JP2021519587A5 - - Google Patents

Info

Publication number
JP2021519587A5
JP2021519587A5 JP2020552746A JP2020552746A JP2021519587A5 JP 2021519587 A5 JP2021519587 A5 JP 2021519587A5 JP 2020552746 A JP2020552746 A JP 2020552746A JP 2020552746 A JP2020552746 A JP 2020552746A JP 2021519587 A5 JP2021519587 A5 JP 2021519587A5
Authority
JP
Japan
Prior art keywords
expression construct
mirna expression
sequence
construct according
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020552746A
Other languages
English (en)
Japanese (ja)
Other versions
JP7607872B2 (ja
JP2021519587A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2019/000328 external-priority patent/WO2019186274A2/en
Publication of JP2021519587A publication Critical patent/JP2021519587A/ja
Publication of JP2021519587A5 publication Critical patent/JP2021519587A5/ja
Application granted granted Critical
Publication of JP7607872B2 publication Critical patent/JP7607872B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020552746A 2018-03-30 2019-04-01 マイクロrna発現構築物及びその使用 Active JP7607872B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862650403P 2018-03-30 2018-03-30
US201862650387P 2018-03-30 2018-03-30
US62/650,387 2018-03-30
US62/650,403 2018-03-30
PCT/IB2019/000328 WO2019186274A2 (en) 2018-03-30 2019-04-01 Micro rna expression constructs and uses thereof

Publications (3)

Publication Number Publication Date
JP2021519587A JP2021519587A (ja) 2021-08-12
JP2021519587A5 true JP2021519587A5 (enExample) 2022-04-11
JP7607872B2 JP7607872B2 (ja) 2025-01-06

Family

ID=66998448

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020552746A Active JP7607872B2 (ja) 2018-03-30 2019-04-01 マイクロrna発現構築物及びその使用

Country Status (9)

Country Link
US (1) US11649455B2 (enExample)
EP (1) EP3775214A2 (enExample)
JP (1) JP7607872B2 (enExample)
CN (1) CN112105731B (enExample)
AU (1) AU2019244479B2 (enExample)
CA (1) CA3133899A1 (enExample)
SG (1) SG11202009697RA (enExample)
WO (1) WO2019186274A2 (enExample)
ZA (1) ZA202006505B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3105816A1 (en) 2018-07-10 2020-01-16 Precigen, Inc. Ror-1 specific chimeric antigen receptors and uses thereof
CN114127268A (zh) * 2019-05-02 2022-03-01 塞利亚德股份公司 具有多重化的抑制性rna的细胞
AU2021278356A1 (en) 2020-05-27 2022-11-03 Antion Biosciences Sa Adapter molecules to re-direct CAR T cells to an antigen of interest
AU2022205683A1 (en) * 2021-01-11 2023-07-06 Precigen, Inc. Chimeric receptor therapy
GB202106354D0 (en) * 2021-05-04 2021-06-16 Celyad S A Improved chimeric and engineered scaffolds doe multiplexed ingibitory RNA
GB202201927D0 (en) * 2022-02-14 2022-03-30 Kings College Artificial microrna construct
CN114774364B (zh) * 2022-04-26 2024-04-26 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其制备方法和应用
GB202206507D0 (en) 2022-05-04 2022-06-15 Antion Biosciences Sa Expression construct
IL318039A (en) * 2022-07-10 2025-02-01 Precigen Inc Polycistronic microRNA constructs for immune checkpoint inhibition
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向psma及ca9之系統
GB202306619D0 (en) 2023-05-04 2023-06-21 Antion Biosciences Sa Cell
GB202402745D0 (en) 2024-02-27 2024-04-10 Antion Biosciences Sa Cell
GB202415862D0 (en) 2024-10-28 2024-12-11 Antion Biosciences Sa Intronic mirna

