JP2021512158A5 - - Google Patents
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- Publication number
- JP2021512158A5 JP2021512158A5 JP2020561950A JP2020561950A JP2021512158A5 JP 2021512158 A5 JP2021512158 A5 JP 2021512158A5 JP 2020561950 A JP2020561950 A JP 2020561950A JP 2020561950 A JP2020561950 A JP 2020561950A JP 2021512158 A5 JP2021512158 A5 JP 2021512158A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- cancer
- syndrome
- arthritis
- substituted
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023200631A JP2024026193A (ja) | 2018-01-25 | 2023-11-28 | Ｒｈｏ関連プロテインキナーゼのモジュレーター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1801226.0 | 2018-01-25 | ||
| GBGB1801226.0A GB201801226D0 (en) | 2018-01-25 | 2018-01-25 | Modulators of Rho-associated protein kinase |
| PCT/GB2019/050215 WO2019145729A1 (en) | 2018-01-25 | 2019-01-25 | Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023200631A Division JP2024026193A (ja) | 2018-01-25 | 2023-11-28 | Ｒｈｏ関連プロテインキナーゼのモジュレーター |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021512158A JP2021512158A (ja) | 2021-05-13 |
| JPWO2019145729A5 JPWO2019145729A5 (https=) | 2022-01-31 |
| JP2021512158A5 true JP2021512158A5 (https=) | 2022-01-31 |
| JP7518324B2 JP7518324B2 (ja) | 2024-07-18 |
Family
ID=61558335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020561950A Active JP7518324B2 (ja) | 2018-01-25 | 2019-01-25 | Ｒｈｏ関連プロテインキナーゼのモジュレーター |
| JP2023200631A Pending JP2024026193A (ja) | 2018-01-25 | 2023-11-28 | Ｒｈｏ関連プロテインキナーゼのモジュレーター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023200631A Pending JP2024026193A (ja) | 2018-01-25 | 2023-11-28 | Ｒｈｏ関連プロテインキナーゼのモジュレーター |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US11497751B2 (https=) |
| EP (2) | EP4026834A1 (https=) |
| JP (2) | JP7518324B2 (https=) |
| KR (1) | KR102737926B1 (https=) |
| CN (1) | CN111655681B (https=) |
| AU (1) | AU2019213214B2 (https=) |
| CA (1) | CA3088330A1 (https=) |
| CY (1) | CY1125017T1 (https=) |
| DK (1) | DK3743420T3 (https=) |
| EA (1) | EA202091711A1 (https=) |
| ES (1) | ES2907833T3 (https=) |
| GB (1) | GB201801226D0 (https=) |
| HR (1) | HRP20220269T8 (https=) |
| HU (1) | HUE058940T2 (https=) |
| IL (1) | IL275988B2 (https=) |
| LT (1) | LT3743420T (https=) |
| MX (1) | MX2020007898A (https=) |
| PH (1) | PH12020550986A1 (https=) |
| PL (1) | PL3743420T3 (https=) |
| PT (1) | PT3743420T (https=) |
| SG (1) | SG11202006087UA (https=) |
| SI (1) | SI3743420T1 (https=) |
| SM (1) | SMT202200099T1 (https=) |
| WO (1) | WO2019145729A1 (https=) |
| ZA (1) | ZA202003983B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| BR112021017354A2 (pt) | 2019-03-01 | 2021-11-16 | Beijing Tide Pharmaceutical Co Ltd | Método para o tratamento de doença hepática adiposa e/ou esteatoepatite |
| CN111718310B (zh) * | 2019-08-19 | 2021-06-11 | 中国药科大学 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
| CN110845410B (zh) * | 2019-10-29 | 2021-02-26 | 暨明医药科技（苏州）有限公司 | 一种一锅法制备6,7-二甲氧基-3,4-二氢异喹啉盐酸盐的方法 |
| US20240131029A1 (en) * | 2021-02-04 | 2024-04-25 | President And Fellows Of Harvard College | Selective rock2 inhibition for treatment of edema and associated conditions |
