JP2020532981A5 - - Google Patents

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Publication number
JP2020532981A5
JP2020532981A5 JP2020512843A JP2020512843A JP2020532981A5 JP 2020532981 A5 JP2020532981 A5 JP 2020532981A5 JP 2020512843 A JP2020512843 A JP 2020512843A JP 2020512843 A JP2020512843 A JP 2020512843A JP 2020532981 A5 JP2020532981 A5 JP 2020532981A5
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JP
Japan
Prior art keywords
cedna vector
cedna
vector according
stem
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020512843A
Other languages
English (en)
Japanese (ja)
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JP2020532981A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/049996 external-priority patent/WO2019051255A1/en
Publication of JP2020532981A publication Critical patent/JP2020532981A/ja
Publication of JP2020532981A5 publication Critical patent/JP2020532981A5/ja
Priority to JP2022176371A priority Critical patent/JP2022190081A/ja
Priority to JP2024189111A priority patent/JP2025010253A/ja
Pending legal-status Critical Current

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JP2020512843A 2017-09-08 2018-09-07 修飾型閉端ｄｎａ（ｃｅｄｎａ） Pending JP2020532981A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022176371A JP2022190081A (ja) 2017-09-08 2022-11-02 修飾型閉端ｄｎａ（ｃｅｄｎａ）
JP2024189111A JP2025010253A (ja) 2017-09-08 2024-10-28 修飾型閉端ｄｎａ（ｃｅｄｎａ）

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762556329P 2017-09-08 2017-09-08
US201762556331P 2017-09-08 2017-09-08
US201762556324P 2017-09-08 2017-09-08
US201762556335P 2017-09-08 2017-09-08
US201762556319P 2017-09-08 2017-09-08
US201762556281P 2017-09-08 2017-09-08
US62/556,331 2017-09-08
US62/556,324 2017-09-08
US62/556,281 2017-09-08
US62/556,335 2017-09-08
US62/556,329 2017-09-08
US62/556,319 2017-09-08
PCT/US2018/049996 WO2019051255A1 (en) 2017-09-08 2018-09-07 CLOSED-ENDED DNA (CEDNA) MODIFIED

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022176371A Division JP2022190081A (ja) 2017-09-08 2022-11-02 修飾型閉端ｄｎａ（ｃｅｄｎａ）

Publications (2)

Publication Number Publication Date
JP2020532981A JP2020532981A (ja) 2020-11-19
JP2020532981A5 true JP2020532981A5 (https=) 2021-10-21

Family

ID=65635235

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020512843A Pending JP2020532981A (ja) 2017-09-08 2018-09-07 修飾型閉端ｄｎａ（ｃｅｄｎａ）
JP2022176371A Pending JP2022190081A (ja) 2017-09-08 2022-11-02 修飾型閉端ｄｎａ（ｃｅｄｎａ）
JP2024189111A Pending JP2025010253A (ja) 2017-09-08 2024-10-28 修飾型閉端ｄｎａ（ｃｅｄｎａ）

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022176371A Pending JP2022190081A (ja) 2017-09-08 2022-11-02 修飾型閉端ｄｎａ（ｃｅｄｎａ）
JP2024189111A Pending JP2025010253A (ja) 2017-09-08 2024-10-28 修飾型閉端ｄｎａ（ｃｅｄｎａ）

Country Status (15)

