ES2951817T3 - Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos - Google Patents

Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos Download PDF

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Publication number
ES2951817T3
ES2951817T3 ES18773000T ES18773000T ES2951817T3 ES 2951817 T3 ES2951817 T3 ES 2951817T3 ES 18773000 T ES18773000 T ES 18773000T ES 18773000 T ES18773000 T ES 18773000T ES 2951817 T3 ES2951817 T3 ES 2951817T3
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Prior art keywords
compound
methyl
compounds
alkyl
antigen
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ES18773000T
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English (en)
Spanish (es)
Inventor
Stewart D Chipman
John Demattei
Radwan Kiwan
Melissa A Kachura
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Dynavax Technologies Corp
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Dynavax Technologies Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES18773000T 2017-08-22 2018-08-21 Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos Active ES2951817T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548848P 2017-08-22 2017-08-22
PCT/US2018/047323 WO2019040491A1 (en) 2017-08-22 2018-08-21 MODIFIED ALKYL CHAIN IMIDAZOQUINOLINE TLR7 / 8 AGONIST COMPOUNDS AND USES THEREOF

Publications (1)

Publication Number Publication Date
ES2951817T3 true ES2951817T3 (es) 2023-10-25

Family

ID=63638354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18773000T Active ES2951817T3 (es) 2017-08-22 2018-08-21 Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos

Country Status (5)

Country Link
US (4) US10618896B2 (https=)
EP (2) EP4257198A3 (https=)
JP (3) JP7386536B2 (https=)
ES (1) ES2951817T3 (https=)
WO (1) WO2019040491A1 (https=)

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ES2951817T3 (es) 2017-08-22 2023-10-25 Dynavax Tech Corp Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos
US10722591B2 (en) 2017-11-14 2020-07-28 Dynavax Technologies Corporation Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof
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CN113967256B (zh) * 2021-10-26 2022-09-30 山东大学 一种具有光热-化疗-免疫功能的纳米粒及其制备方法和应用
WO2023081237A1 (en) * 2021-11-03 2023-05-11 Regents Of The University Of Minnesota Toll-like receptor agonists and antagonists and uses thereof
CN119136795A (zh) * 2021-11-10 2024-12-13 芝加哥大学 具有增强的疗效和降低的毒性的nfkb激活剂的作为佐剂的小分子免疫增强剂的缀合物
CN116731015B (zh) * 2023-05-18 2024-09-27 深圳威科森生物医药科技有限公司 咪唑并喹啉化合物及其制备方法、应用和组合物
EP4731632A1 (en) * 2023-06-21 2026-04-29 The Trustees of The University of Pennsylvania Toll-like receptor (tlr) agonist lipidoid compounds, lipid nanoparticles (lnps) comprising the same, and methods of use thereof
CN119320387B (zh) * 2024-12-19 2025-06-27 杭州天龙药业有限公司 基于Toll样受体激动剂的疫苗佐剂脂质化合物及其应用

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Also Published As

Publication number Publication date
US11124510B2 (en) 2021-09-21
US20220033400A1 (en) 2022-02-03
US10618896B2 (en) 2020-04-14
US20190062329A1 (en) 2019-02-28
US20240368155A1 (en) 2024-11-07
EP3672969B1 (en) 2023-07-05
WO2019040491A1 (en) 2019-02-28
EP4257198A3 (en) 2023-10-18
EP3672969A1 (en) 2020-07-01
JP7386536B2 (ja) 2023-11-27
JP2025131620A (ja) 2025-09-09
US11981670B2 (en) 2024-05-14
JP2020531530A (ja) 2020-11-05
US20200199124A1 (en) 2020-06-25
EP4257198A2 (en) 2023-10-11
JP2023129623A (ja) 2023-09-14

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