JP2020531462A5 - - Google Patents
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- JP2020531462A5 JP2020531462A5 JP2020508983A JP2020508983A JP2020531462A5 JP 2020531462 A5 JP2020531462 A5 JP 2020531462A5 JP 2020508983 A JP2020508983 A JP 2020508983A JP 2020508983 A JP2020508983 A JP 2020508983A JP 2020531462 A5 JP2020531462 A5 JP 2020531462A5
- Authority
- JP
- Japan
- Prior art keywords
- oil
- composition according
- composition
- pores
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 40
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 14
- 239000004094 surface-active agent Substances 0.000 claims 14
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 11
- 206010013774 Dry eye Diseases 0.000 claims 11
- 229920002125 Sokalan® Polymers 0.000 claims 10
- 230000002209 hydrophobic effect Effects 0.000 claims 10
- 239000011148 porous material Substances 0.000 claims 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 9
- 229960001631 carbomer Drugs 0.000 claims 9
- 239000002537 cosmetic Substances 0.000 claims 7
- 239000003623 enhancer Substances 0.000 claims 7
- 235000011187 glycerol Nutrition 0.000 claims 7
- 229920000136 polysorbate Polymers 0.000 claims 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 6
- 239000007951 isotonicity adjuster Substances 0.000 claims 6
- 235000021302 avocado oil Nutrition 0.000 claims 5
- 239000008163 avocado oil Substances 0.000 claims 5
- 239000004359 castor oil Substances 0.000 claims 5
- 235000019438 castor oil Nutrition 0.000 claims 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 229960000686 benzalkonium chloride Drugs 0.000 claims 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 4
- 239000003921 oil Substances 0.000 claims 4
- 235000019198 oils Nutrition 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 235000019486 Sunflower oil Nutrition 0.000 claims 3
- 239000002600 sunflower oil Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 239000003139 biocide Substances 0.000 claims 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 2
- 210000000744 eyelid Anatomy 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- -1 oleuropain Substances 0.000 claims 2
- 239000010677 tea tree oil Substances 0.000 claims 2
- 229940111630 tea tree oil Drugs 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims 1
- 240000000467 Carum carvi Species 0.000 claims 1
- 235000005747 Carum carvi Nutrition 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 244000025272 Persea americana Species 0.000 claims 1
- 235000008673 Persea americana Nutrition 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 235000019484 Rapeseed oil Nutrition 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910001514 alkali metal chloride Inorganic materials 0.000 claims 1
- 239000010478 argan oil Substances 0.000 claims 1
- 239000000607 artificial tear Substances 0.000 claims 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims 1
- 229960001950 benzethonium chloride Drugs 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
- 235000013709 carrot oil Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960004926 chlorobutanol Drugs 0.000 claims 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 claims 1
- 239000003240 coconut oil Substances 0.000 claims 1
- 235000019864 coconut oil Nutrition 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims 1
- 239000010642 eucalyptus oil Substances 0.000 claims 1
- 229940044949 eucalyptus oil Drugs 0.000 claims 1
- 239000010643 fennel seed oil Substances 0.000 claims 1
- 229960004867 hexetidine Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229940119170 jojoba wax Drugs 0.000 claims 1