Country Link
US (1) US20200283794A1 (https=)
EP (1) EP3678710A4 (https=)
JP (3) JP2020532981A (https=)
KR (1) KR20200051011A (https=)
CN (1) CN111132699A (https=)
AU (1) AU2018327348A1 (https=)
BR (1) BR112020004151A2 (https=)
CA (1) CA3075168A1 (https=)
IL (1) IL272797A (https=)
MA (1) MA50100A (https=)
MX (1) MX2020002500A (https=)
PH (1) PH12020500465A1 (https=)
SG (1) SG11202000698SA (https=)
UA (1) UA129010C2 (https=)
WO (1) WO2019051255A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
NZ762100A (en) 2017-08-09 2025-12-19 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
CA3084185A1 (en) * 2017-12-06 2019-06-13 Generation Bio Co. Gene editing using a modified closed-ended dna (cedna)
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
KR20200120649A (ko) * 2018-02-14 2020-10-21 제너레이션 바이오 컴퍼니 비-바이러스 dna 벡터 및 항체 및 융합 단백질 생산을 위한 이의 용도
EP3833766A1 (en) 2018-08-09 2021-06-16 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
KR20210090619A (ko) * 2018-11-09 2021-07-20 제너레이션 바이오 컴퍼니 대칭인 변형된 역말단반복을 포함하는 변형된 폐쇄형 DNA(ceDNA)
GB201905651D0 (en) 2019-04-24 2019-06-05 Lightbio Ltd Nucleic acid constructs and methods for their manufacture
CA3146966A1 (en) * 2019-07-17 2021-01-21 Generation Bio Co. Compositions and production of nicked closed-ended dna vectors
CA3147414A1 (en) * 2019-07-17 2021-01-21 Generation Bio Co. Synthetic production of single-stranded adeno associated viral dna vectors
EP4013414A4 (en) * 2019-08-15 2023-09-27 The Children's Hospital of Philadelphia COMBINED INTRON-DERIVED MIRNA AND TRANSGENE THERAPY FOR THE TREATMENT OF SCA1
WO2021046265A1 (en) * 2019-09-06 2021-03-11 Generation Bio Co. Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof
KR20220128607A (ko) 2019-09-18 2022-09-21 인터갈락틱 테라퓨틱스, 인크. 합성 dna 벡터 및 사용 방법
WO2021072031A1 (en) * 2019-10-11 2021-04-15 Insideoutbio, Inc. Methods and compositions for the manufacture and use of circular dna encoded therapeutics for genetic disorders and other diseases
WO2021169167A1 (en) * 2020-02-29 2021-09-02 Nanjing GenScript Biotech Co., Ltd. Method for treating coronavirus infections
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20230138409A1 (en) * 2020-03-24 2023-05-04 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing factor ix therapeutics
JP2023520763A (ja) * 2020-03-24 2023-05-19 ジェネレーション バイオ カンパニー ゴーシェ治療薬を発現するための非ウイルス性ｄｎａベクター及びその使用
IL298241A (en) * 2020-05-18 2023-01-01 Generation Bio Co New lipids and their nanoparticle preparations
JP2023535632A (ja) 2020-07-27 2023-08-18 アンジャリウム バイオサイエンシズ エージー Ｄｎａ分子の組成物、その作製方法、及びその使用方法
WO2022046665A1 (en) 2020-08-23 2022-03-03 Bioverativ Therapeutics Inc. MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA)
US20220243201A1 (en) * 2020-08-23 2022-08-04 Bioverativ Therapeutics Inc. Engineered itr sequences and methods of use
EP4214309A4 (en) * 2020-09-16 2025-07-16 Generation Bio Co CLOSED-END DNA VECTORS AND RELATED USES FOR EXPRESSING PHENYLALANINE HYDROXYLASE (PAH)
CA3191743A1 (en) * 2020-09-16 2022-03-24 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing fviii therapeutics
GB202014751D0 (en) * 2020-09-18 2020-11-04 Lightbio Ltd Targeting vector
CA3211687A1 (en) * 2021-03-19 2022-09-22 Ozan ALKAN Non-viral dna vectors and uses thereof for expressing pfic therapeutics
US20240209393A1 (en) * 2021-04-26 2024-06-27 University Of Florida Research Foundation, Incorporated Synthetic aav vectors for repeated delivery of therapeutic genes
US20240216535A1 (en) * 2021-04-27 2024-07-04 Generation Bio Co. Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof
AU2022264509A1 (en) * 2021-04-27 2023-12-14 Generation Bio Co. Non-viral dna vectors expressing therapeutic antibodies and uses thereof
CA3218126A1 (en) * 2021-05-07 2022-11-10 Matthew MANGANIELLO Lyophilized non-viral dna vector compositions and uses thereof
KR20240005903A (ko) * 2021-05-07 2024-01-12 제너레이션 바이오 컴퍼니 백신 전달을 위한 비바이러스성 dna 벡터
WO2023069948A1 (en) * 2021-10-18 2023-04-27 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
CN119072330A (zh) 2022-03-14 2024-12-03 世代生物公司 异源初免加强疫苗组合物和使用方法
CN117802161A (zh) * 2022-06-30 2024-04-02 苏州吉恒基因科技有限公司 精准重组腺相关病毒载体及其用途
US20260055426A1 (en) * 2022-08-19 2026-02-26 Generation Bio Co. CLEAVABLE CLOSED-ENDED DNA (ceDNA) AND METHODS OF USE THEREOF
AU2024229184A1 (en) 2023-03-02 2025-08-28 Krystal Biotech, Inc. Interleukin-2 and interleukin-12 for cancer therapy
US11767541B1 (en) * 2023-03-27 2023-09-26 Genecraft, Inc. Adeno-associated virus complex with improved expression of RUNX3 gene and uses for preventing or treating KRAS mutated lung cancer
US11993783B1 (en) * 2023-03-27 2024-05-28 Genecraft Inc. Nucleic acid molecule comprising asymmetrically modified ITR for improving expression rate of inserted gene, and use thereof
US11891617B1 (en) * 2023-03-27 2024-02-06 Genecraft Inc. Modified complex platform of adeno-associated virus with improved rate of expression of loaded genes and reduced genotoxicity
EP4698646A2 (en) * 2023-04-21 2026-02-25 ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 1475 North Scottsdale Road Novel transmembrane sensors and method of characterization for lysis-free detection of intracellular targets
WO2025114932A1 (en) * 2023-11-30 2025-06-05 Sanofi Purification of closed-ended dna molecules
WO2026085495A1 (en) 2024-10-18 2026-04-23 Generation Bio Co. Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019824A1 (en) * 1994-03-08 2005-01-27 Human Genome Sciences, Inc. Fibroblast Growth Factor-10
US20050026838A1 (en) * 1995-06-05 2005-02-03 Human Genome Sciences, Inc. Fibroblast Growth Factor-13
DE10044384A1 (de) * 2000-09-08 2002-04-18 Medigene Ag Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
US20060166363A1 (en) * 2004-01-27 2006-07-27 Sergei Zolotukhin Modified baculovirus expression system for production of pseudotyped rAAV vector
WO2008016391A2 (en) * 2006-01-31 2008-02-07 The Board Of Trustees Of The Leland Stanford Junior University Self-complementary parvoviral vectors, and methods for making and using the same
EP2500434A1 (en) * 2011-03-12 2012-09-19 Association Institut de Myologie Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
US9943574B2 (en) * 2012-06-27 2018-04-17 Arthrogen B.V. Combination for treating an inflammatory disorder
CN104087613B (zh) * 2014-06-30 2017-08-29 中国科学院苏州生物医学工程技术研究所 基于aav‑itr的基因表达微载体及其构建方法和应用
CN116064678A (zh) * 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
MX2018010633A (es) * 2016-03-03 2019-06-13 Univ Massachusetts Acido desoxirribonucleico (adn) lineal duplex de extremos cerrados para transferencia genica no viral.

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