JP2021502356A5 - - Google Patents
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- JP2021502356A5 JP2021502356A5 JP2020524775A JP2020524775A JP2021502356A5 JP 2021502356 A5 JP2021502356 A5 JP 2021502356A5 JP 2020524775 A JP2020524775 A JP 2020524775A JP 2020524775 A JP2020524775 A JP 2020524775A JP 2021502356 A5 JP2021502356 A5 JP 2021502356A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- dimethyl
- hydroxy
- dihydro
- phenylethyl
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762581847P | 2017-11-06 | 2017-11-06 | |
| US62/581,847 | 2017-11-06 | ||
| PCT/US2018/059137 WO2019090198A1 (en) | 2017-11-06 | 2018-11-05 | Isofuranone compounds useful as hpk1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502356A JP2021502356A (ja) | 2021-01-28 |
| JP2021502356A5 true JP2021502356A5 (https=) | 2021-12-09 |
| JP7167146B2 JP7167146B2 (ja) | 2022-11-08 |
Family
ID=64457099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524775A Active JP7167146B2 (ja) | 2017-11-06 | 2018-11-05 | Ｈｐｋ１阻害剤として有用なイソフラノン化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11166959B2 (https=) |
| EP (1) | EP3707138B1 (https=) |
| JP (1) | JP7167146B2 (https=) |
| KR (1) | KR102808367B1 (https=) |
| CN (1) | CN111527084B (https=) |
| ES (1) | ES2925450T3 (https=) |
| WO (1) | WO2019090198A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053191T2 (hu) | 2017-02-09 | 2021-06-28 | Bayer Ag | 2-Heteroaril-3-oxo-2,3-dihidropiridazin-4-karboxamidok rák kezelésére |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| MA56462A (fr) | 2019-07-04 | 2022-05-11 | Qilu Regor Therapeutics Inc | Inhibiteurs de hpk1 et leurs utilisations |
| MX2022002877A (es) * | 2019-09-13 | 2022-08-08 | Nimbus Saturn Inc | Antagonistas de cinasa progenitora hematopoyetica 1 (hpk1) y sus usos. |
| WO2021249913A1 (en) | 2020-06-09 | 2021-12-16 | Bayer Aktiengesellschaft | 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer |
| CN117338775A (zh) * | 2020-06-16 | 2024-01-05 | 格格巫（珠海）生物科技有限公司 | 一种化合物在预防和/或治疗动物的病原体感染中的应用 |
| CN113797202B (zh) * | 2020-06-16 | 2024-06-28 | 珠海宇繁生物科技有限责任公司 | Hpk1激酶抑制剂在预防和/或治疗动物的病原体感染中的应用 |
| WO2022063140A1 (en) * | 2020-09-23 | 2022-03-31 | Shenzhen Ionova Life Science Co., Ltd. | Pyrimidine and pyridine derivatives as hpk1 modulator and methods using same |
| WO2022064459A1 (en) * | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
| CN114437074A (zh) | 2020-11-03 | 2022-05-06 | 北京伯汇生物技术有限公司 | 一种化合物、含该化合物的药物组合物及其用途 |
| US20230416225A1 (en) * | 2020-11-09 | 2023-12-28 | Merck Sharp & Dohme Llc | Diaminopyrimidine carboxamide inhibitors of hpk1 |
| CN121851009A (zh) * | 2021-01-22 | 2026-04-14 | 苏州信诺维医药科技股份有限公司 | Hpk1抑制剂、其制备方法、药物组合物及其应用 |
| US20240174683A1 (en) | 2021-02-05 | 2024-05-30 | Bayer Aktiengesellschaft | Map4k1 inhibitors |
| US11926625B2 (en) * | 2021-03-05 | 2024-03-12 | Nimbus Saturn, Inc. | HPK1 antagonists and uses thereof |
| WO2022188735A1 (en) * | 2021-03-08 | 2022-09-15 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as hpk1 inhibitors |
| WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| WO2022253252A1 (en) * | 2021-06-03 | 2022-12-08 | Silexon Biotech Co., Ltd. | Heterocyclic compounds useful as hpk1 inhibitors |
| TW202321239A (zh) | 2021-07-20 | 2023-06-01 | 瑞典商阿斯特捷利康公司 | 作為ｈｐｋ１抑制劑用於治療癌症之經取代的吡𠯤—２—甲醯胺 |
| WO2023015199A1 (en) * | 2021-08-03 | 2023-02-09 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| EP4401735A4 (en) * | 2021-09-16 | 2025-07-16 | Lomond Therapeutics Inc | COMPOUNDS COMPRISING N-ARYLPYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC AGENTS |
| CN115838373A (zh) | 2021-09-18 | 2023-03-24 | 北京伯汇生物技术有限公司 | 氮杂吲唑大环化合物及其用途 |
| AU2022398484A1 (en) * | 2021-11-23 | 2024-06-13 | Cullinan Oncology, Inc. | Heterobifunctional compounds as hpk1 degraders |
| WO2023138612A1 (en) * | 2022-01-19 | 2023-07-27 | Silexon Ai Technology Co., Ltd. | Heterocyclic compounds useful as hpk1 inhibitors |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
| CN116947883B (zh) * | 2022-04-20 | 2025-10-17 | 南京得恒医药科技有限公司 | 一种大环化合物及其制备方法和应用、一种药物组合物 |
| KR102939283B1 (ko) * | 2022-05-03 | 2026-03-13 | 한국화학연구원 | 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2025080099A1 (ko) * | 2023-10-13 | 2025-04-17 | 주식회사유한양행 | 7,7-다이메틸푸로[3,4-b]피리딘-5(7h)-온 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
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|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
| PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| US8450351B2 (en) | 2005-12-20 | 2013-05-28 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CA2654670A1 (en) * | 2006-07-06 | 2008-01-10 | Boehringer Ingelheim International Gmbh | New compounds |
| WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| US8591886B2 (en) | 2007-07-12 | 2013-11-26 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
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| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
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| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
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| RU2670743C9 (ru) | 2012-05-11 | 2018-12-19 | Файв Прайм Терапьютикс, Инк. | Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
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| JP6215338B2 (ja) * | 2012-11-08 | 2017-10-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | キナーゼモジュレーターとして有用な二環式ヘテロ環置換ピリジル化合物 |
| ES2792979T3 (es) | 2013-08-22 | 2020-11-12 | Jubilant Biosys Ltd | Compuestos de pirimidina sustituidos, composiciones y aplicaciones médicas de los mismos |
| CN107206088A (zh) | 2014-12-05 | 2017-09-26 | 豪夫迈·罗氏有限公司 | 使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物 |
| MA42456B1 (fr) * | 2015-06-25 | 2021-06-30 | Univ Health Network | Inhibiteurs de hpk1 et leurs procédés d'utilisation |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
| WO2018102366A1 (en) | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| AU2018244935A1 (en) | 2017-03-30 | 2019-08-15 | F. Hoffmann-La Roche Ag | Naphthyridines as inhibitors of HPK1 |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
-
2018
- 2018-11-05 EP EP18808167.3A patent/EP3707138B1/en active Active
- 2018-11-05 ES ES18808167T patent/ES2925450T3/es active Active
- 2018-11-05 CN CN201880084880.1A patent/CN111527084B/zh active Active
- 2018-11-05 US US16/761,449 patent/US11166959B2/en active Active
- 2018-11-05 JP JP2020524775A patent/JP7167146B2/ja active Active
- 2018-11-05 WO PCT/US2018/059137 patent/WO2019090198A1/en not_active Ceased
- 2018-11-05 KR KR1020207015987A patent/KR102808367B1/ko active Active
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