JP2021502063A5 - - Google Patents
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- JP2021502063A5 JP2021502063A5 JP2020524000A JP2020524000A JP2021502063A5 JP 2021502063 A5 JP2021502063 A5 JP 2021502063A5 JP 2020524000 A JP2020524000 A JP 2020524000A JP 2020524000 A JP2020524000 A JP 2020524000A JP 2021502063 A5 JP2021502063 A5 JP 2021502063A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding
- chimeric protein
- protein
- binding chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107875A JP2023138991A (ja) | 2017-10-31 | 2023-06-30 | 新規抗原結合性キメラタンパク質とその方法及び使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199472.6 | 2017-10-31 | ||
| EP17199472 | 2017-10-31 | ||
| EP18199709 | 2018-10-10 | ||
| EP18199709.9 | 2018-10-10 | ||
| PCT/EP2018/079891 WO2019086548A1 (en) | 2017-10-31 | 2018-10-31 | Novel antigen-binding chimeric proteins and methods and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107875A Division JP2023138991A (ja) | 2017-10-31 | 2023-06-30 | 新規抗原結合性キメラタンパク質とその方法及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502063A JP2021502063A (ja) | 2021-01-28 |
| JP2021502063A5 true JP2021502063A5 (https=) | 2021-09-24 |
| JP7760115B2 JP7760115B2 (ja) | 2025-10-27 |
Family
ID=64308706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524000A Active JP7760115B2 (ja) | 2017-10-31 | 2018-10-31 | 新規抗原結合性キメラタンパク質とその方法及び使用 |
| JP2023107875A Withdrawn JP2023138991A (ja) | 2017-10-31 | 2023-06-30 | 新規抗原結合性キメラタンパク質とその方法及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107875A Withdrawn JP2023138991A (ja) | 2017-10-31 | 2023-06-30 | 新規抗原結合性キメラタンパク質とその方法及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11873347B2 (https=) |
| EP (2) | EP3704160B1 (https=) |
| JP (2) | JP7760115B2 (https=) |
| KR (2) | KR20200091400A (https=) |
| CN (1) | CN111315784A (https=) |
| CA (1) | CA3076791A1 (https=) |
| WO (1) | WO2019086548A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020127993A1 (en) * | 2018-12-21 | 2020-06-25 | Vib Vzw | Fusion protein with a toxin and scaffold protein |
| JP7627910B2 (ja) * | 2018-12-21 | 2025-02-07 | フエー・イー・ベー・フエー・ゼツト・ウエー | サイトカイン及び足場タンパク質を含む融合タンパク質 |
| EP3986437A4 (en) * | 2019-06-18 | 2023-06-07 | Musc Foundation for Research Development | COMPOSITIONS TARGETED AGAINST THE NUCLEOTIDE-FREE STATE OF RAS AND METHODS FOR BLOCKING ONCOGENIC SIGNALING AND TRANSFORMATION |
| US20220378925A1 (en) * | 2019-09-26 | 2022-12-01 | Orionis Biosciences, Inc. | Conjugated chimeric proteins |
| EP3799881A1 (en) | 2019-10-04 | 2021-04-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Single domain antibodies specifically binding globo - series glycans |
| CN110982824B (zh) * | 2019-10-09 | 2022-04-15 | 天津大学 | 拮抗pd-1的抗体类似物bp基因及蛋白和应用 |
| WO2021078786A1 (en) | 2019-10-21 | 2021-04-29 | Vib Vzw | Nanodisc-specific antigen-binding chimeric proteins |
| US20240027467A1 (en) * | 2019-12-20 | 2024-01-25 | Vib Vzw | Nanobody Exchange Chromatography |
| EP3845553A1 (en) * | 2019-12-30 | 2021-07-07 | Johann Wolfgang Goethe-Universität | Carrier matrix comprising dodecin protein |
| JP7657406B2 (ja) * | 2020-02-17 | 2025-04-07 | 国立大学法人大阪大学 | 膜タンパク質の結晶化方法及び膜タンパク質の構造解析方法 |
| CN111518180B (zh) * | 2020-04-10 | 2023-01-03 | 四川大学 | 一种结核病候选疫苗融合蛋白 |
| US20230382977A1 (en) * | 2020-09-24 | 2023-11-30 | The Regents Of The University Of California | Multimeric protein complexes as antibody substitutes for neutralization of viral pathogens in prophylactic and therapeutic applications |
| WO2022218928A1 (en) * | 2021-04-12 | 2022-10-20 | Saiba AG | Modified virus-like particles of bacteriophage ap205 |
| WO2022268993A1 (en) | 2021-06-23 | 2022-12-29 | Vib Vzw | Means and methods for selection of specific binders |
| US12050189B2 (en) * | 2021-09-10 | 2024-07-30 | President And Fellows Of Harvard College | Compositions and methods relating to structural determination of small proteins |
| EP4408461A1 (en) * | 2021-09-30 | 2024-08-07 | AdaptVac ApS | Methods and particles for modulating an immune response |
| US20230368862A1 (en) * | 2021-12-07 | 2023-11-16 | The Trustees Of Columbia University In The City Of New York | Binding site in type 2 ryanodine receptor |
| CN114540328A (zh) * | 2022-02-18 | 2022-05-27 | 浙江工业大学 | 一种温度敏感型α-淀粉酶及其制备方法与应用 |
| CN115819599B (zh) * | 2022-11-29 | 2024-01-16 | 江苏耀海生物制药有限公司 | 一种利用重组大肠杆菌分泌表达纳米抗体Cablivi的方法 |
| EP4474016A1 (en) | 2023-06-07 | 2024-12-11 | Julius-Maximilians-Universität Würzburg | Strategies to target extracellularly accessible ras protein |
