JP2020536934A5 - - Google Patents

Info

Publication number

JP2020536934A5

JP2020536934A5 JP2020520775A JP2020520775A JP2020536934A5 JP 2020536934 A5 JP2020536934 A5 JP 2020536934A5 JP 2020520775 A JP2020520775 A JP 2020520775A JP 2020520775 A JP2020520775 A JP 2020520775A JP 2020536934 A5 JP2020536934 A5 JP 2020536934A5

Authority

JP

Japan

Prior art keywords

seq

peptide

variant

binding moiety

peptide mimetic

Prior art date

2018-10-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 40
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
• 102000004196 processed proteins & peptides Human genes 0.000 claims 7
• 108010078239 Chemokine CX3CL1 Proteins 0.000 claims 4
• 102000009410 Chemokine receptor Human genes 0.000 claims 4
• 108050000299 Chemokine receptor Proteins 0.000 claims 4
• 102000013818 Fractalkine Human genes 0.000 claims 4
• 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 230000005847 immunogenicity Effects 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 230000004044 response Effects 0.000 claims 4
• 229960005486 vaccine Drugs 0.000 claims 4
• 239000013543 active substance Substances 0.000 claims 3
• 238000003556 assay Methods 0.000 claims 3
• 230000000069 prophylactic effect Effects 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 108091023037 Aptamer Proteins 0.000 claims 2
• 108091006027 G proteins Proteins 0.000 claims 2
• 102000030782 GTP binding Human genes 0.000 claims 2
• 108091000058 GTP-Binding Proteins 0.000 claims 2
• 241000700605 Viruses Species 0.000 claims 2
• 230000035605 chemotaxis Effects 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000000816 peptidomimetic Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• 241000725643 Respiratory syncytial virus Species 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 238000007792 addition Methods 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 238000004132 cross linking Methods 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000003278 mimic effect Effects 0.000 claims 1
• 230000003472 neutralizing effect Effects 0.000 claims 1
• 230000000144 pharmacologic effect Effects 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1