JP2021506941A5 - - Google Patents
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- Publication number
- JP2021506941A5 JP2021506941A5 JP2020534861A JP2020534861A JP2021506941A5 JP 2021506941 A5 JP2021506941 A5 JP 2021506941A5 JP 2020534861 A JP2020534861 A JP 2020534861A JP 2020534861 A JP2020534861 A JP 2020534861A JP 2021506941 A5 JP2021506941 A5 JP 2021506941A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pyrrolo
- piperidinyl
- pyrrolidinyl
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762607941P | 2017-12-20 | 2017-12-20 | |
| US62/607,941 | 2017-12-20 | ||
| PCT/US2018/066108 WO2019126083A1 (en) | 2017-12-20 | 2018-12-18 | Diazaindole compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506941A JP2021506941A (ja) | 2021-02-22 |
| JP2021506941A5 true JP2021506941A5 (https=) | 2022-01-06 |
| JP7382938B2 JP7382938B2 (ja) | 2023-11-17 |
Family
ID=65003573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534861A Active JP7382938B2 (ja) | 2017-12-20 | 2018-12-18 | ジアザインドール化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11299501B2 (https=) |
| EP (1) | EP3728264B1 (https=) |
| JP (1) | JP7382938B2 (https=) |
| KR (1) | KR102722182B1 (https=) |
| CN (1) | CN111511744B (https=) |
| AU (1) | AU2018390544A1 (https=) |
| BR (1) | BR112020012002A2 (https=) |
| CA (1) | CA3085937A1 (https=) |
| EA (1) | EA202091530A1 (https=) |
| ES (1) | ES2904773T3 (https=) |
| IL (1) | IL275505A (https=) |
| MX (1) | MX2020006014A (https=) |
| SG (1) | SG11202005733QA (https=) |
| WO (1) | WO2019126083A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| KR102730859B1 (ko) * | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
| EP3728218B1 (en) * | 2017-12-20 | 2021-12-01 | Bristol-Myers Squibb Company | Amino indole compounds useful as tlr inhibitors |
| JP7328977B2 (ja) | 2018-02-12 | 2023-08-17 | エフ． ホフマン－ラ ロシュ アーゲー | ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体 |
| EP3802539B1 (en) | 2018-06-05 | 2023-09-20 | F. Hoffmann-La Roche AG | Tetrahydro-1h-pyrazino[2,1-a]isoindolylquinoline compounds for the treatment of autoimmune disease |
| EP3807270B1 (en) | 2018-06-12 | 2023-09-13 | F. Hoffmann-La Roche AG | Novel heteroaryl heterocyclyl compounds for the treatment of autoimmune disease |
| CN112584903B (zh) | 2018-07-23 | 2025-12-23 | 豪夫迈·罗氏有限公司 | 用于自身免疫性疾病治疗的哌嗪化合物 |
| EP3847169A1 (en) | 2018-09-04 | 2021-07-14 | F. Hoffmann-La Roche AG | Benzothiazole compounds for the treatment of autoimmune diseases |
| US11548884B2 (en) | 2018-09-06 | 2023-01-10 | Hoffmann-La Roche Inc. | Cyclic amidine compounds for the treatment of autoimmune disease |
| EP3847173B1 (en) | 2018-09-06 | 2023-04-12 | F. Hoffmann-La Roche AG | Novel pyrazolopyridine compounds for the treatment of autoimmune disease |
| WO2021084022A1 (en) | 2019-10-31 | 2021-05-06 | F. Hoffmann-La Roche Ag | Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease |
| CN114728976B (zh) | 2019-11-19 | 2024-08-16 | 豪夫迈·罗氏有限公司 | 用于治疗自身免疫性疾病的氢-1H-吡咯并[1,2-a]吡嗪化合物 |
| WO2021099406A1 (en) | 2019-11-20 | 2021-05-27 | F. Hoffmann-La Roche Ag | Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease |
