JP2021521129A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021521129A5 JP2021521129A5 JP2020555188A JP2020555188A JP2021521129A5 JP 2021521129 A5 JP2021521129 A5 JP 2021521129A5 JP 2020555188 A JP2020555188 A JP 2020555188A JP 2020555188 A JP2020555188 A JP 2020555188A JP 2021521129 A5 JP2021521129 A5 JP 2021521129A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- disease
- group
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 88
- 239000001257 hydrogen Substances 0.000 claims description 88
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 87
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 85
- 201000010099 disease Diseases 0.000 claims description 75
- 206010028980 Neoplasm Diseases 0.000 claims description 68
- 229910052736 halogen Inorganic materials 0.000 claims description 52
- 150000002367 halogens Chemical class 0.000 claims description 52
- 150000002431 hydrogen Chemical class 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 47
- 208000015181 infectious disease Diseases 0.000 claims description 45
- 201000011510 cancer Diseases 0.000 claims description 42
- 206010014599 encephalitis Diseases 0.000 claims description 42
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 40
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 125000001188 haloalkyl group Chemical group 0.000 claims description 32
- 208000027866 inflammatory disease Diseases 0.000 claims description 28
- 125000001072 heteroaryl group Chemical group 0.000 claims description 26
- -1 -OR 5 Inorganic materials 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 208000011580 syndromic disease Diseases 0.000 claims description 16
- 201000004624 Dermatitis Diseases 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 12
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 10
- 241000224489 Amoeba Species 0.000 claims description 10
- 206010015150 Erythema Diseases 0.000 claims description 10
- 208000031888 Mycoses Diseases 0.000 claims description 10
- 230000001154 acute effect Effects 0.000 claims description 10
- 210000003169 central nervous system Anatomy 0.000 claims description 10
- 208000035475 disorder Diseases 0.000 claims description 10
- 201000002491 encephalomyelitis Diseases 0.000 claims description 10
- 231100000321 erythema Toxicity 0.000 claims description 10
- 230000002757 inflammatory effect Effects 0.000 claims description 10
- 201000001441 melanoma Diseases 0.000 claims description 10
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- 206010006187 Breast cancer Diseases 0.000 claims description 8
- 208000026310 Breast neoplasm Diseases 0.000 claims description 8
- 241000282465 Canis Species 0.000 claims description 8
- 201000009030 Carcinoma Diseases 0.000 claims description 8
- 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 claims description 8
- 101710106276 Cyclin-dependent kinase 7 Proteins 0.000 claims description 8
- 241000224431 Entamoeba Species 0.000 claims description 8
- 206010061598 Immunodeficiency Diseases 0.000 claims description 8
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 8
- 206010025323 Lymphomas Diseases 0.000 claims description 8
- 201000009906 Meningitis Diseases 0.000 claims description 8
- 230000007813 immunodeficiency Effects 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 8
- 206010046851 Uveitis Diseases 0.000 claims description 7
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims description 6
- 208000035473 Communicable disease Diseases 0.000 claims description 6
- 241000282324 Felis Species 0.000 claims description 6
- 208000007514 Herpes zoster Diseases 0.000 claims description 6
- 206010020751 Hypersensitivity Diseases 0.000 claims description 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 201000008197 Laryngitis Diseases 0.000 claims description 6
- 201000004681 Psoriasis Diseases 0.000 claims description 6
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 6
- 206010038389 Renal cancer Diseases 0.000 claims description 6
- 208000025747 Rheumatic disease Diseases 0.000 claims description 6
- 206010039491 Sarcoma Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 208000000491 Tendinopathy Diseases 0.000 claims description 6
- 206010043255 Tendonitis Diseases 0.000 claims description 6
- 206010047115 Vasculitis Diseases 0.000 claims description 6
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 230000001684 chronic effect Effects 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 208000026278 immune system disease Diseases 0.000 claims description 6
- 201000010982 kidney cancer Diseases 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 230000003211 malignant effect Effects 0.000 claims description 6
