JP2021501202A5 - - Google Patents
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- Publication number
- JP2021501202A5 JP2021501202A5 JP2020543258A JP2020543258A JP2021501202A5 JP 2021501202 A5 JP2021501202 A5 JP 2021501202A5 JP 2020543258 A JP2020543258 A JP 2020543258A JP 2020543258 A JP2020543258 A JP 2020543258A JP 2021501202 A5 JP2021501202 A5 JP 2021501202A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(cc1)c(*)cc1S(c(cc1)cc(*)c1N(C=NN1)C1=S)(=O)=O Chemical compound *c(cc1)c(*)cc1S(c(cc1)cc(*)c1N(C=NN1)C1=S)(=O)=O 0.000 description 6
- BJWHWZOMLHXKPF-UHFFFAOYSA-N O=S(c(cc1)ccc1N(C=NN1)C1=S)(c(cc1)cc(C(F)(F)F)c1Cl)=O Chemical compound O=S(c(cc1)ccc1N(C=NN1)C1=S)(c(cc1)cc(C(F)(F)F)c1Cl)=O BJWHWZOMLHXKPF-UHFFFAOYSA-N 0.000 description 4
- LVSRXKVDSYTMNS-UHFFFAOYSA-N O=S(c(cc1C(F)(F)F)ccc1Cl)(c(cc1N2CCOCC2)ccc1N(C=NN1)C1=S)=O Chemical compound O=S(c(cc1C(F)(F)F)ccc1Cl)(c(cc1N2CCOCC2)ccc1N(C=NN1)C1=S)=O LVSRXKVDSYTMNS-UHFFFAOYSA-N 0.000 description 4
- MLJOILDVPRGUBB-UHFFFAOYSA-N CC(C=CC(C1)S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)=C1C(F)(F)F Chemical compound CC(C=CC(C1)S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)=C1C(F)(F)F MLJOILDVPRGUBB-UHFFFAOYSA-N 0.000 description 2
- JGYMLRFLRKQKFK-UHFFFAOYSA-N CCOCCCOc1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S Chemical compound CCOCCCOc1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S JGYMLRFLRKQKFK-UHFFFAOYSA-N 0.000 description 2
- PFGRCDCBWOEEFM-UHFFFAOYSA-N CCOCCOC(C1)=CC=CC1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O Chemical compound CCOCCOC(C1)=CC=CC1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O PFGRCDCBWOEEFM-UHFFFAOYSA-N 0.000 description 2
- DDASGMSESIJHPI-UHFFFAOYSA-N CN(CC1)CCN1c1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S Chemical compound CN(CC1)CCN1c1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S DDASGMSESIJHPI-UHFFFAOYSA-N 0.000 description 2
- XGXYECKJJHUMNY-UHFFFAOYSA-N COCCOc1cccc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1 Chemical compound COCCOc1cccc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1 XGXYECKJJHUMNY-UHFFFAOYSA-N 0.000 description 2
- PWHDKJDNBVLTPG-UHFFFAOYSA-N COc(cc1)ccc1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O Chemical compound COc(cc1)ccc1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O PWHDKJDNBVLTPG-UHFFFAOYSA-N 0.000 description 2
- XDKARSCTAIMMMH-UHFFFAOYSA-N Cc(cc(cc1)S(Cc(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1Cl Chemical compound Cc(cc(cc1)S(Cc(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1Cl XDKARSCTAIMMMH-UHFFFAOYSA-N 0.000 description 2
- ZYYUGYKDUZBBPG-UHFFFAOYSA-N Cc(cc1)ccc1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O Chemical compound Cc(cc1)ccc1S(c(cc1)ccc1N(C=NN1)C1=S)(=O)=O ZYYUGYKDUZBBPG-UHFFFAOYSA-N 0.000 description 2
- VVZLDBPRESTKMI-UHFFFAOYSA-N Cc1cccc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1 Chemical compound Cc1cccc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)c1 VVZLDBPRESTKMI-UHFFFAOYSA-N 0.000 description 2
- DYPHXJSMKFKFEV-UHFFFAOYSA-N N#Cc1cc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)ccc1 Chemical compound N#Cc1cc(S(c(cc2)ccc2N(C=NN2)C2=S)(=O)=O)ccc1 DYPHXJSMKFKFEV-UHFFFAOYSA-N 0.000 description 2
- NVUMIZYTPVJJFQ-UHFFFAOYSA-N O=S(c(cc1)cc(C(F)(F)F)c1Cl)(c(cc1N2CCCC2)ccc1N(C=NN1)C1=S)=O Chemical compound O=S(c(cc1)cc(C(F)(F)F)c1Cl)(c(cc1N2CCCC2)ccc1N(C=NN1)C1=S)=O NVUMIZYTPVJJFQ-UHFFFAOYSA-N 0.000 description 2
- NBAWEYFXKDHXDB-UHFFFAOYSA-N O=S(c(cc1)ccc1N(C=NN1)C1=S)(c(cc1)ccc1N1CCOCC1)=O Chemical compound O=S(c(cc1)ccc1N(C=NN1)C1=S)(c(cc1)ccc1N1CCOCC1)=O NBAWEYFXKDHXDB-UHFFFAOYSA-N 0.000 description 2
- BKXODGURHNZWOJ-UHFFFAOYSA-N O=S(c1ccccc1)(c(cc1)ccc1N(C=NN1)C1=S)=O Chemical compound O=S(c1ccccc1)(c(cc1)ccc1N(C=NN1)C1=S)=O BKXODGURHNZWOJ-UHFFFAOYSA-N 0.000 description 2
