JP2021104986A - 皮膚外用組成物 - Google Patents
皮膚外用組成物 Download PDFInfo
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- JP2021104986A JP2021104986A JP2019238226A JP2019238226A JP2021104986A JP 2021104986 A JP2021104986 A JP 2021104986A JP 2019238226 A JP2019238226 A JP 2019238226A JP 2019238226 A JP2019238226 A JP 2019238226A JP 2021104986 A JP2021104986 A JP 2021104986A
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Abstract
Description
そのため、種々の保湿剤を皮膚外用組成物に配合することが行われている。従来の保湿剤としては、水の蒸散を抑制させるための被膜を肌表面に形成させうる油剤やポリマー等の成分や、ヒアルロン酸等の抱水性を有する成分が用いられてきた。
また、特許文献2には、アルキルグリコシドを含有する水中油型乳化組成物が優れた保湿作用を有することが記載されている。
このような状況に鑑みて、表皮の抱水能をより向上させる技術を提供する。
[1]ジアリル4級アンモニウム塩の重合体及び/又は共重合体と、抱水剤とを含有する、皮膚外用組成物。
[2]前記抱水剤が、アルキルグリコシド、ショ糖脂肪酸エステル、セルロース及びその誘導体、並びにヒアルロン酸及びその誘導体から選択される、皮膚外用組成物。
[3]前記アルキルグリコシドが、下記一般式(1)で表されるアルキルグリコシドである、[2]に記載の皮膚外用組成物。
[5]前記ジアリル4級アンモニウム塩の重合体及び/又は共重合体を組成物全体に対して0.1〜5質量%含有する、[1]〜[4]のいずれかに記載の皮膚外用組成物。
[6]前記抱水剤を組成物全体に対して0.01〜1質量%含有する、[1]〜[5]のいずれかに記載の皮膚外用組成物。
[7]前記ジアリル4級アンモニウム塩の重合体及び/又は共重合体と前記抱水剤との含有量の質量比が50:1〜1:10である、[1]〜[6]のいずれかに記載の皮膚外用組成物。
[8]洗浄料である、[1〜[7]のいずれかに記載の皮膚外用組成物。
[9]ジアリル4級アンモニウム塩の重合体及び/又は共重合体を含有する、抱水剤の皮膚貯留性向上剤。
[10]前記ジアリル4級アンモニウム塩が、塩化ジメチルジアリルアンモニウムである、[9]に記載の皮膚貯留性向上剤。
ジアリル4級アンモニウム塩以外のモノマー単位としては、アクリル酸、メタクリル酸、アクリルアミド、メタクリルアミド等が挙げられるが、特に限定されない。
これらの重合体又は共重合体の分子量は特に限定されず、化粧料等の皮膚外用剤に通常用いられるサイズのものでよく、例えばGPCで一般的な条件で測定した分子量が10000〜10000000のものを用いることができる。
そのため、本明細書は、ジアリル4級アンモニウム塩の重合体及び/又は共重合体の、抱水剤の皮膚貯留性を向上させるという新たな用途を提供する。すなわち、本発明の別の側面は、ジアリル4級アンモニウム塩の重合体及び/又は共重合体を含有する、抱水剤の皮膚貯留性向上剤である。
また、本発明の組成物におけるジアリル4級アンモニウム塩の重合体及び/又は共重合体の含有量は、該重合体に含まれるモノマーである塩化ジメチルジアリルアンモニウムの含有量として、組成物全体の0.01〜5質量%が好ましく、0.05〜3.0質量%がより好ましく、0.1〜1.0質量%がさらに好ましい。
このような範囲で用いることにより、抱水剤を表皮(角層)により長く又は多く貯留させやすくなる。
ここで、糖残基としては、ガラクトース、キシロース、マンノース、リキソース、アラビノース、フルクトース、マルトース、キシロビオース、イソマルトース、セロビオース、ラクトース、ゲンチオビース、マルトトリオース、イソマルトトリオース、セロトリオース、マルトテトラオース、マルトペンタオース、マルトヘキサオース、マルトヘプタオース、イソマルトテトラオース、イソマルトペンタオース、イソマルトヘキサオース、及びイソマルトヘプタースから選択されるものが好ましい。
また、アルキル基としては、好ましくは炭素数8〜24、より好ましくは炭素数10〜20、さらに好ましくは炭素数10〜16の、分岐を有していてもよいアルキル基が挙げられる。
なお、かかる脂肪族アルコールは、好ましくは炭素数12〜20、より好ましくは炭素数12〜16の、さらに好ましくは炭素数15の、分岐を有していてもよい脂肪族アルコールである。