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5322783A (en) 1989-10-17 1994-06-21 Pioneer Hi-Bred International, Inc. Soybean transformation by microparticle bombardment
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5610042A (en) 1991-10-07 1997-03-11 Ciba-Geigy Corporation Methods for stable transformation of wheat
DK0604662T3 (da) 1992-07-07 2008-10-20 Japan Tobacco Inc Fremgangsmåde til transformering af monocotyledon
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
AU670316B2 (en) 1992-07-27 1996-07-11 Pioneer Hi-Bred International, Inc. An improved method of (agrobacterium)-mediated transformation of cultured soybean cells
GB9222888D0 (en) 1992-10-30 1992-12-16 British Tech Group Tomography
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5908782A (en) 1995-06-05 1999-06-01 Osiris Therapeutics, Inc. Chemically defined medium for human mesenchymal stem cells
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
CA2326823A1 (en) 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
EP1235842A4 (en) 1999-10-15 2003-04-23 Univ Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US20040019001A1 (en) 2002-02-20 2004-01-29 Mcswiggen James A. RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
DE10224242A1 (de) 2002-05-29 2003-12-11 Max Delbrueck Centrum Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren
CA2539439C (en) 2003-09-19 2012-10-23 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
US8592569B2 (en) 2007-11-22 2013-11-26 Japan Science And Technology Agency Small RNA-dependent translational regulatory system in cell or artificial cell model
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
CN101993992A (zh) * 2009-08-13 2011-03-30 薛晓舟 轮毂单元表面的热处理方法
CN101993892A (zh) * 2009-08-31 2011-03-30 长沙赢润生物技术有限公司 肿瘤细胞中靶向性表达shRNA的真核表达载体
EP2661489A4 (en) 2011-01-03 2014-09-10 Bluebird Bio Inc METHOD FOR INCREASING THE DELIVERY OF GEN-TRANSDUCED CELLS
US9556433B2 (en) 2012-07-17 2017-01-31 Université De Genève Nucleic acids for down-regulation of gene expression
IL298125A (en) 2013-02-26 2023-01-01 Memorial Sloan Kettering Cancer Center Preparations and methods for immunotherapy
US20150051267A1 (en) * 2013-08-16 2015-02-19 Purdue Research Foundation BICISTRONIC GENE TRANSFER TOOLS FOR DELIVERY OF miRNAS AND PROTEIN CODING SEQUENCES
JP6772062B2 (ja) 2013-12-02 2020-10-21 フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. 癌の免疫療法
KR102546296B1 (ko) 2014-10-31 2023-06-21 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도
CN105886473B (zh) * 2015-01-26 2021-05-07 温州医科大学 一种稳定沉默fgfr4基因表达的肝癌细胞株的制备方法
MX2017015239A (es) * 2015-05-29 2018-02-19 Juno Therapeutics Inc Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
DK3375874T3 (da) 2015-11-13 2022-05-09 Id Pharma Co Ltd Forbedret paramyxovirus-vektor
CN105861551B (zh) * 2016-04-21 2019-05-31 南京医科大学 联合表达microRNAs抑制乳腺癌细胞增殖的载体及其构建方法和应用
CN109414512A (zh) 2016-04-22 2019-03-01 科济生物医药(上海)有限公司 用于细胞免疫疗法的组合物和方法
WO2017204874A1 (en) 2016-05-27 2017-11-30 Shi-Lung Lin A composition and method of using mir-302 precursors as anti-cancer drugs for treating human lung cancer
CA3028982A1 (en) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
CN106282212B (zh) * 2016-08-24 2020-03-10 南通大学附属医院 三联人工miRNA抑制VEGFRs制备及其应用
US10457940B2 (en) * 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
CN107312800B (zh) 2017-08-01 2020-02-07 北京舜雷科技有限公司 能敲低内源性pd-1表达的cik及其制备方法与应用

Similar Documents

Publication Publication Date Title
US20260125701A1 (en) Compositions and methods for chimeric ligand receptor (clr)-mediated conditional gene expression
KR102417646B1 (ko) Pd-l1 발현의 감소를 위한 올리고뉴클레오티드
KR102851101B1 (ko) Rna를 편집하기 위한 방법 및 조성물
US20210388389A1 (en) Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
JP2021518160A5 (enExample)
JP2021518161A5 (enExample)
BR112020018049A2 (pt) Composições de cartirina e métodos para uso
CN106967685B (zh) 共表达抗EGFRvIII嵌合抗原受体和免疫检查点抑制分子的转基因淋巴细胞及其用途
KR20230029603A (ko) 필수 유전자 녹-인에 의한 선택
GB2556648A (en) Methods
CN108342363B (zh) 共表达抗msln嵌合抗原受体和免疫检查点抑制分子的转基因淋巴细胞及其用途
KR20210149734A (ko) Rna-가이드된 엔도뉴클레아제를 사용한 dna 작제물의 통합을 위한 개선된 방법
JP2012528588A (ja) 単一またはマルチ標的遺伝子を抑制するマルチ−シストロンshRNA発現カセット
CN111909966A (zh) 一种制备经修饰的免疫细胞的方法
JP2006519594A (ja) 所定のタンパク質ファミリー用に最適化したsiRNAライブラリー
CN104745581A (zh) 一种t细胞高活性的启动子及其用途
WO2022012531A1 (zh) 一种经修饰的免疫细胞的制备方法
JP2025511466A (ja) CRISPR-Cas13システム及びその使用
CA3256516A1 (en) Compositions and methods for modulating a genome in T lymphocytes, induced pluripotent stem cells, and respiratory epithelial cells
CN116507629A (zh) Rna支架
CN104892770A (zh) 一种对t细胞和造血干细胞具有高效感染和促增殖能力的慢病毒载体
CN111051509A (zh) 用于电介质校准的含有c2cl核酸内切酶的组合物以及使用其进行电介质校准的方法
WO2023173137A1 (en) Compositions and methods for efficient and stable genetic modification of eukaryotic cells
RU2820591C2 (ru) Композиции vcar и способы применения
RU2525935C2 (ru) Способ получения кассетных генетических конструкций, экспрессирующих несколько рнк-шпилек