JP2020535815A5 - - Google Patents
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- Publication number
- JP2020535815A5 JP2020535815A5 JP2020518013A JP2020518013A JP2020535815A5 JP 2020535815 A5 JP2020535815 A5 JP 2020535815A5 JP 2020518013 A JP2020518013 A JP 2020518013A JP 2020518013 A JP2020518013 A JP 2020518013A JP 2020535815 A5 JP2020535815 A5 JP 2020535815A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- rodent
- nucleic acid
- chimeric
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023035499A JP7534465B2 (ja) | 2017-09-29 | 2023-03-08 | ヒト化Ｃ１ｑ複合体を発現する非ヒト動物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762565438P | 2017-09-29 | 2017-09-29 | |
| US62/565,438 | 2017-09-29 | ||
| PCT/US2018/053099 WO2019067706A1 (en) | 2017-09-29 | 2018-09-27 | NON-HUMAN ANIMALS EXPRESSING A HUMANIZED C1Q COMPLEX |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023035499A Division JP7534465B2 (ja) | 2017-09-29 | 2023-03-08 | ヒト化Ｃ１ｑ複合体を発現する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535815A JP2020535815A (ja) | 2020-12-10 |
| JP2020535815A5 true JP2020535815A5 (enExample) | 2021-11-04 |
| JP7242650B2 JP7242650B2 (ja) | 2023-03-20 |
Family
ID=63858187
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020518013A Active JP7242650B2 (ja) | 2017-09-29 | 2018-09-27 | ヒト化Ｃ１ｑ複合体を発現する非ヒト動物 |
| JP2023035499A Active JP7534465B2 (ja) | 2017-09-29 | 2023-03-08 | ヒト化Ｃ１ｑ複合体を発現する非ヒト動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023035499A Active JP7534465B2 (ja) | 2017-09-29 | 2023-03-08 | ヒト化Ｃ１ｑ複合体を発現する非ヒト動物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11186848B2 (enExample) |
| EP (2) | EP4249502A3 (enExample) |
| JP (2) | JP7242650B2 (enExample) |
| KR (2) | KR20240128129A (enExample) |
| CN (2) | CN111386039B (enExample) |
| AU (1) | AU2018341685A1 (enExample) |
| CA (1) | CA3077418A1 (enExample) |
| DK (1) | DK3687287T5 (enExample) |
| ES (1) | ES2961713T3 (enExample) |
| FI (1) | FI3687287T3 (enExample) |
| IL (1) | IL273588A (enExample) |
| LT (1) | LT3687287T (enExample) |
| PT (1) | PT3687287T (enExample) |
| RU (1) | RU2020112751A (enExample) |
| SG (1) | SG11202002002XA (enExample) |
| SI (1) | SI3687287T1 (enExample) |
| WO (1) | WO2019067706A1 (enExample) |
| ZA (1) | ZA202001389B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030082546A1 (en) * | 1996-11-06 | 2003-05-01 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2329012T3 (es) | 2000-11-07 | 2009-11-20 | Zymogenetics, Inc. | Receptor del factor de necrosis tumoral humano. |
| GB0322998D0 (en) | 2003-10-01 | 2003-11-05 | Ares Trading Sa | Protein |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| SI1962895T1 (sl) * | 2005-12-16 | 2013-04-30 | Regeneron Pharmaceuticals, Inc. | Terapevtska uporaba DII4 antagonista in VEGF inhibitorja za inhibiranje tumorske rasti |
| ES2529174T3 (es) * | 2007-06-12 | 2015-02-17 | Ac Immune S.A. | Anticuerpos humanizados para amiloide beta |
| ES2984483T3 (es) * | 2010-03-31 | 2024-10-29 | Ablexis Llc | Ingeniería genética de ratones para la producción de anticuerpos quiméricos |
| AU2011343161B2 (en) * | 2010-12-17 | 2017-02-02 | Neurimmune Holding Ag | Human anti-SOD1 antibodies |
| US9043996B2 (en) * | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SMT201900478T1 (it) | 2011-10-28 | 2019-09-09 | Regeneron Pharma | Topi con complesso maggiore di istocompatibilita' geneticamente modificati |
| FR2996561B1 (fr) * | 2012-10-09 | 2016-03-18 | Commissariat Energie Atomique | Procede de preparation de proteine c1q recombinante |
| MX384291B (es) | 2013-02-20 | 2025-03-14 | Regeneron Pharma | Modificación genética de ratas. |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| DK3019240T3 (da) * | 2013-07-09 | 2024-06-03 | Annexon Inc | Anti-komplementfaktor C1Q antistoffer og anvendelser deraf |
| EP3636073B1 (en) * | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| RU2726446C2 (ru) | 2014-11-24 | 2020-07-14 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
-
2018
- 2018-09-27 RU RU2020112751A patent/RU2020112751A/ru unknown
- 2018-09-27 US US16/144,156 patent/US11186848B2/en active Active
- 2018-09-27 DK DK18786611.6T patent/DK3687287T5/da active
- 2018-09-27 KR KR1020247027156A patent/KR20240128129A/ko active Pending
- 2018-09-27 JP JP2020518013A patent/JP7242650B2/ja active Active
- 2018-09-27 AU AU2018341685A patent/AU2018341685A1/en not_active Abandoned
- 2018-09-27 CN CN201880066080.7A patent/CN111386039B/zh active Active
- 2018-09-27 EP EP23174310.5A patent/EP4249502A3/en not_active Withdrawn
- 2018-09-27 LT LTEPPCT/US2018/053099T patent/LT3687287T/lt unknown
- 2018-09-27 EP EP18786611.6A patent/EP3687287B1/en active Active
- 2018-09-27 CN CN202310113182.2A patent/CN116376973A/zh active Pending
- 2018-09-27 SG SG11202002002XA patent/SG11202002002XA/en unknown
- 2018-09-27 KR KR1020207011761A patent/KR102696334B1/ko active Active
- 2018-09-27 WO PCT/US2018/053099 patent/WO2019067706A1/en not_active Ceased
- 2018-09-27 PT PT187866116T patent/PT3687287T/pt unknown
- 2018-09-27 ES ES18786611T patent/ES2961713T3/es active Active
- 2018-09-27 SI SI201831001T patent/SI3687287T1/sl unknown
- 2018-09-27 FI FIEP18786611.6T patent/FI3687287T3/fi active
- 2018-09-27 CA CA3077418A patent/CA3077418A1/en active Pending
-
2020
- 2020-03-04 ZA ZA2020/01389A patent/ZA202001389B/en unknown
- 2020-03-25 IL IL273588A patent/IL273588A/en unknown
-
2021
- 2021-10-21 US US17/506,730 patent/US20220033847A1/en not_active Abandoned
-
2023
- 2023-03-08 JP JP2023035499A patent/JP7534465B2/ja active Active
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