JP2020530299A5 - - Google Patents

Download PDF

Info

Publication number
JP2020530299A5
JP2020530299A5 JP2020507586A JP2020507586A JP2020530299A5 JP 2020530299 A5 JP2020530299 A5 JP 2020530299A5 JP 2020507586 A JP2020507586 A JP 2020507586A JP 2020507586 A JP2020507586 A JP 2020507586A JP 2020530299 A5 JP2020530299 A5 JP 2020530299A5
Authority
JP
Japan
Prior art keywords
cancer
appendix
cell
binding
binding substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020507586A
Other languages
English (en)
Japanese (ja)
Other versions
JP7347899B2 (ja
JP2020530299A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/045741 external-priority patent/WO2019032661A1/en
Publication of JP2020530299A publication Critical patent/JP2020530299A/ja
Publication of JP2020530299A5 publication Critical patent/JP2020530299A5/ja
Priority to JP2023103640A priority Critical patent/JP2023112153A/ja
Application granted granted Critical
Publication of JP7347899B2 publication Critical patent/JP7347899B2/ja
Priority to JP2025076447A priority patent/JP2025109736A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020507586A 2017-08-09 2018-08-08 Cd8結合物質 Active JP7347899B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023103640A JP2023112153A (ja) 2017-08-09 2023-06-23 Cd8結合物質
JP2025076447A JP2025109736A (ja) 2017-08-09 2025-05-01 Cd8結合物質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762542920P 2017-08-09 2017-08-09
US62/542,920 2017-08-09
PCT/US2018/045741 WO2019032661A1 (en) 2017-08-09 2018-08-08 CD8 LIAISON AGENTS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023103640A Division JP2023112153A (ja) 2017-08-09 2023-06-23 Cd8結合物質

Publications (3)

Publication Number Publication Date
JP2020530299A JP2020530299A (ja) 2020-10-22
JP2020530299A5 true JP2020530299A5 (https=) 2021-09-16
JP7347899B2 JP7347899B2 (ja) 2023-09-20

Family

ID=65272669

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020507586A Active JP7347899B2 (ja) 2017-08-09 2018-08-08 Cd8結合物質
JP2023103640A Pending JP2023112153A (ja) 2017-08-09 2023-06-23 Cd8結合物質
JP2025076447A Pending JP2025109736A (ja) 2017-08-09 2025-05-01 Cd8結合物質

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023103640A Pending JP2023112153A (ja) 2017-08-09 2023-06-23 Cd8結合物質
JP2025076447A Pending JP2025109736A (ja) 2017-08-09 2025-05-01 Cd8結合物質

Country Status (6)