- WQWQZKLHSMNXSN-UHFFFAOYSA-N OCCNc1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S Chemical compound OCCNc1cc(S(c(cc2)cc(C(F)(F)F)c2Cl)(=O)=O)ccc1N(C=NN1)C1=S WQWQZKLHSMNXSN-UHFFFAOYSA-N 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076473A JP2023100842A (ja) | 2017-10-30 | 2023-05-08 | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579070P | 2017-10-30 | 2017-10-30 | |
| US62/579,070 | 2017-10-30 | ||
| US201762584630P | 2017-11-10 | 2017-11-10 | |
| US62/584,630 | 2017-11-10 | ||
| PCT/US2018/058050 WO2019089478A1 (en) | 2017-10-30 | 2018-10-29 | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076473A Division JP2023100842A (ja) | 2017-10-30 | 2023-05-08 | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501202A JP2021501202A (ja) | 2021-01-14 |
| JP2021501202A5 true JP2021501202A5 (OSRAM) | 2021-11-18 |
| JP7277473B2 JP7277473B2 (ja) | 2023-05-19 |
Family
ID=66333645
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543258A Active JP7277473B2 (ja) | 2017-10-30 | 2018-10-29 | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
| JP2023076473A Pending JP2023100842A (ja) | 2017-10-30 | 2023-05-08 | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076473A Pending JP2023100842A (ja) | 2017-10-30 | 2023-05-08 | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10501423B2 (OSRAM) |
| EP (1) | EP3703675A4 (OSRAM) |
| JP (2) | JP7277473B2 (OSRAM) |
| KR (1) | KR102639231B1 (OSRAM) |
| CN (1) | CN111372579B (OSRAM) |
| AU (1) | AU2018359224B2 (OSRAM) |
| BR (1) | BR112020008727A2 (OSRAM) |
| CA (1) | CA3080578A1 (OSRAM) |
| IL (1) | IL274010B2 (OSRAM) |
| MX (1) | MX2020004202A (OSRAM) |
| SG (1) | SG11202003879RA (OSRAM) |
| WO (1) | WO2019089478A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3703675A4 (en) | 2017-10-30 | 2021-06-16 | Neuropore Therapies, Inc. | SUBSTITUTED PHENYLSULFONYLPHÉNYLTRIAZOLETHIONES AND ASSOCIATED USES |
| JP2021527692A (ja) * | 2018-06-20 | 2021-10-14 | ニューロポア セラピーズ インコーポレイテッド | Ｏａｔ３の阻害剤を用いた神経変性に関連する状態の処置方法 |
| CN117384029B (zh) * | 2023-12-12 | 2024-02-20 | 山东国邦药业有限公司 | 一种2,4,5-三氟苯乙酸的合成方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476503A (en) | 1973-06-21 | 1977-06-16 | Sterling Drug Inc | 1-arylamino-and 1-arylimino-pyrroles and preparation thereof |
| US4279637A (en) | 1979-06-02 | 1981-07-21 | Velsicol Chemical Corporation | Herbicidal N-substituted 4-imidazolin-2-ones |
| DE3307506A1 (de) | 1983-03-03 | 1984-09-06 | Agfa-Gevaert Ag, 5090 Leverkusen | Fotografisches aufzeichnungsmaterial mit inhibitorvorlaeuferverbindungen |
| US5108486A (en) * | 1990-02-09 | 1992-04-28 | Kanagawa Chemical Laboratory, Ltd. | Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| DE10123586A1 (de) * | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| US20020183306A1 (en) | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
| RU2223952C2 (ru) | 2001-06-04 | 2004-02-20 | Институт физиологически активных веществ РАН | Производные n,s-замещенных n'-1-[(гетеро)арил]-n'-[(гетеро)арил]метилизотиомочевин или их солей с фармакологически приемлемыми кислотами нх, способы получения их солей и оснований, фармацевтическая композиция, способ лечения и способ изучения глутаматэргической системы |
| US20040235877A1 (en) | 2001-09-14 | 2004-11-25 | Natsuki Ishizuka | Novel use of tricyclic compound |
| SE0301232D0 (sv) * | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| MXPA06000269A (es) | 2003-07-09 | 2006-04-07 | Hoffmann La Roche | Tiofenilaminoimidazolinas. |
| DE10344223A1 (de) | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
| US20050228031A1 (en) | 2004-04-13 | 2005-10-13 | Bilodeau Mark T | Tyrosine kinase inhibitors |