糖残基としては、マルトース、マルトトリオース、マルトテトラオース、マルトペンタオース、マルトヘキサオース、及びマルトヘプタオースが挙げられ、マルトース及びマルトトリオースがより好ましい。
脂肪鎖の部分は、分岐鎖があってもなくてもよいが、好ましくは分岐鎖を有する。すなわち、一般式(1)においてRは、独立して水素原子又は炭素数1〜3のアルキル基を表すが、好ましくは炭素数1〜3のアルキル基であり、より好ましくはメチル基である。
一般式(2)に包含される化合物としては、例えば、Mal2Far(マルトースとヘキサヒドロファルネソールのグリコシド体)、Mal3Far(マルトトリオースとヘキサヒドロファルネソールのグリコシド体)、Mal3Phyt(マルトトリオースとヘキサヒドロフィトールのグリコシド体)などが挙げられるが、特に限定されない。
また、本発明に係るアルキルグリコシドが結合した角層においては、抱水能が向上し、水分保持量が高まるため、皮膚のバリア機能の向上も期待される。
ショ糖脂肪酸エステルとしては、例えば炭素数8〜18の脂肪酸とショ糖とのモノ−、ジ−又はトリ−エステルが挙げられ、より具体的には、ポリラウリル酸スクロース、ラウリン酸スクロース、ミリスチン酸スクロース、パルミチン酸スクロース、ジステアリン酸スクロース、ステアリン酸スクロース等が好ましく挙げられるがこれらに限定されない。
セルロース及びその誘導体としては、セルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシエチルセルロース等が好ましく挙げられるがこれらに限定されない。
ヒアルロン酸及びその誘導体としては、ヒアルロン酸、アセチルヒアルロン酸等が好ましく挙げられるがこれらに限定されない。
このような範囲で用いることにより、表皮(角層)の抱水量を向上させやすくなる。
このような範囲で組み合わせて含有させることにより、抱水剤の皮膚貯留性をより向上させやすくなる。
本発明の組成物の剤型としては、特に限定されず、例えば、ローションやエッセンス等の液状剤型や、オイル剤型、ジェル剤型、固型剤型、乳液やクリーム等の乳化剤型が好ましく挙げられる。
、有機アミン、高分子エマルジョン、pH調整剤、ビタミン類、酸化防止剤、防腐剤、水溶性高分子、香料、各種有効成分等が挙げられる。
エチレングリコールモノメチルエーテル、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、エチレングリコールモノフェニルエーテル、エチレングリコールモノヘキシルエーテル、エチレングリコールモノ2−メチルヘキシルエーテル、エチレングリコールイソアミルエーテル、エチレングリコールベンジルエーテル、エチレングリコールイソプロピルエーテル等のアルコールアルキルエーテル類;
ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノブチルエーテル、トリエチレングリコールモノメチルエーテル、トリエチレングリコールモノエチルエーテル、プロピレングリコールモノメチルエーテル、プロピレングリコールモノエチルエーテル、プロピレングリコールモノブチルエーテル、プロピレングリコールイソプロピルエーテル、ジプロピレングリコールメチルエーテル、ジプロピレングリコールエチルエーテル、ジプロピレングリコールブチルエーテル等のアルコールアルキルエーテル類;
キシルアルコール、セラキルアルコール、バチルアルコール等のグリセリンモノアルキルエーテル類;
ジエチレングリコール、トリエチレングリコール、ポリプロピレングリコール、テトラエチレングリコール、ポリエチレングリコール等のアルコール重合体;
グリソリッド;テトラハイドロフルフリルアルコール;POE−テトラハイドロフルフリルアルコール;POP−ブチルエーテル;POP・POE−ブチルエーテル;トリポリオキシプロピレングリセリンエーテル;POP−グリセリンエーテル;POP−グリセリンエーテルリン酸;POP・POE−ペンタンエリスリトールエーテル、等が挙げられる。
エチレングリコールジメチルエーテル、エチレングリコールジエチルエーテル、エチレングリコールジブチルエーテル、ジエチレングリコールジメチルエーテル、ジエチレングリコールジエチルエーテル、、ジエチレングリコールメチルエチルエーテル、エチレングリコールモノメチルエーテルアセテート、エチレングリコールモノエチルエーテルアセテート、エチレングリコールモノブチルエーテルアセテート、エチレングリコールモノフェニルエーテルアセテート、エチレングリコールジアジベート、エチレングリコールジサクシネート、ジエチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノブチルエーテルアセテート、プロピレングリコールモノメチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート、プロピレングリコールモノプロピルエーテルアセテート、プロピレングリコールモノフェニルエーテルアセテート等が挙げられる。
