|
EP0127839B1
(en)
|
1983-05-27 |
1992-07-15 |
THE TEXAS A&M UNIVERSITY SYSTEM |
Method for producing a recombinant baculovirus expression vector
|
|
ZA848495B
(en)
|
1984-01-31 |
1985-09-25 |
Idaho Res Found |
Production of polypeptides in insect cells
|
|
US5449616A
(en)
|
1990-05-23 |
1995-09-12 |
University Of Iowa Research Foundation |
Nucleic acid encoding dystrophin-associated protein
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
WO1995003392A1
(en)
|
1993-07-23 |
1995-02-02 |
Unichema Chemie Bv |
Process for producing transparent soap material
|
|
PT728214E
(pt)
|
1993-11-09 |
2004-11-30 |
Ohio Med College |
Linhas celulares estaveis capazes de expressar o gene de replicacao do virus adeno-associado
|
|
WO1995013365A1
(en)
|
1993-11-09 |
1995-05-18 |
Targeted Genetics Corporation |
Generation of high titers of recombinant aav vectors
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
CA2207927A1
(en)
|
1994-12-06 |
1996-06-13 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
FR2737730B1
(fr)
|
1995-08-10 |
1997-09-05 |
Pasteur Merieux Serums Vacc |
Procede de purification de virus par chromatographie
|
|
WO1997008298A1
(en)
|
1995-08-30 |
1997-03-06 |
Genzyme Corporation |
Chromatographic purification of adenovirus and aav
|
|
US6632670B1
(en)
|
1995-09-08 |
2003-10-14 |
Genzyme Corporation |
AAV vectors for gene therapy
|
|
US5672694A
(en)
|
1995-10-24 |
1997-09-30 |
University Of Iowa Research Foundation |
β-sarcoglycan nucleic acid sequence, and nucleic acid probes
|
|
US5910434A
(en)
|
1995-12-15 |
1999-06-08 |
Systemix, Inc. |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
|
|
JP2001500497A
(ja)
|
1996-09-06 |
2001-01-16 |
トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスに指図される遺伝子治療の方法
|
|
US5843078A
(en)
|
1997-07-01 |
1998-12-01 |
Sharkey; Hugh R. |
Radio frequency device for resurfacing skin and method
|
|
DK1009808T3
(da)
|
1997-09-05 |
2013-01-21 |
Genzyme Corp |
Fremgangsmåder til generering af hjælper-frie præparater af rekombinante aav-vektorer med høj titer
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
WO1999043360A1
(en)
|
1998-02-26 |
1999-09-02 |
The Trustees Of The University Of Pennsylvania |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
US6262035B1
(en)
*
|
1998-10-01 |
2001-07-17 |
University Of Iowa Research Foundation |
Gene replacement therapy for muscular dystrophy
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6632800B1
(en)
|
1999-08-17 |
2003-10-14 |
Mayo Foundation For Medical Education And Research |
System for monitoring the expression of transgenes
|
|
JP4520569B2
(ja)
|
2000-02-18 |
2010-08-04 |
照彦 豊岡 |
拡張型心筋症の遺伝子治療剤
|
|
US7056502B2
(en)
*
|
2000-04-28 |
2006-06-06 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20040126762A1
(en)
|
2002-12-17 |
2004-07-01 |
Morris David W. |
Novel compositions and methods in cancer
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
AU2003212708A1
(en)
|
2002-03-05 |
2003-09-16 |
Stichting Voor De Technische Wetenschappen |
Baculovirus expression system
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
|
BRPI0511764B8
(pt)
|
2004-06-01 |
2021-05-25 |
Avigen Inc |
método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav
|
|
US7972593B2
(en)
|
2004-06-10 |
2011-07-05 |
Saint Louis University |
Delivery of therapeutic agents to the bone
|
|
US20090054823A1
(en)
|
2004-09-30 |
2009-02-26 |
The Trustees Of The University Of Pennsylvania |
Perfusion circuit and use therein in targeted delivery of macromolecules
|
|
JP2006121961A
(ja)
|
2004-10-28 |
2006-05-18 |
Univ Of Tokushima |
顎骨骨幹異形成症ｇｄｄの原因遺伝子ｇｄｄ１とその用途
|
|
US7883858B2
(en)
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
|
US7788045B2
(en)
|
2005-09-01 |
2010-08-31 |
Meditasks, Llc |
Systems and method for homeostatic blood states
|
|
EP1938104A2
(en)
|
2005-10-17 |
2008-07-02 |
Institute for Systems Biology |
Tissue-and serum-derived glycoproteins and methods of their use
|
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
|
EP2018421B1
(en)
|
2006-04-28 |
2012-12-19 |
The Trustees of the University of Pennsylvania |
Scalable production method for aav
|
|
EP2052088A2
(en)
|
2006-08-02 |
2009-04-29 |
Genizon Biosciences |
Genemap of the human genes associated with psoriasis
|
|
AU2007284651B2
(en)
|
2006-08-09 |
2014-03-20 |
Institute For Systems Biology |
Organ-specific proteins and methods of their use
|
|
EP2087098A4
(en)
|
2006-11-09 |
2010-03-31 |
Univ Johns Hopkins |
DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS
|
|
CN101711164B
(zh)
|
2007-01-18 |
2014-06-04 |
密苏里-哥伦比亚大学 |
可修复肌纤维膜中的神经元型一氧化氮合酶的合成小/微-抗肌萎缩蛋白基因
|
|
FR2919305B1
(fr)
|
2007-07-26 |
2009-09-18 |
Genethon Ass Loi De 1901 |
Vecteurs viraux adeno-associes pour l'expression de la dysferline.
