JP2021508672A - シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤 - Google Patents

シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤 Download PDF

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JP2021508672A
JP2021508672A JP2020519016A JP2020519016A JP2021508672A JP 2021508672 A JP2021508672 A JP 2021508672A JP 2020519016 A JP2020519016 A JP 2020519016A JP 2020519016 A JP2020519016 A JP 2020519016A JP 2021508672 A JP2021508672 A JP 2021508672A
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epitope
peptide
antibody
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イ ワン、チャン
イ ワン、チャン
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United Neuroscience
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2020519016A 2017-06-16 2018-06-15 シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤 Pending JP2021508672A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023040466A JP7732676B2 (ja) 2017-06-16 2023-03-15 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤
JP2025032073A JP2025090637A (ja) 2017-06-16 2025-02-28 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762521287P 2017-06-16 2017-06-16
US62/521,287 2017-06-16
PCT/US2018/037938 WO2018232369A1 (en) 2017-06-16 2018-06-15 Peptide immunogens from the c-terminal end of alpha-synuclein protein and formulations thereof for treatment of synucleinopathies

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JP2023040466A Division JP7732676B2 (ja) 2017-06-16 2023-03-15 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤

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JP2021508672A true JP2021508672A (ja) 2021-03-11
JP2021508672A5 JP2021508672A5 (enExample) 2021-07-26

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JP2020519016A Pending JP2021508672A (ja) 2017-06-16 2018-06-15 シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤
JP2023040466A Active JP7732676B2 (ja) 2017-06-16 2023-03-15 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤
JP2025032073A Pending JP2025090637A (ja) 2017-06-16 2025-02-28 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤

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JP2025032073A Pending JP2025090637A (ja) 2017-06-16 2025-02-28 シヌクレイノパチーの治療のためのアルファ－シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤

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US (1) US20210138049A1 (enExample)
EP (1) EP3638298A4 (enExample)
JP (3) JP2021508672A (enExample)
KR (2) KR20240150813A (enExample)
AU (2) AU2018283510B8 (enExample)
BR (1) BR112019026707A2 (enExample)
CA (1) CA3067231A1 (enExample)
MX (1) MX2019015286A (enExample)
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WO (1) WO2018232369A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2022265091A1 (ja) * 2021-06-18 2022-12-22 住友ファーマ株式会社 ヒトαシヌクレインのエピトープペプチド及び該ペプチドを含む医薬組成物

Families Citing this family (9)

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EP3583124A1 (en) 2017-02-17 2019-12-25 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
JP2021508673A (ja) 2017-10-27 2021-03-11 ユナイテッド ニューロサイエンスＵｎｉｔｅｄ Ｎｅｕｒｏｓｃｉｅｎｃｅ タウペプチド免疫原構築物
MX2021007906A (es) * 2018-12-28 2021-10-13 United Biomedical Inc Nmunógenos peptídicos dirigidos a la interleucina 6 (il-6) y sus formulaciones para la inmunoterapia de enfermedades afectadas por la desregulación de la il-6.
AU2021276401A1 (en) 2020-05-19 2022-12-15 Othair Prothena Limited Multi-epitope vaccine for the treatment of Alzheimer's disease
JP2023536497A (ja) * 2020-08-04 2023-08-25 エイシー イミューン ソシエテ アノニム 免疫原性化合物
JP2023541671A (ja) * 2020-09-17 2023-10-03 プロシーナ バイオサイエンシーズ リミテッド シヌクレイノパチーの処置のためのアルファ－シヌクレインワクチン
KR102505164B1 (ko) * 2020-09-29 2023-02-28 서울대학교산학협력단 신경퇴행성 질환의 예방 또는 치료용 펩타이드 및 이를 포함하는 약학 조성물
AU2022337284A1 (en) * 2021-09-01 2024-03-21 Vaxxinity, Inc. Methods for the prevention and treatment of synucleinopathies
EP4486388A1 (en) 2022-02-28 2025-01-08 Tridem Bioscience GmbH & Co KG A conjugate consisting of or comprising at least a ss-glucan or a mannan

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JP2015527369A (ja) * 2012-08-21 2015-09-17 インスティテュート フォー モレキュラー メディシン， インコーポレイテッド アミロイド、タウおよびα−シヌクレインの沈着に関連する疾患に関する組成物および方法
JP2016513638A (ja) * 2013-03-15 2016-05-16 ユナイテッド・バイオメディカル・インコーポレーテッドＵｎｉｔｅｄ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン
US20160184416A1 (en) * 2007-02-23 2016-06-30 Dale B. Schenk Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease

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WO2015157117A2 (en) * 2014-04-09 2015-10-15 The Trustees Of Columbia University In The City Of New York Use of leukocytes and novel biomarkers in the diagnosis, confirmation, and treatment of a neurological disorder
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JP2015527369A (ja) * 2012-08-21 2015-09-17 インスティテュート フォー モレキュラー メディシン， インコーポレイテッド アミロイド、タウおよびα−シヌクレインの沈着に関連する疾患に関する組成物および方法
JP2016513638A (ja) * 2013-03-15 2016-05-16 ユナイテッド・バイオメディカル・インコーポレーテッドＵｎｉｔｅｄ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022265091A1 (ja) * 2021-06-18 2022-12-22 住友ファーマ株式会社 ヒトαシヌクレインのエピトープペプチド及び該ペプチドを含む医薬組成物

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JP2023082018A (ja) 2023-06-13
AU2018283510B8 (en) 2025-09-18
RU2020101121A3 (enExample) 2021-10-15
WO2018232369A1 (en) 2018-12-20
JP7732676B2 (ja) 2025-09-02
EP3638298A1 (en) 2020-04-22
AU2018283510A1 (en) 2020-01-16
SG11201912195TA (en) 2020-01-30
CA3067231A1 (en) 2018-12-20
BR112019026707A2 (pt) 2020-06-30
EP3638298A4 (en) 2021-05-05
KR20200054938A (ko) 2020-05-20
RU2020101121A (ru) 2021-07-16
AU2018283510B2 (en) 2025-06-26
KR20240150813A (ko) 2024-10-16
JP2025090637A (ja) 2025-06-17
US20210138049A1 (en) 2021-05-13
MX2019015286A (es) 2020-08-17
AU2025238083A1 (en) 2025-10-23

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