GB201708655D0 - Cell culture methods - Google Patents

Cell culture methods

Info

Publication number
GB201708655D0
GB201708655D0 GBGB1708655.4A GB201708655A GB201708655D0 GB 201708655 D0 GB201708655 D0 GB 201708655D0 GB 201708655 A GB201708655 A GB 201708655A GB 201708655 D0 GB201708655 D0 GB 201708655D0
Authority
GB
United Kingdom
Prior art keywords
cell culture
culture methods
methods
cell
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1708655.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59270991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB201708655(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Priority to GBGB1708655.4A priority Critical patent/GB201708655D0/en
Publication of GB201708655D0 publication Critical patent/GB201708655D0/en
Priority to PCT/EP2018/064102 priority patent/WO2018219968A1/en
Priority to HUE18743683A priority patent/HUE066922T2/hu
Priority to US16/615,419 priority patent/US12077796B2/en
Priority to EP24164969.8A priority patent/EP4397682A3/en
Priority to AU2018276376A priority patent/AU2018276376C1/en
Priority to ES18743683T priority patent/ES2978394T3/es
Priority to IL317828A priority patent/IL317828A/en
Priority to KR1020257034169A priority patent/KR20250156183A/ko
Priority to BR112019024390-9A priority patent/BR112019024390A2/pt
Priority to PL18743683.7T priority patent/PL3630946T3/pl
Priority to JP2019566198A priority patent/JP7460370B2/ja
Priority to CA3065661A priority patent/CA3065661A1/en
Priority to MYPI2019006875A priority patent/MY193535A/en
Priority to MX2019014140A priority patent/MX2019014140A/es
Priority to RU2019143742A priority patent/RU2758674C2/ru
Priority to KR1020247019609A priority patent/KR20240096888A/ko
Priority to IL270880A priority patent/IL270880B2/en
Priority to EP18743683.7A priority patent/EP3630946B1/en
Priority to CN202411456463.9A priority patent/CN119326882A/zh
Priority to RU2021128024A priority patent/RU2021128024A/ru
Priority to HRP20240585TT priority patent/HRP20240585T1/hr
Priority to KR1020197038895A priority patent/KR20200012972A/ko
Priority to CN201880035870.9A priority patent/CN110741077B/zh
Priority to EA201992828A priority patent/EA201992828A1/ru
Priority to CONC2019/0012871A priority patent/CO2019012871A2/es
Priority to CL2019003459A priority patent/CL2019003459A1/es
Priority to JP2021141016A priority patent/JP7560420B2/ja
Priority to JP2022109106A priority patent/JP7406593B2/ja
Priority to US18/813,117 priority patent/US20250051824A1/en
Priority to AU2024259881A priority patent/AU2024259881B2/en
Priority to US18/948,600 priority patent/US20250066832A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
GBGB1708655.4A 2017-05-31 2017-05-31 Cell culture methods Ceased GB201708655D0 (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
GBGB1708655.4A GB201708655D0 (en) 2017-05-31 2017-05-31 Cell culture methods
CN201880035870.9A CN110741077B (zh) 2017-05-31 2018-05-29 细胞培养方法
EA201992828A EA201992828A1 (ru) 2017-05-31 2018-05-29 Способы культивирования клеток
RU2019143742A RU2758674C2 (ru) 2017-05-31 2018-05-29 Способы культивирования клеток
KR1020247019609A KR20240096888A (ko) 2017-05-31 2018-05-29 세포 배양 방법
US16/615,419 US12077796B2 (en) 2017-05-31 2018-05-29 Cell culture methods
EP24164969.8A EP4397682A3 (en) 2017-05-31 2018-05-29 Cell culture methods
AU2018276376A AU2018276376C1 (en) 2017-05-31 2018-05-29 Cell culture methods
ES18743683T ES2978394T3 (es) 2017-05-31 2018-05-29 Métodos de cultivo celular
IL317828A IL317828A (en) 2017-05-31 2018-05-29 Cell culture methods
KR1020257034169A KR20250156183A (ko) 2017-05-31 2018-05-29 세포 배양 방법
BR112019024390-9A BR112019024390A2 (pt) 2017-05-31 2018-05-29 métodos de cultura celular
PL18743683.7T PL3630946T3 (pl) 2017-05-31 2018-05-29 Sposoby hodowli komórkowych
JP2019566198A JP7460370B2 (ja) 2017-05-31 2018-05-29 細胞培養方法
CA3065661A CA3065661A1 (en) 2017-05-31 2018-05-29 Cell culture methods
MYPI2019006875A MY193535A (en) 2017-05-31 2018-05-29 Cell culture methods
MX2019014140A MX2019014140A (es) 2017-05-31 2018-05-29 Metodos de cultivo celular.
PCT/EP2018/064102 WO2018219968A1 (en) 2017-05-31 2018-05-29 Cell culture methods
HUE18743683A HUE066922T2 (hu) 2017-05-31 2018-05-29 Sejttenyésztési eljárások
IL270880A IL270880B2 (en) 2017-05-31 2018-05-29 Cell culture methods
EP18743683.7A EP3630946B1 (en) 2017-05-31 2018-05-29 Cell culture methods
CN202411456463.9A CN119326882A (zh) 2017-05-31 2018-05-29 细胞培养方法
RU2021128024A RU2021128024A (ru) 2017-05-31 2018-05-29 Способы культивирования клеток
HRP20240585TT HRP20240585T1 (hr) 2017-05-31 2018-05-29 Postupci uzgoja stanica
KR1020197038895A KR20200012972A (ko) 2017-05-31 2018-05-29 세포 배양 방법
CONC2019/0012871A CO2019012871A2 (es) 2017-05-31 2019-11-18 Métodos de cultivo celular para expresar proteínas con heterogeneidad reducida
CL2019003459A CL2019003459A1 (es) 2017-05-31 2019-11-26 Métodos de cultivo celular.
JP2021141016A JP7560420B2 (ja) 2017-05-31 2021-08-31 細胞培養方法
JP2022109106A JP7406593B2 (ja) 2017-05-31 2022-07-06 細胞培養方法
US18/813,117 US20250051824A1 (en) 2017-05-31 2024-08-23 Cell culture methods
AU2024259881A AU2024259881B2 (en) 2017-05-31 2024-11-11 Cell culture methods
US18/948,600 US20250066832A1 (en) 2017-05-31 2024-11-15 Cell culture methods

