JP2021521111A5 - - Google Patents
Info
- Publication number
- JP2021521111A5 JP2021521111A5 JP2020554542A JP2020554542A JP2021521111A5 JP 2021521111 A5 JP2021521111 A5 JP 2021521111A5 JP 2020554542 A JP2020554542 A JP 2020554542A JP 2020554542 A JP2020554542 A JP 2020554542A JP 2021521111 A5 JP2021521111 A5 JP 2021521111A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- gly
- camptothecin
- formula
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024012728A JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862653961P | 2018-04-06 | 2018-04-06 | |
| US62/653,961 | 2018-04-06 | ||
| PCT/US2019/025968 WO2019195665A1 (en) | 2018-04-06 | 2019-04-05 | Camptothecin peptide conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012728A Division JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521111A JP2021521111A (ja) | 2021-08-26 |
| JP2021521111A5 true JP2021521111A5 (enExample) | 2022-04-12 |
| JP7430643B2 JP7430643B2 (ja) | 2024-02-13 |
Family
ID=68101237
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554542A Active JP7430643B2 (ja) | 2018-04-06 | 2019-04-05 | カンプトテシンペプチドコンジュゲート |
| JP2024012728A Pending JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012728A Pending JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20190343828A1 (enExample) |
| EP (1) | EP3773736A4 (enExample) |
| JP (2) | JP7430643B2 (enExample) |
| KR (1) | KR20210006362A (enExample) |
| CN (1) | CN111936169A (enExample) |
| AR (1) | AR114473A1 (enExample) |
| AU (1) | AU2019247434A1 (enExample) |
| BR (1) | BR112020020466A2 (enExample) |
| CA (1) | CA3094313A1 (enExample) |
| EA (1) | EA202092410A1 (enExample) |
| IL (2) | IL310391A (enExample) |
| MA (1) | MA52669A (enExample) |
| MX (1) | MX2020010458A (enExample) |
| SG (1) | SG11202009527PA (enExample) |
| TW (1) | TW202010498A (enExample) |
| WO (1) | WO2019195665A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3046537T3 (en) | 2016-11-08 | 2025-12-02 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| CN118955710A (zh) | 2018-05-09 | 2024-11-15 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
| SG11202110922QA (en) | 2019-04-26 | 2021-10-28 | Immunogen Inc | Camptothecin derivatives |
| CN112125915A (zh) * | 2019-09-18 | 2020-12-25 | 四川百利药业有限责任公司 | 一种喜树碱衍生物及其偶联物 |
| AU2020357941A1 (en) * | 2019-10-01 | 2022-04-28 | Memorial Sloan Kettering Cancer Center | Small molecule inhibitors of Id proteins |
| WO2021067820A1 (en) * | 2019-10-04 | 2021-04-08 | Seagen Inc. | Formulation of antibody-drug conjugate |
| EP4038101A2 (en) * | 2019-10-04 | 2022-08-10 | Seagen Inc. | Anti-pd-l1 antibodies and antibody-drug conjugates |
| CN114929284A (zh) * | 2019-10-04 | 2022-08-19 | 西根公司 | 喜树碱肽缀合物 |
| WO2021143741A1 (zh) * | 2020-01-15 | 2021-07-22 | 北京海步医药科技有限公司 | 靶向多肽-药物缀合物及其用途 |
| CN113274507B (zh) * | 2020-02-20 | 2025-02-28 | 亚飞（上海）生物医药科技有限公司 | 靶向递送和激活的免疫刺激性偶联复合物的制备和用途 |
| WO2021173773A1 (en) | 2020-02-25 | 2021-09-02 | Mediboston, Inc. | Camptothecin derivatives and conjugates thereof |