| CA3226387A1 (en) * | 2021-07-26 | 2023-02-02 | Joel D. Moore | Rock2 inhibitors and uses thereof |
| CN113999211B (zh) * | 2021-11-23 | 2022-11-29 | 郑州大学 | 一类特异性抗前列腺癌活性的含1,2,3-三氮唑的吲唑骨架衍生物 |
| GB202200735D0 (en) * | 2022-01-20 | 2022-03-09 | Redx Pharma Plc | Compounds |
| WO2023182856A1 (ko) * | 2022-03-24 | 2023-09-28 | 서울대학교산학협력단 | 로-키나제 억제제를 포함하는 켈로이드 등 피부 섬유화 질환의 예방 또는 치료용 약학적 조성물 및 그의 용도 |
| DK4514782T3 (da) | 2022-05-19 | 2025-12-15 | Astrazeneca Ab | Heteroaromatiske amidoforbindelser, der er nyttige ved behandling af leversygdomme |
| CN115124558B (zh) * | 2022-07-08 | 2024-08-13 | 闽都创新实验室 | 一种芳基硼酸酯类化合物的制备方法及其应用 |
| WO2024123129A1 (ko) * | 2022-12-08 | 2024-06-13 | 한국과학기술원 | 파브리병의 예방 또는 치료용 조성물 |
| CN116891460A (zh) * | 2023-07-12 | 2023-10-17 | 浙江大学 | 一种吲唑类衍生物或其药用盐及应用 |
| WO2025017499A1 (en) | 2023-07-17 | 2025-01-23 | Graviton Bioscience Bv | Formulations and uses of rock2 inhibitors for als |
| GB202311061D0 (en) * | 2023-07-19 | 2023-08-30 | Redx Pharma Plc | Modulators of rho-associated protein kinase |
| GB202311062D0 (en) * | 2023-07-19 | 2023-08-30 | Redx Pharma Plc | Modulators of rho-associated protein kinase |
| WO2025069008A1 (en) | 2023-09-28 | 2025-04-03 | Graviton Bioscience Bv | Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors |
| WO2025069009A1 (en) | 2023-09-29 | 2025-04-03 | Graviton Bioscience Bv | Rock2 inhibitors in the treatment of obesity |
| TW202542129A (zh) * | 2023-12-22 | 2025-11-01 | 美商美國禮來大藥廠 | Rho相關蛋白激酶抑制劑 |
| IT202400002560A1 (it) * | 2024-02-07 | 2025-08-07 | Univ Pisa | Inibitori della proteina rock per uso nel trattamento della fibrosi polmonare |
| WO2025256614A1 (zh) * | 2024-06-14 | 2025-12-18 | 北京普祺医药科技股份有限公司 | 一种促进胶原蛋白表达的抑制剂 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9207396D0 (en) | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| EP1317450B1 (en) * | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
| WO2005013982A1 (en) * | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| WO2005097758A1 (en) * | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| WO2006135383A2 (en) * | 2004-08-04 | 2006-12-21 | Myriad Genetics, Inc. | Indazoles |
| EP2035396B1 (en) * | 2006-05-25 | 2014-05-14 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| DE102007022565A1 (de) * | 2007-05-14 | 2008-11-20 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
| WO2009155156A1 (en) * | 2008-06-18 | 2009-12-23 | Merck & Co., Inc. | Inhibitors of janus kinases |
| ES2677356T3 (es) * | 2010-03-24 | 2018-08-01 | Amitech Therapeutics Solutions, Inc. | Compuestos heterocíclicos útiles para la inhibición de quinasas |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| BR112013015460B1 (pt) * | 2010-12-20 | 2022-01-25 | Merck Serono S.A. | Derivados de indazolil triazol, kit, e composição farmacêutica |
| WO2013133367A1 (ja) * | 2012-03-09 | 2013-09-12 | カルナバイオサイエンス株式会社 | 新規トリアジン誘導体 |
| EP3055301B1 (en) | 2013-10-07 | 2019-11-20 | Kadmon Corporation, LLC | (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases |
