30 2019-04-26 間葉系間質細胞エキソソームおよびそれらの使用 Active JP7538044B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024033810A JP2024138218A (ja) 2018-04-30 2024-03-06 間葉系間質細胞エキソソームおよびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862664696P 2018-04-30 2018-04-30
US62/664,696 2018-04-30
PCT/US2019/029275 WO2019217091A1 (en) 2018-04-30 2019-04-26 Mesenchymal stromal cell exosomes and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024033810A Division JP2024138218A (ja) 2018-04-30 2024-03-06 間葉系間質細胞エキソソームおよびそれらの使用

Publications (4)

Publication Number Publication Date
JP2021523106A JP2021523106A (ja) 2021-09-02
JP2021523106A5 true JP2021523106A5 (https=) 2022-05-10
JPWO2019217091A5 JPWO2019217091A5 (https=) 2022-05-10
JP7538044B2 JP7538044B2 (ja) 2024-08-21

Family

ID=68466806

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020560991A Active JP7538044B2 (ja) 2018-04-30 2019-04-26 間葉系間質細胞エキソソームおよびそれらの使用
JP2024033810A Pending JP2024138218A (ja) 2018-04-30 2024-03-06 間葉系間質細胞エキソソームおよびそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024033810A Pending JP2024138218A (ja) 2018-04-30 2024-03-06 間葉系間質細胞エキソソームおよびそれらの使用

Country Status (6)

Country Link
US (1) US12521418B2 (https=)
EP (1) EP3810271A4 (https=)
JP (2) JP7538044B2 (https=)
CN (1) CN112334190B (https=)
CA (1) CA3098514A1 (https=)
WO (1) WO2019217091A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2949083C (en) 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes
JP2021526556A (ja) 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞(msc)の調製物を含む助剤、ならびにその使用方法
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN111281889A (zh) * 2020-04-16 2020-06-16 博生众康(厦门)医药生物技术股份有限公司 人脐带间充质干细胞外泌体的用途
US12590310B2 (en) * 2020-04-22 2026-03-31 Direct Biologics, Llc Methods and compositions for treating inflammatory conditions associated with infectious disease
CN117363568B (zh) * 2023-12-04 2024-04-09 山东大学 一种脂肪间充质干细胞外泌体及其制备方法与应用
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
US20040214783A1 (en) 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
BRPI0617085A2 (pt) 2005-09-02 2016-11-08 Agency Science Tech & Res método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada
WO2007124594A1 (en) 2006-04-27 2007-11-08 Cell Therapy Technologies, Inc. Et Al. Stem cells for treating lung diseases
EP2617428A1 (en) 2006-08-15 2013-07-24 Agency for Science, Technology and Research Mesenchymal stem cell conditioned medium
EP2076116A4 (en) 2006-10-11 2010-04-07 Gen Hospital Corp COMPOSITIONS, METHODS, AND DEVICES FOR TREATING HEPATIC DISEASES
EP1944361A1 (en) 2007-01-11 2008-07-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for expanding monocytes
CA2711218C (en) 2008-01-04 2019-08-06 Lydac Neuroscience Limited A method of producing a population of differentiated cells
CN102014934B (zh) 2008-02-22 2014-08-20 新加坡科技研究局 间充质干细胞颗粒
EP2456861A4 (en) 2009-07-23 2013-12-04 Agency Science Tech & Res PRENATAL MESENCHYMAL STEM CELLS
SG2014010698A (en) 2009-11-02 2014-05-29 Agency Science Tech & Res Methods of monitoring cellular states
KR101189655B1 (ko) 2010-06-30 2012-10-11 성균관대학교산학협력단 줄기세포 배양액을 포함하는 폐질환 치료용 조성물
CN101890050B (zh) 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
CA2845280A1 (en) 2010-08-13 2012-02-16 Paul Shiels Therapeutic uses of microvesicles and related micrornas
WO2012115885A1 (en) 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
CA2829586C (en) 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
EP2721179A4 (en) 2011-06-16 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L BIOMARKER COMPOSITIONS AND METHOD THEREFOR
ITTO20111183A1 (it) 2011-12-21 2013-06-22 Univ Degli Studi Torino Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia
US9427450B2 (en) 2012-01-31 2016-08-30 Xon Cells, Inc. Therapeutic immune modulation by stem cell secreted exosomes
SG11201406336YA (en) 2012-04-03 2014-11-27 Reneuron Ltd Stem cell microparticles
KR101399056B1 (ko) 2012-04-16 2014-05-27 연세대학교 산학협력단 줄기세포-유래 미세소포체를 유효성분으로 포함하는 신경질환 예방 또는 치료용 약제학적 조성물
US20130273011A1 (en) 2012-04-17 2013-10-17 Medistem, Inc. Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome
EP2850178A4 (en) 2012-05-18 2015-10-28 Agency Science Tech & Res EXOSOMES OF MESHCHYMIC STROKE CELL OF UMBILICAL CORD
EP2687219A1 (en) 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
AU2013302526B2 (en) 2012-08-15 2018-03-22 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
CN103767985A (zh) 2012-10-22 2014-05-07 吉林省霍普金斯药物研究院有限责任公司 人源血液或间充质干细胞分泌exosome的制备与应用
ES2927175T3 (es) 2013-02-12 2022-11-03 Reneuron Ltd Método de producción de micropartículas
AU2014251388B2 (en) 2013-04-12 2017-03-30 Evox Therapeutics Limited Therapeutic delivery vesicles
WO2015018915A1 (de) 2013-08-07 2015-02-12 Pi Ceramic Gmbh Keramische Technologien Und Bauelemente Piezokeramischer werkstoff mit reduziertem bleigehalt
SG11201601939VA (en) 2013-09-16 2016-04-28 Agency Science Tech & Res Method
US20180273906A1 (en) * 2014-04-17 2018-09-27 Muhammad Ashraf Microvesicle and stem cell compositions for therapeutic applications
CA2949083C (en) * 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes
EP3193890A4 (en) * 2014-09-15 2018-03-14 Agency For Science, Technology And Research Methods of treating graft versus host disease (gvhd) or epidermolysis bullosa (eb) with exosomes
US10166254B2 (en) 2014-09-19 2019-01-01 Wisconsin Alumni Research Foundation Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury
US20210205370A1 (en) * 2016-02-18 2021-07-08 Pluristem Ltd. Methods and compositions for treating cancers and neoplasms
CN105769916B (zh) 2016-04-29 2019-07-23 南京大学 间充质干细胞来源外泌体在制备治疗子痫前期药物或者制剂中的应用
KR20250037589A (ko) * 2016-06-17 2025-03-17 유나이티드 쎄러퓨틱스 코포레이션 향상된 효능을 가진 세포외 소포
KR101973284B1 (ko) 2017-01-16 2019-04-29 사회복지법인 삼성생명공익재단 신생아 hie 치료용 조성물
WO2018183825A1 (en) 2017-03-31 2018-10-04 Wisconsin Alumni Research Foundation Generation of therapeutic cells using extracellular components of target organs
CA3072562A1 (en) 2017-08-15 2019-02-21 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
US10876753B2 (en) 2018-02-12 2020-12-29 Watsco Ventures Llc Integrated sensor and service port for HVAC equipment or HVAC system
CA3099042A1 (en) 2018-05-09 2019-11-14 Children's Medical Center Corporation Mesenchymal stromal cell exosome -treated monocytes and uses thereof
CA3111661A1 (en) 2018-09-05 2020-03-12 Children's Medical Center Corporation Use of mesenchymal stromal cell exosomes in antenatal therapy