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims description 6
- 244000045947 parasite Species 0.000 claims description 6
- 206010038038 rectal cancer Diseases 0.000 claims description 6
- 201000001275 rectum cancer Diseases 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 210000004500 stellate cell Anatomy 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 201000004415 tendinitis Diseases 0.000 claims description 6
- 230000001755 vocal effect Effects 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 4
- 208000030507 AIDS Diseases 0.000 claims description 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 4
- 206010004593 Bile duct cancer Diseases 0.000 claims description 4
- 208000014644 Brain disease Diseases 0.000 claims description 4
- 241000589562 Brucella Species 0.000 claims description 4
- 108091007914 CDKs Proteins 0.000 claims description 4
- 241000222122 Candida albicans Species 0.000 claims description 4
- 206010007134 Candida infections Diseases 0.000 claims description 4
- 241000282472 Canis lupus familiaris Species 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 208000002691 Choroiditis Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 4
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims description 4
- 206010059547 Cutaneous larva migrans Diseases 0.000 claims description 4
- 102000003903 Cyclin-dependent kinases Human genes 0.000 claims description 4
- 108090000266 Cyclin-dependent kinases Proteins 0.000 claims description 4
- 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 208000010772 Dog disease Diseases 0.000 claims description 4
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 4
- 208000030820 Ebola disease Diseases 0.000 claims description 4
- 206010014612 Encephalitis viral Diseases 0.000 claims description 4
- 208000032274 Encephalopathy Diseases 0.000 claims description 4
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 4
- 241000282326 Felis catus Species 0.000 claims description 4
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- 208000024869 Goodpasture syndrome Diseases 0.000 claims description 4
- 208000032843 Hemorrhage Diseases 0.000 claims description 4
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 206010023076 Isosporiasis Diseases 0.000 claims description 4
- 208000004204 Larva Migrans Diseases 0.000 claims description 4
- 208000018142 Leiomyosarcoma Diseases 0.000 claims description 4
- 206010027476 Metastases Diseases 0.000 claims description 4
- 208000003445 Mouth Neoplasms Diseases 0.000 claims description 4
- 206010028372 Muscular weakness Diseases 0.000 claims description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 208000030852 Parasitic disease Diseases 0.000 claims description 4
- 208000005384 Pneumocystis Pneumonia Diseases 0.000 claims description 4
- 206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 claims description 4
- 208000003971 Posterior uveitis Diseases 0.000 claims description 4
- 102000029797 Prion Human genes 0.000 claims description 4
- 108091000054 Prion Proteins 0.000 claims description 4
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- 206010042742 Sympathetic ophthalmia Diseases 0.000 claims description 4
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 4
- 206010057644 Testis cancer Diseases 0.000 claims description 4
- 208000006593 Urologic Neoplasms Diseases 0.000 claims description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
- 241000219094 Vitaceae Species 0.000 claims description 4
- 206010000269 abscess Diseases 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 208000009956 adenocarcinoma Diseases 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 206010003230 arteritis Diseases 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 210000000941 bile Anatomy 0.000 claims description 4
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 4
- 230000000740 bleeding effect Effects 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 201000008275 breast carcinoma Diseases 0.000 claims description 4
- 201000003984 candidiasis Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000002490 cerebral effect Effects 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 4
- 208000016532 chronic granulomatous disease Diseases 0.000 claims description 4
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 230000007812 deficiency Effects 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 210000000959 ear middle Anatomy 0.000 claims description 4
- 201000004101 esophageal cancer Diseases 0.000 claims description 4
- 235000021021 grapes Nutrition 0.000 claims description 4
- 208000006454 hepatitis Diseases 0.000 claims description 4
