JP2020531028A5 - - Google Patents
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- JP2020531028A5 JP2020531028A5 JP2020511361A JP2020511361A JP2020531028A5 JP 2020531028 A5 JP2020531028 A5 JP 2020531028A5 JP 2020511361 A JP2020511361 A JP 2020511361A JP 2020511361 A JP2020511361 A JP 2020511361A JP 2020531028 A5 JP2020531028 A5 JP 2020531028A5
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- JP
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- Prior art keywords
- cells
- human
- nrp1
- reactive
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 118
- 210000000130 stem cell Anatomy 0.000 claims description 68
- 230000002861 ventricular Effects 0.000 claims description 66
- 102000004207 Neuropilin-1 Human genes 0.000 claims description 61
- 108090000772 Neuropilin-1 Proteins 0.000 claims description 61
- 239000003795 chemical substances by application Substances 0.000 claims description 56
- 210000004027 cell Anatomy 0.000 claims description 53
- 210000005260 human cell Anatomy 0.000 claims description 22
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000003550 marker Substances 0.000 claims description 12
- 230000000747 cardiac effect Effects 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000003446 ligand Substances 0.000 claims description 8
- 102100037904 CD9 antigen Human genes 0.000 claims description 4
- 102000000905 Cadherin Human genes 0.000 claims description 4
- 108050007957 Cadherin Proteins 0.000 claims description 4
- 206010048610 Cardiotoxicity Diseases 0.000 claims description 4
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims description 4
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims description 4
- 102100039820 Frizzled-4 Human genes 0.000 claims description 4
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 4
- 101000885581 Homo sapiens Frizzled-4 Proteins 0.000 claims description 4
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims description 4
- 101000994437 Homo sapiens Protein jagged-1 Proteins 0.000 claims description 4
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 4
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims description 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims description 4
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims description 4
- 102100032702 Protein jagged-1 Human genes 0.000 claims description 4
- 102000013008 Semaphorin-3A Human genes 0.000 claims description 4
- 108010090319 Semaphorin-3A Proteins 0.000 claims description 4
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 4
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 4
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims description 4
- 231100000259 cardiotoxicity Toxicity 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 4
- 102000037865 fusion proteins Human genes 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 4
- 108010090448 insulin gene enhancer binding protein Isl-1 Proteins 0.000 claims description 4
- 231100000419 toxicity Toxicity 0.000 claims description 4
- 230000001988 toxicity Effects 0.000 claims description 4
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 3
- 208000020446 Cardiac disease Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 108010068426 Contractile Proteins Proteins 0.000 claims description 2
- 101100540419 Danio rerio kdrl gene Proteins 0.000 claims description 2
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims description 2
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims description 2
- 101710107751 Myelin expression factor 2 Proteins 0.000 claims description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 claims description 2
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims description 2
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 claims description 2
- 210000001557 animal structure Anatomy 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000002771 cell marker Substances 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000004217 heart function Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 description 4
- 238000010187 selection method Methods 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076094A JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549345P | 2017-08-23 | 2017-08-23 | |
| US62/549,345 | 2017-08-23 | ||
| PCT/IB2018/001026 WO2019038587A1 (en) | 2017-08-23 | 2018-08-22 | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076094A Division JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531028A JP2020531028A (ja) | 2020-11-05 |
| JP2020531028A5 true JP2020531028A5 (cg-RX-API-DMAC10.html) | 2021-09-30 |
| JP7275109B2 JP7275109B2 (ja) | 2023-05-17 |
Family
ID=63794530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511361A Active JP7275109B2 (ja) | 2017-08-23 | 2018-08-22 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
| JP2023076094A Pending JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076094A Pending JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11186820B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3663393A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP7275109B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN111133099B (cg-RX-API-DMAC10.html) |
| CA (1) | CA3072579A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK3487988T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2019038587A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| JP7275109B2 (ja) | 2017-08-23 | 2023-05-17 | プロセラ セラピューティクス アーベー | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
| EP4019549B1 (en) * | 2019-08-20 | 2025-06-04 | Orizuru Therapeutics, Inc. | Method for enriching cardiac myocytes |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| US20230330264A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