| US7008748B1 (en) * | 2004-09-07 | 2006-03-07 | Eastman Kodak Company | Silver salt-toner co-precipitates and imaging materials |
| US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
| US20060217390A1 (en) | 2005-02-24 | 2006-09-28 | Esmir Gunic | Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus |
| SG159561A1 (en) | 2005-05-09 | 2010-03-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
| US20060276464A1 (en) | 2005-05-13 | 2006-12-07 | Wyeth | Diarylsulfone sulfonamides and use thereof |
| BRPI0613555A2 (pt) | 2005-07-04 | 2011-01-18 | Reddys Lab Ltd Dr | derivados de tiazóis como ativador de ampk |
| EP2543667B1 (en) | 2006-03-24 | 2015-01-28 | Array Biopharma, Inc. | A method of preparing 2-aminopyridine analogs as glucokinase activators |
| EP2081890B1 (en) | 2006-11-09 | 2011-01-12 | F. Hoffmann-La Roche AG | Arylsulfonyl pyrrolidines as 5-ht6 inhibitors |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| CA2681695A1 (en) | 2007-03-23 | 2008-10-02 | Array Biopharma Inc. | 2-aminopyridine analogs as glucokinase activators |
| UA101166C2 (ru) | 2007-09-21 | 2013-03-11 | Аррей Биофарма Инк. | Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета |
| TW200940542A (en) | 2008-01-09 | 2009-10-01 | Array Biopharma Inc | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| WO2009117444A1 (en) | 2008-03-17 | 2009-09-24 | Northeastern University | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors |
| JP2012518404A (ja) | 2009-02-23 | 2012-08-16 | グレンマーク・ファーマシューティカルズ・エスエー | Ｃｄ１９に結合するヒト化抗体及びその使用 |
| KR102142753B1 (ko) | 2009-03-27 | 2020-09-14 | 히타치가세이가부시끼가이샤 | 열경화성 수지 조성물, 및 이를 이용한 프리프레그, 지지체 부착 절연 필름, 적층판 및 인쇄 배선판 |
| UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| CN102574822A (zh) | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| JP6038792B2 (ja) | 2010-09-03 | 2016-12-07 | フォーマ ティーエム， エルエルシー． | 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体 |
| EP3594245A1 (en) | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013175215A1 (en) | 2012-05-22 | 2013-11-28 | Autifony Therapeutics Limited | Triazoles as kv3 inhibitors |
| US20140044813A1 (en) | 2012-08-09 | 2014-02-13 | Kemin Industries, Inc. | Plant Extracts for Improving Cognitive Health and Function |
| EP2882726A4 (en) | 2012-08-09 | 2016-04-06 | Neuropore Therapies Inc | ARYL AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI-3 KINASE SIGNALING PATHWAYS |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| EP3703675A4 (en) * | 2017-10-30 | 2021-06-16 | Neuropore Therapies, Inc. | SUBSTITUTED PHENYLSULFONYLPHÉNYLTRIAZOLETHIONES AND ASSOCIATED USES |
-
2018
- 2018-10-29 EP EP18873686.2A patent/EP3703675A4/en not_active Withdrawn
- 2018-10-29 CA CA3080578A patent/CA3080578A1/en active Pending
- 2018-10-29 KR KR1020207015547A patent/KR102639231B1/ko active Active
- 2018-10-29 WO PCT/US2018/058050 patent/WO2019089478A1/en not_active Ceased
- 2018-10-29 AU AU2018359224A patent/AU2018359224B2/en not_active Ceased
- 2018-10-29 MX MX2020004202A patent/MX2020004202A/es unknown
- 2018-10-29 JP JP2020543258A patent/JP7277473B2/ja active Active
- 2018-10-29 CN CN201880071304.3A patent/CN111372579B/zh not_active Expired - Fee Related
- 2018-10-29 BR BR112020008727-0A patent/BR112020008727A2/pt not_active IP Right Cessation
- 2018-10-29 SG SG11202003879RA patent/SG11202003879RA/en unknown
-
2019
- 2019-03-27 US US16/366,793 patent/US10501423B2/en active Active
- 2019-10-24 US US16/663,054 patent/US11008294B2/en not_active Expired - Fee Related
-
2020
- 2020-04-16 IL IL274010A patent/IL274010B2/en unknown
-
2021
- 2021-04-06 US US17/223,989 patent/US11708338B2/en active Active
-
2023
- 2023-05-08 JP JP2023076473A patent/JP2023100842A/ja active Pending
- 2023-06-05 US US18/206,005 patent/US20230391734A1/en not_active Abandoned
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