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
ES2639852T3
(es)
|
2007-10-26 |
2017-10-30 |
Academisch Ziekenhuis Leiden |
Medios y métodos para contrarrestar los trastornos musculares
|
|
JP5634272B2
(ja)
|
2008-03-14 |
2014-12-03 |
ヒューマンザイム リミテッド |
ヒト細胞発現系を用いる真正ヒトタンパク質の組換え生産
|
|
US20090280103A1
(en)
|
2008-04-04 |
2009-11-12 |
Martin Flueck |
Regulation of muscle repair
|
|
WO2009137006A2
(en)
|
2008-04-30 |
2009-11-12 |
The University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US8236557B2
(en)
|
2008-05-28 |
2012-08-07 |
University Of Missouri-Columbia |
Hybrid-AAV vectors to deliver large gene expression cassette
|
|
US20100026655A1
(en)
|
2008-07-31 |
2010-02-04 |
Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. |
Capacitive Touchscreen or Touchpad for Finger or Stylus
|
|
US8729041B2
(en)
|
2008-12-03 |
2014-05-20 |
The Johns Hopkins University |
Compositions and methods for treating hepatic neoplasia
|
|
US20110023139A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20100247495A1
(en)
*
|
2009-03-30 |
2010-09-30 |
Tom Ichim |
Treatment of Muscular Dystrophy
|
|
WO2011044138A1
(en)
|
2009-10-05 |
2011-04-14 |
Catabasis Pharmaceuticals, Inc. |
Lipoic acid acylated salicylate derivatives and their uses
|
|
KR101841752B1
(ko)
|
2009-11-03 |
2018-05-04 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
저온 수용액 내에서 성장한 다중 표면들 상의 산화 아연 층들에 의해 커버되는 고휘도 발광 다이오드
|
|
FR2962041B1
(fr)
|
2010-07-01 |
2012-07-27 |
Genethon |
Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies
|
|
EP2736539B1
(en)
|
2011-07-25 |
2017-08-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
WO2013075008A1
(en)
|
2011-11-16 |
2013-05-23 |
University Of Florida Research Foundation Inc. |
Aav dual vector systems for gene therapy
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
MX367100B
(es)
|
2012-02-17 |
2019-08-05 |
The Children´S Hospital Of Philadelphia |
Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos.
|
|
US9254311B2
(en)
*
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
WO2014037526A1
(en)
|
2012-09-07 |
2014-03-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
In vitro genetic diagnostic of inherited neuromuscular disorders
|
|
EP2900821B1
(en)
|
2012-09-25 |
2020-04-01 |
Genzyme Corporation |
Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
|
|
US9624282B2
(en)
|
2012-11-26 |
2017-04-18 |
The Curators Of The University Of Missouri |
Microdystrophin peptides and methods for treating muscular dystrophy using the same
|
|
EP3031921B1
(en)
|
2012-12-12 |
2025-03-12 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
IL239344B2
(en)
|
2012-12-12 |
2024-06-01 |
Broad Inst Inc |
Systems engineering, methods and optimal guiding components for sequence manipulation
|
|
EP2840140B2
(en)
|
2012-12-12 |
2023-02-22 |
The Broad Institute, Inc. |
Crispr-Cas based method for mutation of prokaryotic cells
|
|
FR3004463A1
(fr)
|
2013-04-11 |
2014-10-17 |
Genethon |
Systeme d'expression pour une therapie genique selective
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
ES2666322T3
(es)
|
2013-10-08 |
2018-05-04 |
Ystem S.R.L. |
Composiciones farmacéuticas para el tratamiento de trastornos musculares
|
|
US9850497B2
(en)
|
2013-11-04 |
2017-12-26 |
Regents Of The University Of Minnesota |
Gene targeting methods and tools
|
|
EP3470089A1
(en)
|
2013-12-12 |
2019-04-17 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
PL3097197T3
(pl)
|
2014-01-21 |
2021-06-28 |
Vrije Universiteit Brussel |
Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie
|
|
DE102014207498A1
(de)
|
2014-04-17 |
2015-10-22 |
Universitätsklinikum Hamburg-Eppendorf |
Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
|
|
EP2960336A1
(en)
|
2014-06-27 |
2015-12-30 |
Genethon |
Efficient systemic treatment of dystrophic muscle pathologies
|
|
JP6832280B2
(ja)
|
2015-01-16 |
2021-02-24 |
ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ |
新規のマイクロジストロフィンおよび使用の関連する方法
|
|
KR102877920B1
(ko)
|
2015-11-16 |
2025-10-30 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
티틴-기반 근증 및 다른 티틴성병증의 치료를 위한 물질 및 방법
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
ES2977730T3
(es)
|
2016-04-15 |
2024-08-29 |
Res Inst Nationwide Childrens Hospital |
Administración de microARN-29 y micro-distrofina por virus adenoasociado para tratar la distrofia muscular
|
|
MX2018012537A
(es)
|
2016-04-15 |
2019-02-25 |
Univ Pennsylvania |
Terapia de genes para tratar hemofilia a.
