JP2021521129A5 - - Google Patents

Download PDF

Info

Publication number
JP2021521129A5
JP2021521129A5 JP2020555188A JP2020555188A JP2021521129A5 JP 2021521129 A5 JP2021521129 A5 JP 2021521129A5 JP 2020555188 A JP2020555188 A JP 2020555188A JP 2020555188 A JP2020555188 A JP 2020555188A JP 2021521129 A5 JP2021521129 A5 JP 2021521129A5
Authority
JP
Japan
Prior art keywords
cancer
disease
group
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020555188A
Other languages
English (en)
Japanese (ja)
Other versions
JP7406501B2 (ja
JP2021521129A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2019/059289 external-priority patent/WO2019197546A1/en
Publication of JP2021521129A publication Critical patent/JP2021521129A/ja
Publication of JP2021521129A5 publication Critical patent/JP2021521129A5/ja
Priority to JP2023131905A priority Critical patent/JP2023138859A/ja
Application granted granted Critical
Publication of JP7406501B2 publication Critical patent/JP7406501B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020555188A 2018-04-11 2019-04-11 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体 Active JP7406501B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023131905A JP2023138859A (ja) 2018-04-11 2023-08-14 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862656041P 2018-04-11 2018-04-11
US62/656,041 2018-04-11
PCT/EP2019/059289 WO2019197546A1 (en) 2018-04-11 2019-04-11 Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023131905A Division JP2023138859A (ja) 2018-04-11 2023-08-14 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体

Publications (3)

Publication Number Publication Date
JP2021521129A JP2021521129A (ja) 2021-08-26
JP2021521129A5 true JP2021521129A5 (https=) 2021-11-11
JP7406501B2 JP7406501B2 (ja) 2023-12-27

Family

ID=66334384

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020555188A Active JP7406501B2 (ja) 2018-04-11 2019-04-11 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体
JP2023131905A Withdrawn JP2023138859A (ja) 2018-04-11 2023-08-14 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023131905A Withdrawn JP2023138859A (ja) 2018-04-11 2023-08-14 薬学的に活性なピラゾロ-トリアジン誘導体および/またはピラゾロ-ピリミジン誘導体

Country Status (14)

Country Link
US (1) US11858937B2 (https=)
EP (1) EP3774809A1 (https=)
JP (2) JP7406501B2 (https=)
KR (1) KR20200143429A (https=)
CN (1) CN112334471A (https=)
AU (1) AU2019250504B2 (https=)
BR (1) BR112020020645A2 (https=)
CA (1) CA3095426A1 (https=)
IL (2) IL299105B2 (https=)
MX (1) MX2020010563A (https=)
MY (1) MY207194A (https=)
PH (1) PH12020551638A1 (https=)
SG (1) SG11202009466UA (https=)
WO (1) WO2019197546A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202146416A (zh) * 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
GB201918541D0 (en) 2019-12-16 2020-01-29 Carrick Therapeutics Ltd Therapeutic compounds and their use
US20250263413A1 (en) * 2020-12-02 2025-08-21 Qurient Co., Ltd. Compounds having cyclin-dependent kinase(cdk)-inhibitory function
US20240343732A1 (en) * 2021-05-28 2024-10-17 Qurient Co., Ltd. Compounds for degradation of cyclin-dependent kinase 7(cdk7)
US20250042903A1 (en) * 2021-06-17 2025-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Triazine inhibitors of cyclin-dependent kinases
EP4493193A1 (en) * 2022-03-18 2025-01-22 Qurient Co., Ltd. Cdk7 inhibitors for antiviral treatment
US20260041693A1 (en) 2022-08-05 2026-02-12 Qurient Co., Ltd. Combination therapy of cdk7 inhibitors with other anti-cancer therapies
KR20240095030A (ko) 2022-12-15 2024-06-25 부산대학교 산학협력단 간과 신장의 염증 및 섬유화 치료 효과가 있는 신규 트리아진 유도체 및 이의 제조방법
CN120752238A (zh) * 2023-02-20 2025-10-03 江苏正大丰海制药有限公司 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用
CN120712267A (zh) * 2023-02-21 2025-09-26 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
WO2025040170A1 (zh) * 2023-08-24 2025-02-27 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
WO2025162425A1 (zh) * 2024-02-01 2025-08-07 广州费米子科技有限责任公司 吡唑并嘧啶化合物作为tyk2抑制剂
CN119606955A (zh) * 2024-11-13 2025-03-14 南方医科大学 Txd-174在制备治疗和/或预防黄病毒属病毒感染产品中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US615968A (en) 1898-12-13 Apparatus for treating ores
US8673924B2 (en) * 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) * 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
EP2634189A1 (en) * 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors
EP2634190A1 (en) * 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
EP3129371B1 (en) 2014-04-05 2020-07-29 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
ES2899196T3 (es) * 2015-03-09 2022-03-10 Aurigene Discovery Tech Ltd Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK
WO2019035866A1 (en) * 2017-08-15 2019-02-21 The Brigham & Women's Hospital, Inc. COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX

Similar Documents

Publication Publication Date Title
JP2021521129A5 (https=)
JP2021521120A5 (https=)
JP7195551B2 (ja) 腫瘍性疾患の治療に使用するための組成物
JP2021521129A (ja) 薬学的に活性なピラゾロ−トリアジン誘導体および/またはピラゾロ−ピリミジン誘導体
JP2021521120A (ja) サイクリン依存性キナーゼの選択的インヒビターとしてのピラゾロ−トリアジン誘導体および/またはピラゾロ−ピリミジン誘導体
CN112351778B (zh) 稠合三环杂环类化合物及其治疗用途
CN110372673B (zh) 含酰肼的核运输调节剂及其用途
JP2022550436A (ja) 抗ウイルス性複素環化合物
US9856216B2 (en) Compounds as TNIK, IKKε and TBK1 inhibitors and pharmaceutical composition comprising same
JP2004511483A (ja) Hivインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
JP2021529814A (ja) 化学化合物
WO2023274251A1 (zh) 一类抑制rna解旋酶dhx33的多环化合物及其应用
WO2018130174A1 (zh) 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用
US20190062328A1 (en) Bruton's tyrosine kinase inhibitors
CA2882733A1 (en) Novel 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents
CN105934425A (zh) Ebna1抑制剂和其使用方法
CN116789671B (zh) 作为Toll样受体激动剂的嘧啶并哒嗪酮类化合物
US20240343732A1 (en) Compounds for degradation of cyclin-dependent kinase 7(cdk7)
WO2023088285A1 (zh) 抗鼻咽癌的小分子抑制剂、化合物的制备方法及其应用
WO2022117504A1 (en) Compounds having cyclin-dependent kinase(cdk)-inhibitory function
JP2008532980A (ja) アミド置換された6−フェニルフェナントリジン
RU2818563C2 (ru) Фармацевтически активные производные пиразолотриазина и/или пиразолопиримидина
JP7616609B2 (ja) Rnaウイルス感染症を処置する為のアリール-n-アリール誘導体
RU2020136911A (ru) Производные пиразоло-триазина и/или пиразоло-пиримидина в качестве селективного ингибитора циклинзависимой киназы
HK1226735A1 (en) Inhibitors of bruton’s tyrosine kinase