- 231100000283 hepatitis Toxicity 0.000 claims description 4
- 208000036260 idiopathic disease Diseases 0.000 claims description 4
- 230000001900 immune effect Effects 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims description 4
- 206010025482 malaise Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 230000009401 metastasis Effects 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 230000036473 myasthenia Effects 0.000 claims description 4
- 208000023833 nerve sheath neoplasm Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 230000036281 parasite infection Effects 0.000 claims description 4
- 201000000317 pneumocystosis Diseases 0.000 claims description 4
- 230000002062 proliferating effect Effects 0.000 claims description 4
- 230000000306 recurrent effect Effects 0.000 claims description 4
- 201000000306 sarcoidosis Diseases 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 201000003120 testicular cancer Diseases 0.000 claims description 4
- 230000000472 traumatic effect Effects 0.000 claims description 4
- 201000008827 tuberculosis Diseases 0.000 claims description 4
- 208000025301 tympanitis Diseases 0.000 claims description 4
- 230000002792 vascular Effects 0.000 claims description 4
- 201000002498 viral encephalitis Diseases 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims description 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims description 2
- 241000208140 Acer Species 0.000 claims description 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- 208000004142 Acute Retinal Necrosis Syndrome Diseases 0.000 claims description 2
- 206010000830 Acute leukaemia Diseases 0.000 claims description 2
- 208000003200 Adenoma Diseases 0.000 claims description 2
- 206010001233 Adenoma benign Diseases 0.000 claims description 2
- 208000010370 Adenoviridae Infections Diseases 0.000 claims description 2
- 206010060931 Adenovirus infection Diseases 0.000 claims description 2
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 206010061424 Anal cancer Diseases 0.000 claims description 2
- 201000003076 Angiosarcoma Diseases 0.000 claims description 2
- 208000007860 Anus Neoplasms Diseases 0.000 claims description 2
- 241000244186 Ascaris Species 0.000 claims description 2
- 201000002909 Aspergillosis Diseases 0.000 claims description 2
- 208000036641 Aspergillus infections Diseases 0.000 claims description 2
- 206010003645 Atopy Diseases 0.000 claims description 2
- 241000972773 Aulopiformes Species 0.000 claims description 2
- 241000223836 Babesia Species 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 claims description 2
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 2
- 206010005098 Blastomycosis Diseases 0.000 claims description 2
- 208000019838 Blood disease Diseases 0.000 claims description 2
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 208000024956 Borna Disease Diseases 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 206010006143 Brain stem glioma Diseases 0.000 claims description 2
- 241000680578 Canid alphaherpesvirus 1 Species 0.000 claims description 2
- 241000282461 Canis lupus Species 0.000 claims description 2
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims description 2
- 206010061041 Chlamydial infection Diseases 0.000 claims description 2
- 208000035086 Chlamydophila Infections Diseases 0.000 claims description 2
- 206010008631 Cholera Diseases 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 2
- 208000003495 Coccidiosis Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 206010010741 Conjunctivitis Diseases 0.000 claims description 2
- 206010011409 Cross infection Diseases 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 claims description 2
- 241000223935 Cryptosporidium Species 0.000 claims description 2
- 208000011917 Cyclosporosis Diseases 0.000 claims description 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims description 2
- 208000001490 Dengue Diseases 0.000 claims description 2
- 206010012310 Dengue fever Diseases 0.000 claims description 2
- 206010012335 Dependence Diseases 0.000 claims description 2
- 206010012442 Dermatitis contact Diseases 0.000 claims description 2
- 206010059352 Desmoid tumour Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims description 2
- 241000935792 Dipylidium caninum Species 0.000 claims description 2
- 206010013700 Drug hypersensitivity Diseases 0.000 claims description 2
- 208000009129 Ear Neoplasms Diseases 0.000 claims description 2
- 241000244160 Echinococcus Species 0.000 claims description 2
- 241000204733 Entamoeba dispar Species 0.000 claims description 2
- 206010014950 Eosinophilia Diseases 0.000 claims description 2
- 206010059284 Epidermal necrosis Diseases 0.000 claims description 2
