BR112020020645A2 - Derivados farmaceuticamente aceitáveis de pirazol-triazina e/ou pirazol-pirimidina - Google Patents
Derivados farmaceuticamente aceitáveis de pirazol-triazina e/ou pirazol-pirimidina Download PDFInfo
- Publication number
- BR112020020645A2 BR112020020645A2 BR112020020645-8A BR112020020645A BR112020020645A2 BR 112020020645 A2 BR112020020645 A2 BR 112020020645A2 BR 112020020645 A BR112020020645 A BR 112020020645A BR 112020020645 A2 BR112020020645 A2 BR 112020020645A2
- Authority
- BR
- Brazil
- Prior art keywords
- group
- occurrence
- compound
- cancer
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656041P | 2018-04-11 | 2018-04-11 | |
| US62/656,041 | 2018-04-11 | ||
| PCT/EP2019/059289 WO2019197546A1 (en) | 2018-04-11 | 2019-04-11 | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020020645A2 true BR112020020645A2 (pt) | 2021-01-12 |
Family
ID=66334384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020020645-8A BR112020020645A2 (pt) | 2018-04-11 | 2019-04-11 | Derivados farmaceuticamente aceitáveis de pirazol-triazina e/ou pirazol-pirimidina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11858937B2 (https=) |
| EP (1) | EP3774809A1 (https=) |
| JP (2) | JP7406501B2 (https=) |
| KR (1) | KR20200143429A (https=) |
| CN (1) | CN112334471A (https=) |
| AU (1) | AU2019250504B2 (https=) |
| BR (1) | BR112020020645A2 (https=) |
| CA (1) | CA3095426A1 (https=) |
| IL (2) | IL299105B2 (https=) |
| MX (1) | MX2020010563A (https=) |
| MY (1) | MY207194A (https=) |
| PH (1) | PH12020551638A1 (https=) |
| SG (1) | SG11202009466UA (https=) |
| WO (1) | WO2019197546A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| US20250263413A1 (en) * | 2020-12-02 | 2025-08-21 | Qurient Co., Ltd. | Compounds having cyclin-dependent kinase(cdk)-inhibitory function |
| US20240343732A1 (en) * | 2021-05-28 | 2024-10-17 | Qurient Co., Ltd. | Compounds for degradation of cyclin-dependent kinase 7(cdk7) |
| US20250042903A1 (en) * | 2021-06-17 | 2025-02-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Triazine inhibitors of cyclin-dependent kinases |
| EP4493193A1 (en) * | 2022-03-18 | 2025-01-22 | Qurient Co., Ltd. | Cdk7 inhibitors for antiviral treatment |
| US20260041693A1 (en) | 2022-08-05 | 2026-02-12 | Qurient Co., Ltd. | Combination therapy of cdk7 inhibitors with other anti-cancer therapies |
| KR20240095030A (ko) | 2022-12-15 | 2024-06-25 | 부산대학교 산학협력단 | 간과 신장의 염증 및 섬유화 치료 효과가 있는 신규 트리아진 유도체 및 이의 제조방법 |
| CN120752238A (zh) * | 2023-02-20 | 2025-10-03 | 江苏正大丰海制药有限公司 | 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用 |
| CN120712267A (zh) * | 2023-02-21 | 2025-09-26 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| WO2025040170A1 (zh) * | 2023-08-24 | 2025-02-27 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| WO2025162425A1 (zh) * | 2024-02-01 | 2025-08-07 | 广州费米子科技有限责任公司 | 吡唑并嘧啶化合物作为tyk2抑制剂 |
| CN119606955A (zh) * | 2024-11-13 | 2025-03-14 | 南方医科大学 | Txd-174在制备治疗和/或预防黄病毒属病毒感染产品中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US615968A (en) | 1898-12-13 | Apparatus for treating ores | ||
| US8673924B2 (en) * | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| EP2634189A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP3129371B1 (en) | 2014-04-05 | 2020-07-29 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| ES2899196T3 (es) * | 2015-03-09 | 2022-03-10 | Aurigene Discovery Tech Ltd | Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK |
| WO2019035866A1 (en) * | 2017-08-15 | 2019-02-21 | The Brigham & Women's Hospital, Inc. | COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX |
-
2019
- 2019-04-11 BR BR112020020645-8A patent/BR112020020645A2/pt unknown
- 2019-04-11 MX MX2020010563A patent/MX2020010563A/es unknown
