KR102808367B1 - Hpk1 억제제로서 유용한 이소푸라논 화합물 - Google Patents

Hpk1 억제제로서 유용한 이소푸라논 화합물 Download PDF

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KR102808367B1
KR102808367B1 KR1020207015987A KR20207015987A KR102808367B1 KR 102808367 B1 KR102808367 B1 KR 102808367B1 KR 1020207015987 A KR1020207015987 A KR 1020207015987A KR 20207015987 A KR20207015987 A KR 20207015987A KR 102808367 B1 KR102808367 B1 KR 102808367B1
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amino
hydroxy
dimethyl
phenylethyl
dihydro
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에리카 엠. 브이. 아라우조
얀 첸
비레쉬와르 다스굽타
앤드류 피. 데그난
매튜 디. 힐
고드윈 콰메 쿠미
해럴드 에이. 마스탈레르츠
마크 디. 위트만
브래들리 씨. 피어스
구이펜 장
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브리스톨-마이어스 스큅 컴퍼니
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Plural Heterocyclic Compounds (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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KR1020207015987A 2017-11-06 2018-11-05 Hpk1 억제제로서 유용한 이소푸라논 화합물 Active KR102808367B1 (ko)

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US201762581847P 2017-11-06 2017-11-06
US62/581,847 2017-11-06
PCT/US2018/059137 WO2019090198A1 (en) 2017-11-06 2018-11-05 Isofuranone compounds useful as hpk1 inhibitors

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KR20200085303A KR20200085303A (ko) 2020-07-14
KR102808367B1 true KR102808367B1 (ko) 2025-05-14

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US (1) US11166959B2 (https=)
EP (1) EP3707138B1 (https=)
JP (1) JP7167146B2 (https=)
KR (1) KR102808367B1 (https=)
CN (1) CN111527084B (https=)
ES (1) ES2925450T3 (https=)
WO (1) WO2019090198A1 (https=)

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CN114945366B (zh) * 2019-09-13 2025-01-07 林伯士萨顿公司 Hpk1拮抗剂和其用途
WO2021249913A1 (en) 2020-06-09 2021-12-16 Bayer Aktiengesellschaft 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
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CN113797202B (zh) * 2020-06-16 2024-06-28 珠海宇繁生物科技有限责任公司 Hpk1激酶抑制剂在预防和/或治疗动物的病原体感染中的应用
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CN118804913A (zh) * 2021-11-23 2024-10-18 西奈山伊坎医学院 作为hpk1降解剂的异双功能化合物
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KR102939283B1 (ko) * 2022-05-03 2026-03-13 한국화학연구원 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
WO2025080099A1 (ko) * 2023-10-13 2025-04-17 주식회사유한양행 7,7-다이메틸푸로[3,4-b]피리딘-5(7h)-온 유도체 또는 이의 염 및 이를 포함하는 약학 조성물

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