JP2020531530A5 - - Google Patents
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- JP2020531530A5 JP2020531530A5 JP2020511364A JP2020511364A JP2020531530A5 JP 2020531530 A5 JP2020531530 A5 JP 2020531530A5 JP 2020511364 A JP2020511364 A JP 2020511364A JP 2020511364 A JP2020511364 A JP 2020511364A JP 2020531530 A5 JP2020531530 A5 JP 2020531530A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023121658A JP2023129623A (ja) | 2017-08-22 | 2023-07-26 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
| JP2025083816A JP2025131620A (ja) | 2017-08-22 | 2025-05-20 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762548848P | 2017-08-22 | 2017-08-22 | |
| US62/548,848 | 2017-08-22 | ||
| PCT/US2018/047323 WO2019040491A1 (en) | 2017-08-22 | 2018-08-21 | MODIFIED ALKYL CHAIN IMIDAZOQUINOLINE TLR7 / 8 AGONIST COMPOUNDS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023121658A Division JP2023129623A (ja) | 2017-08-22 | 2023-07-26 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531530A JP2020531530A (ja) | 2020-11-05 |
| JP2020531530A5 true JP2020531530A5 (https=) | 2021-09-16 |
| JP7386536B2 JP7386536B2 (ja) | 2023-11-27 |
Family
ID=63638354
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511364A Active JP7386536B2 (ja) | 2017-08-22 | 2018-08-21 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
| JP2023121658A Pending JP2023129623A (ja) | 2017-08-22 | 2023-07-26 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
| JP2025083816A Pending JP2025131620A (ja) | 2017-08-22 | 2025-05-20 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023121658A Pending JP2023129623A (ja) | 2017-08-22 | 2023-07-26 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
| JP2025083816A Pending JP2025131620A (ja) | 2017-08-22 | 2025-05-20 | アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10618896B2 (https=) |
| EP (2) | EP4257198A3 (https=) |
| JP (3) | JP7386536B2 (https=) |
| ES (1) | ES2951817T3 (https=) |
| WO (1) | WO2019040491A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2951817T3 (es) | 2017-08-22 | 2023-10-25 | Dynavax Tech Corp | Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos |
| US10722591B2 (en) | 2017-11-14 | 2020-07-28 | Dynavax Technologies Corporation | Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof |
| WO2020162705A1 (ko) | 2019-02-08 | 2020-08-13 | 성균관대학교산학협력단 | 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도 |
| BR112022008039A2 (pt) | 2019-10-29 | 2022-07-12 | Prime Reach Trading Ltd | Compostos de 4-amino-imidazoquinolina e usos relacionados |
| CA3170551A1 (en) | 2020-03-02 | 2021-09-10 | Yong Taik Lim | Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof |
| US12564630B2 (en) * | 2020-05-05 | 2026-03-03 | Virovax Llc | Vaccine adjuvants |
| US20230277525A1 (en) | 2020-08-04 | 2023-09-07 | Progeneer Inc | Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof |
| JP7690221B2 (ja) | 2020-08-04 | 2025-06-10 | プロジェニア インコーポレイテッド | 動力学的に作用するアジュバントアンサンブル |
| US20230346924A1 (en) | 2020-08-04 | 2023-11-02 | Progeneer Inc. | Mrna vaccine comprising adjuvant capable of kinetic control |
| CN113967256B (zh) * | 2021-10-26 | 2022-09-30 | 山东大学 | 一种具有光热-化疗-免疫功能的纳米粒及其制备方法和应用 |
| WO2023081237A1 (en) * | 2021-11-03 | 2023-05-11 | Regents Of The University Of Minnesota | Toll-like receptor agonists and antagonists and uses thereof |
| CN119136795A (zh) * | 2021-11-10 | 2024-12-13 | 芝加哥大学 | 具有增强的疗效和降低的毒性的nfkb激活剂的作为佐剂的小分子免疫增强剂的缀合物 |
| CN116731015B (zh) * | 2023-05-18 | 2024-09-27 | 深圳威科森生物医药科技有限公司 | 咪唑并喹啉化合物及其制备方法、应用和组合物 |
| EP4731632A1 (en) * | 2023-06-21 | 2026-04-29 | The Trustees of The University of Pennsylvania | Toll-like receptor (tlr) agonist lipidoid compounds, lipid nanoparticles (lnps) comprising the same, and methods of use thereof |
| CN119320387B (zh) * | 2024-12-19 | 2025-06-27 | 杭州天龙药业有限公司 | 基于Toll样受体激动剂的疫苗佐剂脂质化合物及其应用 |
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| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| JPH09500128A (ja) | 1993-07-15 | 1997-01-07 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | イミダゾ〔４，５−ｃ〕ピリジン−４−アミン |
| JPH1180156A (ja) | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
| UA67760C2 (uk) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| US6180095B1 (en) | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6110929A (en) | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US7238368B2 (en) | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
| ATE340592T1 (de) | 1999-04-23 | 2006-10-15 | Alza Corp | Konjugate enthaltend eine spaltbare bindung zur anwendung in einem liposom |