Country Link
US (2) US11566072B2 (https=)
EP (1) EP3665201A4 (https=)
JP (3) JP7347899B2 (https=)
CN (1) CN111511763B (https=)
CA (1) CA3069930A1 (https=)
WO (1) WO2019032661A1 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150131208A (ko) 2013-03-13 2015-11-24 이미지냅 인코포레이티드 Cd8에의 항원 결합 구조체들
US11254744B2 (en) 2015-08-07 2022-02-22 Imaginab, Inc. Antigen binding constructs to target molecules
EP3455245A2 (en) * 2016-05-13 2019-03-20 Orionis Biosciences NV Therapeutic targeting of non-cellular structures
EP3596108A4 (en) 2017-03-15 2020-12-23 Pandion Operations, Inc. TARGETED IMMUNOTOLERANCE
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
CN111511763B (zh) * 2017-08-09 2024-05-31 奥里尼斯生物科学有限公司 Cd8结合剂
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
KR102877915B1 (ko) 2018-02-05 2025-10-29 오리오니스 바이오사이언시즈 인코포레이티드 섬유아세포 결합제 및 이의 용도
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
JP7773372B2 (ja) 2019-03-28 2025-11-19 オリオニス バイオサイエンシズ,インコーポレイテッド 線維芽細胞活性化タンパク質結合物質およびその使用
US12351614B2 (en) 2019-03-28 2025-07-08 Orionis Biosciences, Inc. CLEC9A-based chimeric protein complexes
US11440943B2 (en) 2019-03-28 2022-09-13 Orionis Biosciences, Inc. Therapeutic interferon alpha 1 proteins
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
BR112021023345A2 (pt) 2019-05-20 2022-02-01 Pandion Operations Inc Imunotolerância com alvo em madcam
WO2020239945A1 (en) 2019-05-28 2020-12-03 Vib Vzw Cancer treatment by targeting plexins in the immune compartment
EP3980051A4 (en) * 2019-06-05 2023-09-13 Asher Biotherapeutics, Inc. FUSIONS OF MUTANT INTERLEUKIN-2 POLYPEPTIDES WITH ANTIGEN-BINDING MOLECULES TO MODULATE THE FUNCTION OF IMMUNE CELLS
TWI873176B (zh) * 2019-09-04 2025-02-21 美商建南德克公司 Cd8結合劑及其用途
EP4041297A4 (en) * 2019-10-11 2024-02-28 The Trustees of The University of Pennsylvania COMPOSITIONS AND METHODS FOR TARGETING CD13 AND TIM-3 WITH CAR-T CELLS FOR TREATING ACUTE MYELOID LEUKEMIA
US20230242655A1 (en) 2019-12-03 2023-08-03 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
EP4107187A4 (en) 2020-02-21 2024-07-03 Pandion Operations, Inc. TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR
WO2022011005A1 (en) * 2020-07-07 2022-01-13 Orionis Biosciences, Inc. Immunostimulatory adjuvants
CN116723857A (zh) * 2020-07-21 2023-09-08 苏州智核生物医药科技有限公司 Cd8结合多肽及其用途
JP2023541601A (ja) 2020-09-10 2023-10-03 プレシリックス・ナームローゼ・ベンノートシヤープ Fapに対する抗体フラグメント
WO2022063957A1 (en) 2020-09-24 2022-03-31 Vib Vzw Biomarker for anti-tumor therapy
MX2023008081A (es) 2021-01-11 2023-09-12 Sana Biotechnology Inc Uso de vectores virales dirigidos a cd8.
EP4288455A1 (en) 2021-02-03 2023-12-13 Mozart Therapeutics, Inc. Binding agents and methods of using the same
IL308609A (en) 2021-05-19 2024-01-01 Asher Biotherapeutics Inc IL-21 polypeptides and target constructs
CN114230665B (zh) * 2021-06-23 2024-03-22 苏州智核生物医药科技有限公司 CD8α结合多肽及其用途
WO2023076876A1 (en) * 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
WO2023114949A1 (en) 2021-12-16 2023-06-22 Sana Biotechnology, Inc. Methods and systems of particle production
IL313877A (en) * 2021-12-29 2024-08-01 Univ Rutgers Antibodies with high affinity to a single site and methods of using them
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023150647A1 (en) 2022-02-02 2023-08-10 Sana Biotechnology, Inc. Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
AU2023264245A1 (en) 2022-05-02 2024-12-19 Precirix N.V. Pre-targeting
CN115927342B (zh) * 2022-07-08 2025-09-23 新疆医科大学 特异识别CD8α分子的高亲和力核酸适配体
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
US20260055146A1 (en) 2022-08-24 2026-02-26 Sana Biotechnology, Inc. Delivery of heterologous proteins
WO2024064838A1 (en) 2022-09-21 2024-03-28 Sana Biotechnology, Inc. Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024156881A1 (en) * 2023-01-27 2024-08-02 Vib Vzw CD8b-BINDING POLYPEPTIDES
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
EP4716750A1 (en) 2023-05-23 2026-04-01 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69007975T2 (de) 1989-08-22 1994-07-21 Immunex Corp Fusionsprotein bestehend aus gm-csf und il-3.
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5914254A (en) 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
WO2000055305A1 (en) 1999-03-12 2000-09-21 Ortho-Mcneil Pharmaceutical, Inc. Method of isolating cd8+ cells, and related hybridoma cells, antibodies and polypeptides
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