| CN114752688B (zh) * | 2022-04-28 | 2024-02-23 | 北京大学口腔医学院 | 鉴定人类胚胎骨髓来源的间充质干细胞的方法、探针和试剂盒及其用途 |
| GB202314218D0 (en) | 2023-09-18 | 2023-11-01 | Astrazeneca Ab | Cell therapy |
| CN120699894A (zh) * | 2024-03-25 | 2025-09-26 | 中国科学院分子细胞科学卓越创新中心 | Clusterin阳性心脏类器官及其应用 |
Family Cites Families (51)
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| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| US7745113B2 (en) | 2003-01-31 | 2010-06-29 | The Regents Of The University Of California | Use of islet 1 as a marker for isolating or generating stem cells |
| ATE419334T1 (de) | 2005-07-29 | 2009-01-15 | Stiftung Caesar | Verfahren zur isolierung von stammzellen aus ein kissenformiges gewebe der zähne |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| US20100166714A1 (en) | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2518140A1 (en) | 2006-11-09 | 2012-10-31 | The Johns Hopkins University | Dedifferentation of adult mammalian cardiomyocytes into cardiac stem cells |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| EP2222837A2 (en) | 2007-02-09 | 2010-09-01 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| GB2465502B (en) | 2007-07-31 | 2013-06-26 | Es Cell Int Pte Ltd | Method for identifying and selecting cardiomyocytes |
| AU2008333972A1 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| WO2009094561A1 (en) * | 2008-01-24 | 2009-07-30 | The Government Of The United States Of America As Represented By The Secretary Of The Departmentof | Induced internalization of surface receptors |
| US20120027807A1 (en) | 2008-10-09 | 2012-02-02 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| US8765117B2 (en) | 2009-06-10 | 2014-07-01 | The General Hospital Corporation | Generation of vascularized human heart tissue and uses thereof |
| AU2010312291A1 (en) * | 2009-10-29 | 2012-06-21 | Mcmaster University | Generating induced pluripotent stem cells and progenitor cells from fibroblasts |
| WO2011091944A1 (en) | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US20130209415A1 (en) | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| NZ605449A (en) * | 2010-07-09 | 2015-03-27 | Genentech Inc | Anti-neuropilin antibodies and methods of use |
| AU2010100830A4 (en) | 2010-08-03 | 2010-09-16 | Robert Fallshaw | Biased Pin Lock |
| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| US10813950B2 (en) | 2010-12-02 | 2020-10-27 | Riken | Immunotherapy using allo-NKT cells, cells for immunotherapy in which alpha chain of t-cell receptor (TCR) gene has been rearranged to uniform Vα-Jα, and banking of NKT cells derived from said cells |
| CA2829804A1 (en) * | 2011-03-29 | 2012-10-04 | Geron Corporation | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| KR101323650B1 (ko) * | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 제거방법 |
| WO2012162740A1 (en) | 2011-05-31 | 2012-12-06 | Sonomedical Pty Ltd | Electronic monitoring system for the production of data packages for analytic and diagnostic purposes |
| WO2012162741A1 (en) | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| CN104411331B (zh) * | 2012-01-13 | 2018-08-21 | 哈佛学院董事会 | 在结构聚合装置中tlr激动剂的控制传递 |
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| WO2014078414A1 (en) | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US20150079626A1 (en) | 2013-03-19 | 2015-03-19 | Lsip, Llc | Method of obtaining a cell population containing cancer stem cells |
| WO2015058117A1 (en) * | 2013-10-18 | 2015-04-23 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| ES2689804T3 (es) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Composiciones de subpoblaciones de cardiomiocitos |
| WO2015081094A1 (en) * | 2013-11-27 | 2015-06-04 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| SI3105253T1 (sl) | 2014-02-12 | 2018-10-30 | F. Hoffmann-La Roche Ag | Protitelesa anti-Jagged1 in načini njihove uporabe |
| US10563175B2 (en) * | 2014-03-11 | 2020-02-18 | Indiana University Research And Technology Corporation | Method for generating endothelial colony forming cell-like cells |
| US10208287B2 (en) * | 2014-05-01 | 2019-02-19 | Iheart Japan Corporation | CD82-positive cardiac progenitor cells |
| WO2015172037A1 (en) * | 2014-05-09 | 2015-11-12 | Becton, Dickinson And Company | Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| WO2016029122A1 (en) | 2014-08-22 | 2016-02-25 | Chien Kenneth R | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| US9765299B2 (en) | 2014-09-10 | 2017-09-19 | Wisconsin Alumni Research Foundation | Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells |
| EP3241844B1 (en) * | 2014-12-03 | 2021-04-21 | Aimed Bio Inc. | Antibody against neuropilin 1 and use thereof |
| JP2018510649A (ja) | 2015-02-17 | 2018-04-19 | ユニバーシティー ヘルス ネットワーク | 洞房結節様ペースメーカー心筋細胞および心室様心筋細胞を作製および使用するための方法 |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| JP7275109B2 (ja) | 2017-08-23 | 2023-05-17 | プロセラ セラピューティクス アーベー | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
-
2018
- 2018-08-22 JP JP2020511361A patent/JP7275109B2/ja active Active
- 2018-08-22 US US16/109,218 patent/US11186820B2/en active Active
- 2018-08-22 WO PCT/IB2018/001026 patent/WO2019038587A1/en not_active Ceased
- 2018-08-22 CA CA3072579A patent/CA3072579A1/en active Pending
- 2018-08-22 DK DK18783080.7T patent/DK3487988T3/da active
- 2018-08-22 EP EP19210435.4A patent/EP3663393A1/en not_active Withdrawn
- 2018-08-22 CN CN201880054988.6A patent/CN111133099B/zh active Active
- 2018-08-22 EP EP18783080.7A patent/EP3487988B1/en active Active
-
2021
- 2021-10-21 US US17/507,454 patent/US12404488B2/en active Active
-
2023
- 2023-05-02 JP JP2023076094A patent/JP2023093754A/ja active Pending
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