| US6677349B1 (en) | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| DK1545597T3 (da) | 2002-08-15 | 2011-01-31 | 3M Innovative Properties Co | Immunstimulerende sammensætninger og fremgangsmåde til stimulering af en immunrespons |
| JP2006503068A (ja) | 2002-09-26 | 2006-01-26 | スリーエム イノベイティブ プロパティズ カンパニー | １ｈ−イミダゾダイマー |
| CA2510375A1 (en) | 2002-12-20 | 2004-07-15 | 3M Innovative Properties Company | Aryl / hetaryl substituted imidazoquinolines |
| EP2572714A1 (en) | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
| JP2006517974A (ja) | 2003-02-13 | 2006-08-03 | スリーエム イノベイティブ プロパティズ カンパニー | Ｉｒｍ化合物およびトル様受容体８に関する方法および組成物 |
| EP1615665A4 (en) | 2003-04-10 | 2010-10-06 | 3M Innovative Properties Co | DISTRIBUTION OF THE IMMUNE RESPONSE MODIFYING LINKS |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| US7799800B2 (en) | 2003-08-14 | 2010-09-21 | 3M Innovative Properties Company | Lipid-modified immune response modifiers |
| PT1687305E (pt) | 2003-11-21 | 2008-10-17 | Novartis Ag | Derivados de 1h-imidazoquinolina como inibidores de proteína quinase |
| US7884207B2 (en) | 2004-06-18 | 2011-02-08 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| WO2007079086A1 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Pyrazoloalkyl substituted imidazo ring compounds and methods |
| EP1988896A4 (en) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
| JP2013512859A (ja) | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体（ｔｌｒ）を介して作用するイミダゾキノリン |
| US8728486B2 (en) | 2011-05-18 | 2014-05-20 | University Of Kansas | Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds |
| WO2013166110A1 (en) | 2012-05-02 | 2013-11-07 | Yale University | Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms) |
| EP2674170B1 (en) | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
| EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
| WO2014113634A1 (en) | 2013-01-17 | 2014-07-24 | University Of Kansas | Toll-like receptor 2-agonistic lipopeptides, and method of making the same |
| EP2769738B1 (en) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
| US10471139B2 (en) | 2013-08-15 | 2019-11-12 | The University Of Kansas | Toll-like receptor agonists |
| GB201321242D0 (en) | 2013-12-02 | 2014-01-15 | Immune Targeting Systems Its Ltd | Immunogenic compound |
| DK3092256T3 (da) | 2014-01-10 | 2022-06-20 | Birdie Biopharmaceuticals Inc | Forbindelser og sammensætninger til immunterapi |
| ES2908150T3 (es) | 2014-05-01 | 2022-04-27 | Novartis Ag | Compuestos y composiciones como agonistas del receptor de tipo Toll 7 |
| GB201418004D0 (en) | 2014-10-10 | 2014-11-26 | Isis Innovation | Polymer adjuvant |
| WO2017044803A1 (en) | 2015-09-09 | 2017-03-16 | The United States Of America, As Represented By The Secretary Department Of Health And Human Service | Expression vector delivery system and use thereof for inducing an immune response |
| EP3356371A4 (en) | 2015-09-29 | 2020-06-24 | The University of Chicago | POLYMER CONJUGATE VACCINE |
| EP3368092B9 (en) | 2015-10-29 | 2020-07-29 | Novartis AG | Antibody conjugates comprising toll-like receptor agonist |
| AU2017376460A1 (en) | 2016-12-13 | 2019-06-20 | Bolt Biotherapeutics, Inc. | Antibody adjuvant conjugates |
| US10328895B2 (en) | 2017-03-17 | 2019-06-25 | Autoliv Asp, Inc. | Seatbelt pretensioning retractor assembly including a pretensioner rod |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| US20180311334A1 (en) | 2017-04-29 | 2018-11-01 | Yale University | Compositions and Methods for Inducing an Immune Response |
| ES2951817T3 (es) | 2017-08-22 | 2023-10-25 | Dynavax Tech Corp | Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos |
| BR112020004505A2 (pt) | 2017-09-06 | 2020-09-15 | BioNTech SE | imidazoquinolinas substituídas como agonistas de tlr7 |
| US10722591B2 (en) | 2017-11-14 | 2020-07-28 | Dynavax Technologies Corporation | Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof |
-
2018
- 2018-08-21 ES ES18773000T patent/ES2951817T3/es active Active
- 2018-08-21 WO PCT/US2018/047323 patent/WO2019040491A1/en not_active Ceased
- 2018-08-21 EP EP23177052.0A patent/EP4257198A3/en active Pending
- 2018-08-21 EP EP18773000.7A patent/EP3672969B1/en active Active
- 2018-08-21 US US16/107,605 patent/US10618896B2/en active Active
- 2018-08-21 JP JP2020511364A patent/JP7386536B2/ja active Active
-
2020
- 2020-03-02 US US16/806,733 patent/US11124510B2/en active Active
-
2021
- 2021-08-16 US US17/403,312 patent/US11981670B2/en active Active
-
2023
- 2023-07-26 JP JP2023121658A patent/JP2023129623A/ja active Pending
-
2024
- 2024-04-08 US US18/629,809 patent/US20240368155A1/en active Pending
-
2025
- 2025-05-20 JP JP2025083816A patent/JP2025131620A/ja active Pending
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