ム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、シリカ、アルミナ、ゼオライト、硫酸バリウム、焼成硫酸カルシウム(焼セッコウ)、リン酸カルシウム、フッ素アパタイト、ヒドロキシアパタイト、セラミックパウダー、窒化ホウ素等);有機粉末(例えば、ポリアミド樹脂粉末(ナイロン粉末)、ポリエチレン粉末、ポリ(メタ)アクリル酸メチル粉末、ポリスチレン粉末、スチレンとアクリル酸の共重合体樹脂粉末、シリコーン樹脂粉末、ベンゾグアナミン樹脂粉末、ポリ四フッ化エチレン粉末、セルロース粉末等);金属石鹸(例えば、ミ
リスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム);無機白色顔料
(例えば、二酸化チタン、酸化亜鉛等);無機赤色系顔料(例えば、酸化鉄(ベンガラ)、チタン酸鉄等);無機褐色系顔料(例えば、γ−酸化鉄等);無機黄色系顔料(例えば、黄酸化鉄、黄土等);無機黒色系顔料(例えば、黒酸化鉄、低次酸化チタン等);無機紫色系顔料(例えば、マンゴバイオレット、コバルトバイオレット等);無機緑色系顔料(例えば、酸化クロム、水酸化クロム、チタン酸コバルト等);無機青色系顔料(例えば、群青、紺青等);パール顔料(例えば、酸化チタンコーテッド雲母、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッド雲母、オキシ塩化ビスマス、魚鱗箔等);金属粉末顔料(例えば、アルミニウムパウダー、カッパーパウダー等);ジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料(例えば、赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、及び青色404号などの有機顔料、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号及び青色1号等);天然色素(例えば、クロロフィル、β−カロチン等)等が挙げられる。
ー等が挙げられる。
ート等が挙げられる。
3,5−メチレンピペリジニウム);アルキル四級アンモニウム塩;アルキルジメチルベ
ンジルアンモニウム塩;アルキルイソキノリニウム塩;ジアルキルモリホニウム塩;POEアルキルアミン;アルキルアミン塩;ポリアミン脂肪酸誘導体;アミルアルコール脂肪
酸誘導体;塩化ベンザルコニウム;塩化ベンゼトニウム等が挙げられる。
;POEヒマシ油硬化ヒマシ油誘導体(例えば、POEヒマシ油、POE硬化ヒマシ油、POE硬化ヒマシ油モノイソステアレート、POE硬化ヒマシ油トリイソステアレート、POE硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、POE硬化ヒマシ油マレイン酸等);POEミツロウ・ラノリン誘導体(例えば、POEソルビットミツロウ等);アルカノールアミド(例えば、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等);POEプロピレングリコール脂肪酸エステル;POEアルキルアミン;POE脂肪酸アミド;ショ糖脂肪酸エステル;他のアルキルグリコシド;アルキルエトキシジメチルアミンオキシド;トリオレイルリン酸等の親水性非イオン性界面活性剤も挙げられる。
ルグルタミン酸塩、アシルβ−アラニンナトリウム、グルタチオン、ピロリドンカルボン酸等が挙げられる。
、パントテン酸及びその誘導体、ビオチン等が挙げられる。
メ、トウモロコシ、バレイショ、コムギ)、グリチルリチン酸);微生物系高分子(例え
ば、キサンタンガム、デキストラン、サクシノグルカン、ブルラン等);動物系高分子(例えば、コラーゲン、カゼイン、アルブミン、ゼラチン等)等の天然の水溶性高分子、
デンプン系高分子(例えば、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン等);セルロース系高分子(ヒドロキシプロピルメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、エチルセルロース、ヒドロキシプロピルメチルセルロースステアロキシエーテル、セルロース硫酸ナトリウム、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、結晶セルロース、セルロース末等);アルギン酸系高分子(例えば、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等)等の半合成の水溶性高分子、
