JP2021508474A - カートリッジを用いた核酸抽出方法 - Google Patents
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- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 67
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 67
- 238000000605 extraction Methods 0.000 title claims abstract description 28
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 78
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 239000011324 bead Substances 0.000 claims abstract description 26
- 230000003321 amplification Effects 0.000 claims abstract description 16
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 16
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- 208000022362 bacterial infectious disease Diseases 0.000 description 1
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Abstract
Description
Claims (10)
- (a)ピストンの上部ボディーの内部空間に配置される制御棒モジュール及びピストンの下部ボディーに結合される回転調節モジュールに、核酸抽出装置の駆動部が連結されるステップと、
(b)回転調節モジュール及び制御棒モジュールを駆動させて、カートリッジの互いに分離された複数のチャンバから前記内部空間にサンプル及び試薬を順次吸入し、前記内部空間の混合液をカートリッジのチャンバに排出させるステップと、
(c)回転調節モジュール及び制御棒モジュールを駆動させて、カートリッジのマスターミックスビーズチャンバの内部の試薬をピストンの上部ボディーの内部空間に吸入した後、混合された試薬を核酸増幅モジュールに排出させるステップと、を含むことを特徴とするカートリッジを用いた核酸抽出方法。 - 前記(b)ステップにおいて、混合液は核酸捕捉フィルターを経て排出されることを特徴とする請求項1に記載のカートリッジを用いた核酸抽出方法。
- 前記(b)ステップは、
前記回転調節モジュールを駆動させてピストンの下部ボディーの液体ポートとカートリッジのサンプルチャンバポートを重畳させ、前記制御棒モジュールを駆動させてサンプルチャンバ内のサンプルを上部ボディーの内部空間に吸入するステップを含むことを特徴とする請求項2に記載のカートリッジを用いた核酸抽出方法。 - 前記回転調節モジュールを駆動させてピストンの下部ボディーの液体ポートとカートリッジの第1試薬チャンバポートを重畳させ、前記制御棒モジュールを駆動させて第1試薬を上部ボディーの内部空間に吸入した後、サンプルと混合させるステップをさらに含むことを特徴とする請求項3に記載のカートリッジを用いた核酸抽出方法。
- 前記回転調節モジュールを駆動させてピストンの下部ボディーの液体ポートとカートリッジの第2試薬チャンバポートを重畳させ、前記制御棒モジュールを駆動させて第2試薬を上部ボディーの内部空間に吸入した後、混合させるステップをさらに含むことを特徴とする請求項4に記載のカートリッジを用いた核酸抽出方法。
- 前記回転調節モジュールを駆動させてピストンの下部ボディーのフィルターポートとカートリッジの第2試薬チャンバポートを重畳させ、前記制御棒モジュールを駆動させて混合液を第2チャンバポートに排出させるステップを含むことを特徴とする請求項5に記載のカートリッジを用いた核酸抽出方法。
- 前記(b)ステップは、前記試薬と異なる種類の試薬を順次吸入、混合、排出させるステップをさらに含むことを特徴とする請求項6に記載のカートリッジを用いた核酸抽出方法。
- 最後に吸入した試薬は、カートリッジのマスターミックスビーズチャンバに排出されることを特徴とする請求項7に記載のカートリッジを用いた核酸抽出方法。
- 前記(c)ステップは、
前記回転調節モジュールを駆動させてピストンの下部ボディーのフィルターポートとカートリッジのマスターミックスビーズチャンバポートを重畳させ、前記制御棒モジュールを駆動させて前記最後に吸入した試薬をマスターミックスビーズチャンバポートに排出させるステップを含むことを特徴とする請求項8に記載のカートリッジを用いた核酸抽出方法。 - 前記回転調節モジュールを駆動させてピストンの下部ボディーの液体ポートとカートリッジのマスターミックスビーズチャンバポートを重畳させ、前記制御棒モジュールを駆動させてマスターミックスビーズチャンバの内部の試薬を上部ボディーの内部空間に吸入した後、混合させるステップと、
前記ピストンの上部ボディーの内部空間の試薬を増幅モジュールに移動させるステップと、をさらに含むことを特徴とする請求項9に記載のカートリッジを用いた核酸抽出方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR10-2017-0182631 | 2017-12-28 | ||
