JP2020526483A - 心筋節活性化剤で心不全を治療する方法 - Google Patents

心筋節活性化剤で心不全を治療する方法 Download PDF

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JP2020526483A
JP2020526483A JP2019570045A JP2019570045A JP2020526483A JP 2020526483 A JP2020526483 A JP 2020526483A JP 2019570045 A JP2019570045 A JP 2019570045A JP 2019570045 A JP2019570045 A JP 2019570045A JP 2020526483 A JP2020526483 A JP 2020526483A
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JP2020526483A5 (cg-RX-API-DMAC10.html
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オナールプール，ナリモン
ファディ，マリク
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Cytokinetics Inc
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Priority to JP2025121073A priority patent/JP2025165979A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019570045A 2017-06-30 2018-06-29 心筋節活性化剤で心不全を治療する方法 Pending JP2020526483A (ja)

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JP2023040600A JP2023088944A (ja) 2017-06-30 2023-03-15 心筋節活性化剤で心不全を治療する方法
JP2025121073A JP2025165979A (ja) 2017-06-30 2025-07-18 心筋節活性化剤で心不全を治療する方法

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US201762527983P 2017-06-30 2017-06-30
US62/527,983 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

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JP2022535195A (ja) * 2019-05-19 2022-08-05 マイオカーディア，インク 収縮不全の処置
JP2023088944A (ja) * 2017-06-30 2023-06-27 アムジエン・インコーポレーテツド 心筋節活性化剤で心不全を治療する方法
JP2024500616A (ja) * 2020-11-12 2024-01-10 アムジェン インコーポレイテッド オメカムチブメカルビルの投与により心不全を処置する方法

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EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
MX2022000498A (es) 2019-07-17 2022-02-03 Cytokinetics Inc Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.
WO2021163172A1 (en) * 2020-02-10 2021-08-19 Amgen Inc. Omecamtiv mecarbil tablet
JP7832128B2 (ja) * 2020-06-15 2026-03-17 マイオカーディア，インク 心房機能不全の治療
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
AU2022232919A1 (en) 2021-03-10 2023-10-19 Amgen Inc. Synthesis of omecamtiv mecarbil
WO2023164452A2 (en) * 2022-02-22 2023-08-31 Yale University Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth
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WO2024081611A1 (en) * 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
JP7858148B1 (ja) 2023-03-27 2026-05-13 エッジワイズ セラピューティクス， インコーポレイテッド キナゾリンジオン化合物およびその使用
KR20250174911A (ko) 2023-03-27 2025-12-15 엣지와이즈 테라퓨틱스, 인크. 퀴놀리논 아미드 화합물 및 이의 용도
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
WO2026050494A1 (en) 2024-08-29 2026-03-05 Cytokinetics, Incorporated Omecamtiv mecarbil for use in treating heart failure by activating cardiac sarcomere

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Cited By (5)

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Publication number Priority date Publication date Assignee Title
JP2023088944A (ja) * 2017-06-30 2023-06-27 アムジエン・インコーポレーテツド 心筋節活性化剤で心不全を治療する方法
US12295952B2 (en) 2017-06-30 2025-05-13 Cytokinetics, Inc. Methods of treating heart failure with cardiac sarcomere activators
JP2022535195A (ja) * 2019-05-19 2022-08-05 マイオカーディア，インク 収縮不全の処置
JP2024500616A (ja) * 2020-11-12 2024-01-10 アムジェン インコーポレイテッド オメカムチブメカルビルの投与により心不全を処置する方法
US12194039B2 (en) 2020-11-12 2025-01-14 Amgen Inc Methods of treating heart failure by administering omecamtiv mecarbil

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MD3645002T2 (ro) 2025-04-30
CN110996953A (zh) 2020-04-10
MA49508B1 (fr) 2024-12-31
US11931358B2 (en) 2024-03-19
CA3068588A1 (en) 2019-01-03
HUE069805T2 (hu) 2025-04-28
FI3645002T3 (fi) 2025-01-29
US20230149394A1 (en) 2023-05-18
MX2020000190A (es) 2020-07-22
MA49508A (fr) 2020-05-06
US20230355615A1 (en) 2023-11-09
RS66581B1 (sr) 2025-04-30
PT3645002T (pt) 2025-01-24
EP3645002B1 (en) 2024-10-30
ES3008457T3 (en) 2025-03-24
AU2018290983A1 (en) 2020-01-23
BR112019028046A2 (pt) 2020-07-07
DK3645002T3 (da) 2024-12-16
US11576910B2 (en) 2023-02-14
LT3645002T (lt) 2025-02-10
SMT202500067T1 (it) 2025-03-12
EP3645002A1 (en) 2020-05-06
EP4512470A3 (en) 2025-04-23
AU2024200991A1 (en) 2024-03-07
SI3645002T1 (sl) 2025-03-31
US12295952B2 (en) 2025-05-13
US20250255862A1 (en) 2025-08-14
EP4512470A2 (en) 2025-02-26
US20200155547A1 (en) 2020-05-21
WO2019006235A1 (en) 2019-01-03
AU2018290983B2 (en) 2023-11-23
MX2022015115A (es) 2023-01-18
AU2024200991B2 (en) 2025-04-10
JP2025165979A (ja) 2025-11-05
HRP20241729T1 (hr) 2025-03-14
PL3645002T3 (pl) 2025-03-24
JP2023088944A (ja) 2023-06-27

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