JP2021185185A5 - - Google Patents
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- Publication number
- JP2021185185A5 JP2021185185A5 JP2021141016A JP2021141016A JP2021185185A5 JP 2021185185 A5 JP2021185185 A5 JP 2021185185A5 JP 2021141016 A JP2021141016 A JP 2021141016A JP 2021141016 A JP2021141016 A JP 2021141016A JP 2021185185 A5 JP2021185185 A5 JP 2021185185A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence defined
- antibody
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- 229960003067 cystine Drugs 0.000 description 3
- 239000013628 high molecular weight specie Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022109106A JP7406593B2 (ja) | 2017-05-31 | 2022-07-06 | 細胞培養方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1708655.4A GB201708655D0 (en) | 2017-05-31 | 2017-05-31 | Cell culture methods |
| GB1708655.4 | 2017-05-31 | ||
| JP2019566198A JP7460370B2 (ja) | 2017-05-31 | 2018-05-29 | 細胞培養方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566198A Division JP7460370B2 (ja) | 2017-05-31 | 2018-05-29 | 細胞培養方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022109106A Division JP7406593B2 (ja) | 2017-05-31 | 2022-07-06 | 細胞培養方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021185185A JP2021185185A (ja) | 2021-12-09 |
| JP2021185185A5 true JP2021185185A5 (https=) | 2022-07-25 |
| JP7560420B2 JP7560420B2 (ja) | 2024-10-02 |
Family
ID=59270991
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566198A Active JP7460370B2 (ja) | 2017-05-31 | 2018-05-29 | 細胞培養方法 |
| JP2021141016A Active JP7560420B2 (ja) | 2017-05-31 | 2021-08-31 | 細胞培養方法 |
| JP2022109106A Active JP7406593B2 (ja) | 2017-05-31 | 2022-07-06 | 細胞培養方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566198A Active JP7460370B2 (ja) | 2017-05-31 | 2018-05-29 | 細胞培養方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022109106A Active JP7406593B2 (ja) | 2017-05-31 | 2022-07-06 | 細胞培養方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US12077796B2 (https=) |
| EP (2) | EP3630946B1 (https=) |
| JP (3) | JP7460370B2 (https=) |
| KR (3) | KR20200012972A (https=) |
| CN (2) | CN119326882A (https=) |
| AU (2) | AU2018276376C1 (https=) |
| BR (1) | BR112019024390A2 (https=) |
| CA (1) | CA3065661A1 (https=) |
| CL (1) | CL2019003459A1 (https=) |
| CO (1) | CO2019012871A2 (https=) |
| EA (1) | EA201992828A1 (https=) |
| ES (1) | ES2978394T3 (https=) |
| GB (1) | GB201708655D0 (https=) |
| HR (1) | HRP20240585T1 (https=) |
| HU (1) | HUE066922T2 (https=) |
| IL (2) | IL270880B2 (https=) |
| MX (1) | MX2019014140A (https=) |
| MY (1) | MY193535A (https=) |
| PL (1) | PL3630946T3 (https=) |
| RU (2) | RU2021128024A (https=) |
| WO (1) | WO2018219968A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201708655D0 (en) * | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| JP2023554489A (ja) * | 2020-12-22 | 2023-12-27 | ノバルティス アーゲー | 細胞培養中の分泌された組換え発現タンパク質中のシステイン残基の酸化レベルを低減するための方法 |
| GB202105424D0 (en) * | 2021-04-16 | 2021-06-02 | UCB Biopharma SRL | Cell culture processes |
| WO2025262319A1 (en) | 2024-06-21 | 2025-12-26 | Boehringer Ingelheim International Gmbh | Modifying blue color formation in bioprocesses |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| AU4330597A (en) | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| IL161677A0 (en) | 2001-11-08 | 2004-09-27 | Protein Design Labs | Stable liquid pharmaceutical formulation of igg antibodies |
| EP1623019B2 (en) | 2003-05-15 | 2017-01-25 | Wyeth LLC | Restricted glucose feed for animal cell culture |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| TWI364458B (en) | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| SI2078071T1 (sl) * | 2006-11-08 | 2015-05-29 | Wyeth Llc | Racionalno zasnovana gojišča za celično kulturo |
| US8030027B2 (en) * | 2008-04-29 | 2011-10-04 | St. Jude Children's Research Hospital | Method for enhancing recombinant antibody production |