- 239000000944 linseed oil Substances 0.000 claims 1
- 235000021388 linseed oil Nutrition 0.000 claims 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 235000019488 nut oil Nutrition 0.000 claims 1
- 239000010466 nut oil Substances 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 235000019477 peppermint oil Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical class [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 1
- 229940099429 polyoxyl 40 stearate Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000010668 rosemary oil Substances 0.000 claims 1
- 229940058206 rosemary oil Drugs 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 229960001922 sodium perborate Drugs 0.000 claims 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 229940033663 thimerosal Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762547553P | 2017-08-18 | 2017-08-18 | |
| US62/547,553 | 2017-08-18 | ||
| PCT/US2018/046918 WO2019036625A1 (en) | 2017-08-18 | 2018-08-17 | METHODS FOR DIAGNOSING AND TREATING DRY-LIKE SYNDROME AND COMPOSITIONS FOR TREATING A HUMAN EYE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531462A JP2020531462A (ja) | 2020-11-05 |
| JP2020531462A5 true JP2020531462A5 (enExample) | 2021-09-24 |
| JP7311160B2 JP7311160B2 (ja) | 2023-07-19 |
Family
ID=65363005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508983A Active JP7311160B2 (ja) | 2017-08-18 | 2018-08-17 | ドライアイ症候群を診断及び処置する方法及びヒトの眼を処置するための組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11622982B2 (enExample) |
| EP (1) | EP3668474A4 (enExample) |
| JP (1) | JP7311160B2 (enExample) |
| CN (2) | CN111295169A (enExample) |
| BR (1) | BR112020003276A2 (enExample) |
| CA (1) | CA3072494A1 (enExample) |
| WO (1) | WO2019036625A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019524892A (ja) | 2016-08-19 | 2019-09-05 | アクリビスタ エルエルシーＡｋｒｉｖｉｓｔａ，Ｌｌｃ | ドライアイ症候群を診断及び治療する方法ならびにヒト眼を治療するための組成物 |
| WO2019036625A1 (en) | 2017-08-18 | 2019-02-21 | Akrivista, LLC | METHODS FOR DIAGNOSING AND TREATING DRY-LIKE SYNDROME AND COMPOSITIONS FOR TREATING A HUMAN EYE |
| TWI833913B (zh) * | 2019-02-27 | 2024-03-01 | 日商參天製藥股份有限公司 | 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物 |
| PL3888634T3 (pl) * | 2020-03-31 | 2023-09-11 | Oy Finnsusp Ab | Preparat oftalmiczny i jego zastosowanie |
| EP3919047A1 (en) * | 2020-06-03 | 2021-12-08 | AZAD Pharma AG | Microemulsion for the treatment of dry eye syndrome |
| ES2916152A1 (es) * | 2020-12-28 | 2022-06-28 | Univ Valladolid | Compuestos para su uso en la prevencion y/o tratamiento de la inflamacion y el estres oxidativo del segmento anterior del ojo |
| CN112842936A (zh) * | 2021-03-15 | 2021-05-28 | 傅博 | 一种眼部清洁液及其制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| US4146499A (en) | 1976-09-18 | 1979-03-27 | Rosano Henri L | Method for preparing microemulsions |
| US4585656A (en) | 1984-08-20 | 1986-04-29 | Rosenthal Harold R | Treatment of herpes |
| CA2052950A1 (en) | 1990-10-10 | 1992-04-11 | David P. Evitts | Aqueous ophthalmic microemulsions of tepoxalin |
| SG45449A1 (en) | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| US5527488A (en) * | 1992-08-07 | 1996-06-18 | Amway Corporation | High viscosity anhydrous makeup remover gel |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| US20030086986A1 (en) | 1998-08-06 | 2003-05-08 | Bruijn Chris De | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives |
| US7262224B2 (en) * | 1999-11-30 | 2007-08-28 | Hanna Isul Skin Therapy, Inc. | Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof |
| CA2462272A1 (en) | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue |
