CN112292390A - 经工程改造以在免疫检查点阻断的情况下表达嵌合抗原受体的自然杀伤细胞 - Google Patents

经工程改造以在免疫检查点阻断的情况下表达嵌合抗原受体的自然杀伤细胞 Download PDF

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CN112292390A
CN112292390A CN201980037453.2A CN201980037453A CN112292390A CN 112292390 A CN112292390 A CN 112292390A CN 201980037453 A CN201980037453 A CN 201980037453A CN 112292390 A CN112292390 A CN 112292390A
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cells
cell
cish
car
antigen
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M·达赫尔
R·巴萨尔
E·施帕尔
K·雷兹瓦尼
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University of Texas System
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CN201980037453.2A 2018-05-03 2019-05-03 经工程改造以在免疫检查点阻断的情况下表达嵌合抗原受体的自然杀伤细胞 Pending CN112292390A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862666665P 2018-05-03 2018-05-03
US62/666,665 2018-05-03
US201862666965P 2018-05-04 2018-05-04
US62/666,965 2018-05-04
PCT/US2019/030721 WO2019213610A1 (en) 2018-05-03 2019-05-03 Natural killer cells engineered to express chimeric antigen receptors with immune checkpoint blockade

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CN112292390A true CN112292390A (zh) 2021-01-29

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US (1) US20210230548A1 (enExample)
EP (1) EP3788061A4 (enExample)
JP (2) JP2021522798A (enExample)
KR (1) KR20210005240A (enExample)
CN (1) CN112292390A (enExample)
AU (1) AU2019262218B2 (enExample)
BR (1) BR112020022010A2 (enExample)
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WO (1) WO2019213610A1 (enExample)

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CN113005151A (zh) * 2021-03-12 2021-06-22 广东药科大学 一种kdr-car-nk细胞的制备方法及其应用
CN114774364A (zh) * 2022-04-26 2022-07-22 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其制备方法和应用
CN115948344A (zh) * 2023-02-10 2023-04-11 上海交通大学 嵌合抗原受体nk细胞、制备方法及其用途
CN115947869A (zh) * 2022-11-28 2023-04-11 广州佰芮慷生物科技有限公司 一种靶向人巨细胞病毒的嵌合抗原受体、car-nk细胞及用途
CN116769722A (zh) * 2023-07-04 2023-09-19 杭州荣谷生物科技有限公司 功能增强型car-nk细胞、其制备方法及其在免疫疗法中的应用

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CN110753555A (zh) * 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
JP2021502085A (ja) 2017-11-09 2021-01-28 サンガモ セラピューティクス， インコーポレイテッド サイトカイン誘導性ｓｈ２含有タンパク質（ｃｉｓｈ）遺伝子の遺伝子改変
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KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
AU2020254420A1 (en) * 2019-03-29 2021-11-11 Board Of Regents, The University Of Texas System Methods for production of CAR-NK cells and use thereof
WO2020247392A1 (en) * 2019-06-04 2020-12-10 Nkarta, Inc. Combinations of engineered natural killer cells and engineered t cells for immunotherapy
CN118178645A (zh) 2019-10-18 2024-06-14 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
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AU2020392225A1 (en) * 2019-11-27 2022-06-16 Board Of Regents, The University Of Texas System Large-scale combined CAR transduction and CRISPR gene editing of MSC cells
WO2021108671A1 (en) * 2019-11-27 2021-06-03 Board Of Regents, The University Of Texas System Large-scale combined car transduction and crispr gene editing of nk cells
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MX2022008485A (es) * 2020-01-08 2022-08-02 Univ Texas Un metodo para modificar celulas asesinas naturales para dirigirse a tumores positivos a cd70.
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KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
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WO2022129216A1 (en) 2020-12-15 2022-06-23 Universiteit Antwerpen Cell-based therapeutics targeting cd70
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
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EP4341383A4 (en) * 2021-05-20 2024-12-04 Wuxi Biologics Ireland Limited Genetically modified nk cells and uses thereof
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