JP2021523106A5 - - Google Patents
Info
- Publication number
- JP2021523106A5 JP2021523106A5 JP2020560991A JP2020560991A JP2021523106A5 JP 2021523106 A5 JP2021523106 A5 JP 2021523106A5 JP 2020560991 A JP2020560991 A JP 2020560991A JP 2020560991 A JP2020560991 A JP 2020560991A JP 2021523106 A5 JP2021523106 A5 JP 2021523106A5
- Authority
- JP
- Japan
- Prior art keywords
- msc
- exosomes
- stem cell
- mesenchymal stem
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024033810A JP2024138218A (ja) | 2018-04-30 | 2024-03-06 | 間葉系間質細胞エキソソームおよびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664696P | 2018-04-30 | 2018-04-30 | |
| US62/664,696 | 2018-04-30 | ||
| PCT/US2019/029275 WO2019217091A1 (en) | 2018-04-30 | 2019-04-26 | Mesenchymal stromal cell exosomes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024033810A Division JP2024138218A (ja) | 2018-04-30 | 2024-03-06 | 間葉系間質細胞エキソソームおよびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523106A JP2021523106A (ja) | 2021-09-02 |
| JP2021523106A5 true JP2021523106A5 (cg-RX-API-DMAC7.html) | 2022-05-10 |
| JP7538044B2 JP7538044B2 (ja) | 2024-08-21 |
Family
ID=68466806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560991A Active JP7538044B2 (ja) | 2018-04-30 | 2019-04-26 | 間葉系間質細胞エキソソームおよびそれらの使用 |
| JP2024033810A Pending JP2024138218A (ja) | 2018-04-30 | 2024-03-06 | 間葉系間質細胞エキソソームおよびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024033810A Pending JP2024138218A (ja) | 2018-04-30 | 2024-03-06 | 間葉系間質細胞エキソソームおよびそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12521418B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3810271A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7538044B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN112334190B (cg-RX-API-DMAC7.html) |
| CA (1) | CA3098514A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019217091A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3145493T3 (da) | 2014-05-18 | 2022-10-31 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende exosomer |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| US12569517B2 (en) | 2019-02-07 | 2026-03-10 | Direct Biologics, Llc | Method for treating osteoarthritis with mesenchymal stem cell exosomes |
| US12213995B2 (en) | 2019-07-18 | 2025-02-04 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| CN111281889A (zh) * | 2020-04-16 | 2020-06-16 | 博生众康(厦门)医药生物技术股份有限公司 | 人脐带间充质干细胞外泌体的用途 |
| KR20230004709A (ko) * | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| CN117363568B (zh) * | 2023-12-04 | 2024-04-09 | 山东大学 | 一种脂肪间充质干细胞外泌体及其制备方法与应用 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US20040214783A1 (en) | 2002-05-08 | 2004-10-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
| US8021847B2 (en) | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| US8337815B2 (en) | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| WO2006110582A1 (en) | 2005-04-08 | 2006-10-19 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
| WO2008020815A1 (en) | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
| EP1937801A1 (en) | 2005-09-02 | 2008-07-02 | Agency for Science, Technology and Research | Method of deriving mesenchymal stem cells |
| US20090274665A1 (en) | 2006-04-27 | 2009-11-05 | Cell Therapy Technologies, Inc. | Stem Cells For Treating Lung Diseases |
| PT2578081E (pt) | 2006-10-11 | 2016-06-17 | Massachusetts Inst Technology | Composições, métodos e dispositivos para o tratamento de doenças hepáticas |
| EP1944361A1 (en) | 2007-01-11 | 2008-07-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for expanding monocytes |
| AU2009203638C1 (en) | 2008-01-04 | 2013-07-25 | Lydac Neuroscience Limited | Microvesicles |
| EP2254586B1 (en) | 2008-02-22 | 2015-04-08 | Agency For Science, Technology And Research (A*star) | Mesenchymal stem cell particles |
| SG177467A1 (en) | 2009-07-23 | 2012-02-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| WO2011053257A2 (en) | 2009-11-02 | 2011-05-05 | Agency For Science, Technology And Research (A*Star) | Methods of monitoring cellular states |
| KR101189655B1 (ko) | 2010-06-30 | 2012-10-11 | 성균관대학교산학협력단 | 줄기세포 배양액을 포함하는 폐질환 치료용 조성물 |