| US6559182B1 (en) | 2001-11-07 | 2003-05-06 | Purcell Jojoba International, Llc | Method for treatment of enveloped viruses using jojoba oil esters |
| US20060251685A1 (en) | 2003-03-18 | 2006-11-09 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20050202097A1 (en) | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
| WO2006004577A2 (en) | 2004-03-12 | 2006-01-12 | Melbj Holdings, Llc | Lubricant for the ocular surface |
| JP5272307B2 (ja) | 2004-07-16 | 2013-08-28 | 大正製薬株式会社 | 水性点眼剤 |
| WO2006073786A2 (en) | 2004-12-30 | 2006-07-13 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy |
| US9161905B2 (en) | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
| JP2006233398A (ja) | 2005-02-23 | 2006-09-07 | Daiwa Kagaku Kogyo Kk | アボガド油及びアボガド油不けん化物を処理したことを特徴とする機能化繊維材料および機能化繊維材料の処理方法。 |
| AU2006247136C1 (en) | 2005-05-17 | 2020-01-16 | Bausch + Lomb Ireland Limited | Compositions and methods for treatment of eye disorders |
| CN101668511A (zh) | 2007-02-28 | 2010-03-10 | 阿西克斯医疗公司 | 正常化睑板腺分泌的方法和化合物 |
| FR2916636B1 (fr) | 2007-05-29 | 2009-09-04 | Octalia Technologies | Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation ophtalmique ou dermocosmetique |
| US8669241B2 (en) | 2008-12-02 | 2014-03-11 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| CA2764477A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations, methods of manufacture, and methods of using same |
| EP2437762B1 (en) | 2009-06-05 | 2017-08-09 | Allergan, Inc. | Artificial tears and therapeutic uses |
| US9119827B2 (en) | 2009-06-30 | 2015-09-01 | Lion Corporation | Ophthalmic composition |
| US8909327B1 (en) | 2010-06-23 | 2014-12-09 | Allergan, Inc. | Instrument and method for diagnosing dry eye in a patient |
| WO2012092320A2 (en) | 2010-12-29 | 2012-07-05 | Nichamin Louis D | Eye treatment |
| JP6093701B2 (ja) | 2011-07-08 | 2017-03-08 | ロート製薬株式会社 | 眼科用水性組成物 |
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| EP2787969B1 (en) | 2011-12-07 | 2021-09-29 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| ITFI20120044A1 (it) | 2012-03-01 | 2013-09-02 | Biodue Spa | Formulazione ad uso oftalmico comprendente olio di jojoba. |
| JP5988855B2 (ja) | 2012-06-27 | 2016-09-07 | ロート製薬株式会社 | 水性眼科組成物 |
| WO2015137357A1 (ja) | 2014-03-10 | 2015-09-17 | サラヤ株式会社 | ソホロリピッドと生理活性物質と油脂とを含有する組成物およびその製造方法 |
| JP6768653B2 (ja) | 2014-11-25 | 2020-10-14 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 安定したオメガ−３眼科用組成物 |
| LT3266446T (lt) | 2016-07-07 | 2019-01-25 | Laboratorios Salvat, S.A. | Oftalmologinė kompozicija, apimanti ricinos aliejų ir vidutinio grandinės ilgio trigliceridą |
| JP2019524892A (ja) * | 2016-08-19 | 2019-09-05 | アクリビスタ エルエルシーＡｋｒｉｖｉｓｔａ，Ｌｌｃ | ドライアイ症候群を診断及び治療する方法ならびにヒト眼を治療するための組成物 |
| CN106389218A (zh) | 2016-10-28 | 2017-02-15 | 林振慧 | 一种眼部凝露 |
| WO2019036625A1 (en) | 2017-08-18 | 2019-02-21 | Akrivista, LLC | METHODS FOR DIAGNOSING AND TREATING DRY-LIKE SYNDROME AND COMPOSITIONS FOR TREATING A HUMAN EYE |
-
2018
- 2018-08-17 WO PCT/US2018/046918 patent/WO2019036625A1/en not_active Ceased
- 2018-08-17 JP JP2020508983A patent/JP7311160B2/ja active Active
- 2018-08-17 CA CA3072494A patent/CA3072494A1/en active Pending
- 2018-08-17 CN CN201880061919.8A patent/CN111295169A/zh active Pending
- 2018-08-17 EP EP18846695.7A patent/EP3668474A4/en active Pending
- 2018-08-17 US US16/638,546 patent/US11622982B2/en active Active
- 2018-08-17 CN CN202111484102.1A patent/CN114376961A/zh active Pending
- 2018-08-17 BR BR112020003276-0A patent/BR112020003276A2/pt not_active Application Discontinuation
-
2023
- 2023-03-31 US US18/129,182 patent/US12220439B2/en active Active
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