JP2021518432A5 - - Google Patents

Info

Publication number
JP2021518432A5
JP2021518432A5 JP2020573089A JP2020573089A JP2021518432A5 JP 2021518432 A5 JP2021518432 A5 JP 2021518432A5 JP 2020573089 A JP2020573089 A JP 2020573089A JP 2020573089 A JP2020573089 A JP 2020573089A JP 2021518432 A5 JP2021518432 A5 JP 2021518432A5
Authority
JP
Japan
Prior art keywords
gene expression
response signature
subject
tnf
expression response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020573089A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021518432A (ja
JP7496324B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/022588 external-priority patent/WO2019178546A1/en
Publication of JP2021518432A publication Critical patent/JP2021518432A/ja
Publication of JP2021518432A5 publication Critical patent/JP2021518432A5/ja
Application granted granted Critical
Publication of JP7496324B2 publication Critical patent/JP7496324B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020573089A 2018-03-16 2019-03-15 抗tnf療法に対する応答性を予測するための方法及びシステム Active JP7496324B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644070P 2018-03-16 2018-03-16
US62/644,070 2018-03-16
PCT/US2019/022588 WO2019178546A1 (en) 2018-03-16 2019-03-15 Methods and systems for predicting response to anti-tnf therapies

Publications (3)

Publication Number Publication Date
JP2021518432A JP2021518432A (ja) 2021-08-02
JP2021518432A5 true JP2021518432A5 (https=) 2022-02-14
JP7496324B2 JP7496324B2 (ja) 2024-06-06

Family

ID=67907331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020573089A Active JP7496324B2 (ja) 2018-03-16 2019-03-15 抗tnf療法に対する応答性を予測するための方法及びシステム

Country Status (4)

Country Link
US (3) US11198727B2 (https=)
EP (1) EP3765634A4 (https=)
JP (1) JP7496324B2 (https=)
WO (1) WO2019178546A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7496324B2 (ja) 2018-03-16 2024-06-06 サイファー メディシン コーポレイション 抗tnf療法に対する応答性を予測するための方法及びシステム
GB2603294A (en) 2019-06-27 2022-08-03 Scipher Medicine Corp Developing classifiers for stratifying patients
WO2021231713A2 (en) 2020-05-14 2021-11-18 Ampel Biosolutions, Llc Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
KR20240018404A (ko) * 2020-09-01 2024-02-13 사이퍼 메디슨 코퍼레이션 항-tnf 요법에 대한 반응을 예측하기 위한 방법 및 시스템
CN116782827A (zh) * 2020-11-30 2023-09-19 明德拉公司 微针装置和方法以及皮肤病状测定
EP4015651A1 (en) * 2020-12-17 2022-06-22 Koninklijke Philips N.V. Treatment prediction and effectiveness of anti-tnf alpha treatment in ibd patients
AU2022240733A1 (en) * 2021-03-19 2023-09-28 Scipher Medicine Corporation Methods of classifying and treating patients
WO2022240875A1 (en) 2021-05-13 2022-11-17 Scipher Medicine Corporation Assessing responsiveness to therapy
JP2024527529A (ja) * 2021-06-22 2024-07-25 サイファー メディシン コーポレーション 治療モニタリングおよび試験設計のための方法とシステム
GB2624985A (en) * 2021-06-22 2024-06-05 Scipher Medicine Corp Methods and systems for personalized therapies
WO2024249568A1 (en) 2023-05-30 2024-12-05 Paragon Therapeutics, Inc. Alpha4beta7 integrin antibody compositions and methods of use
CN121889424A (zh) 2023-08-14 2026-04-17 派拉冈医疗公司 α4β7整联蛋白结合蛋白及使用方法
GB202410224D0 (en) * 2024-07-12 2024-08-28 Univ London Queen Mary Method for treating rhematoid arthritis