US20110020273A1 (en) 2005-04-06 2011-01-27 Ibc Pharmaceuticals, Inc. Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof
EP1812038A1 (en) 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domain as leptin receptor antagonists
WO2006115800A2 (en) 2005-04-15 2006-11-02 The Regents Of The University Of California Enhanced wound healing utilizing an anti-her2 antibody coupled to a tnf alpha
US20080038224A1 (en) * 2006-03-28 2008-02-14 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
NZ573646A (en) * 2006-06-12 2012-04-27 Wyeth Llc Single-chain multivalent binding proteins with effector function
US7947265B2 (en) 2006-08-02 2011-05-24 Mcgill University Fusion proteins and methods for modulation of immune response
WO2008124086A2 (en) 2007-04-05 2008-10-16 President And Fellows Of Harvard College Chimeric activators: quantitatively designed protein therapeutics and uses thereof
WO2009003145A1 (en) 2007-06-26 2008-12-31 University Of Miami Antibody-endostatin fusion protein and its variants
GB0805159D0 (en) 2008-03-19 2008-04-23 Sancho Madrid David Immune modulation via C-type lectin
CN101868246A (zh) 2007-09-21 2010-10-20 加利福尼亚大学董事会 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性
WO2010030671A1 (en) 2008-09-09 2010-03-18 University Of Medicine And Dentistry Of New Jersey Type i interferon antagonists
US8334101B2 (en) 2008-09-26 2012-12-18 University Of Massachusetts Intracellular DNA receptor
WO2010066740A1 (en) 2008-12-08 2010-06-17 Complix Nv Single-chain antiparallel coiled coil proteins
JP5764127B2 (ja) 2009-08-17 2015-08-12 ロシュ グリクアート アーゲー 標的化イムノコンジュゲート
JP2013504539A (ja) 2009-09-10 2013-02-07 サイトス バイオテクノロジー アーゲー 糖尿病治療におけるインターロイキン1βムテイン・コンジュゲートの使用
ES2993140T3 (en) * 2010-04-02 2024-12-23 Amunix Pharmaceuticals Inc Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
GB201014715D0 (en) * 2010-09-06 2010-10-20 Vib Vzw Nanobodies stabilizing functional conformational states of GPCRS
RU2577299C2 (ru) 2011-07-04 2016-03-10 Олег Ильич Эпштейн Способ лечения инфекционных заболеваний и комплексное лекарственное средство для лечения инфекционных заболеваний
US9534056B2 (en) 2011-06-06 2017-01-03 Immungene Inc Engineered TAA antibody-TNFSF member ligand fusion molecules
WO2013053008A2 (en) 2011-10-14 2013-04-18 The Walter And Eliza Hall Institute Of Medical Research Molecules which bind clec9a
EP3559049B1 (en) 2011-10-28 2025-06-11 Teva Pharmaceuticals Australia Pty Ltd Polypeptide constructs and uses thereof
ES2694180T3 (es) 2012-01-20 2018-12-18 Vib Vzw Citocinas de haz alfa-helicoidal mutantes dirigidas
PT2822575T (pt) 2012-03-03 2020-07-02 Immungene Inc Moléculas de fusão anticorpos-mutante de interferão modificadas
CN104379169A (zh) * 2012-08-14 2015-02-25 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体
US10101324B2 (en) * 2012-12-03 2018-10-16 The Regents Of The University Of California Non-competitive immunoassays to detect small molecules using nanopeptamers
US20150368339A1 (en) 2013-02-05 2015-12-24 Vib Vzw Muscarinic acetylcholine receptor binding agents and uses thereof
KR20150131208A (ko) 2013-03-13 2015-11-24 이미지냅 인코포레이티드 Cd8에의 항원 결합 구조체들
KR102322510B1 (ko) 2013-07-18 2021-11-08 브이아이비 브이지더블유 수용체 결합친화성이 현격히 감소된 사이토카인을 수반하는 푸소카인
JP6595988B2 (ja) 2013-07-19 2019-10-23 ヴィブ ブイゼットダブリュー ターゲットされる修飾tnfファミリーメンバー
SG10202010429YA (en) 2013-07-19 2020-11-27 Vib Vzw Targeting of cytokine antagonists
BR112016001128A2 (pt) 2013-07-19 2018-01-23 Vib Vzw membros da família il-1 modificados direcionados
PT3444271T (pt) 2013-08-08 2022-01-05 Inst Nat Sante Rech Med Modulocinas baseadas em il-15 e no domínio sushi de il-15ralfa
UA119352C2 (uk) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
WO2017077382A1 (en) 2015-11-06 2017-05-11 Orionis Biosciences Nv Bi-functional chimeric proteins and uses thereof
CN116769054A (zh) 2016-02-05 2023-09-19 奥里尼斯生物科学私人有限公司 双特异性信号传导剂及其用途
WO2017194783A1 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Targeted mutant interferon-beta and uses thereof
EP3455245A2 (en) 2016-05-13 2019-03-20 Orionis Biosciences NV Therapeutic targeting of non-cellular structures
WO2018077893A1 (en) * 2016-10-24 2018-05-03 Orionis Biosciences Nv Targeted mutant interferon-gamma and uses thereof
CN110573172A (zh) 2017-02-06 2019-12-13 奥里尼斯生物科学有限公司 靶向的工程化干扰素及其用途
KR102642385B1 (ko) 2017-02-06 2024-03-04 오리오니스 바이오사이언시스 엔브이 표적화된 키메라 단백질 및 이의 용도
WO2018146074A1 (en) 2017-02-07 2018-08-16 Vib Vzw Immune-cell targeted bispecific chimeric proteins and uses thereof
CN111511763B (zh) * 2017-08-09 2024-05-31 奥里尼斯生物科学有限公司 Cd8结合剂

