JP2021522798A - 免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞 - Google Patents

免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞 Download PDF

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JP2021522798A
JP2021522798A JP2020561821A JP2020561821A JP2021522798A JP 2021522798 A JP2021522798 A JP 2021522798A JP 2020561821 A JP2020561821 A JP 2020561821A JP 2020561821 A JP2020561821 A JP 2020561821A JP 2021522798 A JP2021522798 A JP 2021522798A
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cells
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cish
car
antigen
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JPWO2019213610A5 (enExample
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ダヘール、メイ
バサール、ラフェット
シュポール、エリザベス
レズヴァニ、ケイティ
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University of Texas System
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JP2020561821A 2018-05-03 2019-05-03 免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞 Pending JP2021522798A (ja)

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JP2024000389A JP2024045179A (ja) 2018-05-03 2024-01-05 免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞

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US201862666665P 2018-05-03 2018-05-03
US62/666,665 2018-05-03
US201862666965P 2018-05-04 2018-05-04
US62/666,965 2018-05-04
PCT/US2019/030721 WO2019213610A1 (en) 2018-05-03 2019-05-03 Natural killer cells engineered to express chimeric antigen receptors with immune checkpoint blockade

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JP2024000389A Division JP2024045179A (ja) 2018-05-03 2024-01-05 免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞

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JPWO2019213610A5 JPWO2019213610A5 (enExample) 2022-05-09

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JP2024000389A Pending JP2024045179A (ja) 2018-05-03 2024-01-05 免疫チェックポイント遮断によりキメラ抗原受容体を発現するように操作されたナチュラルキラー細胞

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US (1) US20210230548A1 (enExample)
EP (1) EP3788061A4 (enExample)
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KR (1) KR20210005240A (enExample)
CN (1) CN112292390A (enExample)
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Cited By (3)

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JP2021523725A (ja) * 2018-05-16 2021-09-09 リサーチ インスティテュート アット ネイションワイド チルドレンズ ホスピタルＲｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ａｔ Ｎａｔｉｏｎｗｉｄｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｃａｓ９リボ核タンパク質を使用したノックアウト初代および増殖ヒトｎｋ細胞の生成
JP2022519935A (ja) * 2019-03-29 2022-03-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｃａｒ－ｎｋ細胞の作製方法およびその使用方法
JP2022535429A (ja) * 2019-06-04 2022-08-08 ンカルタ・インコーポレイテッド 免疫療法のための操作されたナチュラルキラー細胞と操作されたｔ細胞の組み合わせ

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CN101918028B (zh) 2007-09-18 2015-01-07 莱戈赛特医药股份有限公司 赋予针对诺如病毒的保护性免疫应答的疫苗
DK3299030T3 (da) 2011-07-11 2022-09-05 Takeda Vaccines Inc Parenterale norovirus-vaccineformuleringer
CN110753555A (zh) * 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
JP2021502085A (ja) 2017-11-09 2021-01-28 サンガモ セラピューティクス， インコーポレイテッド サイトカイン誘導性ｓｈ２含有タンパク質（ｃｉｓｈ）遺伝子の遺伝子改変
AU2019215034C1 (en) 2018-02-01 2022-01-06 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
CN118178645A (zh) 2019-10-18 2024-06-14 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
US20210147568A1 (en) 2019-10-31 2021-05-20 Forty Seven, Inc. Anti-cd47 based treatment of blood cancer
US12195723B2 (en) * 2019-11-08 2025-01-14 The Broad Institute, Inc. Engineered antigen presenting cells and uses thereof
CN110760007B (zh) * 2019-11-21 2022-08-26 博生吉医药科技(苏州)有限公司 Cd7-car-t细胞及其制备和应用
AU2020392225A1 (en) * 2019-11-27 2022-06-16 Board Of Regents, The University Of Texas System Large-scale combined CAR transduction and CRISPR gene editing of MSC cells
WO2021108671A1 (en) * 2019-11-27 2021-06-03 Board Of Regents, The University Of Texas System Large-scale combined car transduction and crispr gene editing of nk cells
LT4081305T (lt) 2019-12-24 2024-11-25 Carna Biosciences, Inc. Diacilglicerolio kinazę moduliuojantys junginiai
MX2022008485A (es) * 2020-01-08 2022-08-02 Univ Texas Un metodo para modificar celulas asesinas naturales para dirigirse a tumores positivos a cd70.
WO2021202581A1 (en) * 2020-03-30 2021-10-07 WUGEN, Inc. Engineered immune cells for adoptive cell therapy
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
JP2023552998A (ja) * 2020-12-03 2023-12-20 ンカルタ・インコーポレイテッド 効力および持続性の増強のために免疫細胞を操作する方法、ならびに免疫療法における操作された細胞の使用
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
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