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040120952A1 (en) 2000-08-07 2004-06-24 Centocor, Inc Anti-TNF antibodies and peptides of human tumor necrosis factor
EP1945814A2 (en) 2005-09-27 2008-07-23 Source MDX Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
CN103336129A (zh) 2005-11-01 2013-10-02 阿布维生物技术有限公司 使用生物标志物诊断强直性脊柱炎的方法和组合物
WO2007123976A2 (en) 2006-04-18 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Antibody profiling for determination of patient responsiveness
WO2008150491A2 (en) 2007-05-31 2008-12-11 Abbott Laboratories BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFα INHIBITORS IN AUTOIMMUNE DISORDERS
US20100303813A1 (en) * 2007-06-08 2010-12-02 Biogen Idec Ma Inc. Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
US7863021B2 (en) 2007-09-05 2011-01-04 Celera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2009102957A2 (en) 2008-02-14 2009-08-20 The Johns Hopkins University Methods to connect gene set expression profiles to drug sensitivity
EP2307563B1 (en) * 2008-03-28 2014-08-06 Katholieke Universiteit Leuven KU Leuven Research & Development Mucosal gene signatures
ES2445892T3 (es) * 2008-08-25 2014-03-05 Janssen Biotech, Inc. Biomarcadores para el tratamiento anti-TNF en colitis ulcerosa y trastornos relacionados
EP2342664A1 (en) 2008-09-03 2011-07-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Computer implemented model of biological networks
CA2737485A1 (en) 2008-10-10 2010-04-15 Mount Sinai Hospital Methods for classifying samples based on network modularity
JP5996429B2 (ja) 2009-09-03 2016-09-21 ジェネンテック, インコーポレイテッド 関節リウマチの治療、診断及びモニターするための方法
WO2011047358A1 (en) 2009-10-15 2011-04-21 Crescendo Bioscience Biomarkers and methods for measuring and monitoring inflammatory disease activity
US10192641B2 (en) 2010-04-29 2019-01-29 The Regents Of The University Of California Method of generating a dynamic pathway map
WO2011139345A2 (en) 2010-04-29 2011-11-10 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
WO2012066536A2 (en) * 2010-11-16 2012-05-24 Prediguard Transcriptome signatures discriminate etanercept-treated rheumatoid arthritis (ra) patients according to their response or refractory status
US20130040835A1 (en) * 2011-05-05 2013-02-14 Exagen Diagnostics, Inc Genes predictive of anti-TNF response in inflammatory diseases
AU2012253422B2 (en) 2011-05-10 2015-08-13 Société des Produits Nestlé S.A. Methods of disease activity profiling for personalized therapy management
CN104955845B (zh) 2012-09-27 2018-11-16 美国政府(由卫生和人类服务部的部长所代表) 间皮素抗体和引起有效的抗肿瘤活性的方法
HU230680B1 (hu) * 2012-10-19 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Diagnosztikai eljárás
EP2914739B1 (en) 2012-11-05 2017-09-13 Novigenix SA Biomarker combinations for colorectal tumors
WO2014082083A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
US10161936B2 (en) 2013-03-08 2018-12-25 University Of Leipzig Method and kit for cytokine analysis from a human whole blood sample
US9945870B2 (en) 2013-05-17 2018-04-17 The Board Of Trustees Of The Leland Stanford Junior University Methods for determining responsiveness to an anti-CD47 agent
WO2015006213A1 (en) 2013-07-08 2015-01-15 Northeastern University Methods for identifying complex disease subtypes
US9387246B2 (en) 2013-09-03 2016-07-12 L. Douglas Graham Treatment methods for rheumatoid arthritis
WO2015084461A2 (en) 2013-09-23 2015-06-11 Northeastern University System and methods for disease module detection
WO2015153437A1 (en) 2014-04-02 2015-10-08 Crescendo Bioscience Biomarkers and methods for measuring and monitoring juvenile idiopathic arthritis activity
WO2015164406A1 (en) 2014-04-21 2015-10-29 University Of South Florida Salivary inflammatory biomarkers associated with glycemic control and oral health
CA2964857A1 (en) 2014-10-20 2016-04-28 Nestec S.A. Methods for prediction of anti-tnf alpha drug levels and autoantibody formation
HK1244881A1 (zh) 2014-12-02 2018-08-17 Société des Produits Nestlé S.A. 建立维多珠单坑给药方案以治疗患有易激惹肠病的患者的方法
EP3730188B1 (en) 2015-08-21 2024-07-31 The Children's Hospital of Philadelphia Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases
US10018637B2 (en) 2015-10-06 2018-07-10 Celgene International Ii Sarl Methods for treating inflammatory and other diseases and the use of biomarkers as predictors of clinical sensitivity to treatment with apremilast
ES2716900T3 (es) * 2015-11-06 2019-06-17 Promise Advanced Proteomics Un método para cuantificar anticuerpos anti-TNF
US20190080051A1 (en) 2015-11-11 2019-03-14 Northeastern University Methods And Systems For Profiling Personalized Biomarker Expression Perturbations
US20170145501A1 (en) * 2015-11-20 2017-05-25 Lasse Folkersen Apparatus and methods of using of biomarkers for predicting tnf-inhibitor response
EP3440579A4 (en) * 2015-11-24 2020-03-25 Klaritos, Inc. INNOVATIVE MODEL OF DELIVERY, PROCESSING AND PAYMENT FOR SPECIALIZED MEDICINES
GB201521357D0 (en) * 2015-12-03 2016-01-20 Univ Liverpool Methods for predicting response to anti-TNF therapy
JP6572120B2 (ja) 2015-12-14 2019-09-04 浜松ホトニクス株式会社 光ビーム照射装置
WO2017151755A1 (en) * 2016-03-02 2017-09-08 Crescendo Bioscience Biomarkers and methods for predicting response to discontinuation of inflammatory disease therapy
AU2017281039A1 (en) 2016-06-20 2019-01-24 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
US12105089B2 (en) 2017-07-17 2024-10-01 The Broad Institute, Inc. Cell atlas of the healthy and ulcerative colitis human colon
US20200165677A1 (en) 2017-07-18 2020-05-28 Thaddeus Stappenbeck Methods and uses of inflammatory bowel disease biomarkers
US20190287644A1 (en) 2018-02-15 2019-09-19 Northeastern University Correlation Method To Identify Relevant Genes For Personalized Treatment Of Complex Disease
JP7496324B2 (ja) 2018-03-16 2024-06-06 サイファー メディシン コーポレイション 抗tnf療法に対する応答性を予測するための方法及びシステム
AU2020244763A1 (en) 2019-03-22 2021-09-30 Inflammatix, Inc. Systems and methods for deriving and optimizing classifiers from multiple datasets
JP7621967B2 (ja) 2019-03-28 2025-01-27 フェーズ ゲノミクス インコーポレイテッド シーケンシングによる核型分析のためのシステムおよび方法
GB2603294A (en) 2019-06-27 2022-08-03 Scipher Medicine Corp Developing classifiers for stratifying patients
KR20240018404A (ko) 2020-09-01 2024-02-13 사이퍼 메디슨 코퍼레이션 항-tnf 요법에 대한 반응을 예측하기 위한 방법 및 시스템
AU2022240733A1 (en) 2021-03-19 2023-09-28 Scipher Medicine Corporation Methods of classifying and treating patients
WO2023150731A2 (en) 2022-02-04 2023-08-10 Scipher Medicine Corporation Systems and methods for predicting response to anti-tnf therapies

