JP2020533966A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020533966A5 JP2020533966A5 JP2020510102A JP2020510102A JP2020533966A5 JP 2020533966 A5 JP2020533966 A5 JP 2020533966A5 JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020533966 A5 JP2020533966 A5 JP 2020533966A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- influenza virus
- virus surface
- promoter
- myceliophthora thermophila
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010052285 Membrane Proteins Proteins 0.000 claims 14
- 102000018697 Membrane Proteins Human genes 0.000 claims 14
- 241000712461 unidentified influenza virus Species 0.000 claims 12
- 241001313536 Thermothelomyces thermophila Species 0.000 claims 10
- 101710154606 Hemagglutinin Proteins 0.000 claims 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 6
- 101710176177 Protein A56 Proteins 0.000 claims 6
- 239000000185 hemagglutinin Substances 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000005348 Neuraminidase Human genes 0.000 claims 5
- 108010006232 Neuraminidase Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 208000037797 influenza A Diseases 0.000 claims 4
- 208000037798 influenza B Diseases 0.000 claims 4
- 101150026303 HEX1 gene Proteins 0.000 claims 3
- 101150052795 cbh-1 gene Proteins 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 1
- 101150015099 CHIA1 gene Proteins 0.000 claims 1
- 101710151413 Chitinase 1 Proteins 0.000 claims 1
- 102100037328 Chitotriosidase-1 Human genes 0.000 claims 1
- 101710132290 Chitotriosidase-1 Proteins 0.000 claims 1
- 101710107327 Endochitinase 1 Proteins 0.000 claims 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 1
- 102100022624 Glucoamylase Human genes 0.000 claims 1
- 101710082868 Glucoamylase 1 Proteins 0.000 claims 1
- 101100216047 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gla-1 gene Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 101150014959 chi1 gene Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 229960003971 influenza vaccine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762547885P | 2017-08-21 | 2017-08-21 | |
| US62/547,885 | 2017-08-21 | ||
| PCT/IB2018/056003 WO2019038623A1 (en) | 2017-08-21 | 2018-08-09 | PRODUCTION OF AN INFLUENZA VACCINE IN MYCELIOPHTHORA THERMOPHILA |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533966A JP2020533966A (ja) | 2020-11-26 |
| JP2020533966A5 true JP2020533966A5 (enExample) | 2021-09-16 |
Family
ID=65438455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510102A Pending JP2020533966A (ja) | 2017-08-21 | 2018-08-09 | Ｍｙｃｅｌｉｏｐｈｔｈｏｒａ ｔｈｅｒｍｏｐｈｉｌａ中でのフルワクチンの産生 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11738080B2 (enExample) |
| EP (1) | EP3672630A4 (enExample) |
| JP (1) | JP2020533966A (enExample) |
| KR (1) | KR20200090143A (enExample) |
| CN (1) | CN111315408A (enExample) |
| AU (1) | AU2018319501A1 (enExample) |
| CA (1) | CA3073646A1 (enExample) |
| IL (1) | IL272568A (enExample) |
| WO (1) | WO2019038623A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230313121A1 (en) * | 2020-05-14 | 2023-10-05 | Dyadic International (Usa), Inc. | Modified filamentous fungi for production of exogenous proteins |
| CN117377752A (zh) * | 2021-03-11 | 2024-01-09 | 二进国际(美国)有限公司 | 用于生产具有减少的或不含n-连接的糖基化的外源蛋白的遗传修饰的丝状真菌 |
| CN119836469A (zh) | 2022-05-20 | 2025-04-15 | 辉宝动物保健公司 | 使用真菌构建体产生病毒蛋白抗原 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE245199T1 (de) | 1994-05-20 | 2003-08-15 | Sinai School Medicine | Behandlung von influenzavirus-infektion unter verwendung von antiviralen acylierung/palmitylierung von hemagglutinin hemmen |
| ATE286136T1 (de) | 1998-10-06 | 2005-01-15 | Mark Aaron Emalfarb | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen |
| CN100420753C (zh) | 2000-04-13 | 2008-09-24 | 马克·阿龙·埃马尔法尔布 | 丝状真菌领域的新的表达调节序列和表达产物 |
| US8506967B2 (en) | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| JP5060958B2 (ja) | 2004-10-15 | 2012-10-31 | イントレキソン コーポレーション | 多価組換え抗原のコンビナトリアルベースの生産のための方法および組成物 |