- 206010061126 Escherichia infection Diseases 0.000 claims description 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims description 2
- 208000004413 Eyelid Neoplasms Diseases 0.000 claims description 2
- 206010050497 Eyelid tumour Diseases 0.000 claims description 2
- 208000009849 Female Genital Neoplasms Diseases 0.000 claims description 2
- 208000001640 Fibromyalgia Diseases 0.000 claims description 2
- 206010016936 Folliculitis Diseases 0.000 claims description 2
- 208000004262 Food Hypersensitivity Diseases 0.000 claims description 2
- 208000014770 Foot disease Diseases 0.000 claims description 2
- 206010017543 Fungal skin infection Diseases 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims description 2
- 206010064147 Gastrointestinal inflammation Diseases 0.000 claims description 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims description 2
- 208000010412 Glaucoma Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 206010018612 Gonorrhoea Diseases 0.000 claims description 2
- 206010018691 Granuloma Diseases 0.000 claims description 2
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 2
- 208000031886 HIV Infections Diseases 0.000 claims description 2
- 208000037357 HIV infectious disease Diseases 0.000 claims description 2
- 206010061192 Haemorrhagic fever Diseases 0.000 claims description 2
- 208000001204 Hashimoto Disease Diseases 0.000 claims description 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 2
- 206010019375 Helicobacter infections Diseases 0.000 claims description 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims description 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims description 2
- 208000025164 Hendra virus infection Diseases 0.000 claims description 2
- 208000000464 Henipavirus Infections Diseases 0.000 claims description 2
- 208000037319 Hepatitis infectious Diseases 0.000 claims description 2
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims description 2
- 208000002291 Histiocytic Sarcoma Diseases 0.000 claims description 2
- 201000002563 Histoplasmosis Diseases 0.000 claims description 2
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims description 2
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 206010061252 Intraocular melanoma Diseases 0.000 claims description 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 2
- 208000011200 Kawasaki disease Diseases 0.000 claims description 2
- 206010023825 Laryngeal cancer Diseases 0.000 claims description 2
- 206010023927 Lassa fever Diseases 0.000 claims description 2
- 206010024229 Leprosy Diseases 0.000 claims description 2
- 206010024238 Leptospirosis Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims description 2
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims description 2
- 208000000932 Marburg Virus Disease Diseases 0.000 claims description 2
- 201000011013 Marburg hemorrhagic fever Diseases 0.000 claims description 2
- 201000005505 Measles Diseases 0.000 claims description 2
- 206010027202 Meningitis bacterial Diseases 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 208000021642 Muscular disease Diseases 0.000 claims description 2
- 201000009623 Myopathy Diseases 0.000 claims description 2
- 206010061302 Myringitis Diseases 0.000 claims description 2
- 206010028729 Nasal cavity cancer Diseases 0.000 claims description 2
- 206010028780 Nasal ulcer Diseases 0.000 claims description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 2
- 241000244206 Nematoda Species 0.000 claims description 2
- 206010062701 Nematodiasis Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 208000009608 Papillomavirus Infections Diseases 0.000 claims description 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims description 2
- 208000008071 Parvoviridae Infections Diseases 0.000 claims description 2
- 206010057343 Parvovirus infection Diseases 0.000 claims description 2
- 206010061336 Pelvic neoplasm Diseases 0.000 claims description 2
- 208000002471 Penile Neoplasms Diseases 0.000 claims description 2
- 206010034299 Penile cancer Diseases 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010034811 Pharyngeal cancer Diseases 0.000 claims description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 2
- 235000011613 Pinus brutia Nutrition 0.000 claims description 2
- 241000018646 Pinus brutia Species 0.000 claims description 2
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000033014 Plasma cell tumor Diseases 0.000 claims description 2
- 208000007452 Plasmacytoma Diseases 0.000 claims description 2
- 208000000474 Poliomyelitis Diseases 0.000 claims description 2
- 206010065159 Polychondritis Diseases 0.000 claims description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