| US8252557B2 (en) | 2008-10-28 | 2012-08-28 | Chugai Seiyaku Kabushiki Kaisha | Peptide-containing culture medium for culturing animal cell |
| US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| RU2563353C2 (ru) | 2010-04-26 | 2015-09-20 | Новартис Аг | Улучшенная среда для культивирования клеток |
| PL2563906T3 (pl) | 2010-04-26 | 2018-04-30 | Novartis Ag | Sposób hodowli komórek cho |
| CN102653729B (zh) | 2011-03-04 | 2014-07-16 | 上海赛金生物医药有限公司 | 一种用于中国仓鼠卵巢细胞的培养基 |
| WO2012145682A1 (en) * | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
| EP4527855A3 (en) * | 2012-03-26 | 2025-06-11 | Sanofi | Stable igg4 based binding agent formulations |
| WO2013158275A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Cell culture methods to reduce acidic species |
| US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| JP2016513478A (ja) * | 2013-03-15 | 2016-05-16 | ジェネンテック， インコーポレイテッド | 細胞培養培地及び抗体を産生する方法 |
| CN106715707A (zh) | 2014-06-18 | 2017-05-24 | 免疫医疗公司 | 包含n‑乙酰半胱氨酸的细胞培养方法和培养基 |
| WO2016108765A1 (en) | 2014-12-29 | 2016-07-07 | Wirojpaisi Wanlop | Engine combustion system oxygen efficiency enhancing device with raised electrical voltage and improved installation method |
| GB201508180D0 (en) * | 2015-05-13 | 2015-06-24 | Ucb Biopharma Sprl | Antibodies |
| KR102425040B1 (ko) | 2016-04-28 | 2022-07-25 | 메르크 파텐트 게엠베하 | 단백질 내 트리술파이드 수준을 감소시키기 위한 방법 |
| GB201608323D0 (en) | 2016-05-12 | 2016-06-29 | Ucb Biopharma Sprl | Pharmaceutical compositions |
| WO2018018613A1 (zh) * | 2016-07-29 | 2018-02-01 | 广东东阳光药业有限公司 | 一种提高抗体纯度的细胞培养基和培养方法 |
| CN106222129A (zh) | 2016-07-29 | 2016-12-14 | 广东东阳光药业有限公司 | 一种提高抗体纯度的细胞培养基和培养方法 |
| GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
-
2017
- 2017-05-31 GB GBGB1708655.4A patent/GB201708655D0/en not_active Ceased
-
2018
- 2018-05-29 IL IL270880A patent/IL270880B2/en unknown
- 2018-05-29 US US16/615,419 patent/US12077796B2/en active Active
- 2018-05-29 EA EA201992828A patent/EA201992828A1/ru unknown
- 2018-05-29 KR KR1020197038895A patent/KR20200012972A/ko not_active Ceased
- 2018-05-29 IL IL317828A patent/IL317828A/en unknown
- 2018-05-29 RU RU2021128024A patent/RU2021128024A/ru unknown
- 2018-05-29 BR BR112019024390-9A patent/BR112019024390A2/pt unknown
- 2018-05-29 CN CN202411456463.9A patent/CN119326882A/zh active Pending
- 2018-05-29 HU HUE18743683A patent/HUE066922T2/hu unknown
- 2018-05-29 KR KR1020247019609A patent/KR20240096888A/ko active Pending
- 2018-05-29 CA CA3065661A patent/CA3065661A1/en active Pending
- 2018-05-29 MX MX2019014140A patent/MX2019014140A/es unknown
- 2018-05-29 EP EP18743683.7A patent/EP3630946B1/en not_active Revoked
- 2018-05-29 HR HRP20240585TT patent/HRP20240585T1/hr unknown
- 2018-05-29 PL PL18743683.7T patent/PL3630946T3/pl unknown
- 2018-05-29 JP JP2019566198A patent/JP7460370B2/ja active Active
- 2018-05-29 RU RU2019143742A patent/RU2758674C2/ru active
- 2018-05-29 ES ES18743683T patent/ES2978394T3/es active Active
- 2018-05-29 MY MYPI2019006875A patent/MY193535A/en unknown
- 2018-05-29 WO PCT/EP2018/064102 patent/WO2018219968A1/en not_active Ceased
- 2018-05-29 EP EP24164969.8A patent/EP4397682A3/en active Pending
- 2018-05-29 AU AU2018276376A patent/AU2018276376C1/en active Active
- 2018-05-29 CN CN201880035870.9A patent/CN110741077B/zh active Active
- 2018-05-29 KR KR1020257034169A patent/KR20250156183A/ko active Pending
-
2019
- 2019-11-18 CO CONC2019/0012871A patent/CO2019012871A2/es unknown
- 2019-11-26 CL CL2019003459A patent/CL2019003459A1/es unknown
-
2021
- 2021-08-31 JP JP2021141016A patent/JP7560420B2/ja active Active
-
2022
- 2022-07-06 JP JP2022109106A patent/JP7406593B2/ja active Active
-
2024
- 2024-08-23 US US18/813,117 patent/US20250051824A1/en active Pending
- 2024-11-11 AU AU2024259881A patent/AU2024259881B2/en active Active
- 2024-11-15 US US18/948,600 patent/US20250066832A1/en active Pending
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