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1708655.4A GB201708655D0 (en) 2017-05-31 2017-05-31 Cell culture methods

Publications (1)

Publication Number Publication Date
GB201708655D0 true GB201708655D0 (en) 2017-07-12

Family

ID=59270991

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1708655.4A Ceased GB201708655D0 (en) 2017-05-31 2017-05-31 Cell culture methods

Country Status (21)

Country Link
US (3) US12077796B2 (https=)
EP (2) EP4397682A3 (https=)
JP (3) JP7460370B2 (https=)
KR (3) KR20240096888A (https=)
CN (2) CN110741077B (https=)
AU (2) AU2018276376C1 (https=)
BR (1) BR112019024390A2 (https=)
CA (1) CA3065661A1 (https=)
CL (1) CL2019003459A1 (https=)
CO (1) CO2019012871A2 (https=)
EA (1) EA201992828A1 (https=)
ES (1) ES2978394T3 (https=)
GB (1) GB201708655D0 (https=)
HR (1) HRP20240585T1 (https=)
HU (1) HUE066922T2 (https=)
IL (2) IL270880B2 (https=)
MX (1) MX2019014140A (https=)
MY (1) MY193535A (https=)
PL (1) PL3630946T3 (https=)
RU (2) RU2021128024A (https=)
WO (1) WO2018219968A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708655D0 (en) * 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
JP2023554489A (ja) * 2020-12-22 2023-12-27 ノバルティス アーゲー 細胞培養中の分泌された組換え発現タンパク質中のシステイン残基の酸化レベルを低減するための方法
GB202105424D0 (en) * 2021-04-16 2021-06-02 UCB Biopharma SRL Cell culture processes
WO2025262319A1 (en) 2024-06-21 2025-12-26 Boehringer Ingelheim International Gmbh Modifying blue color formation in bioprocesses

Family Cites Families (30)