| WO2016138336A1 (en) | 2015-02-27 | 2016-09-01 | Purdue Research Foundation | Perimeter fill syringe |
| WO2016138335A1 (en) * | 2015-02-27 | 2016-09-01 | Lycera Corporation | Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
| WO2017103611A1 (en) | 2015-12-16 | 2017-06-22 | Redx Pharma Plc | Compounds useful as kinase inhibitors |
| US10323023B2 (en) * | 2017-06-30 | 2019-06-18 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof |
| WO2019000682A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| CN110582489B (zh) | 2017-06-30 | 2023-10-27 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| GB201801226D0 (en) * | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| JP7490569B2 (ja) | 2018-04-24 | 2024-05-27 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | キナーゼ阻害剤としてのアミド化合物、組成物および処置方法 |
| US20240131029A1 (en) | 2021-02-04 | 2024-04-25 | President And Fellows Of Harvard College | Selective rock2 inhibition for treatment of edema and associated conditions |
| GB202200735D0 (en) | 2022-01-20 | 2022-03-09 | Redx Pharma Plc | Compounds |
-
2018
- 2018-01-25 GB GBGB1801226.0A patent/GB201801226D0/en not_active Ceased
-
2019
- 2019-01-25 CN CN201980010083.3A patent/CN111655681B/zh active Active
- 2019-01-25 LT LTEPPCT/GB2019/050215T patent/LT3743420T/lt unknown
- 2019-01-25 EP EP21214072.7A patent/EP4026834A1/en active Pending
- 2019-01-25 CA CA3088330A patent/CA3088330A1/en active Pending
- 2019-01-25 HR HRP20220269TT patent/HRP20220269T8/hr unknown
- 2019-01-25 SM SM20220099T patent/SMT202200099T1/it unknown
- 2019-01-25 MX MX2020007898A patent/MX2020007898A/es unknown
- 2019-01-25 EP EP19702694.1A patent/EP3743420B1/en active Active
- 2019-01-25 WO PCT/GB2019/050215 patent/WO2019145729A1/en not_active Ceased
- 2019-01-25 AU AU2019213214A patent/AU2019213214B2/en active Active
- 2019-01-25 JP JP2020561950A patent/JP7518324B2/ja active Active
- 2019-01-25 EA EA202091711A patent/EA202091711A1/ru unknown
- 2019-01-25 PT PT197026941T patent/PT3743420T/pt unknown
- 2019-01-25 PL PL19702694T patent/PL3743420T3/pl unknown
- 2019-01-25 KR KR1020207022578A patent/KR102737926B1/ko active Active
- 2019-01-25 SG SG11202006087UA patent/SG11202006087UA/en unknown
- 2019-01-25 ES ES19702694T patent/ES2907833T3/es active Active
- 2019-01-25 US US16/964,904 patent/US11497751B2/en active Active
- 2019-01-25 DK DK19702694.1T patent/DK3743420T3/da active
- 2019-01-25 HU HUE19702694A patent/HUE058940T2/hu unknown
- 2019-01-25 SI SI201930178T patent/SI3743420T1/sl unknown
-
2020
- 2020-06-25 PH PH12020550986A patent/PH12020550986A1/en unknown
- 2020-06-30 ZA ZA2020/03983A patent/ZA202003983B/en unknown
- 2020-07-12 IL IL275988A patent/IL275988B2/en unknown
-
2022
- 2022-02-16 CY CY20221100132T patent/CY1125017T1/el unknown
- 2022-08-26 US US17/896,626 patent/US11878020B2/en active Active
-
2023
- 2023-11-28 JP JP2023200631A patent/JP2024026193A/ja active Pending
- 2023-12-08 US US18/534,285 patent/US12453734B2/en active Active
-
2025
- 2025-10-02 US US19/348,406 patent/US20260034140A1/en active Pending
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