ビニル系高分子(例えば、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、カルボキシビニルポリマー等);ポリオキシエチレン系高分子(例えば、ポリエチレングリコール20,000、40,000、60,000等);アクリル系高分子(例えば、ポリアクリル酸ナトリウム、ポリエチルアクリレート、ポリアクリルアミド等);ポリエチレンイミン;カチオンポリマー等の合成の水溶性高分子が挙げられる。
以下の手順で、アルキルグリコシド(Mal2Far)が角層の主要構成成分であるケラチンに結合するかを検討した。
ケラチンパウダー(Keratin from wool K0044、東京化成工業株式会社製)を1.2、6、12、又は60mgずつ2mLエッペンドルフチューブにとり、そこに0.5mg/mL Mal2Far水溶液を1.2mLずつ添加し、40℃で3時間インキュベートした
。エッペンドルフチューブを遠心分離(15000rpm、室温、3分間を3回)して、上清を1mL採取した。該上清に含まれる、ケラチンパウダーに結合していないMal2Farの量を、Corona HPLCで定量した。HPLCの条件は以下の通り。
カラム:Atlantis T3(100×3.0mm、3.5μm)
溶媒:A:水、B:アセトニトリル
グラジエント:B10%(-30min)→10%(0min)→98%(30min)→98%(35min)
検出:Corona CAD
流速:0.3 mL/min
カラム温度:40℃
シリンジ洗浄:50%アセトニトリル水溶液
インジェクト:1μL
以下の手順で、アルキルグリコシド(Mal2Far)が結合したケラチンの抱水性を検討した。
シャーレ1〜3の重量を予め重量を測定した。シャーレ1に、ケラチンパウダーを約150mg秤量し、さらに0.5mg/mL Mal2Far水溶液を3mL添加した。シ
ャーレ2に、ケラチンパウダーを約150mg秤量し、水を3mL添加した。シャーレ3に、0.5mg/mL Mal2Far水溶液を3mL添加した。シャーレ1〜3を、4
0度で10分間インキュベートした後、デシケーターに入れて、減圧下で一晩乾燥させた。乾燥後の各シャーレの重量(内容物含む)を測定し、ケラチンパウダー1g当たりの脱水量を算出した。ケラチンパウダー1gあたりの脱水量は以下の式で算出した。
以下の手順で、本発明の組成物が角層の抱水性に与える影響を検討した。
表1に示す組成物を常法により調製した。
予め重量を測定したシャーレに、ケラチンパウダーを0mg又は約150mgずつ秤量した。各シャーレに含有する実施例又は比較例の組成物を水で10倍に希釈した水溶液を、それぞれ3mL添加し、40℃で10分間インキュベートした。インキュベート後の各シャーレをデシケーターに入れて、減圧下で一晩乾燥させた。乾燥後の各シャーレの重量(内容物含む)を測定し、参考例2で脱水量を算出したのと同様に、ケラチンパウダー1gあたりの重量増加量を算出した。
組成物を添加したケラチンパウダーよりも水が蒸発しにくく、抱水量の有意な増加が認められた。このことから、本発明の組成物は角層の抱水性をより向上させることが認められた。
Claims (10)
- ジアリル4級アンモニウム塩の重合体及び/又は共重合体と、抱水剤とを含有する、皮膚外用組成物。
- 前記抱水剤が、アルキルグリコシド、ショ糖脂肪酸エステル、セルロース及びその誘導体、並びにヒアルロン酸及びその誘導体から選択される、皮膚外用組成物。
- 前記ジアリル4級アンモニウム塩が、塩化ジメチルジアリルアンモニウムである、請求項1〜3のいずれか一項に記載の皮膚外用組成物。
- 前記ジアリル4級アンモニウム塩の重合体及び/又は共重合体を組成物全体に対して0.1〜5質量%含有する、請求項1〜4のいずれか一項に記載の皮膚外用組成物。
- 前記抱水剤を組成物全体に対して0.01〜1質量%含有する、請求項1〜5のいずれか一項に記載の皮膚外用組成物。
- 前記ジアリル4級アンモニウム塩の重合体及び/又は共重合体と前記抱水剤との含有量の質量比が50:1〜1:10である、請求項1〜6のいずれか一項に記載の皮膚外用組成物。
- 洗浄料である、請求項1〜7のいずれか一項に記載の皮膚外用組成物。
- ジアリル4級アンモニウム塩の重合体及び/又は共重合体を含有する、抱水剤の皮膚貯留性向上剤。
- 前記ジアリル4級アンモニウム塩が、塩化ジメチルジアリルアンモニウムである、請求項9に記載の皮膚貯留性向上剤。
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