KR1020170182631A KR102065650B1 (ko) | 2017-12-28 | 2017-12-28 | 카트리지를 이용한 핵산 추출 방법 |
PCT/KR2018/016309 WO2019132406A1 (ko) | 2017-12-28 | 2018-12-20 | 카트리지를 이용한 핵산 추출 방법 |
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JP2021508474A true JP2021508474A (ja) | 2021-03-11 |
JP7003273B2 JP7003273B2 (ja) | 2022-01-20 |
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US (1) | US11585739B2 (ja) |
EP (1) | EP3734294A4 (ja) |
JP (1) | JP7003273B2 (ja) |
KR (1) | KR102065650B1 (ja) |
CN (1) | CN111602060B (ja) |
WO (1) | WO2019132406A1 (ja) |
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KR20220081789A (ko) * | 2020-12-09 | 2022-06-16 | (주)오상헬스케어 | 분자 진단 카트리지 및 이를 이용하는 분자 진단 장치 |
CN215947247U (zh) * | 2021-01-15 | 2022-03-04 | 江苏汇先医药技术有限公司 | 一种环介导等温扩增芯片 |
CN113203602B (zh) * | 2021-05-24 | 2022-10-04 | 重庆医科大学附属第一医院 | 一种用于医学检验的取样装置 |
CN113373042A (zh) * | 2021-06-09 | 2021-09-10 | 北京卓诚惠生生物科技股份有限公司 | 一种模块化核酸提取扩增检测一体机 |
KR102346703B1 (ko) | 2021-06-29 | 2022-01-04 | 에스디바이오센서 주식회사 | 외측 챔버와 내측 챔버가 결합된 이중 챔버 구조의 유전체 추출 장치 |
KR102293717B1 (ko) | 2021-06-29 | 2021-08-26 | 에스디바이오센서 주식회사 | 플로우 커버를 포함하는 유전체 추출 장치 |
KR102375252B1 (ko) | 2021-06-29 | 2022-03-18 | 에스디바이오센서 주식회사 | 외측 챔버와 비드 챔버가 결합된 이중 챔버 구조의 유전체 추출 장치 |
KR102416335B1 (ko) | 2021-06-29 | 2022-07-05 | 에스디바이오센서 주식회사 | 기체 이동 통로와 추출액 이동 통로를 갖는 증폭 모듈 |
CN113430096A (zh) * | 2021-07-19 | 2021-09-24 | 杭州奥盛仪器有限公司 | 一种全封闭式样本处理及检测装置 |
KR102362853B1 (ko) | 2021-08-13 | 2022-02-15 | 에스디바이오센서 주식회사 | 내측 챔버와 결합되는 안전 클립을 포함하는 유전체 추출 장치 |
CN115960707A (zh) * | 2021-10-08 | 2023-04-14 | 苏州国科均豪生物科技有限公司 | 用于免疫荧光检测的试剂盒及使用方法、荧光免疫检测装置 |
CN114200134B (zh) * | 2021-11-26 | 2023-11-07 | 中国农业大学 | 用于微生物检测的自动化快速检测装置、系统及方法 |
WO2023149787A1 (ko) * | 2022-02-07 | 2023-08-10 | 주식회사 퀀타매트릭스 | 감염원 분리 및 농축기능을 포함하는 핵산분석장치 |
WO2023247543A1 (en) * | 2022-06-20 | 2023-12-28 | Testmate Health Sa | Urine, saliva, and/or mouthwash sample preparation system |
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WO2019132406A1 (ko) | 2019-07-04 |
KR102065650B1 (ko) | 2020-02-11 |
CN111602060B (zh) | 2023-06-30 |
KR20190080268A (ko) | 2019-07-08 |
US11585739B2 (en) | 2023-02-21 |
JP7003273B2 (ja) | 2022-01-20 |
EP3734294A1 (en) | 2020-11-04 |
CN111602060A (zh) | 2020-08-28 |
US20210285855A1 (en) | 2021-09-16 |
EP3734294A4 (en) | 2021-09-29 |
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