JP2021501183A - 二環式のスルホン及びスルホキシド、並びにその使用方法 - Google Patents

二環式のスルホン及びスルホキシド、並びにその使用方法 Download PDF

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Publication number
JP2021501183A
JP2021501183A JP2020524177A JP2020524177A JP2021501183A JP 2021501183 A JP2021501183 A JP 2021501183A JP 2020524177 A JP2020524177 A JP 2020524177A JP 2020524177 A JP2020524177 A JP 2020524177A JP 2021501183 A JP2021501183 A JP 2021501183A
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JP
Japan
Prior art keywords
dihydro
pyrrolo
triazole
fluoro
phenyl
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Pending
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JP2020524177A
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English (en)
Japanese (ja)
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JP2021501183A5 (https=
Inventor
パテル，スナヘル
ハミルトン，グレゴリー
スティバラ，クレイグ
チェン，ホイフェン
ダニエルズ，ブレイク
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2021501183A publication Critical patent/JP2021501183A/ja
Publication of JP2021501183A5 publication Critical patent/JP2021501183A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020524177A 2017-10-31 2018-10-30 二環式のスルホン及びスルホキシド、並びにその使用方法 Pending JP2021501183A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762579392P 2017-10-31 2017-10-31
US62/579,392 2017-10-31
PCT/EP2018/079772 WO2019086494A1 (en) 2017-10-31 2018-10-30 Bicyclic sulfones and sulfoxides and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2021501183A true JP2021501183A (ja) 2021-01-14
JP2021501183A5 JP2021501183A5 (https=) 2021-12-09

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Country Link
US (2) US11072617B2 (https=)
EP (1) EP3704097B1 (https=)
JP (1) JP2021501183A (https=)
KR (1) KR20200083515A (https=)
CN (1) CN111278809B (https=)
AR (1) AR113811A1 (https=)
AU (1) AU2018360270A1 (https=)
BR (1) BR112020008446A2 (https=)
CA (1) CA3078688A1 (https=)
CL (1) CL2020001062A1 (https=)
CO (1) CO2020003475A2 (https=)
CR (1) CR20200168A (https=)
IL (1) IL273847A (https=)
MA (1) MA50503A (https=)
MX (1) MX2020003451A (https=)
PE (1) PE20211247A1 (https=)
PH (1) PH12020550537A1 (https=)
RU (1) RU2020115915A (https=)
SG (1) SG11202002877RA (https=)
TW (1) TW201922748A (https=)
WO (1) WO2019086494A1 (https=)

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US11098058B2 (en) 2017-07-14 2021-08-24 Genentech, Inc. Bicyclic ketone compounds and methods of use thereof
SG11202002877RA (en) 2017-10-31 2020-04-29 Hoffmann La Roche Bicyclic sulfones and sulfoxides and methods of use thereof
CN113302193A (zh) 2019-01-11 2021-08-24 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
TW202214617A (zh) 2020-06-02 2022-04-16 法商賽諾菲公司 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
WO2023083847A1 (en) 2021-11-11 2023-05-19 Sanofi Isoxazolidines as ripk1 inhibitors and use thereof

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Also Published As

Publication number Publication date
EP3704097B1 (en) 2023-10-25
EP3704097C0 (en) 2023-10-25
IL273847A (en) 2020-05-31
CN111278809A (zh) 2020-06-12
EP3704097A1 (en) 2020-09-09
AU2018360270A1 (en) 2020-03-26
US11072617B2 (en) 2021-07-27
AR113811A1 (es) 2020-06-10
SG11202002877RA (en) 2020-04-29
KR20200083515A (ko) 2020-07-08
MA50503A (fr) 2020-09-09
BR112020008446A2 (pt) 2020-12-29
RU2020115915A (ru) 2021-12-01
CA3078688A1 (en) 2019-05-09
US20230002391A1 (en) 2023-01-05
CL2020001062A1 (es) 2020-08-21
MX2020003451A (es) 2020-08-03
RU2020115915A3 (https=) 2022-05-06
PE20211247A1 (es) 2021-07-13
US20190127382A1 (en) 2019-05-02
WO2019086494A1 (en) 2019-05-09
CR20200168A (es) 2020-07-12
US12338241B2 (en) 2025-06-24
CN111278809B (zh) 2024-06-25
TW201922748A (zh) 2019-06-16
CO2020003475A2 (es) 2020-04-24
PH12020550537A1 (en) 2021-03-22

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