JP2021521266A5 - - Google Patents
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- Publication number
- JP2021521266A5 JP2021521266A5 JP2020569776A JP2020569776A JP2021521266A5 JP 2021521266 A5 JP2021521266 A5 JP 2021521266A5 JP 2020569776 A JP2020569776 A JP 2020569776A JP 2020569776 A JP2020569776 A JP 2020569776A JP 2021521266 A5 JP2021521266 A5 JP 2021521266A5
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- Japan
- Prior art keywords
- alkyl
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670323P | 2018-05-11 | 2018-05-11 | |
| US62/670,323 | 2018-05-11 | ||
| PCT/US2019/032043 WO2019217972A1 (en) | 2018-05-11 | 2019-05-13 | Kdm1a inhibitors for the treatment of disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521266A JP2021521266A (ja) | 2021-08-26 |
| JP2021521266A5 true JP2021521266A5 (enExample) | 2022-05-16 |
| JP7450559B2 JP7450559B2 (ja) | 2024-03-15 |
Family
ID=68468431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569776A Active JP7450559B2 (ja) | 2018-05-11 | 2019-05-13 | 疾患の処置のためのｋｄｍ１ａ阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11578059B2 (enExample) |
| EP (1) | EP3790867B1 (enExample) |
| JP (1) | JP7450559B2 (enExample) |
| KR (1) | KR102684364B1 (enExample) |
| CN (1) | CN112513020B (enExample) |
| AU (1) | AU2019265022B2 (enExample) |
| BR (1) | BR112021001066A2 (enExample) |
| CA (1) | CA3103392A1 (enExample) |
| ES (1) | ES2977656T3 (enExample) |
| IL (1) | IL279260B2 (enExample) |
| PH (1) | PH12020552135A1 (enExample) |
| SG (1) | SG11202012289UA (enExample) |
| WO (1) | WO2019217972A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014306149B2 (en) | 2013-08-06 | 2019-09-19 | Imago Biosciences Inc. | KDM1A inhibitors for the treatment of disease |
| KR102626978B1 (ko) | 2015-02-12 | 2024-01-18 | 이마고 바이오사이언시즈 인코포레이티드 | 질환 치료를 위한 kdm1a 저해제 |
| US11390590B2 (en) | 2016-08-16 | 2022-07-19 | Imago Biosciences, Inc. | Methods and processes for the preparation of KDM1A inhibitors |
| KR102684364B1 (ko) | 2018-05-11 | 2024-07-11 | 이마고 바이오사이언시즈 인코포레이티드 | 질환의 치료를 위한 kdm1a 저해제 |
| MX2022007113A (es) * | 2019-12-09 | 2022-07-11 | Imago Biosciences Inc | Inhibidores de la desmetilasa de la histona especifica de la lisina para el tratamiento de las neoplasias mieloproliferativas. |
| WO2022199662A1 (zh) * | 2021-03-24 | 2022-09-29 | 四川汇宇制药股份有限公司 | 一种多环化合物及其应用 |
| CN114591324B (zh) * | 2021-03-30 | 2023-05-05 | 深圳微芯生物科技股份有限公司 | 一类吡嗪酮衍生物、其制备及其应用 |
| CA3231846A1 (en) | 2021-04-08 | 2022-10-13 | Tamara Maes | Combinations of lsd1 inhibitors for treating myeloid cancers |
| EP4522136A1 (en) | 2022-05-09 | 2025-03-19 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| CN119497613A (zh) | 2022-05-09 | 2025-02-21 | 奥莱松基因组股份有限公司 | 使用lsd1抑制剂治疗nf1-突变肿瘤的方法 |
| WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
| EP4637760A1 (en) * | 2022-12-23 | 2025-10-29 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008514639A (ja) * | 2004-09-24 | 2008-05-08 | イデニクス（ケイマン）リミテツド | フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物 |
| US8314087B2 (en) * | 2007-02-16 | 2012-11-20 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and methods of use |
| RU2479580C2 (ru) * | 2007-06-27 | 2013-04-20 | Астразенека Аб | Производные пиразинона и их применение для лечения легочных заболеваний |
| CN101855342B (zh) | 2007-09-13 | 2013-07-10 | 科德克希思公司 | 用于还原苯乙酮的酮还原酶多肽 |
| JP5646328B2 (ja) | 2007-10-01 | 2014-12-24 | コデクシス， インコーポレイテッド | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010043721A1 (en) | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| EP2177502A1 (en) | 2008-10-17 | 2010-04-21 | Oryzon Genomics, S.A. | Compounds and their use |
| WO2010143582A1 (ja) | 2009-06-11 | 2010-12-16 | 公立大学法人名古屋市立大学 | フェニルシクロプロピルアミン誘導体及びlsd1阻害剤 |
| US8415381B2 (en) * | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
| US8859555B2 (en) | 2009-09-25 | 2014-10-14 | Oryzon Genomics S.A. | Lysine Specific Demethylase-1 inhibitors and their use |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| MX2012012111A (es) | 2010-04-19 | 2013-05-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especifica de lisina y su uso. |
| AU2011244478B2 (en) | 2010-04-20 | 2014-07-17 | Fondazione IEO-CCM | Tranylcypromine derivatives as inhibitors of histone demethylase LSD1 and/or LSD2 |
