JP2020533966A - Myceliophthora thermophila中でのフルワクチンの産生 - Google Patents
Myceliophthora thermophila中でのフルワクチンの産生 Download PDFInfo
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- JP2020533966A JP2020533966A JP2020510102A JP2020510102A JP2020533966A JP 2020533966 A JP2020533966 A JP 2020533966A JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020510102 A JP2020510102 A JP 2020510102A JP 2020533966 A JP2020533966 A JP 2020533966A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762547885P | 2017-08-21 | 2017-08-21 | |
| US62/547,885 | 2017-08-21 | ||
| PCT/IB2018/056003 WO2019038623A1 (en) | 2017-08-21 | 2018-08-09 | PRODUCTION OF AN INFLUENZA VACCINE IN MYCELIOPHTHORA THERMOPHILA |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533966A true JP2020533966A (ja) | 2020-11-26 |
| JP2020533966A5 JP2020533966A5 (enExample) | 2021-09-16 |
Family
ID=65438455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510102A Pending JP2020533966A (ja) | 2017-08-21 | 2018-08-09 | Myceliophthora thermophila中でのフルワクチンの産生 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11738080B2 (enExample) |
| EP (1) | EP3672630A4 (enExample) |
| JP (1) | JP2020533966A (enExample) |
| KR (1) | KR20200090143A (enExample) |
| CN (1) | CN111315408A (enExample) |
| AU (1) | AU2018319501A1 (enExample) |
| CA (1) | CA3073646A1 (enExample) |
| IL (1) | IL272568A (enExample) |
| WO (1) | WO2019038623A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021229483A1 (en) * | 2020-05-14 | 2021-11-18 | Dyadic International (Usa), Inc. | Modified filamentous fungi for production of exogenous proteins |
| CN117377752A (zh) * | 2021-03-11 | 2024-01-09 | 二进国际(美国)有限公司 | 用于生产具有减少的或不含n-连接的糖基化的外源蛋白的遗传修饰的丝状真菌 |
| WO2023225646A1 (en) | 2022-05-20 | 2023-11-23 | Phibro Animal Health Corporation | Using fungal constructs to produce viral protein antigens |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004504012A (ja) * | 2000-04-13 | 2004-02-12 | エマルフアーブ,マーク・アーロン | 糸状菌の分野における新規発現調節配列および発現産物 |
| WO2016097369A1 (en) * | 2014-12-19 | 2016-06-23 | Sanofi Pasteur | Multimerization of recombinant protein by fusion to a sequence from lamprey |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3621995B2 (ja) | 1994-05-20 | 2005-02-23 | マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー | 赤血球凝集素のアシル化/パルミチル化を抑制する抗ウイルス剤を用いるインフルエンザウイルス感染の治療 |
| AU771539C (en) * | 1998-10-06 | 2005-01-13 | Dyadic International (Usa), Inc. | Transformation system in the field of filamentous fungal hosts |
| US8506967B2 (en) * | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| EP1799261B1 (en) * | 2004-10-15 | 2012-12-05 | Intrexon Corporation | Methods and compositions for combinatoral-based production of multivalent recombinant antigens |
| US8680252B2 (en) * | 2006-12-10 | 2014-03-25 | Dyadic International (Usa), Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
| WO2008073490A1 (en) * | 2006-12-12 | 2008-06-19 | Carrington Laboratories Inc., | Purification of influenza viral antigens |
| CA2755417C (en) | 2009-03-16 | 2018-11-13 | Dyadic Nederland B.V. | New fungal production system |
| EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| WO2010150982A2 (ko) | 2009-06-23 | 2010-12-29 | 한밭대학교 산학협력단 | 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 plga 미립자의 제조 방법 |
| CN102985107A (zh) | 2010-01-24 | 2013-03-20 | 生物模仿公司 | 免疫性流感成分 |
| BR112014022506A2 (pt) * | 2012-03-12 | 2018-11-06 | Codexis Inc | variantes de cbh1a |
| US20130315955A1 (en) | 2012-04-13 | 2013-11-28 | Protein Sciences Corporation | Stability and potency of hemagglutinin |
| EP3384002A1 (en) | 2015-12-02 | 2018-10-10 | Basf Se | Method of producing proteins in filamentous fungi with decreased clr2 activity |
-
2018
- 2018-08-09 US US16/640,483 patent/US11738080B2/en active Active
- 2018-08-09 JP JP2020510102A patent/JP2020533966A/ja active Pending
- 2018-08-09 EP EP18848087.5A patent/EP3672630A4/en active Pending
- 2018-08-09 KR KR1020207004901A patent/KR20200090143A/ko not_active Ceased
- 2018-08-09 CA CA3073646A patent/CA3073646A1/en not_active Abandoned
- 2018-08-09 AU AU2018319501A patent/AU2018319501A1/en not_active Abandoned
- 2018-08-09 CN CN201880053773.2A patent/CN111315408A/zh active Pending
- 2018-08-09 WO PCT/IB2018/056003 patent/WO2019038623A1/en not_active Ceased
-
2020
- 2020-02-09 IL IL272568A patent/IL272568A/en unknown
-
2023
- 2023-07-11 US US18/350,646 patent/US20230346913A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004504012A (ja) * | 2000-04-13 | 2004-02-12 | エマルフアーブ,マーク・アーロン | 糸状菌の分野における新規発現調節配列および発現産物 |
| WO2016097369A1 (en) * | 2014-12-19 | 2016-06-23 | Sanofi Pasteur | Multimerization of recombinant protein by fusion to a sequence from lamprey |
Non-Patent Citations (1)
| Title |
|---|
| 上原記念生命科学財団研究報告集[ONLINE],2015, VOL.29, P.1-9, 139.インフルエンザウイルス粒子形成スイ, JPN6022024102, ISSN: 0004970890 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019038623A1 (en) | 2019-02-28 |
| US11738080B2 (en) | 2023-08-29 |
| EP3672630A4 (en) | 2021-06-02 |
| US20200215183A1 (en) | 2020-07-09 |
| US20230346913A1 (en) | 2023-11-02 |
| KR20200090143A (ko) | 2020-07-28 |
| EP3672630A1 (en) | 2020-07-01 |
| CA3073646A1 (en) | 2019-02-28 |
| CN111315408A (zh) | 2020-06-19 |
| AU2018319501A1 (en) | 2020-04-02 |
| IL272568A (en) | 2020-03-31 |
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