AU2019250504B2 - Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives - Google Patents

Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives Download PDF

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Publication number
AU2019250504B2
AU2019250504B2 AU2019250504A AU2019250504A AU2019250504B2 AU 2019250504 B2 AU2019250504 B2 AU 2019250504B2 AU 2019250504 A AU2019250504 A AU 2019250504A AU 2019250504 A AU2019250504 A AU 2019250504A AU 2019250504 B2 AU2019250504 B2 AU 2019250504B2
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Australia
Prior art keywords
compound
occurrence
group
cancer
alkyl
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AU2019250504A
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English (en)
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AU2019250504A1 (en
Inventor
Jan Eickhoff
Yeejin JEON
Jaeseung Kim
Uwe Koch
Kiyean NAM
Dongsik Park
Mooyoung SEO
Donghoon Yu
Gunther Zischinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lead Discovery Center GmbH
Qurient Co Ltd
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Lead Discovery Center GmbH
Qurient Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019250504A 2018-04-11 2019-04-11 Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives Active AU2019250504B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862656041P 2018-04-11 2018-04-11
US62/656,041 2018-04-11
PCT/EP2019/059289 WO2019197546A1 (en) 2018-04-11 2019-04-11 Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives

Publications (2)

Publication Number Publication Date
AU2019250504A1 AU2019250504A1 (en) 2020-10-15
AU2019250504B2 true AU2019250504B2 (en) 2023-05-18

Family

ID=66334384

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019250504A Active AU2019250504B2 (en) 2018-04-11 2019-04-11 Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives

Country Status (14)

Country Link
US (1) US11858937B2 (https=)
EP (1) EP3774809A1 (https=)
JP (2) JP7406501B2 (https=)
KR (1) KR20200143429A (https=)
CN (1) CN112334471A (https=)
AU (1) AU2019250504B2 (https=)
BR (1) BR112020020645A2 (https=)
CA (1) CA3095426A1 (https=)
IL (2) IL299105B2 (https=)
MX (1) MX2020010563A (https=)
MY (1) MY207194A (https=)
PH (1) PH12020551638A1 (https=)
SG (1) SG11202009466UA (https=)
WO (1) WO2019197546A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202146416A (zh) * 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
GB201918541D0 (en) 2019-12-16 2020-01-29 Carrick Therapeutics Ltd Therapeutic compounds and their use
US20250263413A1 (en) * 2020-12-02 2025-08-21 Qurient Co., Ltd. Compounds having cyclin-dependent kinase(cdk)-inhibitory function
US20240343732A1 (en) * 2021-05-28 2024-10-17 Qurient Co., Ltd. Compounds for degradation of cyclin-dependent kinase 7(cdk7)
US20250042903A1 (en) * 2021-06-17 2025-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Triazine inhibitors of cyclin-dependent kinases
EP4493193A1 (en) * 2022-03-18 2025-01-22 Qurient Co., Ltd. Cdk7 inhibitors for antiviral treatment
US20260041693A1 (en) 2022-08-05 2026-02-12 Qurient Co., Ltd. Combination therapy of cdk7 inhibitors with other anti-cancer therapies
KR20240095030A (ko) 2022-12-15 2024-06-25 부산대학교 산학협력단 간과 신장의 염증 및 섬유화 치료 효과가 있는 신규 트리아진 유도체 및 이의 제조방법
CN120752238A (zh) * 2023-02-20 2025-10-03 江苏正大丰海制药有限公司 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用
CN120712267A (zh) * 2023-02-21 2025-09-26 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
WO2025040170A1 (zh) * 2023-08-24 2025-02-27 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
WO2025162425A1 (zh) * 2024-02-01 2025-08-07 广州费米子科技有限责任公司 吡唑并嘧啶化合物作为tyk2抑制剂
CN119606955A (zh) * 2024-11-13 2025-03-14 南方医科大学 Txd-174在制备治疗和/或预防黄病毒属病毒感染产品中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013128028A1 (en) * 2012-03-01 2013-09-06 Lead Discovery Center Gmbh Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors
WO2013128029A1 (en) * 2012-03-01 2013-09-06 Lead Discovery Center Gmbh Pharmaceutically active pyrazolo-triazine derivatives
WO2015154022A1 (en) * 2014-04-05 2015-10-08 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2016142855A2 (en) * 2015-03-09 2016-09-15 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US615968A (en) 1898-12-13 Apparatus for treating ores
US8673924B2 (en) * 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) * 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2019035866A1 (en) * 2017-08-15 2019-02-21 The Brigham & Women's Hospital, Inc. COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013128028A1 (en) * 2012-03-01 2013-09-06 Lead Discovery Center Gmbh Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors
WO2013128029A1 (en) * 2012-03-01 2013-09-06 Lead Discovery Center Gmbh Pharmaceutically active pyrazolo-triazine derivatives
WO2015154022A1 (en) * 2014-04-05 2015-10-08 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2016142855A2 (en) * 2015-03-09 2016-09-15 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Mol. Cancer Ther., 17, 1156-1166 (2018). Doi: 10.1158/1535-7163.MCT-16-0847 *

Also Published As

Publication number Publication date
IL299105B2 (en) 2024-02-01
MY207194A (en) 2025-02-05
JP7406501B2 (ja) 2023-12-27
US11858937B2 (en) 2024-01-02
NZ768400A (en) 2024-07-05
CN112334471A (zh) 2021-02-05
SG11202009466UA (en) 2020-10-29
BR112020020645A2 (pt) 2021-01-12
US20210139483A1 (en) 2021-05-13
EP3774809A1 (en) 2021-02-17
MX2020010563A (es) 2020-10-22
WO2019197546A1 (en) 2019-10-17
IL299105A (en) 2023-02-01
AU2019250504A1 (en) 2020-10-15
JP2023138859A (ja) 2023-10-02
CA3095426A1 (en) 2019-10-17
PH12020551638A1 (en) 2021-07-26
KR20200143429A (ko) 2020-12-23
IL299105B1 (en) 2023-10-01
IL277694A (en) 2020-11-30
JP2021521129A (ja) 2021-08-26

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