| CA3183602A1 (en) * | 2020-05-13 | 2021-11-18 | Seagen Inc. | Methods of treating cancer using a combination of anti-cd30 antibody-drug conjugates |
| WO2022078279A1 (zh) * | 2020-10-12 | 2022-04-21 | 昆山新蕴达生物科技有限公司 | 抗体-药物偶联物及其应用 |
| WO2022093800A2 (en) | 2020-10-27 | 2022-05-05 | Elucida Oncology, Inc. | Carrier particle-drug conjugates, self-immolative linkers, and uses thereof |
| AU2022207454A1 (en) * | 2021-01-15 | 2023-06-22 | R.P. Scherer Technologies, Llc | Camptothecine antibody-drug conjugates and methods of use thereof |
| EP4628165A3 (en) * | 2021-02-05 | 2026-03-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
| EP4257154A4 (en) * | 2021-02-09 | 2026-04-22 | Medilink Therapeutics Suzhou Co Ltd | CONJUGATED WITH A BIOACTIVE SUBSTANCE, ITS PREPARATION PROCESS AND ITS USE |
| US12521444B2 (en) * | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| CN117015549A (zh) * | 2021-03-17 | 2023-11-07 | 江苏恒瑞医药股份有限公司 | 一种喜树碱衍生物的制备方法 |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| TW202547842A (zh) * | 2021-04-29 | 2025-12-16 | 愛爾蘭商艾伯維製造管理無限公司 | 抗c-Met抗體藥物結合物 |
| CN117295524A (zh) * | 2021-06-02 | 2023-12-26 | 百奥泰生物制药股份有限公司 | 药物偶联物及其用途 |
| CN113527418B (zh) * | 2021-07-16 | 2022-05-03 | 成都普康唯新生物科技有限公司 | 一种ADC linker的制备方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| JP2024532768A (ja) * | 2021-08-19 | 2024-09-10 | ハイナン シムセレ ザイミン ファーマシューティカル カンパニー リミテッド | カンプトテシン誘導体、その薬物組成物およびその応用 |
| KR20240082348A (ko) | 2021-09-27 | 2024-06-10 | 에보포인트 바이오사이언시스 컴퍼니 리미티드 | 항체, 이의 항체-약물 접합체 및 이의 용도 |
| ES3001145T1 (es) * | 2021-11-09 | 2025-03-04 | Tubulis Gmbh | Conjugados que comprenden un fosforo (v) y un resto de camptotecina |
| US20250049938A1 (en) * | 2021-12-01 | 2025-02-13 | Shanghai Institute Of Biological Products Co., Ltd. | Antibody-drug conjugate and use thereof |
| CN116354976B (zh) * | 2021-12-27 | 2025-01-24 | 上海复旦张江生物医药股份有限公司 | 喜树碱衍生物的纯化方法 |
| IL314470A (en) | 2022-01-25 | 2024-09-01 | Medilink Therapeutics Suzhou Co Ltd | Anti-Her3 antibody, conjugate and use thereof |
| US20250177542A1 (en) * | 2022-01-26 | 2025-06-05 | Medilink Therapeutics (Suzhou) Co., Ltd. | Preparation method for drug linker conjugate |
| JP2025508779A (ja) | 2022-02-24 | 2025-04-10 | エボポイント、バイオサイエンシズ、カンパニー、リミテッド | 抗体及びその薬物コンジュゲート並びに用途 |
| WO2023178289A2 (en) | 2022-03-17 | 2023-09-21 | Seagen Inc. | Camptothecin conjugates |
| AU2023239448A1 (en) | 2022-03-25 | 2024-11-07 | Zymeworks Bc Inc. | Antibody-drug conjugates targeting folate receptor alpha and methods of use |
| JP2025512384A (ja) * | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| TW202345904A (zh) * | 2022-04-14 | 2023-12-01 | 瑞士商德彪製藥研究暨製造股份有限公司 | 具有改良之藥物動力學及藥物釋放特性之配體藥物結合物 |
| KR20230149752A (ko) * | 2022-04-20 | 2023-10-27 | 주식회사 피노바이오 | Ddx5 단백질에 결합하는 캄토테신 유도체 및 이의 프로드럭 |
| WO2023208168A1 (zh) | 2022-04-29 | 2023-11-02 | 成都百利多特生物药业有限责任公司 | 一种包含亲水性糖结构的配体-药物偶联物 |
| KR20230155992A (ko) * | 2022-05-04 | 2023-11-13 | 주식회사 피노바이오 | Ddx5 단백질에 결합하는 캄토테신계 약물이 산 민감성 링커에 연결된 접합체 및 이를 이용한 면역접합체 |
| US20230357763A1 (en) * | 2022-05-06 | 2023-11-09 | James E. Summerton | Morpholinos with Increased Delivery Efficiency |