- 208000031951 Primary immunodeficiency Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 2
- 201000008183 Pulmonary blastoma Diseases 0.000 claims description 2
- 206010037688 Q fever Diseases 0.000 claims description 2
- 208000019155 Radiation injury Diseases 0.000 claims description 2
- 206010067362 Radiation necrosis Diseases 0.000 claims description 2
- 208000035415 Reinfection Diseases 0.000 claims description 2
- 208000033464 Reiter syndrome Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 201000007737 Retinal degeneration Diseases 0.000 claims description 2
- 201000000582 Retinoblastoma Diseases 0.000 claims description 2
- 206010067470 Rotavirus infection Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 208000034189 Sclerosis Diseases 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims description 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims description 2
- 201000002661 Spondylitis Diseases 0.000 claims description 2
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims description 2
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims description 2
- 201000002014 Suppurative Otitis Media Diseases 0.000 claims description 2
- 208000004732 Systemic Vasculitis Diseases 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims description 2
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 2
- 206010062129 Tongue neoplasm Diseases 0.000 claims description 2
- 206010044223 Toxic epidermal necrolysis Diseases 0.000 claims description 2
- 201000005485 Toxoplasmosis Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims description 2
- 208000024780 Urticaria Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 201000005969 Uveal melanoma Diseases 0.000 claims description 2
- 208000035868 Vascular inflammations Diseases 0.000 claims description 2
- 241000607598 Vibrio Species 0.000 claims description 2
- 208000028227 Viral hemorrhagic fever Diseases 0.000 claims description 2
- 241000282485 Vulpes vulpes Species 0.000 claims description 2
- 201000006449 West Nile encephalitis Diseases 0.000 claims description 2
- 206010057293 West Nile viral infection Diseases 0.000 claims description 2
- 208000027207 Whipple disease Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 208000003152 Yellow Fever Diseases 0.000 claims description 2
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 208000011589 adenoviridae infectious disease Diseases 0.000 claims description 2
- 208000002029 allergic contact dermatitis Diseases 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 230000000172 allergic effect Effects 0.000 claims description 2
- 231100000360 alopecia Toxicity 0.000 claims description 2
- 239000003708 ampul Substances 0.000 claims description 2
- 206010002022 amyloidosis Diseases 0.000 claims description 2
- 230000002052 anaphylactic effect Effects 0.000 claims description 2
- 208000003455 anaphylaxis Diseases 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 201000008170 anus adenocarcinoma Diseases 0.000 claims description 2
- 201000011165 anus cancer Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims description 2
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 2
- 201000008680 babesiosis Diseases 0.000 claims description 2
- 201000009904 bacterial meningitis Diseases 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 210000003969 blast cell Anatomy 0.000 claims description 2
- 201000000053 blastoma Diseases 0.000 claims description 2
- 208000034158 bleeding Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 201000002143 bronchus adenoma Diseases 0.000 claims description 2
- 210000000845 cartilage Anatomy 0.000 claims description 2
- 230000025084 cell cycle arrest Effects 0.000 claims description 2
- 201000007455 central nervous system cancer Diseases 0.000 claims description 2
- 208000010353 central nervous system vasculitis Diseases 0.000 claims description 2
- 210000003679 cervix uteri Anatomy 0.000 claims description 2
- 239000003610 charcoal Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 2
- 201000010354 chronic purulent otitis media Diseases 0.000 claims description 2
- 201000003486 coccidioidomycosis Diseases 0.000 claims description 2
- 210000000860 cochlear nerve Anatomy 0.000 claims description 2
- 230000000112 colonic effect Effects 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 238000011109 contamination Methods 0.000 claims description 2
- 201000002641 cyclosporiasis Diseases 0.000 claims description 2
- 201000008167 cystoisosporiasis Diseases 0.000 claims description 2
- 208000025729 dengue disease Diseases 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 201000006827 desmoid tumor Diseases 0.000 claims description 2