Similar Documents

Publication Publication Date Title
JP2021523106A5 (https=)
JP6327647B2 (ja) 炎症性疾患の予防又は治療用組成物
Zhao et al. Transplantation of cerebral dopamine neurotrophic factor transducted BMSCs in contusion spinal cord injury of rats: promotion of nerve regeneration by alleviating neuroinflammation
JP2021522824A5 (https=)
KR20170121340A (ko) 불사화 줄기세포 및 그 생산물을 유효 성분으로 하는 의약 조성물 및 의약 제제
Galipeau Mesenchymal stromal cells for graft-versus-host disease: a trilogy
Gordiienko et al. Empty nose syndrome pathogenesis and cell-based biotechnology products as a new option for treatment
JPWO2019217091A5 (https=)
CN112826833A (zh) 间充质干细胞在制备新冠肺炎引起的肺损伤修复药物中的应用
Soliman et al. COVID-19 disease treatment: pivotal challenges in the arena of umbilical cord-mesenchymal stem cells (UC-MSCs)
Rostami et al. The role of Dental-derived stem cell-based therapy and their derived extracellular vesicles in post-COVID-19 syndrome-induced tissue damage
CN107661501A (zh) 一种治疗强直性脊柱炎的药物组合物、药物靶点及其应用
Prokopyuk et al. Experience in clinical application of cryopreserved placental derivatives: cells, tissue, membranes, extract, and cord blood serum
JPWO2019217646A5 (https=)
JP2021155335A (ja) 変形性関節症の処置および/または予防方法
WO2025208891A1 (zh) 一种使用成纤维细胞抑制炎症反应的方法
KR20220077986A (ko) 불멸화 개줄기세포 또는 이의 엑소좀풍부배양액을 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 조성물
Chand et al. Stem cell therapy for neuroprotection in the growth-restricted newborn
KR20200114769A (ko) 저선량방사선에 의한 류마티스 관절염 치료 효과
Pawelec et al. Stem cell experiments moves into clinic: new hope for children with bronchopulmonary dysplasia
CN117679493B (zh) 一种通过免疫调控来治疗或预防肌腱病的药物及其应用
Hutchison Report on a case of hemi-hypertrophy, with post-mortem examination
CN119235921B (zh) 一种治疗与脂肪变性相关疾病的细胞治疗药物
Koul et al. Longitudinal Extensive Transverse Myelitis in a Four-Year-Old Boy Liver Transplant Recipient
Stewart et al. Spinal Muscular Atrophy and the Possible Use of Stem Cells as Therapy