JP2021517132A5 - - Google Patents
Info
- Publication number
- JP2021517132A5 JP2021517132A5 JP2020546962A JP2020546962A JP2021517132A5 JP 2021517132 A5 JP2021517132 A5 JP 2021517132A5 JP 2020546962 A JP2020546962 A JP 2020546962A JP 2020546962 A JP2020546962 A JP 2020546962A JP 2021517132 A5 JP2021517132 A5 JP 2021517132A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- virus
- alkyl
- different
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023176993A JP7786743B2 (ja) | 2018-03-07 | 2023-10-12 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
| JP2025207111A JP2026062641A (ja) | 2018-03-07 | 2025-11-27 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862639725P | 2018-03-07 | 2018-03-07 | |
| US62/639,725 | 2018-03-07 | ||
| PCT/US2019/021168 WO2019173602A1 (en) | 2018-03-07 | 2019-03-07 | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176993A Division JP7786743B2 (ja) | 2018-03-07 | 2023-10-12 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021517132A JP2021517132A (ja) | 2021-07-15 |
| JP2021517132A5 true JP2021517132A5 (https=) | 2022-03-14 |
| JP7371931B2 JP7371931B2 (ja) | 2023-10-31 |
Family
ID=67846796
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546962A Active JP7371931B2 (ja) | 2018-03-07 | 2019-03-07 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
| JP2023176993A Active JP7786743B2 (ja) | 2018-03-07 | 2023-10-12 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
| JP2025207111A Pending JP2026062641A (ja) | 2018-03-07 | 2025-11-27 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176993A Active JP7786743B2 (ja) | 2018-03-07 | 2023-10-12 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
| JP2025207111A Pending JP2026062641A (ja) | 2018-03-07 | 2025-11-27 | ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20210308168A1 (https=) |
| EP (1) | EP3762372A4 (https=) |
| JP (3) | JP7371931B2 (https=) |
| KR (2) | KR20200140274A (https=) |
| CN (2) | CN112074506B (https=) |
| AU (2) | AU2019231725B2 (https=) |
| BR (1) | BR112020018209A2 (https=) |
| CA (1) | CA3093222A1 (https=) |
| EA (1) | EA202092117A1 (https=) |
| GB (2) | GB2611644B (https=) |
| IL (1) | IL277160B2 (https=) |
| PH (1) | PH12020551404A1 (https=) |
| SG (1) | SG11202008527WA (https=) |
| WO (1) | WO2019173602A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| WO2020072931A2 (en) * | 2018-10-04 | 2020-04-09 | Octagon Therapeutics Inc. | Pre-activated nucleoside impdh inhibitors as anti-infective drugs |
| CN118477090A (zh) * | 2019-10-08 | 2024-08-13 | 埃默里大学 | 含4'-卤素的核苷酸和核苷治疗组合物以及其相关用途 |
| CA3176661A1 (en) * | 2020-04-24 | 2021-10-28 | Memorial Sloan-Kettering Cancer Center | Targeted therapy for the treatment & prevention of life-threatening complications of infection |
| US20240025938A1 (en) * | 2020-08-27 | 2024-01-25 | Emory University | Novel forms of antiviral nucleosides |
| CN114644666B (zh) * | 2020-12-18 | 2026-03-03 | 上海特化医药科技有限公司 | 5’-核苷前药的制备方法及中间体 |
| KR20230121622A (ko) * | 2020-12-18 | 2023-08-18 | 머크 샤프 앤드 돔 엘엘씨 | 항바이러스 뉴클레오시드의 합성 |
| CN112608357B (zh) * | 2020-12-21 | 2022-12-09 | 杭州科巢生物科技有限公司 | 一种抗病毒药物Molnupiravir的制备方法 |
| CN112778387A (zh) * | 2021-01-15 | 2021-05-11 | 杭州科巢生物科技有限公司 | 一种Molnupiravir晶型A及其制备方法 |
| WO2022174194A1 (en) * | 2021-02-15 | 2022-08-18 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| WO2022174179A1 (en) * | 2021-02-15 | 2022-08-18 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| MX2023011870A (es) * | 2021-04-09 | 2023-12-07 | Univ Emory | Análogos de nucleósidos y de nucleótidos como agentes antivirales para coronavirus y otros virus. |
| US20240166680A1 (en) * | 2021-04-15 | 2024-05-23 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Nucleoside analog and use thereof |
| US11407779B1 (en) * | 2021-04-23 | 2022-08-09 | Divi's Laboratories Ltd. | Process for the preparation of molnupiravir |
| CN112979733B (zh) * | 2021-04-25 | 2021-09-10 | 南京颐媛生物医学研究院有限公司 | 抗乙肝病毒的化合物及其制备方法和应用 |
| US20250281519A1 (en) * | 2021-05-05 | 2025-09-11 | Emory University | Nucleotide and nucleoside therapeutic compositions, combinations and uses related thereto |
| CN113278040B (zh) * | 2021-06-16 | 2022-07-05 | 苏州立新制药有限公司 | 5’-异丁酰基-n4-羟基胞苷的制备方法 |
| CN117642410A (zh) * | 2021-06-18 | 2024-03-01 | 苏州春海生物医药有限公司 | N4-羟基胞苷的酯衍生物及其用途 |
| CA3226836A1 (en) | 2021-08-06 | 2023-02-09 | Intervet International B.V. | Method of treating veterinary viral diseases |
| CN118234862A (zh) | 2021-09-08 | 2024-06-21 | 阿利戈斯治疗公司 | 经修饰的短干扰核酸分子(siNA)及其用途 |
| CN113880902A (zh) * | 2021-10-26 | 2022-01-04 | 江苏睿实生物科技有限公司 | 一种Molnupiravir药物中间体及其制备方法 |
| US11541071B1 (en) * | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
| CN114478658A (zh) * | 2022-02-22 | 2022-05-13 | 苏州正济药业有限公司 | 一种莫那比拉韦的合成方法 |
| US20250282812A1 (en) * | 2022-04-20 | 2025-09-11 | Shanghai Institute Of Materia Medica , Chinese Academy Of Sciences | Antiviral nucleoside analogue, and pharmaceutical composition and use thereof |