| EP4523704A1 (en) | 2022-05-12 | 2025-03-19 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | Camptothecin derivative and ligand-drug conjugate |
| IL317271A (en) * | 2022-05-30 | 2025-01-01 | Medilink Therapeutics Suzhou Co Ltd | Preparation method for Drug Linker Conjugate and between them |
| WO2024008102A1 (en) * | 2022-07-05 | 2024-01-11 | Wuxi Xdc (Shanghai) Co., Ltd. | Linker for conjugation |
| CA3261603A1 (en) * | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | ANTIBODY-DRUG CONJUGATES |
| KR20240035370A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 피노바이오 | 신규 캄토테신 유도체 및 이를 포함하는 운반체-약물 접합체 |
| CN117752813A (zh) | 2022-09-26 | 2024-03-26 | 成都百利多特生物药业有限责任公司 | 抗cd33抗体和抗cd33抗体-药物偶联物及其用途 |
| CN120282967A (zh) * | 2022-09-28 | 2025-07-08 | 索尔夫治疗公司 | 组合物及其用途 |
| CN119997983A (zh) | 2022-10-14 | 2025-05-13 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物及其制备方法和用途 |
| TW202426058A (zh) * | 2022-10-18 | 2024-07-01 | 加拿大商酵活英屬哥倫比亞有限公司 | 靶向磷脂醯肌醇蛋白聚糖－３之抗體－藥物結合物及使用方法 |
| WO2024114318A1 (zh) | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| CN116712561A (zh) | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | 含n-亚甲基酰胺连接子的抗体-药物偶联物 |
| AU2024218327A1 (en) * | 2023-02-09 | 2025-09-25 | Beone Medicines I Gmbh | Self-stabilizing linker conjugates |
| CN118666946A (zh) * | 2023-03-15 | 2024-09-20 | 上海亲合力生物医药科技股份有限公司 | 连接子及使用其的偶联药物、抗体偶联药物及其应用 |
| KR20240149823A (ko) * | 2023-04-06 | 2024-10-15 | 주식회사 피노바이오 | 항암 내성 극복을 위한 신규 캄토테신 유도체 및 이를 포함하는 항체-약물 접합체 |
| CN120858098A (zh) * | 2023-05-04 | 2025-10-28 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和应用 |
| CN121263179A (zh) * | 2023-06-05 | 2026-01-02 | 瀚阳生物科技股份有限公司 | 配体-极性药物缀合物 |
| WO2025040012A1 (zh) * | 2023-08-18 | 2025-02-27 | 康诺亚生物医药科技（成都）有限公司 | 五环类活性化合物及其偶联物和用途 |
| CN121752572A (zh) * | 2023-08-31 | 2026-03-27 | 匹诺生物股份有限公司 | 新型喜树碱衍生物及包含其的抗体-药物偶联物 |
| WO2025051241A1 (zh) * | 2023-09-06 | 2025-03-13 | 劲方医药科技(上海)股份有限公司 | 大环化合物及其抗体-药物偶联物 |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
| CN120053678A (zh) * | 2023-11-30 | 2025-05-30 | 上海医药集团股份有限公司 | 一种高喜树碱类抗体偶联药物、其制备方法及应用 |
| WO2025124555A1 (en) * | 2023-12-14 | 2025-06-19 | Shanghai Micurx Pharmaceutical Co., Ltd. | Ligand-drug conjugate of camptothecin analogs and use thereof |
| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
| WO2025196639A1 (en) | 2024-03-21 | 2025-09-25 | Seagen Inc. | Cd25 antibodies, antibody-drug conjugates, and uses thereof |
| WO2025221986A1 (en) * | 2024-04-18 | 2025-10-23 | Cedars-Sinai Medical Center | Targeted camptothecin derivatives for cancer treatment |
| WO2025223507A1 (zh) * | 2024-04-25 | 2025-10-30 | 江苏康宁杰瑞生物制药有限公司 | 化合物及其偶联物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0540099B1 (en) | 1991-10-29 | 1996-04-17 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
| JPH06228141A (ja) * | 1992-01-24 | 1994-08-16 | Takeda Chem Ind Ltd | 縮合複素環誘導体、その塩、その製造法および用途 |
| US5496830A (en) * | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