| EP4731770A1 (en) | 2023-06-22 | 2026-04-29 | Ablynx NV | Chimeric proteins for modulating cytokine receptor activity |
| US20250084130A1 (en) * | 2023-08-25 | 2025-03-13 | Trustees Of Boston University | Engineered mcp and pcp proteins and systems and methods thereof |
| WO2025061726A1 (en) * | 2023-09-18 | 2025-03-27 | John Innes Centre | Vlp-scaffold based binding proteins |
| WO2025129010A1 (en) * | 2023-12-14 | 2025-06-19 | Genentech, Inc. | Methods of structure determination using antibodies |
| WO2025172894A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified nanoparticle subunits and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| ES2294799T3 (es) | 1996-06-27 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana. |
| AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
| EP1141711A1 (en) | 1999-01-05 | 2001-10-10 | Unilever Plc | Binding of antibody fragments to solid supports |
| DK1144616T4 (da) | 1999-01-19 | 2009-03-30 | Unilever Nv | Fremgangsmåde til fremstilling af antistoffragmenter |
| CA2370351A1 (en) | 1999-04-22 | 2000-11-02 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| WO2001040310A2 (en) | 1999-11-29 | 2001-06-07 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| ES2331051T3 (es) | 1999-11-29 | 2009-12-21 | Bac Ip B.V. | Inmovilizacion de moleculas de union de antigenos de un dominio. |
| ES2324280T3 (es) | 2000-03-14 | 2009-08-04 | Unilever N.V. | Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos. |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| ATE513854T1 (de) | 2000-12-13 | 2011-07-15 | Bac Ip B V | Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen |
| DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| JP4213586B2 (ja) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| EP1456410A2 (en) | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| EP1456237A2 (en) | 2001-12-21 | 2004-09-15 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Method for cloning of variable domain sequences |
| CA2471645A1 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| WO2004041863A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
| MXPA05007151A (es) | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| JP2006517789A (ja) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| EP1656128A4 (en) | 2003-08-12 | 2007-02-28 | William M Yarbrough | SINGLE ACNE TREATMENT AND METHOD OF USE |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| US8188223B2 (en) | 2005-05-18 | 2012-05-29 | Ablynx N.V. | Serum albumin binding proteins |
| ES2694247T3 (es) | 2005-05-20 | 2018-12-19 | Ablynx N.V. | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| EP2121757A2 (en) | 2007-02-21 | 2009-11-25 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| CA2687903C (en) | 2007-05-24 | 2016-09-13 | Ablynx N.V. | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
| GB201008682D0 (en) | 2010-05-25 | 2010-07-07 | Vib Vzw | Epitope tag for affinity based applications |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| SG10201805064SA (en) | 2011-06-23 | 2018-07-30 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| NO2723764T3 (https=) * | 2011-09-15 | 2018-05-26 | ||
| CN105102478A (zh) * | 2013-01-30 | 2015-11-25 | 弗拉芒区生物技术研究所 | 用于筛选和药物发现目的的新型嵌合多肽 |
| US20150368339A1 (en) | 2013-02-05 | 2015-12-24 | Vib Vzw | Muscarinic acetylcholine receptor binding agents and uses thereof |
| PL3097197T3 (pl) | 2014-01-21 | 2021-06-28 | Vrije Universiteit Brussel | Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie |
| EP4707303A2 (en) | 2014-05-16 | 2026-03-11 | Ablynx NV | Improved immunoglobulin variable domains |
-
2018
- 2018-10-31 KR KR1020207013860A patent/KR20200091400A/ko not_active Ceased
- 2018-10-31 CA CA3076791A patent/CA3076791A1/en active Pending
- 2018-10-31 CN CN201880071396.5A patent/CN111315784A/zh active Pending
- 2018-10-31 EP EP18803339.3A patent/EP3704160B1/en active Active
- 2018-10-31 JP JP2020524000A patent/JP7760115B2/ja active Active
- 2018-10-31 EP EP25196498.7A patent/EP4635987A3/en active Pending
- 2018-10-31 KR KR1020257015867A patent/KR20250070615A/ko active Pending
- 2018-10-31 US US16/760,394 patent/US11873347B2/en active Active
- 2018-10-31 WO PCT/EP2018/079891 patent/WO2019086548A1/en not_active Ceased
-
2023
- 2023-06-30 JP JP2023107875A patent/JP2023138991A/ja not_active Withdrawn
- 2023-11-21 US US18/516,777 patent/US20240174767A1/en active Pending
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