JP2020536953A - デキストロメトルファン経皮送達デバイス - Google Patents

デキストロメトルファン経皮送達デバイス Download PDF

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Publication number
JP2020536953A
JP2020536953A JP2020540680A JP2020540680A JP2020536953A JP 2020536953 A JP2020536953 A JP 2020536953A JP 2020540680 A JP2020540680 A JP 2020540680A JP 2020540680 A JP2020540680 A JP 2020540680A JP 2020536953 A JP2020536953 A JP 2020536953A
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Prior art keywords
dextromethorphan
application
day
average
transdermal delivery
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JP2020540680A
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Japanese (ja)
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JP2020536953A5 (enExample
Inventor
スレシュ ボルサディア
スレシュ ボルサディア
Original Assignee
シンケイ セラピューティクス リミテッド ライアビリティ カンパニー
シンケイ セラピューティクス リミテッド ライアビリティ カンパニー
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Application filed by シンケイ セラピューティクス リミテッド ライアビリティ カンパニー, シンケイ セラピューティクス リミテッド ライアビリティ カンパニー filed Critical シンケイ セラピューティクス リミテッド ライアビリティ カンパニー
Publication of JP2020536953A publication Critical patent/JP2020536953A/ja
Publication of JP2020536953A5 publication Critical patent/JP2020536953A5/ja
Priority to JP2023136898A priority Critical patent/JP7609943B2/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020540680A 2017-10-04 2018-10-03 デキストロメトルファン経皮送達デバイス Pending JP2020536953A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023136898A JP7609943B2 (ja) 2017-10-04 2023-08-25 デキストロメトルファン経皮送達デバイス

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568028P 2017-10-04 2017-10-04
US62/568,028 2017-10-04
US201862680182P 2018-06-04 2018-06-04
US62/680,182 2018-06-04
PCT/US2018/054178 WO2019070864A1 (en) 2017-10-04 2018-10-03 DEVICE FOR TRANSDERMAL DEXTROMETHORPHAN DELIVERY

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023136898A Division JP7609943B2 (ja) 2017-10-04 2023-08-25 デキストロメトルファン経皮送達デバイス

Publications (2)

Publication Number Publication Date
JP2020536953A true JP2020536953A (ja) 2020-12-17
JP2020536953A5 JP2020536953A5 (enExample) 2021-11-04

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020540680A Pending JP2020536953A (ja) 2017-10-04 2018-10-03 デキストロメトルファン経皮送達デバイス
JP2023136898A Active JP7609943B2 (ja) 2017-10-04 2023-08-25 デキストロメトルファン経皮送達デバイス

Family Applications After (1)

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Country Status (13)

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US (3) US11382869B2 (enExample)
EP (1) EP3691641A4 (enExample)
JP (2) JP2020536953A (enExample)
KR (1) KR20200062254A (enExample)
CN (1) CN111343980B (enExample)
AU (1) AU2018345723B2 (enExample)
BR (1) BR112020006723A2 (enExample)
CA (1) CA3078369A1 (enExample)
IL (1) IL273735B2 (enExample)
MX (1) MX2020003044A (enExample)
TW (1) TWI795446B (enExample)
WO (1) WO2019070864A1 (enExample)
ZA (1) ZA202001834B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024503114A (ja) * 2021-01-18 2024-01-24 アンテシップ バイオベンチャーズ トゥー エルエルシー 神経精神疾患に対する抗うつ剤とデキストロメトルファンとの組み合わせ

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置
US20240216358A1 (en) * 2020-03-30 2024-07-04 Shinkei Therapeutics Llc Transdermal delivery of dextromethorphan
CN117100750A (zh) * 2020-07-20 2023-11-24 深圳信立泰药业股份有限公司 一种药物组合物及其应用
CN113720944B (zh) * 2021-09-30 2023-04-28 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊含量的检测方法
AU2023356341A1 (en) * 2022-10-06 2025-05-15 Shinkei Therapeutics, Inc. Transdermal delivery of dextromethorphan