| EP2505651A3 (en) | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Isolated fungus with reduced protease activity |
| WO2008073490A1 (en) * | 2006-12-12 | 2008-06-19 | Carrington Laboratories Inc., | Purification of influenza viral antigens |
| DK3421597T3 (da) | 2009-03-16 | 2021-01-25 | Danisco Us Inc | System til chrysosporium lucknowense-proteinfremstilling |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| WO2010150982A2 (ko) | 2009-06-23 | 2010-12-29 | 한밭대학교 산학협력단 | 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 ｐｌｇａ 미립자의 제조 방법 |
| CA2787974A1 (en) | 2010-01-24 | 2011-07-28 | Biological Mimetics, Inc. | Immunogenic influenza composition |
| US20150087028A1 (en) * | 2012-03-12 | 2015-03-26 | Codexis, Inc. | Cbh1a variants |
| US20130315955A1 (en) | 2012-04-13 | 2013-11-28 | Protein Sciences Corporation | Stability and potency of hemagglutinin |
| EP3233924B1 (en) | 2014-12-19 | 2019-05-15 | Sanofi Pasteur | Multimerization of recombinant protein by fusion to a sequence from lamprey |
| JP2019503168A (ja) | 2015-12-02 | 2019-02-07 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | Ｃｌｒ２活性が低減した糸状菌においてタンパク質を生産する方法 |
-
2018
- 2018-08-09 CA CA3073646A patent/CA3073646A1/en not_active Abandoned
- 2018-08-09 EP EP18848087.5A patent/EP3672630A4/en active Pending
- 2018-08-09 KR KR1020207004901A patent/KR20200090143A/ko not_active Ceased
- 2018-08-09 US US16/640,483 patent/US11738080B2/en active Active
- 2018-08-09 AU AU2018319501A patent/AU2018319501A1/en not_active Abandoned
- 2018-08-09 WO PCT/IB2018/056003 patent/WO2019038623A1/en not_active Ceased
- 2018-08-09 CN CN201880053773.2A patent/CN111315408A/zh active Pending
- 2018-08-09 JP JP2020510102A patent/JP2020533966A/ja active Pending
-
2020
- 2020-02-09 IL IL272568A patent/IL272568A/en unknown
-
2023
- 2023-07-11 US US18/350,646 patent/US20230346913A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20260001918A1 (en) | Influenza virus vaccines and uses thereof | |
| Margine et al. | Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses | |
| US20260048114A1 (en) | Influenza virus vaccination regimens | |
| Wohlbold et al. | Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses | |
| US9968670B2 (en) | Influenza virus vaccines and uses thereof | |
| CA2669485C (en) | Papaya mosaic virus-based vaccines for influenza | |
| JP2010533737A5 (enExample) | ||
| Klausberger et al. | One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge | |
| JP2009528987A5 (enExample) | ||
| JP2016516415A5 (enExample) | ||
| JP2013216685A5 (enExample) | ||
| RU2015146097A (ru) | Получение вирусоподобных частиц вируса гриппа в растениях | |
| Mallajosyula et al. | Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype | |
| US20220403358A1 (en) | Recombinant neuraminidase and uses thereof | |
| Ravin et al. | Plant-produced recombinant influenza vaccine based on virus-like HBc particles carrying an extracellular domain of M2 protein | |
| JP2023539356A5 (enExample) | ||
| CN101899461B (zh) | 一种编码甲型流感病毒NP蛋白和M2e多肽的融合基因 | |
| Subathra et al. | Evaluation of antibody response in mice against avian influenza A (H5N1) strain neuraminidase expressed in yeast Pichia pastoris | |
| JP6978079B2 (ja) | ウシ免疫不全ウイルスｇａｇタンパク質を使用する組換えウイルス様粒子 | |
| Kesik-Brodacka et al. | A universal flu vaccine | |
| Ramly et al. | Infectious salmon anaemia virus nuclear export protein is encoded by a spliced gene product of genomic segment 7 | |
| Qian et al. | Secretion of truncated recombinant rabies virus glycoprotein with preserved antigenic properties using a co-expression system in Hansenula polymorpha | |
| US9150620B2 (en) | Vaccine against multitypes of avian influenza viruses and uses thereof | |
| Gong et al. | Identification of a linear epitope within domain I of Duck Tembusu virus envelope protein using a novel neutralizing monoclonal antibody | |
| JP2020533966A (ja) | Ｍｙｃｅｌｉｏｐｈｔｈｏｒａ ｔｈｅｒｍｏｐｈｉｌａ中でのフルワクチンの産生 |