JP2020533966A5 - - Google Patents
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- Publication number
- JP2020533966A5 JP2020533966A5 JP2020510102A JP2020510102A JP2020533966A5 JP 2020533966 A5 JP2020533966 A5 JP 2020533966A5 JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020533966 A5 JP2020533966 A5 JP 2020533966A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- influenza virus
- virus surface
- promoter
- myceliophthora thermophila
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010052285 Membrane Proteins Proteins 0.000 claims 14
- 102000018697 Membrane Proteins Human genes 0.000 claims 14
- 241000712461 unidentified influenza virus Species 0.000 claims 12
- 241001313536 Thermothelomyces thermophila Species 0.000 claims 10
- 101710154606 Hemagglutinin Proteins 0.000 claims 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 6
- 101710176177 Protein A56 Proteins 0.000 claims 6
- 239000000185 hemagglutinin Substances 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000005348 Neuraminidase Human genes 0.000 claims 5
- 108010006232 Neuraminidase Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 208000037797 influenza A Diseases 0.000 claims 4
- 208000037798 influenza B Diseases 0.000 claims 4
- 101150026303 HEX1 gene Proteins 0.000 claims 3
- 101150052795 cbh-1 gene Proteins 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 1
- 101150015099 CHIA1 gene Proteins 0.000 claims 1
- 101710151413 Chitinase 1 Proteins 0.000 claims 1
- 102100037328 Chitotriosidase-1 Human genes 0.000 claims 1
- 101710132290 Chitotriosidase-1 Proteins 0.000 claims 1
- 101710107327 Endochitinase 1 Proteins 0.000 claims 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 1
- 102100022624 Glucoamylase Human genes 0.000 claims 1
- 101710082868 Glucoamylase 1 Proteins 0.000 claims 1
- 101100216047 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gla-1 gene Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 101150014959 chi1 gene Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 229960003971 influenza vaccine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762547885P | 2017-08-21 | 2017-08-21 | |
| US62/547,885 | 2017-08-21 | ||
| PCT/IB2018/056003 WO2019038623A1 (en) | 2017-08-21 | 2018-08-09 | PRODUCTION OF AN INFLUENZA VACCINE IN MYCELIOPHTHORA THERMOPHILA |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533966A JP2020533966A (ja) | 2020-11-26 |
| JP2020533966A5 true JP2020533966A5 (enExample) | 2021-09-16 |
Family
ID=65438455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510102A Pending JP2020533966A (ja) | 2017-08-21 | 2018-08-09 | Ｍｙｃｅｌｉｏｐｈｔｈｏｒａ ｔｈｅｒｍｏｐｈｉｌａ中でのフルワクチンの産生 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11738080B2 (enExample) |
| EP (1) | EP3672630A4 (enExample) |
| JP (1) | JP2020533966A (enExample) |
| KR (1) | KR20200090143A (enExample) |
| CN (1) | CN111315408A (enExample) |
| AU (1) | AU2018319501A1 (enExample) |
| CA (1) | CA3073646A1 (enExample) |
| IL (1) | IL272568A (enExample) |
| WO (1) | WO2019038623A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021229483A1 (en) * | 2020-05-14 | 2021-11-18 | Dyadic International (Usa), Inc. | Modified filamentous fungi for production of exogenous proteins |
| CN117377752A (zh) * | 2021-03-11 | 2024-01-09 | 二进国际(美国)有限公司 | 用于生产具有减少的或不含n-连接的糖基化的外源蛋白的遗传修饰的丝状真菌 |
| WO2023225646A1 (en) | 2022-05-20 | 2023-11-23 | Phibro Animal Health Corporation | Using fungal constructs to produce viral protein antigens |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3621995B2 (ja) | 1994-05-20 | 2005-02-23 | マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー | 赤血球凝集素のアシル化／パルミチル化を抑制する抗ウイルス剤を用いるインフルエンザウイルス感染の治療 |
| AU771539C (en) * | 1998-10-06 | 2005-01-13 | Dyadic International (Usa), Inc. | Transformation system in the field of filamentous fungal hosts |
| HUP0300469A2 (hu) | 2000-04-13 | 2003-06-28 | Emalfarb, Mark Aaron | Új, expressziós szabályzó szekvenciák és expressziós termékek fonalas gombákban |
| US8506967B2 (en) * | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| EP1799261B1 (en) * | 2004-10-15 | 2012-12-05 | Intrexon Corporation | Methods and compositions for combinatoral-based production of multivalent recombinant antigens |
| US8680252B2 (en) * | 2006-12-10 | 2014-03-25 | Dyadic International (Usa), Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
| WO2008073490A1 (en) * | 2006-12-12 | 2008-06-19 | Carrington Laboratories Inc., | Purification of influenza viral antigens |
| CA2755417C (en) | 2009-03-16 | 2018-11-13 | Dyadic Nederland B.V. | New fungal production system |
| EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| WO2010150982A2 (ko) | 2009-06-23 | 2010-12-29 | 한밭대학교 산학협력단 | 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 ｐｌｇａ 미립자의 제조 방법 |
| CN102985107A (zh) | 2010-01-24 | 2013-03-20 | 生物模仿公司 | 免疫性流感成分 |
| BR112014022506A2 (pt) * | 2012-03-12 | 2018-11-06 | Codexis Inc | variantes de cbh1a |
| US20130315955A1 (en) | 2012-04-13 | 2013-11-28 | Protein Sciences Corporation | Stability and potency of hemagglutinin |
| US10118951B2 (en) | 2014-12-19 | 2018-11-06 | Sanofi Pasteur | Multimerization of recombinant protein by fusion to a sequence from lamprey |
| EP3384002A1 (en) | 2015-12-02 | 2018-10-10 | Basf Se | Method of producing proteins in filamentous fungi with decreased clr2 activity |
-
2018
- 2018-08-09 US US16/640,483 patent/US11738080B2/en active Active
- 2018-08-09 JP JP2020510102A patent/JP2020533966A/ja active Pending
- 2018-08-09 EP EP18848087.5A patent/EP3672630A4/en active Pending
- 2018-08-09 KR KR1020207004901A patent/KR20200090143A/ko not_active Ceased
- 2018-08-09 CA CA3073646A patent/CA3073646A1/en not_active Abandoned
- 2018-08-09 AU AU2018319501A patent/AU2018319501A1/en not_active Abandoned
- 2018-08-09 CN CN201880053773.2A patent/CN111315408A/zh active Pending
- 2018-08-09 WO PCT/IB2018/056003 patent/WO2019038623A1/en not_active Ceased
-
2020
- 2020-02-09 IL IL272568A patent/IL272568A/en unknown
-
2023
- 2023-07-11 US US18/350,646 patent/US20230346913A1/en active Pending
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