Similar Documents

Publication Publication Date Title
JP2021518432A5 (https=)
AU2023208145B2 (en) Methods of monitoring immunosuppressive therapies in a transplant recipient
Czarnewski et al. Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification
US11456056B2 (en) Methods of treating a subject suffering from rheumatoid arthritis based in part on a trained machine learning classifier
US20240199729A1 (en) Methods and systems for predicting response to anti-tnf therapies
JP6931125B2 (ja) 標的遺伝子発現の数学的モデル化を使用する、jak−stat1/2細胞シグナル伝達経路活性の評価
JP2022541125A5 (https=)
CN110168106B (zh) 预测进展期胃癌患者的术后预后或抗癌药物适合性的系统
JP2023538963A5 (https=)
GB2622147A (en) Methods of classifying and treating patients
AU2021336781A9 (en) Methods and systems for predicting response to anti-tnf therapies
US20170145501A1 (en) Apparatus and methods of using of biomarkers for predicting tnf-inhibitor response
JP2022048190A (ja) ドライアイ疾患の予後のための遺伝子シグネチャー
JP2023521168A (ja) 関節リウマチにおける疾患進行を予測する方法
WO2023061240A1 (zh) 免疫球蛋白A肾病RhoGTPase相关诊断标志物
WO2023061241A1 (zh) 免疫球蛋白a肾病t细胞诊断标志物
EP4203921A2 (en) Mrna biomarkers for diagnosis of liver disease
CN115772213B (zh) Notch3突变体及其应用
GB2547406A (en) Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response
Roberts Evaluating the clinical utility of Tumour Mutational Burden assessment in combination with PD-L1 expression analysis in guiding immunotherapy treatment stratification in a Welsh lung cancer patient group
Eken et al. POS0675 DIFFERENCES IN THE CHARACTERISTICS OF D2T/NOND2T-RA PATIENTS AND FACTORS ASSOCIATED WITH D2T-RA AT B/TSDMARD START
Bai From Molecules to Medicine: Expanding the Therapeutic Streetlight for Inflammatory Bowel Diseases
WO2024077282A2 (en) Biomarkers for the diagnosis of amyotrophic lateral sclerosis
WO2025155886A1 (en) Methods for determining responsiveness to cancer therapy
WO2014080204A1 (en) Assay method