| WO2024129985A2 (en) * | 2022-12-14 | 2024-06-20 | Lakewood Amedex, Inc. | Antiviral compounds, compositions, and uses thereof |
| IL321635A (en) | 2022-12-23 | 2025-08-01 | Meiji Seika Pharma Co Ltd | The aftermath of avermectin |
| WO2024182446A2 (en) | 2023-02-28 | 2024-09-06 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
| US20240352464A1 (en) | 2023-03-07 | 2024-10-24 | Aligos Therapeutics, Inc. | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof |
| EP4705284A1 (en) * | 2023-05-05 | 2026-03-11 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| CN117567310A (zh) * | 2023-11-28 | 2024-02-20 | 重庆智合生物医药有限公司 | 一种神经酰胺np1的合成方法 |
| WO2025144872A2 (en) * | 2023-12-29 | 2025-07-03 | Adarx Pharmaceuticals, Inc. | Nucleoside-derived lipids for drug delivery |
| WO2026011167A1 (en) * | 2024-07-05 | 2026-01-08 | Emory University | Thionucleosides as antiviral agents |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4207363A1 (de) * | 1992-03-04 | 1993-09-09 | Max Delbrueck Centrum | Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung |
| WO2004024185A1 (ja) * | 2002-09-11 | 2004-03-25 | Michio Ishibashi | 医薬または化粧料 |
| MX2009003403A (es) * | 2006-09-27 | 2009-04-09 | Coley Pharm Group Inc | Composiciones de ligandos de tlr y antivirales. |
| WO2009058800A2 (en) * | 2007-10-29 | 2009-05-07 | President And Fellows Of Harvard College | Synthesis of nucleosides |
| AU2009298802A1 (en) * | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| AU2012357940B2 (en) * | 2011-12-20 | 2017-02-16 | Riboscience Llc | 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication |
| JP6165848B2 (ja) * | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのｄ−アミノ酸化合物 |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| BR112015014457A2 (pt) * | 2012-12-21 | 2017-11-21 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c |
| EP2981542B1 (en) * | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| JP6366693B2 (ja) | 2013-05-16 | 2018-08-01 | リボサイエンス・エルエルシー | ４’−フルオロ−２’−メチル置換ヌクレオシド誘導体 |
| AU2014302711A1 (en) * | 2013-06-26 | 2015-12-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3052511A4 (en) * | 2013-10-02 | 2017-05-31 | Moderna Therapeutics, Inc. | Polynucleotide molecules and uses thereof |
| WO2015054465A1 (en) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| MA40031A (fr) | 2014-06-24 | 2015-12-30 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| HUE051986T2 (hu) * | 2014-06-24 | 2021-04-28 | Janssen Biopharma Inc | Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| WO2016134056A1 (en) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
| WO2016134054A1 (en) * | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
| AU2016301188A1 (en) * | 2015-08-06 | 2018-02-15 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
| WO2017040892A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040896A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040895A1 (en) | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017165489A1 (en) * | 2016-03-23 | 2017-09-28 | Emory University | Antiviral agents for treating zika and dengue virus infections |
| EP3471738A4 (en) * | 2016-06-20 | 2020-01-01 | Merck Sharp & Dohme Corp. | CYCLIC PHOSPHONATE-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR USE THEREOF FOR TREATING VIRUS DISEASES |
-
2019
- 2019-03-07 KR KR1020207028655A patent/KR20200140274A/ko not_active Ceased
- 2019-03-07 CN CN201980030574.4A patent/CN112074506B/zh active Active
- 2019-03-07 GB GB2218405.5A patent/GB2611644B/en active Active
- 2019-03-07 IL IL277160A patent/IL277160B2/en unknown
- 2019-03-07 JP JP2020546962A patent/JP7371931B2/ja active Active
- 2019-03-07 BR BR112020018209-5A patent/BR112020018209A2/pt active Search and Examination
- 2019-03-07 CN CN202411351705.8A patent/CN119633010A/zh active Pending
- 2019-03-07 EA EA202092117A patent/EA202092117A1/ru unknown
- 2019-03-07 EP EP19764729.0A patent/EP3762372A4/en active Pending
- 2019-03-07 AU AU2019231725A patent/AU2019231725B2/en active Active
- 2019-03-07 KR KR1020267004999A patent/KR20260028884A/ko active Pending
- 2019-03-07 US US16/979,108 patent/US20210308168A1/en not_active Abandoned
- 2019-03-07 GB GB2015827.5A patent/GB2589205B/en active Active
- 2019-03-07 WO PCT/US2019/021168 patent/WO2019173602A1/en not_active Ceased
- 2019-03-07 SG SG11202008527WA patent/SG11202008527WA/en unknown
- 2019-03-07 CA CA3093222A patent/CA3093222A1/en active Pending
-
2020
- 2020-09-07 PH PH12020551404A patent/PH12020551404A1/en unknown
-
2023
- 2023-07-26 US US18/359,435 patent/US20240180948A1/en active Pending
- 2023-10-12 JP JP2023176993A patent/JP7786743B2/ja active Active
-
2024
- 2024-09-19 AU AU2024219862A patent/AU2024219862A1/en active Pending
-
2025
- 2025-11-27 JP JP2025207111A patent/JP2026062641A/ja active Pending
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