BR112020006723A2 - dispositivo de distribuição transdérmica de dextrometorfano - Google Patents
dispositivo de distribuição transdérmica de dextrometorfano Download PDFInfo
- Publication number
- BR112020006723A2 BR112020006723A2 BR112020006723-7A BR112020006723A BR112020006723A2 BR 112020006723 A2 BR112020006723 A2 BR 112020006723A2 BR 112020006723 A BR112020006723 A BR 112020006723A BR 112020006723 A2 BR112020006723 A2 BR 112020006723A2
- Authority
- BR
- Brazil
- Prior art keywords
- dextromethorphan
- application
- day
- transdermal delivery
- delivery device
- Prior art date
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- 230000002459 sustained effect Effects 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568028P | 2017-10-04 | 2017-10-04 | |
| US62/568,028 | 2017-10-04 | ||
| US201862680182P | 2018-06-04 | 2018-06-04 | |
| US62/680,182 | 2018-06-04 | ||
| PCT/US2018/054178 WO2019070864A1 (en) | 2017-10-04 | 2018-10-03 | DEVICE FOR TRANSDERMAL DEXTROMETHORPHAN DELIVERY |
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| BR112020006723A2 true BR112020006723A2 (pt) | 2020-10-06 |
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| BR112020006723-7A BR112020006723A2 (pt) | 2017-10-04 | 2018-10-03 | dispositivo de distribuição transdérmica de dextrometorfano |
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| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
| US20240216358A1 (en) * | 2020-03-30 | 2024-07-04 | Shinkei Therapeutics Llc | Transdermal delivery of dextromethorphan |
| CN117100750A (zh) * | 2020-07-20 | 2023-11-24 | 深圳信立泰药业股份有限公司 | 一种药物组合物及其应用 |
| JP2024503114A (ja) * | 2021-01-18 | 2024-01-24 | アンテシップ バイオベンチャーズ トゥー エルエルシー | 神経精神疾患に対する抗うつ剤とデキストロメトルファンとの組み合わせ |
| CN113720944B (zh) * | 2021-09-30 | 2023-04-28 | 珠海润都制药股份有限公司 | 一种氢溴酸右美沙芬硫酸奎尼丁胶囊含量的检测方法 |
| AU2023356341A1 (en) * | 2022-10-06 | 2025-05-15 | Shinkei Therapeutics, Inc. | Transdermal delivery of dextromethorphan |
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| JP3020630B2 (ja) * | 1991-03-27 | 2000-03-15 | 三井化学株式会社 | 薬物投与用粘着剤 |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| WO1995024172A1 (en) * | 1994-03-07 | 1995-09-14 | Theratech, Inc. | Drug-containing adhesive composite transdermal delivery device |
| SE9601528D0 (sv) * | 1996-04-23 | 1996-04-23 | Pharmacia Ab | Transdermally administered dextromethorphan as antitissue agent |
| TWI326214B (en) | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| WO2004017941A2 (en) * | 2002-08-20 | 2004-03-04 | Euro-Celtique, S.A. | Transdermal dosage form comprising an active agent and a salt and free-baseform of an antagonist |
| CA2548596A1 (en) * | 2003-12-10 | 2005-06-23 | Acrux Dds Pty Ltd. | Method of treatment for undesired effect following transdermal or topical drug delivery |
| US20060223786A1 (en) | 2005-04-01 | 2006-10-05 | Smith David J | Transdermal pain control method and device |
| BRPI0607017B8 (pt) * | 2005-04-06 | 2021-05-25 | Adamas Pharmaceuticals Inc | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc |
| KR20080097443A (ko) * | 2006-02-03 | 2008-11-05 | 아바니르 파마슈티컬스 | 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물 |
| US20070248657A1 (en) * | 2006-04-25 | 2007-10-25 | Smith David J | Multi-compartment transdermal pain control device |
| EA200970369A1 (ru) * | 2006-10-09 | 2009-08-28 | Смитклайн Бичам Корпорейшн | Композиции для снижения симптомов никотиновой абстиненции и/или отказа от употребления табака |
| WO2009021058A2 (en) * | 2007-08-06 | 2009-02-12 | Trinity Labortories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2010062690A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
| JP5680061B2 (ja) * | 2009-04-24 | 2015-03-04 | ヘンケル・ユーエス・アイピー・リミテッド・ライアビリティ・カンパニーＨｅｎｋｅｌ ＵＳ ＩＰ ＬＬＣ | シリコーンアクリルハイブリッドポリマーを基剤とする接着剤 |
| US20140051718A1 (en) | 2012-04-16 | 2014-02-20 | Antecip Bioventures Ii Llc | Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan |
| JP6605485B2 (ja) * | 2013-11-05 | 2019-11-13 | アンテシップ バイオベンチャーズ トゥー エルエルシー | ブプロピオンまたは関連組成物およびデキストロメトルファンを含む組成物 |
| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
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| JP7609943B2 (ja) | 2025-01-07 |
| TW201922232A (zh) | 2019-06-16 |
| AU2018345723B2 (en) | 2024-09-19 |
| RU2020115169A3 (enExample) | 2022-02-16 |
| MX2020003044A (es) | 2020-08-13 |
| CN111343980A (zh) | 2020-06-26 |
| ZA202001834B (en) | 2024-10-30 |
| CA3078369A1 (en) | 2019-04-11 |
| WO2019070864A1 (en) | 2019-04-11 |
| IL273735B2 (en) | 2024-08-01 |
| CN111343980B (zh) | 2024-02-27 |
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| US20220331264A1 (en) | 2022-10-20 |
| US11382869B2 (en) | 2022-07-12 |
| EP3691641A1 (en) | 2020-08-12 |
| IL273735B1 (en) | 2024-04-01 |
| KR20200062254A (ko) | 2020-06-03 |
| US20240189252A1 (en) | 2024-06-13 |
| AU2018345723A8 (en) | 2020-04-23 |
| JP2023159366A (ja) | 2023-10-31 |
| TWI795446B (zh) | 2023-03-11 |
| AU2018345723A1 (en) | 2020-04-16 |
| EP3691641A4 (en) | 2021-04-07 |
| JP2020536953A (ja) | 2020-12-17 |
| US20200323788A1 (en) | 2020-10-15 |
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