| SG103322A1 (en) * | 1996-10-30 | 2004-04-29 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| CZ20014083A3 (cs) * | 1999-05-14 | 2002-08-14 | Imclone Systems Incorporated | Léčivo pro indikaci růstu refrakterních nádorů |
| US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
| US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
| US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US7591994B2 (en) * | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| EA020696B1 (ru) * | 2007-10-12 | 2015-01-30 | Сиэтл Дженетикс, Инк. | Способ лечения лимфомы ходжкина с использованием комбинации гемцитабина и конъюгата антитела против cd30 с ауристатином |
| ES2773710T3 (es) * | 2012-10-11 | 2020-07-14 | Daiichi Sankyo Co Ltd | Enlazadores para conjugados de anticuerpo - fármaco |
| KR102442906B1 (ko) | 2013-12-19 | 2022-09-14 | 씨젠 인크. | 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커 |
| JP7244987B2 (ja) * | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
| TWI851577B (zh) * | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN114929284A (zh) * | 2019-10-04 | 2022-08-19 | 西根公司 | 喜树碱肽缀合物 |
| EP4038101A2 (en) * | 2019-10-04 | 2022-08-10 | Seagen Inc. | Anti-pd-l1 antibodies and antibody-drug conjugates |
| CA3183602A1 (en) * | 2020-05-13 | 2021-11-18 | Seagen Inc. | Methods of treating cancer using a combination of anti-cd30 antibody-drug conjugates |
| JP2023551894A (ja) * | 2020-12-03 | 2023-12-13 | シージェン インコーポレイテッド | 抗ｃｄ３０抗体－薬物コンジュゲートを使用した免疫応答の調節 |
| JP2025501978A (ja) * | 2022-01-05 | 2025-01-24 | アジェンシス，インコーポレイテッド | １９１ｐ４ｄ１２タンパク質に結合する抗体薬物コンジュゲート（ａｄｃ）で筋層浸潤性尿路上皮癌または筋層浸潤性膀胱癌を治療するための方法 |
| WO2023178289A2 (en) * | 2022-03-17 | 2023-09-21 | Seagen Inc. | Camptothecin conjugates |
-
2019
- 2019-04-05 BR BR112020020466-8A patent/BR112020020466A2/pt unknown
- 2019-04-05 US US16/376,302 patent/US20190343828A1/en not_active Abandoned
- 2019-04-05 KR KR1020207031963A patent/KR20210006362A/ko not_active Withdrawn
- 2019-04-05 MX MX2020010458A patent/MX2020010458A/es unknown
- 2019-04-05 AU AU2019247434A patent/AU2019247434A1/en not_active Abandoned
- 2019-04-05 MA MA052669A patent/MA52669A/fr unknown
- 2019-04-05 EA EA202092410A patent/EA202092410A1/ru unknown
- 2019-04-05 IL IL310391A patent/IL310391A/en unknown
- 2019-04-05 CA CA3094313A patent/CA3094313A1/en active Pending
- 2019-04-05 WO PCT/US2019/025968 patent/WO2019195665A1/en not_active Ceased
- 2019-04-05 SG SG11202009527PA patent/SG11202009527PA/en unknown
- 2019-04-05 IL IL277748A patent/IL277748B2/en unknown
- 2019-04-05 JP JP2020554542A patent/JP7430643B2/ja active Active
- 2019-04-05 EP EP19781578.0A patent/EP3773736A4/en not_active Withdrawn
- 2019-04-05 CN CN201980024331.XA patent/CN111936169A/zh active Pending
- 2019-04-05 AR ARP190100908A patent/AR114473A1/es not_active Application Discontinuation
- 2019-04-08 TW TW108112067A patent/TW202010498A/zh unknown
-
2021
- 2021-10-27 US US17/452,516 patent/US20220193069A1/en not_active Abandoned
-
2023
- 2023-10-27 US US18/496,756 patent/US20250135018A1/en active Pending
-
2024
- 2024-01-31 JP JP2024012728A patent/JP2024042054A/ja active Pending
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