- 230000029087 digestion Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000018345 drug-induced vasculitis Diseases 0.000 claims description 2
- 210000001198 duodenum Anatomy 0.000 claims description 2
- 244000078703 ectoparasite Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 201000008184 embryoma Diseases 0.000 claims description 2
- 210000002308 embryonic cell Anatomy 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 208000020612 escherichia coli infection Diseases 0.000 claims description 2
- 229940011871 estrogen Drugs 0.000 claims description 2
- 239000000262 estrogen Substances 0.000 claims description 2
- CKSJXOVLXUMMFF-UHFFFAOYSA-N exalamide Chemical compound CCCCCCOC1=CC=CC=C1C(N)=O CKSJXOVLXUMMFF-UHFFFAOYSA-N 0.000 claims description 2
- 229950010333 exalamide Drugs 0.000 claims description 2
- 208000024519 eye neoplasm Diseases 0.000 claims description 2
- 208000005098 feline infectious peritonitis Diseases 0.000 claims description 2
- 230000003328 fibroblastic effect Effects 0.000 claims description 2
- 201000008825 fibrosarcoma of bone Diseases 0.000 claims description 2
- 235000020932 food allergy Nutrition 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 2
- 210000004392 genitalia Anatomy 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 208000001786 gonorrhea Diseases 0.000 claims description 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims description 2
- 235000015220 hamburgers Nutrition 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 208000014951 hematologic disease Diseases 0.000 claims description 2
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims description 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 2
- 230000002440 hepatic effect Effects 0.000 claims description 2
- 208000005252 hepatitis A Diseases 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 210000003494 hepatocyte Anatomy 0.000 claims description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 2
- 201000006866 hypopharynx cancer Diseases 0.000 claims description 2
- 230000002267 hypothalamic effect Effects 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 201000006334 interstitial nephritis Diseases 0.000 claims description 2
- 201000002313 intestinal cancer Diseases 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims description 2
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims description 2
- 239000002085 irritant Substances 0.000 claims description 2
- 231100000021 irritant Toxicity 0.000 claims description 2
- 208000001875 irritant dermatitis Diseases 0.000 claims description 2
- 230000000366 juvenile effect Effects 0.000 claims description 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 2
- 206010023841 laryngeal neoplasm Diseases 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 208000002741 leukoplakia Diseases 0.000 claims description 2
- 239000004571 lime Substances 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 210000002751 lymph Anatomy 0.000 claims description 2
- 208000025036 lymphosarcoma Diseases 0.000 claims description 2
- 201000004792 malaria Diseases 0.000 claims description 2
- 201000006812 malignant histiocytosis Diseases 0.000 claims description 2
- 210000004379 membrane Anatomy 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 210000000716 merkel cell Anatomy 0.000 claims description 2
- 230000002503 metabolic effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 206010063344 microscopic polyangiitis Diseases 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 230000003274 myotonic effect Effects 0.000 claims description 2
- 230000001338 necrotic effect Effects 0.000 claims description 2
- 230000002956 necrotizing effect Effects 0.000 claims description 2
- 230000006654 negative regulation of apoptotic process Effects 0.000 claims description 2
- 230000009826 neoplastic cell growth Effects 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 210000001331 nose Anatomy 0.000 claims description 2
- 230000000414 obstructive effect Effects 0.000 claims description 2
- 201000002575 ocular melanoma Diseases 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 230000002188 osteogenic effect Effects 0.000 claims description 2
- 230000000010 osteolytic effect Effects 0.000 claims description 2
- 201000008968 osteosarcoma Diseases 0.000 claims description 2
- 230000002018 overexpression Effects 0.000 claims description 2
- 210000004786 perivascular cell Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000023974 pharynx neoplasm Diseases 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 208000010916 pituitary tumor Diseases 0.000 claims description 2