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297415A (ja) * 1991-03-27 1992-10-21 Mitsui Petrochem Ind Ltd 薬物投与用粘着剤
JP2000509037A (ja) * 1996-04-23 2000-07-18 フアーマシア・アンド・アツプジヨン・アー・ベー 鎮咳剤として経皮投与されるデキストロメトルファン
JP2009525343A (ja) * 2006-02-03 2009-07-09 アバニール・ファーマシューティカルズ 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物
US20160038464A1 (en) * 2012-04-16 2016-02-11 Antecip Bioventures Ii Llc Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan
JP2016535786A (ja) * 2013-11-05 2016-11-17 アンテシップ バイオベンチャーズ トゥー エルエルシー ブプロピオンまたは関連組成物およびデキストロメトルファンを含む組成物および方法

Family Cites Families (13)

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US5206248A (en) 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
WO1995024172A1 (en) * 1994-03-07 1995-09-14 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
TWI326214B (en) 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
WO2004017941A2 (en) * 2002-08-20 2004-03-04 Euro-Celtique, S.A. Transdermal dosage form comprising an active agent and a salt and free-baseform of an antagonist
CA2548596A1 (en) * 2003-12-10 2005-06-23 Acrux Dds Pty Ltd. Method of treatment for undesired effect following transdermal or topical drug delivery
US20060223786A1 (en) 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
BRPI0607017B8 (pt) * 2005-04-06 2021-05-25 Adamas Pharmaceuticals Inc composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
EA200970369A1 (ru) * 2006-10-09 2009-08-28 Смитклайн Бичам Корпорейшн Композиции для снижения симптомов никотиновой абстиненции и/или отказа от употребления табака
WO2009021058A2 (en) * 2007-08-06 2009-02-12 Trinity Labortories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
WO2010062690A1 (en) * 2008-10-30 2010-06-03 Concert Pharmaceuticals Inc. Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury
JP5680061B2 (ja) * 2009-04-24 2015-03-04 ヘンケル・ユーエス・アイピー・リミテッド・ライアビリティ・カンパニーＨｅｎｋｅｌ ＵＳ ＩＰ ＬＬＣ シリコーンアクリルハイブリッドポリマーを基剤とする接着剤
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297415A (ja) * 1991-03-27 1992-10-21 Mitsui Petrochem Ind Ltd 薬物投与用粘着剤
JP2000509037A (ja) * 1996-04-23 2000-07-18 フアーマシア・アンド・アツプジヨン・アー・ベー 鎮咳剤として経皮投与されるデキストロメトルファン
JP2009525343A (ja) * 2006-02-03 2009-07-09 アバニール・ファーマシューティカルズ 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物
US20160038464A1 (en) * 2012-04-16 2016-02-11 Antecip Bioventures Ii Llc Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan
JP2016535786A (ja) * 2013-11-05 2016-11-17 アンテシップ バイオベンチャーズ トゥー エルエルシー ブプロピオンまたは関連組成物およびデキストロメトルファンを含む組成物および方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024503114A (ja) * 2021-01-18 2024-01-24 アンテシップ バイオベンチャーズ トゥー エルエルシー 神経精神疾患に対する抗うつ剤とデキストロメトルファンとの組み合わせ

Also Published As

Publication number Publication date
IL273735A (en) 2020-05-31
JP7609943B2 (ja) 2025-01-07
TW201922232A (zh) 2019-06-16
AU2018345723B2 (en) 2024-09-19
RU2020115169A3 (enExample) 2022-02-16
MX2020003044A (es) 2020-08-13
CN111343980A (zh) 2020-06-26
ZA202001834B (en) 2024-10-30
BR112020006723A2 (pt) 2020-10-06
CA3078369A1 (en) 2019-04-11
WO2019070864A1 (en) 2019-04-11
IL273735B2 (en) 2024-08-01
CN111343980B (zh) 2024-02-27
RU2020115169A (ru) 2021-11-08
US20220331264A1 (en) 2022-10-20
US11382869B2 (en) 2022-07-12
EP3691641A1 (en) 2020-08-12
IL273735B1 (en) 2024-04-01
KR20200062254A (ko) 2020-06-03
US20240189252A1 (en) 2024-06-13
AU2018345723A8 (en) 2020-04-23
JP2023159366A (ja) 2023-10-31
TWI795446B (zh) 2023-03-11
AU2018345723A1 (en) 2020-04-16
EP3691641A4 (en) 2021-04-07
US20200323788A1 (en) 2020-10-15

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