JP2021501760A5 - - Google Patents
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- Publication number
- JP2021501760A5 JP2021501760A5 JP2020524345A JP2020524345A JP2021501760A5 JP 2021501760 A5 JP2021501760 A5 JP 2021501760A5 JP 2020524345 A JP2020524345 A JP 2020524345A JP 2020524345 A JP2020524345 A JP 2020524345A JP 2021501760 A5 JP2021501760 A5 JP 2021501760A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- branched
- linear
- substituted
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- -1 -CF 3 groups Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382741.1A EP3480201A1 (en) | 2017-11-06 | 2017-11-06 | New analogs as androgen receptor and glucocorticoid receptor modulators |
| EP17382741.1 | 2017-11-06 | ||
| PCT/EP2018/080367 WO2019086720A1 (en) | 2017-11-06 | 2018-11-06 | New analogs as androgen receptor and glucocorticoid receptor modulators |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021501760A JP2021501760A (ja) | 2021-01-21 |
| JP2021501760A5 true JP2021501760A5 (enExample) | 2021-12-16 |
| JPWO2019086720A5 JPWO2019086720A5 (enExample) | 2023-01-19 |
| JP7239246B2 JP7239246B2 (ja) | 2023-03-14 |
Family
ID=60327253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524345A Active JP7239246B2 (ja) | 2017-11-06 | 2018-11-06 | アンドロゲン受容体調節因子及びグルココルチコイド受容体調節因子としての新規アナログ |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11453660B2 (enExample) |
| EP (2) | EP3480201A1 (enExample) |
| JP (1) | JP7239246B2 (enExample) |
| KR (1) | KR102762303B1 (enExample) |
| CN (1) | CN111491935B (enExample) |
| AU (1) | AU2018361566B2 (enExample) |
| CA (1) | CA3079804A1 (enExample) |
| DK (1) | DK3707143T3 (enExample) |
| EA (1) | EA202091148A1 (enExample) |
| ES (1) | ES2941263T3 (enExample) |
| FI (1) | FI3707143T3 (enExample) |
| HR (1) | HRP20230270T1 (enExample) |
| HU (1) | HUE061436T2 (enExample) |
| LT (1) | LT3707143T (enExample) |
| MX (1) | MX2020004688A (enExample) |
| PL (1) | PL3707143T3 (enExample) |
| PT (1) | PT3707143T (enExample) |
| RS (1) | RS64101B9 (enExample) |
| SI (1) | SI3707143T1 (enExample) |
| WO (1) | WO2019086720A1 (enExample) |
| ZA (1) | ZA202002920B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102737686B1 (ko) * | 2021-09-10 | 2024-12-03 | 계명대학교 산학협력단 | Jnj38877605를 유효성분으로 함유하는 비만 예방 또는 치료용 조성물 |
| CN113979883A (zh) * | 2021-12-08 | 2022-01-28 | 新华制药（寿光）有限公司 | 一种乙酰乙酰苯胺高效精制工艺及其设备 |
| TWI864587B (zh) | 2022-02-14 | 2024-12-01 | 美商基利科學股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| CN116496296A (zh) * | 2022-09-02 | 2023-07-28 | 河南师范大学 | 具有抗肿瘤功用的度鲁特韦衍生物及其制备方法 |
| WO2024229221A1 (en) * | 2023-05-03 | 2024-11-07 | Capulus Therapeutics, Llc | Androgen receptor modulators and methods for their use |
| CN117298108A (zh) * | 2023-09-07 | 2023-12-29 | 浙江师范大学 | 雄激素受体和糖皮激素受体双靶抑制剂及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659717A (en) * | 1985-08-21 | 1987-04-21 | Eli Lilly And Company | Dihydropyridines useful in the treatment of angina and stroke |
| US4902694A (en) * | 1988-08-11 | 1990-02-20 | Eli Lilly And Company | Dihydropyridine calcium channel modulators |
| DE4321030A1 (de) * | 1993-06-24 | 1995-01-05 | Bayer Ag | 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel |
| WO2005016885A2 (en) | 2003-08-14 | 2005-02-24 | Artesian Therapeutics, Inc. | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE |
| US20060116369A1 (en) | 2004-10-25 | 2006-06-01 | Shyamlal Ramchandani | Certain compounds, compositions, and methods |
| KR20070087602A (ko) * | 2004-12-13 | 2007-08-28 | 아이알엠 엘엘씨 | 화합물 및 스테로이드성 수용체 및 칼슘 채널 활성의조절제로서의 조성물 |
| WO2008070875A2 (en) * | 2006-12-08 | 2008-06-12 | Roskamp Research Llc | Polyhydroquinoline compounds and dihydropyridine compounds for inhibiting beta-amyloid production |
| CL2007003609A1 (es) * | 2006-12-14 | 2008-07-25 | Bayer Schering Pharma Ag | Compuestos derivados de dihidropiridinas sustituidas; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; proceso para producir la composicion farmaceutica; y uso en el tratamiento de una enfermedad mejorada con la inhibicion |
| EP2178563A2 (en) | 2007-07-06 | 2010-04-28 | OSI Pharmaceuticals, Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mtorc2 |
| TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
| EP2817019A4 (en) | 2012-02-24 | 2016-04-06 | Univ Chicago | METHOD AND COMPOSITIONS RELATED TO GLUCOCORTICOIDREZEPTORANTAGONISM AND PROSTATE CANCER |
| US20180303807A1 (en) | 2015-10-01 | 2018-10-25 | John Katzenellenbogen | Androgen receptor ligands |
-
2017
- 2017-11-06 EP EP17382741.1A patent/EP3480201A1/en not_active Withdrawn
-
2018
- 2018-11-06 JP JP2020524345A patent/JP7239246B2/ja active Active
- 2018-11-06 AU AU2018361566A patent/AU2018361566B2/en active Active
- 2018-11-06 HR HRP20230270TT patent/HRP20230270T1/hr unknown
- 2018-11-06 US US16/761,921 patent/US11453660B2/en active Active
- 2018-11-06 KR KR1020207015024A patent/KR102762303B1/ko active Active
- 2018-11-06 PT PT187956875T patent/PT3707143T/pt unknown
- 2018-11-06 LT LTEPPCT/EP2018/080367T patent/LT3707143T/lt unknown
- 2018-11-06 SI SI201830883T patent/SI3707143T1/sl unknown
- 2018-11-06 HU HUE18795687A patent/HUE061436T2/hu unknown
- 2018-11-06 EA EA202091148A patent/EA202091148A1/ru unknown
- 2018-11-06 RS RS20230220A patent/RS64101B9/sr unknown
- 2018-11-06 PL PL18795687.5T patent/PL3707143T3/pl unknown
- 2018-11-06 MX MX2020004688A patent/MX2020004688A/es unknown
- 2018-11-06 DK DK18795687.5T patent/DK3707143T3/da active
- 2018-11-06 CN CN201880081730.5A patent/CN111491935B/zh active Active
- 2018-11-06 ES ES18795687T patent/ES2941263T3/es active Active
- 2018-11-06 CA CA3079804A patent/CA3079804A1/en active Pending
- 2018-11-06 FI FIEP18795687.5T patent/FI3707143T3/fi active
- 2018-11-06 WO PCT/EP2018/080367 patent/WO2019086720A1/en not_active Ceased
- 2018-11-06 EP EP18795687.5A patent/EP3707143B9/en active Active
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2020
- 2020-05-19 ZA ZA2020/02920A patent/ZA202002920B/en unknown