- 208000010626 plasma cell neoplasm Diseases 0.000 claims description 2
- 208000005987 polymyositis Diseases 0.000 claims description 2
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims description 2
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 208000002574 reactive arthritis Diseases 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 210000001525 retina Anatomy 0.000 claims description 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims description 2
- 201000003068 rheumatic fever Diseases 0.000 claims description 2
- 206010039083 rhinitis Diseases 0.000 claims description 2
- 235000019515 salmon Nutrition 0.000 claims description 2
- 230000037390 scarring Effects 0.000 claims description 2
- 206010039722 scoliosis Diseases 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 201000008261 skin carcinoma Diseases 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
- 208000014680 small intestine neoplasm Diseases 0.000 claims description 2
- 230000001148 spastic effect Effects 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 201000004595 synovitis Diseases 0.000 claims description 2
- 208000006379 syphilis Diseases 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 206010043207 temporal arteritis Diseases 0.000 claims description 2
- 210000000115 thoracic cavity Anatomy 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 201000006134 tongue cancer Diseases 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 230000002103 transcriptional effect Effects 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- 230000002485 urinary effect Effects 0.000 claims description 2
- 208000029584 urinary system neoplasm Diseases 0.000 claims description 2
- 210000001635 urinary tract Anatomy 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 208000037965 uterine sarcoma Diseases 0.000 claims description 2
- 206010046885 vaginal cancer Diseases 0.000 claims description 2
- 208000013139 vaginal neoplasm Diseases 0.000 claims description 2
- 230000009278 visceral effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000005784 autoimmunity Effects 0.000 claims 2
- 241000992348 Myodermum Species 0.000 claims 1
- 208000024799 Thyroid disease Diseases 0.000 claims 1
- 210000004252 chorionic villi Anatomy 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 208000021510 thyroid gland disease Diseases 0.000 claims 1
- 0 Cc1c(*)c(*)c(*)c(*)c1* Chemical compound Cc1c(*)c(*)c(*)c(*)c1* 0.000 description 16
- MEGVOYSBEPAXPU-UHFFFAOYSA-N CC(CC1)CCN1C=C Chemical compound CC(CC1)CCN1C=C MEGVOYSBEPAXPU-UHFFFAOYSA-N 0.000 description 1
- VYLUUNJZSOFGRJ-UHFFFAOYSA-N CN(C)c1nc2ccccc2[o]1 Chemical compound CN(C)c1nc2ccccc2[o]1 VYLUUNJZSOFGRJ-UHFFFAOYSA-N 0.000 description 1
- ZKUKXSWKWGHYKJ-UHFFFAOYSA-N CN1CCCCCC1 Chemical compound CN1CCCCCC1 ZKUKXSWKWGHYKJ-UHFFFAOYSA-N 0.000 description 1
- IHNKMJLDBGGAOD-UHFFFAOYSA-N Cc1c[n](CCCC2)c2n1 Chemical compound Cc1c[n](CCCC2)c2n1 IHNKMJLDBGGAOD-UHFFFAOYSA-N 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- GLKZKYSZPVHLDK-UHFFFAOYSA-N Ic1ccc2[s]cnc2c1 Chemical compound Ic1ccc2[s]cnc2c1 GLKZKYSZPVHLDK-UHFFFAOYSA-N 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023131905A JP2023138859A (ja) | 2018-04-11 | 2023-08-14 | 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656041P | 2018-04-11 | 2018-04-11 | |
| US62/656,041 | 2018-04-11 | ||
| PCT/EP2019/059289 WO2019197546A1 (en) | 2018-04-11 | 2019-04-11 | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131905A Division JP2023138859A (ja) | 2018-04-11 | 2023-08-14 | 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521129A JP2021521129A (ja) | 2021-08-26 |
| JP2021521129A5 true JP2021521129A5 (https=) | 2021-11-11 |
| JP7406501B2 JP7406501B2 (ja) | 2023-12-27 |
Family
ID=66334384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555188A Active JP7406501B2 (ja) | 2018-04-11 | 2019-04-11 | 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 |
| JP2023131905A Withdrawn JP2023138859A (ja) | 2018-04-11 | 2023-08-14 | 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131905A Withdrawn JP2023138859A (ja) | 2018-04-11 | 2023-08-14 | 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11858937B2 (https=) |
| EP (1) | EP3774809A1 (https=) |
| JP (2) | JP7406501B2 (https=) |
| KR (1) | KR20200143429A (https=) |
| CN (1) | CN112334471A (https=) |
| AU (1) | AU2019250504B2 (https=) |
| BR (1) | BR112020020645A2 (https=) |
| CA (1) | CA3095426A1 (https=) |
| IL (2) | IL299105B2 (https=) |
| MX (1) | MX2020010563A (https=) |
| MY (1) | MY207194A (https=) |
| PH (1) | PH12020551638A1 (https=) |
| SG (1) | SG11202009466UA (https=) |