| CN101890050B (zh) | 2010-07-14 | 2012-07-04 | 江苏大学 | 脐带间质干细胞来源膜性囊泡及其应用 |
| WO2012020308A2 (en) | 2010-08-13 | 2012-02-16 | The University Court Of The University Of Glasgow | Cellular and molecular therapies |
| EP2678448A4 (en) | 2011-02-22 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS |
| US9901600B2 (en) | 2011-03-11 | 2018-02-27 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| JP2014519340A (ja) | 2011-06-16 | 2014-08-14 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. | バイオマーカー組成物および方法 |
| ITTO20111183A1 (it) | 2011-12-21 | 2013-06-22 | Univ Degli Studi Torino | Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia |
| US9427450B2 (en) | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| EP2833893B1 (en) | 2012-04-03 | 2018-08-29 | Reneuron Limited | Stem cell microparticles |
| KR101399056B1 (ko) | 2012-04-16 | 2014-05-27 | 연세대학교 산학협력단 | 줄기세포-유래 미세소포체를 유효성분으로 포함하는 신경질환 예방 또는 치료용 약제학적 조성물 |
| US20130273011A1 (en) | 2012-04-17 | 2013-10-17 | Medistem, Inc. | Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome |
| US20150125950A1 (en) | 2012-05-18 | 2015-05-07 | Agency For Science, Technology And Research (A*Sta (A*Star) | Umbilical cord mesenchymal stem cell exosomes |
| EP2687219A1 (en) | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| JP2015524849A (ja) | 2012-08-15 | 2015-08-27 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 神経変性疾患に対するエキソソームに基づく治療法 |
| CN103767985A (zh) | 2012-10-22 | 2014-05-07 | 吉林省霍普金斯药物研究院有限责任公司 | 人源血液或间充质干细胞分泌exosome的制备与应用 |
| US20160002597A1 (en) | 2013-02-12 | 2016-01-07 | Reneuron Limited | Method of producing microparticles |
| CA2910802A1 (en) | 2013-04-12 | 2014-10-16 | Samir El Andaloussi | Therapeutic delivery vesicles |
| JP2016528151A (ja) | 2013-08-07 | 2016-09-15 | ピーアイ セラミック ゲーエムベーハー | 鉛含有量が低減された圧電セラミック材料 |
| WO2015038075A1 (en) | 2013-09-16 | 2015-03-19 | Agency For Science, Technology And Research | Method |
| WO2016043654A1 (en) | 2014-09-15 | 2016-03-24 | Agency For Science, Technology And Research | Methods of treating graft versus host disease (gvhd) or epidermolysis bullosa (eb) with exosomes |
| US20180273906A1 (en) * | 2014-04-17 | 2018-09-27 | Muhammad Ashraf | Microvesicle and stem cell compositions for therapeutic applications |
| DK3145493T3 (da) | 2014-05-18 | 2022-10-31 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende exosomer |
| US10166254B2 (en) | 2014-09-19 | 2019-01-01 | Wisconsin Alumni Research Foundation | Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury |
| AU2017220148A1 (en) * | 2016-02-18 | 2018-07-19 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| CN105769916B (zh) | 2016-04-29 | 2019-07-23 | 南京大学 | 间充质干细胞来源外泌体在制备治疗子痫前期药物或者制剂中的应用 |
| CA3027970A1 (en) | 2016-06-17 | 2017-12-21 | United Therapeutics Corporation | Extracellular vesicles with enhanced potency |
| KR101973284B1 (ko) * | 2017-01-16 | 2019-04-29 | 사회복지법인 삼성생명공익재단 | 신생아 hie 치료용 조성물 |
| US11760975B2 (en) | 2017-03-31 | 2023-09-19 | Wisconsin Alumi Research Foundation | Generation of therapeutic cells using extracellular components of target organs |
| CN111212653A (zh) | 2017-08-15 | 2020-05-29 | 儿童医学中心公司 | 经纯化间充质干细胞外排体及其用途 |
| US11499730B2 (en) | 2018-02-12 | 2022-11-15 | Wisconsin Alumni Research Foundation | LPS priming of stromal cells to generate LPS-specific exosome educated macrophages |
| CA3099042A1 (en) | 2018-05-09 | 2019-11-14 | Children's Medical Center Corporation | Mesenchymal stromal cell exosome -treated monocytes and uses thereof |
| EP3846782A4 (en) | 2018-09-05 | 2022-07-13 | Children's Medical Center Corporation | Use of mesenchymal stromal cell exosomes in antenatal therapy |
-
2019
- 2019-04-26 JP JP2020560991A patent/JP7538044B2/ja active Active
- 2019-04-26 EP EP19800074.7A patent/EP3810271A4/en active Pending
- 2019-04-26 WO PCT/US2019/029275 patent/WO2019217091A1/en not_active Ceased
- 2019-04-26 CN CN201980029284.8A patent/CN112334190B/zh active Active
- 2019-04-26 CA CA3098514A patent/CA3098514A1/en active Pending
- 2019-04-26 US US17/051,744 patent/US12521418B2/en active Active
-
2024
- 2024-03-06 JP JP2024033810A patent/JP2024138218A/ja active Pending
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