| WO2012013727A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| SI2598482T1 (sl) | 2010-07-29 | 2018-09-28 | Oryzon Genomics, S.A. | Inhibitorji demetilaze lsd1 na osnovi arilciklopropilamina in njihova medicinska uporaba |
| US9527805B2 (en) | 2010-09-10 | 2016-12-27 | Robert A. Casero | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders |
| WO2012047852A2 (en) | 2010-10-07 | 2012-04-12 | The J. David Gladstone Institutes | Compositions and methods for modulating immunodeficiency virus transcription |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012071469A2 (en) | 2010-11-23 | 2012-05-31 | Nevada Cancer Institute | Histone demethylase inhibitors and uses thereof for treatment o f cancer |
| WO2012107498A1 (en) | 2011-02-08 | 2012-08-16 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| WO2012107499A1 (en) | 2011-02-08 | 2012-08-16 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders |
| CA2831143C (en) | 2011-03-25 | 2019-05-21 | Glaxosmithkline Intellectual Property Development Limited | Cyclopropylamines as lsd1 inhibitors |
| UA114406C2 (uk) | 2011-08-09 | 2017-06-12 | Такеда Фармасьютікал Компані Лімітед | Похідні циклопропанаміну як інгібітори lsd1 |
| RS58475B1 (sr) | 2011-10-20 | 2019-04-30 | Oryzon Genomics Sa | Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori |
| CN107266345B (zh) | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
| EP2927212A4 (en) | 2012-11-28 | 2016-06-08 | Univ Kyoto | LSD1-SELECTIVE HEMMER WITH LYSINE STRUCTURE |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2014164867A1 (en) | 2013-03-11 | 2014-10-09 | Imago Biosciences | Kdm1a inhibitors for the treatment of disease |
| AU2014302038B2 (en) | 2013-06-25 | 2019-11-14 | Epiaxis Therapeutics Pty Ltd | Methods and compositions for modulating cancer stem cells |
| AU2014306149B2 (en) | 2013-08-06 | 2019-09-19 | Imago Biosciences Inc. | KDM1A inhibitors for the treatment of disease |
| KR102421235B1 (ko) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Lsd1 저해제로서 사이클로프로필아민 |
| CN121203988A (zh) | 2014-04-22 | 2025-12-26 | C-乐克塔股份有限公司 | 酮还原酶 |
| MX376632B (es) * | 2014-06-27 | 2025-03-07 | Celgene Quanticel Res Inc | Inhibidores de demetilasa-1 especifica de lisina. |
| KR102626978B1 (ko) * | 2015-02-12 | 2024-01-18 | 이마고 바이오사이언시즈 인코포레이티드 | 질환 치료를 위한 kdm1a 저해제 |
| US10093668B2 (en) * | 2015-10-28 | 2018-10-09 | Northwestern University | Substituted aromatic N-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (Mnk1) and 2 (Mnk2) |
| WO2017079753A1 (en) | 2015-11-05 | 2017-05-11 | Imago Biosciences, Inc. | Lysine-specific histone demethylase as a novel therapeutic target in myeloproliferative neoplasms |
| SG11201805645QA (en) | 2015-12-29 | 2018-07-30 | Mirati Therapeutics Inc | Lsd1 inhibitors |
| SI3455204T1 (sl) * | 2016-05-09 | 2026-03-31 | Jubilant Epicore LLC | Ciklopropil-amidne spojine kot dvojni zaviralci lsd1/hdac |
| CN110268067A (zh) | 2016-08-16 | 2019-09-20 | 伊美格生物科学公司 | 用于产生立体异构纯的氨基环丙烷的组合物和方法 |
| US11390590B2 (en) | 2016-08-16 | 2022-07-19 | Imago Biosciences, Inc. | Methods and processes for the preparation of KDM1A inhibitors |
| WO2018106984A1 (en) | 2016-12-09 | 2018-06-14 | Constellation Pharmaceuticals, Inc. | Markers for personalized cancer treatment with lsd1 inhibitors |
| KR102684364B1 (ko) | 2018-05-11 | 2024-07-11 | 이마고 바이오사이언시즈 인코포레이티드 | 질환의 치료를 위한 kdm1a 저해제 |
-
2019
- 2019-05-13 KR KR1020207035544A patent/KR102684364B1/ko active Active
- 2019-05-13 AU AU2019265022A patent/AU2019265022B2/en active Active
- 2019-05-13 EP EP19800758.5A patent/EP3790867B1/en active Active
- 2019-05-13 US US17/054,126 patent/US11578059B2/en active Active
- 2019-05-13 BR BR112021001066-1A patent/BR112021001066A2/pt unknown
- 2019-05-13 SG SG11202012289UA patent/SG11202012289UA/en unknown
- 2019-05-13 CA CA3103392A patent/CA3103392A1/en active Pending
- 2019-05-13 CN CN201980046308.0A patent/CN112513020B/zh active Active
- 2019-05-13 ES ES19800758T patent/ES2977656T3/es active Active
- 2019-05-13 WO PCT/US2019/032043 patent/WO2019217972A1/en not_active Ceased
- 2019-05-13 IL IL279260A patent/IL279260B2/en unknown
- 2019-05-13 JP JP2020569776A patent/JP7450559B2/ja active Active
-
2020
- 2020-12-11 PH PH12020552135A patent/PH12020552135A1/en unknown
-
2022
- 2022-12-15 US US18/066,667 patent/US11932629B2/en active Active
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