| WO (1) | WO2019197546A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| US20250263413A1 (en) * | 2020-12-02 | 2025-08-21 | Qurient Co., Ltd. | Compounds having cyclin-dependent kinase(cdk)-inhibitory function |
| US20240343732A1 (en) * | 2021-05-28 | 2024-10-17 | Qurient Co., Ltd. | Compounds for degradation of cyclin-dependent kinase 7(cdk7) |
| US20250042903A1 (en) * | 2021-06-17 | 2025-02-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Triazine inhibitors of cyclin-dependent kinases |
| EP4493193A1 (en) * | 2022-03-18 | 2025-01-22 | Qurient Co., Ltd. | Cdk7 inhibitors for antiviral treatment |
| US20260041693A1 (en) | 2022-08-05 | 2026-02-12 | Qurient Co., Ltd. | Combination therapy of cdk7 inhibitors with other anti-cancer therapies |
| KR20240095030A (ko) | 2022-12-15 | 2024-06-25 | 부산대학교 산학협력단 | 간과 신장의 염증 및 섬유화 치료 효과가 있는 신규 트리아진 유도체 및 이의 제조방법 |
| CN120752238A (zh) * | 2023-02-20 | 2025-10-03 | 江苏正大丰海制药有限公司 | 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用 |
| CN120712267A (zh) * | 2023-02-21 | 2025-09-26 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| WO2025040170A1 (zh) * | 2023-08-24 | 2025-02-27 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| WO2025162425A1 (zh) * | 2024-02-01 | 2025-08-07 | 广州费米子科技有限责任公司 | 吡唑并嘧啶化合物作为tyk2抑制剂 |
| CN119606955A (zh) * | 2024-11-13 | 2025-03-14 | 南方医科大学 | Txd-174在制备治疗和/或预防黄病毒属病毒感染产品中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US615968A (en) | 1898-12-13 | Apparatus for treating ores | ||
| US8673924B2 (en) * | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| EP2634189A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP3129371B1 (en) | 2014-04-05 | 2020-07-29 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| ES2899196T3 (es) * | 2015-03-09 | 2022-03-10 | Aurigene Discovery Tech Ltd | Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK |
| WO2019035866A1 (en) * | 2017-08-15 | 2019-02-21 | The Brigham & Women's Hospital, Inc. | COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX |
-
2019
- 2019-04-11 BR BR112020020645-8A patent/BR112020020645A2/pt unknown
- 2019-04-11 MX MX2020010563A patent/MX2020010563A/es unknown
- 2019-04-11 SG SG11202009466UA patent/SG11202009466UA/en unknown
- 2019-04-11 JP JP2020555188A patent/JP7406501B2/ja active Active
- 2019-04-11 CN CN201980039675.8A patent/CN112334471A/zh active Pending
- 2019-04-11 IL IL299105A patent/IL299105B2/en unknown
- 2019-04-11 KR KR1020207032377A patent/KR20200143429A/ko active Pending
- 2019-04-11 CA CA3095426A patent/CA3095426A1/en active Pending
- 2019-04-11 EP EP19720424.1A patent/EP3774809A1/en active Pending
- 2019-04-11 US US17/045,009 patent/US11858937B2/en active Active
- 2019-04-11 MY MYPI2020005131A patent/MY207194A/en unknown
- 2019-04-11 WO PCT/EP2019/059289 patent/WO2019197546A1/en not_active Ceased
- 2019-04-11 AU AU2019250504A patent/AU2019250504B2/en active Active
-
2020
- 2020-09-30 IL IL277694A patent/IL277694A/en unknown
- 2020-10-05 PH PH12020551638A patent/PH12020551638A1/en unknown
-
2023
- 2023-08-14 JP JP2023131905A patent/JP2023138859A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021521129A5 (https=) | ||
| JP2021521120A5 (https=) | ||
| JP7195551B2 (ja) | 腫瘍性疾患の治療に使用するための組成物 | |
| JP2021521129A (ja) | 薬学的に活性なピラゾロ−トリアジン誘導体および/またはピラゾロ−ピリミジン誘導体 | |
| JP2021521120A (ja) | サイクリン依存性キナーゼの選択的インヒビターとしてのピラゾロ−トリアジン誘導体および/またはピラゾロ−ピリミジン誘導体 | |
| CN112351778B (zh) | 稠合三环杂环类化合物及其治疗用途 | |
| CN110372673B (zh) | 含酰肼的核运输调节剂及其用途 | |
| JP2022550436A (ja) | 抗ウイルス性複素環化合物 | |
| US9856216B2 (en) | Compounds as TNIK, IKKε and TBK1 inhibitors and pharmaceutical composition comprising same | |
| JP2004511483A (ja) | Hivインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類 | |
| JP2021529814A (ja) | 化学化合物 | |
| WO2023274251A1 (zh) | 一类抑制rna解旋酶dhx33的多环化合物及其应用 | |
| WO2018130174A1 (zh) | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 | |
| US20190062328A1 (en) | Bruton's tyrosine kinase inhibitors | |
| CA2882733A1 (en) | Novel 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents | |
| CN105934425A (zh) | Ebna1抑制剂和其使用方法 | |
| CN116789671B (zh) | 作为Toll样受体激动剂的嘧啶并哒嗪酮类化合物 | |
| US20240343732A1 (en) | Compounds for degradation of cyclin-dependent kinase 7(cdk7) | |
| WO2023088285A1 (zh) | 抗鼻咽癌的小分子抑制剂、化合物的制备方法及其应用 | |
| WO2022117504A1 (en) | Compounds having cyclin-dependent kinase(cdk)-inhibitory function | |
| JP2008532980A (ja) | アミド置換された6−フェニルフェナントリジン | |
| RU2818563C2 (ru) | Фармацевтически активные производные пиразолотриазина и/или пиразолопиримидина | |
| JP7616609B2 (ja) | Rnaウイルス感染症を処置する為のアリール-n-アリール誘導体 | |
| RU2020136911A (ru) | Производные пиразоло-триазина и/или пиразоло-пиримидина в качестве селективного ингибитора циклинзависимой киназы | |
| HK1226735A1 (en) | Inhibitors of bruton’s tyrosine kinase |