Similar Documents

Publication Publication Date Title
JP2020530299A5 (https=)
JP7744479B2 (ja) 抗ヒトパピローマウイルス16 e7 t細胞受容体
JP2020506727A5 (https=)
Bielamowicz et al. Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma
JP2020530298A5 (https=)
JP7656401B2 (ja) バイシストロン性キメラ抗原受容体及びそれらの使用
Andreu-Saumell et al. CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition
US10738116B2 (en) Dual specific anti-CD22-anti-CD19 chimeric antigen receptors
US10562952B2 (en) Anti-CD276 chimeric antigen receptors
JP2020505955A5 (https=)
JP6449359B2 (ja) 免疫原性の低いt細胞及び/又はb細胞エピトープを有するシュードモナス外毒素a
JP6901493B2 (ja) 抗bcmaポリペプチド及びタンパク質
JP2019534246A5 (https=)
JP2024500847A5 (https=)
JP2023546725A5 (https=)
JP2024037918A (ja) 抗cd19免疫療法によりがんを処置するための組成物および方法
CN113862292A (zh) 嵌合抗原受体、组合物以及方法
CN108463469B (zh) 一种与抗可替宁抗体连接的嵌合抗原受体及其用途
US20160333422A1 (en) Anti-ny-br-1 polypeptides, proteins, and chimeric antigen receptors
CN114364801A (zh) 用于用抗bcma免疫治疗来治疗癌症的组合物和方法
JP2022512541A5 (https=)
JP2020516681A5 (https=)
Siegemund et al. IgG-single-chain TRAIL fusion proteins for tumour therapy
CN103965363A (zh) 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途
CA3232668A1 (en) Switch receptors using il-9 signaling domains