JP2021501201A5 - - Google Patents
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- Publication number
- JP2021501201A5 JP2021501201A5 JP2020543254A JP2020543254A JP2021501201A5 JP 2021501201 A5 JP2021501201 A5 JP 2021501201A5 JP 2020543254 A JP2020543254 A JP 2020543254A JP 2020543254 A JP2020543254 A JP 2020543254A JP 2021501201 A5 JP2021501201 A5 JP 2021501201A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- polypeptide conjugate
- staple
- amino acid
- conjugate according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023115915A JP2023134675A (ja) | 2017-10-27 | 2023-07-14 | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762578213P | 2017-10-27 | 2017-10-27 | |
| US62/578,213 | 2017-10-27 | ||
| PCT/US2018/057894 WO2019084528A1 (en) | 2017-10-27 | 2018-10-28 | POLYPEPTIDE CONJUGATES FOR INTRACELLULAR ADMINISTRATION OF STAPLED PEPTIDES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023115915A Division JP2023134675A (ja) | 2017-10-27 | 2023-07-14 | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501201A JP2021501201A (ja) | 2021-01-14 |
| JP2021501201A5 true JP2021501201A5 (enExample) | 2021-12-09 |
| JP7780253B2 JP7780253B2 (ja) | 2025-12-04 |
Family
ID=66247031
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543254A Active JP7780253B2 (ja) | 2017-10-27 | 2018-10-28 | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
| JP2023115915A Pending JP2023134675A (ja) | 2017-10-27 | 2023-07-14 | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023115915A Pending JP2023134675A (ja) | 2017-10-27 | 2023-07-14 | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11510991B2 (enExample) |
| EP (1) | EP3700548A4 (enExample) |
| JP (2) | JP7780253B2 (enExample) |
| CN (2) | CN111447941B (enExample) |
| CA (1) | CA3080617A1 (enExample) |
| WO (1) | WO2019084528A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CA3080617A1 (en) | 2017-10-27 | 2019-05-02 | Ohio State Innovation Foundation | Polypeptide conjugates for intracellular delivery of stapled peptides |
| US20220315631A1 (en) * | 2019-08-30 | 2022-10-06 | Ohio State Innovation Foundation | Stapled beta-catenin ligands |
| CN112245593B (zh) * | 2020-10-30 | 2022-05-13 | 西南交通大学 | 具有疏水性侧链的稳定化细胞穿膜肽及制备方法与应用 |
| KR20240031957A (ko) * | 2021-06-08 | 2024-03-08 | 포그 파마슈티컬스 인코포레이티드 | 스테이플화된 펩티드 및 이의 방법 |
| EP4448543A1 (en) | 2022-01-06 | 2024-10-23 | Oak Crest Institute of Science | Subdermal implant for sustained drug delivery |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032235A1 (de) | 1998-11-26 | 2000-06-08 | Pentapharm Ag | Transportsystemkonjugate |
| US7033597B2 (en) | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
| EP1345956A2 (en) | 2000-10-13 | 2003-09-24 | University of Lausanne | Intracellular delivery of biological effectors by novel transporter peptide sequences |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| WO2013150338A1 (en) | 2012-04-04 | 2013-10-10 | Centre National De La Recherche Scientifique | Stapled cell penetrating peptides for intracellular delivery of molecules |
| JP6272853B2 (ja) * | 2012-07-11 | 2018-01-31 | ジェムバックス アンド カエル カンパニー，リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
| EP3142679A4 (en) * | 2014-03-25 | 2017-10-11 | University of Utah Research Foundation | Peptide inhibitors of bcr-abl oligomerization |
| EP3126375B1 (en) | 2014-04-02 | 2023-12-13 | University of Rochester | Macrocyclic peptidomimetics for alpha-helix mimicry |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| PL3149025T3 (pl) | 2014-05-21 | 2019-11-29 | Entrada Therapeutics Inc | Peptydy penetrujące komórkę i sposoby ich wytwarzania i stosowania |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| WO2017147283A1 (en) * | 2016-02-23 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Method for generating cell-penetrating stapled peptides that lack nonspecific membrane-lytic properties for therapeutic targeting |
| CN110114075B (zh) | 2016-11-09 | 2024-01-12 | 俄亥俄州国家创新基金会 | 含有二硫化物的细胞穿透肽及其制备和使用方法 |
| US20190309020A1 (en) | 2016-11-22 | 2019-10-10 | Ohio State Innovation Foundation | Cell-penetrating peptide sequences |
| TWI853790B (zh) | 2016-11-22 | 2024-09-01 | 俄亥俄州立創新基金會 | 細胞穿透肽序列 |
| CA3080617A1 (en) | 2017-10-27 | 2019-05-02 | Ohio State Innovation Foundation | Polypeptide conjugates for intracellular delivery of stapled peptides |
-
2018
- 2018-10-28 CA CA3080617A patent/CA3080617A1/en active Pending
- 2018-10-28 JP JP2020543254A patent/JP7780253B2/ja active Active
- 2018-10-28 CN CN201880070271.0A patent/CN111447941B/zh active Active
- 2018-10-28 US US16/759,600 patent/US11510991B2/en active Active
- 2018-10-28 CN CN202311469512.8A patent/CN117567639A/zh active Pending
- 2018-10-28 WO PCT/US2018/057894 patent/WO2019084528A1/en not_active Ceased
- 2018-10-28 EP EP18870802.8A patent/EP3700548A4/en active Pending
-
2022
- 2022-08-05 US US17/817,836 patent/US12115224B2/en active Active
-
2023
- 2023-07-14 JP JP2023115915A patent/JP2023134675A/ja active Pending
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