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US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
EP1482031B1 (en) 1996-08-30 2015-10-28 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
JP5290489B2 (ja) 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｉｇｇ抗体の安定な液体医薬製剤
ATE472597T2 (de) 2003-05-15 2010-07-15 Wyeth Llc Kontrollierte glukosezufuhr für tierzellkultur
TWI364458B (en) 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
ES2538986T3 (es) * 2006-11-08 2015-06-25 Wyeth Llc Medios diseñados racionalmente para un cultivo celular
US8030027B2 (en) * 2008-04-29 2011-10-04 St. Jude Children's Research Hospital Method for enhancing recombinant antibody production
US8252557B2 (en) 2008-10-28 2012-08-28 Chugai Seiyaku Kabushiki Kaisha Peptide-containing culture medium for culturing animal cell
US20110262965A1 (en) 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
SG185037A1 (en) 2010-04-26 2012-11-29 Novartis Ag Improved cell culture medium
AU2011246502B2 (en) 2010-04-26 2014-08-28 Novartis Ag Improved cell cultivation process
CN102653729B (zh) 2011-03-04 2014-07-16 上海赛金生物医药有限公司 一种用于中国仓鼠卵巢细胞的培养基
WO2012145682A1 (en) * 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
JP6265970B2 (ja) * 2012-03-26 2018-01-24 サノフイ 安定なＩｇＧ４に基づく結合剤の製剤
WO2013158275A1 (en) * 2012-04-20 2013-10-24 Abbvie Inc. Cell culture methods to reduce acidic species
US20130281355A1 (en) 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
EP2968544A4 (en) * 2013-03-15 2016-10-12 Hoffmann La Roche CELL CULTURE MEDIA AND METHOD FOR PRODUCING ANTIBODY
BR112016027797A2 (pt) 2014-06-18 2017-10-31 Medimmune Llc métodos e meios de cultura de células compreendendo n-acetilcisteína
WO2016108765A1 (en) 2014-12-29 2016-07-07 Wirojpaisi Wanlop Engine combustion system oxygen efficiency enhancing device with raised electrical voltage and improved installation method
GB201508180D0 (en) * 2015-05-13 2015-06-24 Ucb Biopharma Sprl Antibodies
US11220668B2 (en) * 2016-04-28 2022-01-11 Merck Patent Gmbh Method for reducing the trisulfide level in proteins
GB201608323D0 (en) * 2016-05-12 2016-06-29 Ucb Biopharma Sprl Pharmaceutical compositions
CN106222129A (zh) 2016-07-29 2016-12-14 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
WO2018018613A1 (zh) * 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
GB201708655D0 (en) 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods

Also Published As

Publication number Publication date
CN119326882A (zh) 2025-01-21
IL270880B2 (en) 2025-05-01
EP3630946A1 (en) 2020-04-08
IL317828A (en) 2025-02-01
AU2024259881A1 (en) 2024-11-28
JP7560420B2 (ja) 2024-10-02
BR112019024390A2 (pt) 2020-07-14
US20250066832A1 (en) 2025-02-27
KR20250156183A (ko) 2025-10-31
EP4397682A3 (en) 2024-08-21
JP2022153421A (ja) 2022-10-12
IL270880A (en) 2020-01-30
JP7406593B2 (ja) 2023-12-27
MY193535A (en) 2022-10-18
ES2978394T3 (es) 2024-09-11
CO2019012871A2 (es) 2020-01-17
AU2018276376A1 (en) 2019-12-12
RU2019143742A3 (https=) 2021-06-30
AU2018276376B2 (en) 2024-08-15
CL2019003459A1 (es) 2020-04-24
RU2021128024A (ru) 2021-12-08
AU2018276376C1 (en) 2025-01-30
HRP20240585T1 (hr) 2024-07-19
EP4397682A2 (en) 2024-07-10
IL270880B1 (en) 2025-01-01
PL3630946T3 (pl) 2024-07-01
EP3630946C0 (en) 2024-03-27
US20200239923A1 (en) 2020-07-30
MX2019014140A (es) 2020-02-07
AU2024259881B2 (en) 2025-02-13
JP2020521490A (ja) 2020-07-27
WO2018219968A1 (en) 2018-12-06
US12077796B2 (en) 2024-09-03
RU2758674C2 (ru) 2021-11-01
JP7460370B2 (ja) 2024-04-02
HUE066922T2 (hu) 2024-09-28
EP3630946B1 (en) 2024-03-27
JP2021185185A (ja) 2021-12-09
EA201992828A1 (ru) 2020-04-21
CA3065661A1 (en) 2018-12-06
US20250051824A1 (en) 2025-02-13
KR20200012972A (ko) 2020-02-05
CN110741077A (zh) 2020-01-31
KR20240096888A (ko) 2024-06-26
CN110741077B (zh) 2024-10-11
RU2019143742A (ru) 2021-06-30

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