| CN116075510A (zh) | 2020-08-19 | 2023-05-05 | 百时美施贵宝公司 | 1H-苯并[d]咪唑衍生物作为TLR9抑制剂用于治疗纤维化 |
| AU2021328575A1 (en) | 2020-08-19 | 2023-03-16 | Bristol-Myers Squibb Company | Imidazo(1,2-a)pyridine and (1,2,4)triazolo(1,5-a)pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis |
| WO2022040267A1 (en) | 2020-08-19 | 2022-02-24 | Bristol-Myers Squibb Company | 1h-pyrrolo[3,2-c]pyridine and 1h-pyrrolo[2,3-c]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
| WO2022166920A1 (zh) * | 2021-02-08 | 2022-08-11 | 杭州中美华东制药有限公司 | 一种吡咯并哒嗪类化合物及其制备方法和用途 |
| CN116783202A (zh) * | 2021-02-09 | 2023-09-19 | 吉利德科学公司 | 噻吩并吡咯化合物 |
| CR20230478A (es) | 2021-04-16 | 2023-11-30 | Gilead Sciences Inc | Compuestos de tienopirrol. |
| KR20240056747A (ko) | 2021-09-10 | 2024-04-30 | 길리애드 사이언시즈, 인코포레이티드 | 티에노피롤 화합물 |
| MX2024009441A (es) * | 2022-02-18 | 2024-08-14 | Bristol Myers Squibb Co | Compuestos de imidazopiridinilo sustituidos utiles como inhibidores del receptor tipo toll 9 (tlr9). |
| CN114591339B (zh) * | 2022-05-10 | 2022-08-02 | 上海维申医药有限公司 | 一类Toll样受体抑制剂及其制备和应用 |
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| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| WO2000035886A2 (en) | 1998-12-18 | 2000-06-22 | Axys Pharmaceuticals, Inc. | (hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors |
| HRP20020349A2 (en) | 1999-10-19 | 2004-02-29 | Merck & Co Inc | Tyrosine kinase inhibitors |
| AU2003235741B8 (en) | 2002-01-07 | 2009-01-15 | Eisai R&D Management Co., Ltd. | Deazapurines and uses thereof |
| BRPI0411514A (pt) | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
| WO2006113458A1 (en) | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
| CA2648652A1 (en) | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| US8027888B2 (en) | 2006-08-31 | 2011-09-27 | Experian Interactive Innovation Center, Llc | Online credit card prescreen systems and methods |
| JP2010511018A (ja) | 2006-12-01 | 2010-04-08 | ガラパゴス・ナムローゼ・フェンノートシャップ | 変性疾患及び炎症性疾患の治療に有用なトリアゾロピリジン化合物 |
| WO2008152471A1 (en) | 2007-06-12 | 2008-12-18 | Coley Pharmaceutical Group, Inc. | Quinazoline derivative useful as toll-like receptor antagonist |
| WO2009030996A1 (en) | 2007-09-05 | 2009-03-12 | Coley Pharmaceutical Group, Inc. | Triazole compounds as toll-like receptor (tlr) agonists |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| WO2010036905A1 (en) | 2008-09-26 | 2010-04-01 | Eisai R & D Management Co., Ltd. | Benzoxazole compounds and methods of use |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| JP5864417B2 (ja) | 2009-07-16 | 2016-02-17 | マリンクロッド エルエルシー | トール様受容体９のアンタゴニストとしての（＋）−モルフィナンおよびその治療的使用 |
| RU2012116207A (ru) | 2009-09-24 | 2013-10-27 | Ф.Хоффманн-Ля Рош Аг | Производные индола в качестве модуляторов crac |
| MX2012004792A (es) | 2009-10-22 | 2013-02-01 | Vertex Pharma | Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas. |
| JP2013166700A (ja) * | 2010-06-02 | 2013-08-29 | Dainippon Sumitomo Pharma Co Ltd | 新規４，５−縮環ピリミジン誘導体 |
| WO2012054862A2 (en) | 2010-10-21 | 2012-04-26 | The Brigham And Women's Hospital, Inc. | Agents, compositions, and methods for treating pruritis and related skin conditions |