|
|
LT3442600T
(lt)
|
2016-04-15 |
2024-05-27 |
Research Institute At Nationwide Children's Hospital |
Su adeno virusu susijusio viruso vektoriaus iš β-sarkoglikano ir mikro- rnr-29 pristatymas ir raumenų distrofijos gydymas
|
|
WO2017191274A2
(en)
*
|
2016-05-04 |
2017-11-09 |
Curevac Ag |
Rna encoding a therapeutic protein
|
|
CA2971303C
(en)
|
2016-06-21 |
2026-03-03 |
Bamboo Therapeutics, Inc. |
Optimized mini-dystrophin genes and expression cassettes and their use
|
|
JP7676111B2
(ja)
|
2017-03-17 |
2025-05-14 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーを治療するための筋肉特異的マイクロジストロフィンのアデノ随伴ウイルスベクター送達
|
|
EP3596112A2
(en)
|
2017-03-17 |
2020-01-22 |
Newcastle University |
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
|
|
MA50836A
(fr)
|
2017-10-18 |
2020-08-26 |
Res Inst Nationwide Childrens Hospital |
Administration par vecteur à virus adéno-associé de micro-dystrophine spécifique de muscles pour traiter la dystrophie musculaire
|
|
US11926653B2
(en)
|
2017-10-20 |
2024-03-12 |
Research Institute At Nationwide Children's Hospital |
Methods and materials for NT-3 gene therapy
|
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
|
AR114350A1
(es)
|
2018-01-31 |
2020-08-26 |
Res Institute At Nationwide ChildrenS Hospital |
Terapia genética para la distrofia muscular de cinturas del tipo 2c
|
|
US20210139550A1
(en)
|
2018-04-03 |
2021-05-13 |
Curators Of The University Of Missouri |
Hinges 1 and/or 4 modified dystrophins for dystrophinopathy therapy
|
|
US12152242B2
(en)
|
2018-04-23 |
2024-11-26 |
The Curators Of The University Of Missouri |
CRISPR therapy
|
|
MY208145A
(en)
|
2018-06-18 |
2025-04-18 |
Res Inst Nationwide Childrens Hospital |
Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy
|
|
KR20210028162A
(ko)
|
2018-06-29 |
2021-03-11 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
지대근 이영양증 2a형을 치료하기 위한 재조합 아데노 연관 바이러스 생성물 및 방법
|
|
WO2020123645A1
(en)
|
2018-12-12 |
2020-06-18 |
Solid Biosciences Inc. |
Combination therapy for treating muscular dystrophy
|
|
AU2020229340A1
(en)
|
2019-02-26 |
2021-09-16 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of B-sarcoglycan and the treatment of muscular dystrophy
|
|
RS65421B1
(sr)
|
2019-08-21 |
2024-05-31 |
Res Inst Nationwide Childrens Hospital |
Isporuka adeno-asociranog virusnog vektora alfa-sarkoglikana i lečenje mišićne distrofije
|
|
IL299094A
(en)
|
2020-06-15 |
2023-02-01 |
Res Inst Nationwide Childrens Hospital |
Administration of an adeno-associated virus vector for muscular dystrophies
|
|
JP2023534127A
(ja)
|
2020-06-17 |
2023-08-08 |
アクセルロン ファーマ インコーポレイテッド |
ＡｃｔＲＩＩ－ＡＬＫ４アンタゴニストおよび心不全を処置する方法
|