- 2019-04-11 SG SG11202009466UA patent/SG11202009466UA/en unknown
- 2019-04-11 JP JP2020555188A patent/JP7406501B2/ja active Active
- 2019-04-11 CN CN201980039675.8A patent/CN112334471A/zh active Pending
- 2019-04-11 IL IL299105A patent/IL299105B2/en unknown
- 2019-04-11 KR KR1020207032377A patent/KR20200143429A/ko active Pending
- 2019-04-11 CA CA3095426A patent/CA3095426A1/en active Pending
- 2019-04-11 EP EP19720424.1A patent/EP3774809A1/en active Pending
- 2019-04-11 US US17/045,009 patent/US11858937B2/en active Active
- 2019-04-11 MY MYPI2020005131A patent/MY207194A/en unknown
- 2019-04-11 WO PCT/EP2019/059289 patent/WO2019197546A1/en not_active Ceased
- 2019-04-11 AU AU2019250504A patent/AU2019250504B2/en active Active
-
2020
- 2020-09-30 IL IL277694A patent/IL277694A/en unknown
- 2020-10-05 PH PH12020551638A patent/PH12020551638A1/en unknown
-
2023
- 2023-08-14 JP JP2023131905A patent/JP2023138859A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL299105B2 (en) | 2024-02-01 |
| MY207194A (en) | 2025-02-05 |
| JP7406501B2 (ja) | 2023-12-27 |
| US11858937B2 (en) | 2024-01-02 |
| AU2019250504B2 (en) | 2023-05-18 |
| NZ768400A (en) | 2024-07-05 |
| CN112334471A (zh) | 2021-02-05 |
| SG11202009466UA (en) | 2020-10-29 |
| US20210139483A1 (en) | 2021-05-13 |
| EP3774809A1 (en) | 2021-02-17 |
| MX2020010563A (es) | 2020-10-22 |
| WO2019197546A1 (en) | 2019-10-17 |
| IL299105A (en) | 2023-02-01 |
| AU2019250504A1 (en) | 2020-10-15 |
| JP2023138859A (ja) | 2023-10-02 |
| CA3095426A1 (en) | 2019-10-17 |
| PH12020551638A1 (en) | 2021-07-26 |
| KR20200143429A (ko) | 2020-12-23 |
| IL299105B1 (en) | 2023-10-01 |
| IL277694A (en) | 2020-11-30 |
| JP2021521129A (ja) | 2021-08-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112020020645A2 (pt) | Derivados farmaceuticamente aceitáveis de pirazol-triazina e/ou pirazol-pirimidina | |
| AU2023248067B2 (en) | Cereblon ligands and bifunctional compounds comprising the same | |
| AU2019391016B2 (en) | Small molecule degraders of helios and methods of use | |
| AU2019214089B2 (en) | Biaryl derivative, preparation method therefor and pharmaceutical use thereof | |
| BR112020020768A2 (pt) | Derivados de pirazol-triazina e/ou pirazol-pirimidina como inibidor seletivo de cinase dependente de ciclina | |
| TWI292401B (en) | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents | |
| AU2003235741B8 (en) | Deazapurines and uses thereof | |
| US11851433B2 (en) | Compounds, compositions and methods | |
| CA2857346C (en) | 1,5-naphthyridine derivatives and melk inhibitors containing the same | |
| CA3063804A1 (en) | A class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof | |
| AU2009275929B2 (en) | Nitrogenated derivatives of pancratistatin | |
| AU2009284086A1 (en) | New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents | |
| JP7597710B2 (ja) | 置換インドール二量体の化合物 | |
| US20220098208A1 (en) | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives | |
| CN101365461B (zh) | 舒林酸衍生物、其用途和其制备 | |
| TW407151B (en) | Substituted quinoline derivatives, a process for their preparation, and their use for combating human immunodeficiency virus | |
| JP6927959B2 (ja) | ベンジリデングアニジン誘導体と化学療法剤の併用による癌の治療方法 | |
| US20170267679A1 (en) | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | |
| US20250263413A1 (en) | Compounds having cyclin-dependent kinase(cdk)-inhibitory function | |
| US20160355503A1 (en) | NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | |
| RU2818563C2 (ru) | Фармацевтически активные производные пиразолотриазина и/или пиразолопиримидина | |
| JP2025530501A (ja) | Ｎｓｄ活性の修飾物質としての複素環 | |
| WO2013061669A1 (ja) | G2/m期停止及び細胞死を誘導するベンゾヒドラジド誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |