JP2021138628A - 美白剤 - Google Patents
美白剤 Download PDFInfo
- Publication number
- JP2021138628A JP2021138628A JP2020035906A JP2020035906A JP2021138628A JP 2021138628 A JP2021138628 A JP 2021138628A JP 2020035906 A JP2020035906 A JP 2020035906A JP 2020035906 A JP2020035906 A JP 2020035906A JP 2021138628 A JP2021138628 A JP 2021138628A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- whitening
- ether
- oil
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007854 depigmenting agent Substances 0.000 title abstract 5
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract description 109
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims abstract description 54
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims abstract description 54
- 230000002087 whitening effect Effects 0.000 claims abstract description 52
- 239000002537 cosmetic Substances 0.000 claims abstract description 29
- 239000000843 powder Substances 0.000 claims abstract description 28
- 239000006210 lotion Substances 0.000 claims abstract description 25
- 235000013305 food Nutrition 0.000 claims abstract description 24
- 239000006071 cream Substances 0.000 claims abstract description 19
- 235000013402 health food Nutrition 0.000 claims abstract description 15
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 230000000475 sunscreen effect Effects 0.000 claims abstract description 6
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 6
- 239000003599 detergent Substances 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 235000013336 milk Nutrition 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 239000000344 soap Substances 0.000 claims description 6
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 54
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 42
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- 229930195729 fatty acid Natural products 0.000 description 30
- 239000000194 fatty acid Substances 0.000 description 30
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
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- 108060008724 Tyrosinase Proteins 0.000 description 16
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- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
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- 239000006096 absorbing agent Substances 0.000 description 6
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 6
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
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- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 5
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 5
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- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 5
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 4
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Abstract
Description
通常は、この黒色メラニンが皮膚のターンオーバーにより、適切に排出されていればよいが、そのバランスが崩れ、黒色メラミンが表皮に蓄積されたものが、シミ斑である。
さらに、本発明は、美白用食品または美白用健康食品であることを特徴とする。
また、インドールは人体に対する広い安全域を有する化合物であり、濃度依存的にチロシナーゼ活性を阻害するので、効果を得るための配合量を調整し易いという利点がある。
すなわち、強力な美白効果が必要な場合には、配合量を多く、緩和な美白効果が必要な場合には、配合量を少なくすることで、所望の美白効果を得ることができる。
さらに、インドールは、希薄濃度では、ジャスミンやオレンジ様の香りを有するので、本発明の美白剤においては、特段の香り付けをしなくても、好ましい香りが得られるという利点も併せ有する。
さらには、基礎化粧品として、各種ジェル、各種乳液、各種オイル、各種美容液、シートマスク、フェイスパック、ボディソープ、ボディミルクなどがあげられる。
赤色3号、赤色104号、赤色106号、赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色227号、赤色228号、赤色230号、赤色401号、赤色405号、赤色505号、橙色203号、橙色204号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、黄色205号、黄色401号、青色1号、青色404号、緑色3号などの有機顔料、さらにはクロロフィル、β−カロチンなどの天然色素があげられる。
ビタミン類としては、たとえば、ビタミンA、B1、B2、B6、C、E及びその誘導体、パントテン酸およびその誘導体、ビオチンなどがあげられる。
本発明の美白用食品または美白用健康食品は、食品または健康食品における可食成分に加えて、インドールを含むものである。
本発明で使用されるインドールは極めて微量であり、オレンジなどの香りを有することから、美白用食品または美白用健康食品として、香料の添加を省略することもでき、好都合である。
<チロシナーゼ活性阻害作用>
インドールのチロシナーゼ活性阻害作用を調べた。
20%DMSO含有リン酸緩衝液(pH6.8)に、濃度を変えて溶解したインドール液(20μl)に0.1モルのL−ドーパを含む基質(100μl)に懸濁した酵素液(マッシュルーム由来チロシナーゼ30U シグマ社製 20μl)をよく混合し、37℃の恒温槽中で15分間酵素反応させた。その後、反応停止液として0.1N HCl水溶液(20μl)を加えた(S)。同時に基質と試料に代えてリン酸緩衝液を用いたもの(SB1)、試料に代えてリン酸緩衝液を用いたもの(B1)を調製した。
阻害率(%)=B1−(S−SB1)/B1×100
<バニシングクリームの製造>
インドール 0.2
ステアリン酸 5.0
ステアリルアルコール 4.0
ステアリン酸ブチルアルコールエステル 8.0
グリセリンモノステアリン酸エステル 2.0
プロピレングリコール 10.0
グリセリン 4.0
水酸化カリウム 0.2
防腐剤・抗酸化剤 適 量
香料 適 量
精製水 残 余
なお、上記の組成は、重量部であることを表す。
<コールドクリームの製造>
インドール 0.2
固形パラフィン 5.0
ミツロウ 10.0
ワセリン 15.0
流動パラフィン 41.0
グリセリンモノステアリン酸エステル
ポリオキシエチレン 2.0
ソルビタンモノラウリン酸エステル 2.0
ブチルヒドロキシトルエン 0.4
石鹸粉末 0.1
精製水 残 余
香料 適 量
防腐剤 適 量
<乳液の製造>
インドール 0.2
マイクロクリスタリンワックス 1.0
ミツロウ 2.0
ラノリン 20.0
流動パラフィン 10.0
スクワラン 5.0
ソルビタンセスキオレイン酸エステル 4.0
ポリオキシエチレン(20モル)
ソルビタンモノオレイン酸エステル 1.0
プロピレングリコール 7.0
精製水 残 余
香料 適 量
防腐剤・抗酸化剤 適 量
<化粧水の製造>
(アルコール相)
95%エチルアルコール 10.0
ポリオキシエチレン硬化ヒマシ油 2.0
プロピレングリコール 0.1
オレイルアルコール 0.1
レシチン 2.5
インドール 0.2
グリセリン 5.0
精製水 残 余
紫外線吸収剤 適 量
<ピールオフ型パックの製造>
(アルコール相)
95%エタノール 10.0
ポリオキシエチレン(15モル)
オレイルアルコールエーテル 2.0
防腐剤 適 量
香料 適 量
インドール 0.2
ポリビニルアルコール 12.0
グリセリン 3.0
ポリエチレングリコール1500 1.0
精製水 残 余
<美白スキンローションの製造>
(A)成分
エタノール 10.0
モノラウリン酸
ポリオキシエチレン(20モル)ソルビタン 5.0
ジブチルヒドロキシトルエン 0.01
香料 0.05
インドール 0.2
グリセリン 5.0
キサンタンガム 0.1
ヒドロキシエチルセルロース 0.1
精製水 残 余
<日焼け止めクリームの製造>
(A)成分
親油型モノステアリン酸グリセリル 0.1
ポリオキシエチレンセチルエーテル 0.1
テトラオレイン酸ポリオキシエチレン
ソルビット 0.05
ベヘニルアルコール 5.0
トリエチルヘキサノイン 7.0
メトキシケイヒ酸エチルヘキシル 6.0
オキシベンゾン 2.0
キサンタンガム 0.3
ジラウロイルグルタミン酸リシン
ナトリウム液 0.1
1、3ブチレングリコール 0.1
インドール 0.2
精製水 残 余
<クレンジングジェルの製造>
(A)成分
インドール 0.2
ジラウロイルグルタミン酸ナトリウム液 0.3
グリセリン 20.0
ソルビトール 3.5
精製水 残 余
流動パラフィン 47.0
イソノナン酸イソノニル 15.0
メチルポリシロキサン 5.0
デカメチルシクロペンタシロキサン 5.0
トリイソステアリン酸ポリオキシエチ
レングリセリル 2.0
<クレンジングミルクの製造>
(A)成分
インドール 0.2
グリセリン 7.5
グリセリン脂肪酸エステル 0.5
精製水 残 余
ジイソステアリン酸ポリグリセリル 7.0
ジステアリン酸ポリグリセリル 3.0
トリ(カプリル酸/カプリン酸)グリセリル 55.5
キサンタンガム 0.05
精製水 4.95
<美容液の製造>
(A)成分
1,3ブチレングリコール 5.0
グリセリン 5.0
キサンタンガム 0.5
ヒドロキシエチルセルロース 0.5
ヒアルロン酸ナトリウム 0.2
防腐剤 適 量
キレート剤 0.1
精製水 残 余
インドール 0.2
クエン酸ナトリウム 適 量
クエン酸 適 量
<美容サプリメントの製造>
(製品原料)
インドール 0.2
ミツロウ 5.0
グリセリン脂肪酸エステル 2.0
γ-トコフェロール 3.0
オリーブ油 残 余
さらに、本発明は、美白用食品または美白用健康食品であることを特徴とする。
Claims (5)
- インドールを有効成分として含むことを特徴とする美白剤。
- 化粧品であることを特徴とする請求項1に記載の美白剤。
- ジェル、乳液、オイル、美容液、シートマスク、フェイスパック、ボディソープ、ボディミルク、化粧水、クレンジング剤、クリーム、ファンデーション、白粉および日焼け止め化粧料のいずれかであることを特徴とする請求項1または2に記載の美白剤。
- インドールを含むことを特徴とする食品。
- 美白用食品または美白用健康食品であることを特徴とする請求項4に記載の食品。
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EP0478036A2 (en) * | 1990-09-04 | 1992-04-01 | Unilever N.V. | Naturally flavoured food product |
JP2009171856A (ja) * | 2008-01-21 | 2009-08-06 | Suntory Holdings Ltd | ルチン高含有そば茶飲料 |
JP2011157286A (ja) * | 2010-01-29 | 2011-08-18 | Soda Aromatic Co Ltd | メラニン生成抑制剤及びこれらを含有する美白用香粧品 |
JP2014083030A (ja) * | 2012-10-26 | 2014-05-12 | Ogawa & Co Ltd | 醤油又は醤油香味付与剤の香味改善剤 |
JP2014205667A (ja) * | 2013-04-14 | 2014-10-30 | シムライズ アーゲー | スキン/ヘアライトニング組成物 |
CN106137868A (zh) * | 2016-08-24 | 2016-11-23 | 李云海 | 一种含有杏仁精油的美白护肤乳液 |
-
2020
- 2020-03-03 JP JP2020035906A patent/JP7037780B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0478036A2 (en) * | 1990-09-04 | 1992-04-01 | Unilever N.V. | Naturally flavoured food product |
JP2009171856A (ja) * | 2008-01-21 | 2009-08-06 | Suntory Holdings Ltd | ルチン高含有そば茶飲料 |
JP2011157286A (ja) * | 2010-01-29 | 2011-08-18 | Soda Aromatic Co Ltd | メラニン生成抑制剤及びこれらを含有する美白用香粧品 |
JP2014083030A (ja) * | 2012-10-26 | 2014-05-12 | Ogawa & Co Ltd | 醤油又は醤油香味付与剤の香味改善剤 |
JP2014205667A (ja) * | 2013-04-14 | 2014-10-30 | シムライズ アーゲー | スキン/ヘアライトニング組成物 |
CN106137868A (zh) * | 2016-08-24 | 2016-11-23 | 李云海 | 一种含有杏仁精油的美白护肤乳液 |
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