| CN103562201B (zh) | 2011-01-12 | 2016-10-19 | 帆德制药股份有限公司 | 作为toll样受体调节剂的取代的苯并氮杂卓 |
| DK2663550T3 (en) | 2011-01-12 | 2017-03-27 | Ventirx Pharmaceuticals Inc | SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS |
| KR102052215B1 (ko) | 2011-06-01 | 2019-12-04 | 야누스 바이오테라퓨틱스, 인크. | 신규한 면역 시스템 조절제 |
| WO2012167053A1 (en) | 2011-06-01 | 2012-12-06 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
| KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
| KR101913135B1 (ko) | 2011-07-15 | 2018-10-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체 |
| JP2013075834A (ja) * | 2011-09-29 | 2013-04-25 | Kowa Co | Ｔｌｒ９阻害活性を有するピラゾロピリミジン−７−アミン誘導体 |
| WO2013052550A2 (en) | 2011-10-04 | 2013-04-11 | Janus Biotherapeutics, Inc. | Novel imidazole quinoline-based immune system modulators |
| US20130158040A1 (en) | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | Diazaindole inhibitors of crac |
| TWI619704B (zh) | 2012-05-18 | 2018-04-01 | 大日本住友製藥股份有限公司 | 羧酸化合物 |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| EP2738172A1 (en) | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
| JP6223563B2 (ja) | 2013-10-14 | 2017-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的に置換されたキノリン化合物 |
| CN105992766A (zh) | 2013-12-13 | 2016-10-05 | 武田药品工业株式会社 | 作为tlr抑制剂的吡咯并[3,2-c]吡啶衍生物 |
| HUE054672T2 (hu) | 2014-08-15 | 2021-09-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | TLR7 agonistaként alkalmazott pirrolopirimidin vegyületek |
| EP3398948A3 (en) | 2014-08-22 | 2018-12-05 | Janus Biotherapeutics, Inc. | 2,4,6,7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof |
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| BR112019001270A2 (pt) | 2016-07-30 | 2019-04-30 | Bristol-Myers Squibb Company | compostos indol substituídos com dimetoxifenila como inibidores de tlr7, tlr8 ou tlr9 |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| JP7265554B2 (ja) | 2017-11-14 | 2023-04-26 | ブリストル－マイヤーズ スクイブ カンパニー | 置換インドール化合物 |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| JP7304352B2 (ja) | 2017-12-19 | 2023-07-06 | ブリストル－マイヤーズ スクイブ カンパニー | ６－アザインドール化合物 |
-
2018
- 2018-12-18 SG SG11202005733QA patent/SG11202005733QA/en unknown
- 2018-12-18 EP EP18830674.0A patent/EP3728264B1/en active Active
- 2018-12-18 EA EA202091530A patent/EA202091530A1/ru unknown
- 2018-12-18 BR BR112020012002-2A patent/BR112020012002A2/pt not_active Application Discontinuation
- 2018-12-18 CN CN201880082762.7A patent/CN111511744B/zh active Active
- 2018-12-18 WO PCT/US2018/066108 patent/WO2019126083A1/en not_active Ceased
- 2018-12-18 CA CA3085937A patent/CA3085937A1/en active Pending
- 2018-12-18 KR KR1020207020851A patent/KR102722182B1/ko active Active
- 2018-12-18 US US16/955,108 patent/US11299501B2/en active Active
- 2018-12-18 AU AU2018390544A patent/AU2018390544A1/en not_active Abandoned
- 2018-12-18 MX MX2020006014A patent/MX2020006014A/es unknown
- 2018-12-18 JP JP2020534861A patent/JP7382938B2/ja active Active
- 2018-12-18 ES ES18830674T patent/ES2904773T3/es active Active
-
2020
- 2020-06-18 IL IL275505A patent/IL275505A/en unknown
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